Project Details
Description
The contract will use the mouse model to address 1) the susceptibility to
persistent infection following intradermal low-dose inoculation; 2)
sequential immune response to tissue adapted spirochete antigens; 3)
kinetics of spirochate growth in target tissues using quantitative PCR and
4) mRNA expression of spirochetes. The experiments will characterize the
model for chronic infection and answer questions about mechanisms of
persistence in the unaltered, immunologically responsive host.
persistent infection following intradermal low-dose inoculation; 2)
sequential immune response to tissue adapted spirochete antigens; 3)
kinetics of spirochate growth in target tissues using quantitative PCR and
4) mRNA expression of spirochetes. The experiments will characterize the
model for chronic infection and answer questions about mechanisms of
persistence in the unaltered, immunologically responsive host.
| Status | Finished |
|---|---|
| Effective start/end date | 9/30/94 → 3/31/00 |
Funding
- National Institutes of Health
- National Institutes of Health
- National Institutes of Health
- National Institutes of Health
ASJC
- Medicine(all)
- Immunology and Microbiology(all)
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