Project: Research project

Project Details


The main objective of this program project is to determine how structural
changes in the cerebral vasculature affect brain function and behavior
in elderly persons. The knowledge and understanding obtained from this
project is intended to provide a solid base for developing effective
treatment for highly prevalent and clinically significant disorders.
Various changes in the cerebral vasculature (atherosclerosis,
arteriosclerosis, amyloid angiopathy) will be systematically quantified
in Project 4. The pathophysiology of chronic ischemia, which may play
a particularly important role in persons with slowly progressive
cognitive decline, will be examined in project 3. The metabolic,
physiologic, and behavioral correlates of lacunar infarction and deep
white matter changes will be investigated in projects 1, 2, and 3.
Finally, questions related to natural history, clinico-pathologic
correlation and diagnosis are addressed jointly by three Cores. The relationship between vasculature, ischemia, and behavior is complex;
understanding requires a comprehensive inter-disciplinary approach. The
program project represents a multi-institutional collaborative effort
involving investigators at the University of Southern California and the
University of California at Irvine, Los Angeles, San Francisco and Davis.
Clinical recruitment and longitudinal follow-up will take place at 6
Alzheimer Disease Diagnostic and Treatment Centers (ADDTC) supported by
the State of California. Whenever possible, provisions have been made
to share resources (such as patients, protocols, data, and tissues)
across the program. From both a thematic and logistical standpoints, we
have attempted to create a highly-cohesive and cost-effective research
Effective start/end date9/30/945/31/15


  • National Institutes of Health


  • Medicine(all)


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