ANIMAL MODELS FOR CHRONIC LYME DISEASE

Project: Research project

Project Details

Description

The contract will use the mouse model to address 1) the susceptibility to
persistent infection following intradermal low-dose inoculation; 2)
sequential immune response to tissue adapted spirochete antigens; 3)
kinetics of spirochate growth in target tissues using quantitative PCR and
4) mRNA expression of spirochetes. The experiments will characterize the
model for chronic infection and answer questions about mechanisms of
persistence in the unaltered, immunologically responsive host.
StatusFinished
Effective start/end date9/30/943/31/00

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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