ANIMAL MODEL OF NEUROPSYCHIATRIC DISORDERS

Project: Research project

Project Details

Description

In situ hybridization analysis of mRNAs for tyrosine hydroxylase,
cholecystokinin, enkephalin, the D-1 and D-2 dopamine receptor subtypes,
and the dopamine transporter, in brains from rats treated neonatally with
cocaine, are almost completed. No difference between cocaine treatment
and dietary controls has been seen in mRNA concentrations in the ventral
tegmentum, substantia nigra, caudate nucleus, or nucleus accumbens, for
TH, CCK, ENK, D-1, or D-2 mRNAs. Dr. de Bartolomeis has recently
developed a new oligonucleotide probe for the dopamine transporter, which
he has characterized for specificity, and is now quantitating in the
prenatal cocaine experiment.
StatusNot started

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,776,673.00
  • National Institutes of Health
  • National Institutes of Health: $1,769,941.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,835,912.00
  • National Institutes of Health
  • National Institutes of Health: $1,862,667.00
  • National Institutes of Health: $1,537,274.00
  • National Institutes of Health: $974,415.00
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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