Aromatase regulation of paternal behavior and aggression

  • Trainor, Brian C (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant): Many of the behavioral effects of
testosterone occur after conversion to estradiol by the aromatase enzyme.
Although there has been interest in the role of aromatase as a regulator of
male mating behavior, relatively little research has considered whether
aromatase regulates other social behaviors. This application proposes to
examine how aromatase mediates the effects of testosterone on paternal behavior
and inter-male aggression in the monogamous California mouse, a species in
which males show high levels of both paternal behavior and aggression. First,
the proposed research will test whether the positive effect of testosterone on
paternal behavior in this species occurs through conversion to estradiol.
Second, this research will examine whether increased testosterone after winning
an aggressive encounter increases aggression, and whether aromatase mediates
such an effect. Finally, this research will determine if central aromatase
activity is correlated with paternal and aggressive experience. Understanding
how aromatase modulates behavioral effects of T has potentially important
implications both for our understanding of the neuroendocrine control of
mammalian social behavior and for human health. Testosterone replacement
therapy in humans is becoming increasingly common, and most studies restrict
behavioral analyses to sexual functions, mood, and cognition. In summary, this
proposal examines how aromatase mediates the effects of testosterone and social
Effective start/end date7/1/015/30/03


  • National Institutes of Health: $22,296.00
  • National Institutes of Health: $22,689.00


  • Medicine(all)


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