• 9322 Citations
  • 51 h-Index
1991 …2021
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Research Output 1991 2019

  • 9322 Citations
  • 51 h-Index
  • 159 Article
  • 1 Comment/debate
  • 1 Review article
2019

A POLH transcript with a short 30UTR enhances POLH expression and mediates cisplatin resistance

Zhang, J., Sun, W., Ren, C., Kong, X., Yan, W. & Chen, X., Jan 1 2019, In : Cancer Research. 79, 14, p. 3714-3724 11 p.

Research output: Contribution to journalArticle

Cisplatin
Polyadenylation
Urinary Bladder Neoplasms
Lung Neoplasms
DNA
1 Citation (Scopus)

Disruption of the RBM38-eIF4E complex with a synthetic peptide PEP8 increases p53 expression

Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X., Feb 15 2019, In : Cancer Research. 79, 4, p. 807-818 12 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Peptides
Neoplasms
RNA-Binding Proteins

Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis

Zhang, Y., Feng, X., Zhang, J., Chen, M., Huang, E. & Chen, X., Aug 29 2019, In : Oncogene. 38, 35, p. 6256-6269 14 p.

Research output: Contribution to journalArticle

Iron Regulatory Protein 2
Carcinogenesis
Iron
Neoplasms
Growth
Phosphorylation
RNA-Binding Proteins
Serine
RNA Stability
Fibroblasts
2018

Clusterin, a novel DEC1 target, modulates DNA damage-mediated cell death

Ming, X., Bao, C., Hong, T., Yang, Y., Chen, X., Jung, Y. S. & Qian, Y., Nov 1 2018, In : Molecular Cancer Research. 16, 11, p. 1641-1651 11 p.

Research output: Contribution to journalArticle

Clusterin
DNA Damage
Cell Death
Breast Neoplasms
Genes
4 Citations (Scopus)

Genetic ablation of Rbm38 promotes lymphomagenesis in the context of mutant p53 by downregulating PTEN

Zhang, J., Xu, E., Ren, C., Yang, H. J., Zhang, Y., Sun, W., Kong, X., Zhang, W., Chen, M., Huang, E. C. & Chen, X., Mar 15 2018, In : Cancer Research. 78, 6, p. 1511-1521 11 p.

Research output: Contribution to journalArticle

Down-Regulation
T-Lymphocytes
Neoplasms
RNA-Binding Proteins
AU Rich Elements
4 Citations (Scopus)

p53 tumor suppressor and iron homeostasis

Zhang, J. & Chen, X., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Tumors
Homeostasis
Iron
Neoplasms
Biochemical Phenomena
4 Citations (Scopus)

Rbm24, a target of p53, is necessary for proper expression of p53 and heart development

Zhang, M., Zhang, Y., Xu, E., Mohibi, S., de Anda, D. M., Jiang, Y., Zhang, J. & Chen, X., Jan 22 2018, (Accepted/In press) In : Cell Death and Differentiation. p. 1-13 13 p.

Research output: Contribution to journalArticle

Apoptosis
Endocardial Cushion Defects
Heart Failure
Peptide Initiation Factors
Messenger RNA
1 Citation (Scopus)

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity

Jiang, Y., Xu, E., Zhang, J., Chen, M., Flores, E. & Chen, X., Mar 9 2018, (Accepted/In press) In : Oncogene. p. 1-10 10 p.

Research output: Contribution to journalArticle

Neoplasms
RNA-Binding Proteins
Cell Aging
RNA Stability
Fatty Liver
2017
8 Citations (Scopus)

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2

Zhang, Y., Qian, Y., Zhang, J., Yan, W., Jung, Y. S., Chen, M., Huang, E. C., Lloyd, K. C. K., Duan, Y., Wang, J., Liu, G. & Chen, X., Jun 15 2017, In : Genes and Development. 31, 12, p. 1243-1256 14 p.

Research output: Contribution to journalArticle

Iron Regulatory Protein 2
Ferredoxins
Oxidoreductases
Neoplasms
Iron
4 Citations (Scopus)

Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner

Yang, H. J., Zhang, J., Yan, W., Cho, S. J., Lucchesi, C., Chen, M., Huang, E. C., Scoumanne, A., Zhang, W. & Chen, X., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. 11500-11505 6 p.

Research output: Contribution to journalArticle

Carcinogenesis
Wounds and Injuries
Proteins
Protein Deficiency
Neoplasms
4 Citations (Scopus)

TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression

Yan, W., Zhang, Y. & Chen, X., 2017, In : Oncotarget. 8, 45, p. 78327-78339 13 p.

Research output: Contribution to journalArticle

RNA Stability
3' Untranslated Regions
Protein Isoforms
Growth
Cell Movement
2016

A new function for p53 tetramerization domain in cell fate control

Zhang, J., Lucchesi, C. & Chen, X., Nov 1 2016, In : Cell Cycle. 15, 21, p. 2854-2855 2 p.

Research output: Contribution to journalComment/debate

Acetylation
Cell Cycle Checkpoints
Apoptosis
5 Citations (Scopus)

Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation

Yan, W., Scoumanne, A., Jung, Y. S., Xu, E., Zhang, J., Zhang, Y., Ren, C., Sun, P. & Chen, X., Mar 1 2016, In : Genes and Development. 30, 5, p. 522-534 13 p.

Research output: Contribution to journalArticle

Poly C
Carrier Proteins
Neoplasms
Embryonic Structures
Fibroblasts
2 Citations (Scopus)

Modulation of the p53 family network by RNA-binding proteins

Lucchesi, C., Zhang, J. & Chen, X., 2016, In : Translational Cancer Research. 5, 6, p. 676-684 9 p.

Research output: Contribution to journalReview article

RNA-Binding Proteins
Neoplasms
Autophagy
Post Translational Protein Processing
Cell Cycle Checkpoints
5 Citations (Scopus)

p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

Zhang, M., Zhang, J., Yan, W. & Chen, X., 2016, In : Oncotarget. 7, 48, p. 78255-78268 14 p.

Research output: Contribution to journalArticle

Protein Stability
Ribosomal Proteins
RNA Stability
Protein Biosynthesis
3' Untranslated Regions
4 Citations (Scopus)

RNA-binding protein PCBP2 regulates p73 expression and p73-dependent antioxidant defense

Ren, C., Zhang, J., Yan, W., Zhang, Y. & Chen, X., Apr 29 2016, In : Journal of Biological Chemistry. 291, 18, p. 9629-9637 9 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Reactive Oxygen Species
Antioxidants
Cell Aging
RNA Stability
7 Citations (Scopus)

Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy

Wang, J., Wang, H., Wang, L. Y., Cai, D., Duan, Z., Zhang, Y., Chen, P., Zou, J. X., Xu, J., Chen, X., Kung, H-J. & Chen, H., Sep 9 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Epigenomics
Neoplasms
Death Domain Receptors
Therapeutics
Cell Death
2015
48 Citations (Scopus)

Companion animals: Translational scientist's new best friends

Kol, A., Arzi, B., Athanasiou, K. A., Farmer, D. L., Nolta, J., Rebhun, R. B., Chen, X., Griffiths, L. G., Verstraete, F. J., Murphy, C. J. & Borjesson, D. L., Oct 7 2015, In : Science Translational Medicine. 7, 308, 308ps21.

Research output: Contribution to journalArticle

Pets
Clinical Trials
Translational Medical Research
Veterinary Medicine
Animal Models
9 Citations (Scopus)

Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, via mRNA translation

Cho, S. J., Teng, I. F., Zhang, M., Yin, T., Jung, Y. S., Zhang, J. & Chen, X., 2015, In : Oncotarget. 6, 1, p. 305-316 12 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Protein Biosynthesis
Proteins
3' Untranslated Regions
Prolyl Hydroxylases
6 Citations (Scopus)
Madin Darby Canine Kidney Cells
Epithelial-Mesenchymal Transition
Morphogenesis
Cell Movement
Neoplasms
8 Citations (Scopus)

PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38

Zhang, M., Xu, E., Zhang, J. & Chen, X., Nov 26 2015, In : Oncogene. 34, 48, p. 5900-5901 2 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
3' Untranslated Regions
Serine
Messenger RNA
Reporter Genes
2 Citations (Scopus)

PPM1D regulates p21 expression via dephoshporylation at serine 123

Cao, R., Zhang, J., Zhang, M. & Chen, X., Feb 15 2015, In : Cell Cycle. 14, 4, p. 641-647 7 p.

Research output: Contribution to journalArticle

Serine
Dogs
Phosphoric Monoester Hydrolases
Cyclin-Dependent Kinase Inhibitor p21
Cyclin B
2014
10 Citations (Scopus)

Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase

Yan, W., Jung, Y. S., Zhang, Y. & Chen, X., Aug 12 2014, In : PLoS One. 9, 8, e103497.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
Mutant Proteins
arsenic
5 Citations (Scopus)

Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer

Qiu, J., Wang, X., Meng, X., Zheng, Y., Li, G., Ma, J., Ye, G., Li, Y., Li, J. & Chen, X., Dec 23 2014, In : PLoS One. 9, 12, e115224.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Genes
Smoking
Recurrence
Defects
18 Citations (Scopus)

DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression

Qian, Y., Zhang, J., Jung, Y. S. & Chen, X., Jan 3 2014, In : PLoS One. 9, 1, e84015.

Research output: Contribution to journalArticle

Transcription
Tumors
Protein Isoforms
Chemical activation
Cells
11 Citations (Scopus)

DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability

Ren, C., Cho, S. J., Jung, Y. S. & Chen, X., Dec 15 2014, In : Biochemical Journal. 464, p. 377-386 10 p.

Research output: Contribution to journalArticle

AU Rich Elements
RNA Stability
DNA-Directed DNA Polymerase
Carrier Proteins
Messenger RNA
22 Citations (Scopus)
RNA-Binding Proteins
Neoplasms
Protein Deficiency
Ionizing Radiation
RNA-Binding Motifs
14 Citations (Scopus)

P63 regulates tubular formation via epithelial-to-mesenchymal transition

Zhang, Y., Yan, W. & Chen, X., Mar 20 2014, In : Oncogene. 33, 12, p. 1548-1557 10 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Down-Regulation
Madin Darby Canine Kidney Cells
Cell Movement
Cysts
23 Citations (Scopus)

Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability

Jiang, Y., Zhang, M., Qian, Y., Xu, E., Zhang, J. & Chen, X., Feb 7 2014, In : Journal of Biological Chemistry. 289, 6, p. 3164-3175 12 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
RNA Stability
3' Untranslated Regions
Genes
Cell Cycle Checkpoints
16 Citations (Scopus)

RNA-binding protein RBM24 regulates p63 expression via mRNA stability

Xu, E., Zhang, J., Zhang, M., Jiang, Y., Cho, S. J. & Chen, X., 2014, In : Molecular Cancer Research. 12, 3, p. 359-369 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
RNA Stability
3' Untranslated Regions
Carcinogenesis
Proteins
2013
13 Citations (Scopus)

Arsenic suppresses cell survival via pirh2-mediated proteasomal degradation of ΔNp63 protein

Yan, W., Chen, X., Zhang, Y., Zhang, J., Jung, Y. S. & Chen, X., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 2907-2913 7 p.

Research output: Contribution to journalArticle

Arsenic
Proteolysis
Cell Survival
Cells
Tumors
1 Citation (Scopus)

Corrigendum to "Development and characterization of 5 canine B-cell lymphoma cell lines" [Leuk. Res. 36(5) (2011) 601-606]

Zwingenberger, A., Vernau, W., Sh, C., Yan, W., Chen, X., Gordon, I. K. & Kent, M. S., Jan 2013, In : Leukemia Research. 37, 1, p. 120 1 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Canidae
Cell Line
corrigendum
65 Citations (Scopus)

Functional p53 determines docetaxel sensitivity in prostate cancer cells

Liu, C., Zhu, Y., Lou, W., Nadiminty, N., Chen, X., Zhou, Q., Shi, X. B., deVere White, R. W. & Gao, A. C., Mar 2013, In : Prostate. 73, 4, p. 418-427 10 p.

Research output: Contribution to journalArticle

docetaxel
Prostatic Neoplasms
Phosphorylation
Small Interfering RNA
30 Citations (Scopus)

Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1

Zhang, M., Zhang, J., Chen, X., Cho, S. J. & Chen, X., Oct 15 2013, In : Genes and Development. 27, 20, p. 2246-2258 13 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Protein Biosynthesis
Phosphorylation
Phosphatidylinositol 3-Kinase
Messenger RNA
28 Citations (Scopus)

MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability

Xu, E., Zhang, J. & Chen, X., 2013, In : Oncogene. 32, 17, p. 2169-2178 10 p.

Research output: Contribution to journalArticle

AU Rich Elements
RNA-Binding Proteins
RNA Stability
Proto-Oncogene Proteins c-mdm2
Gene Amplification
6 Citations (Scopus)

Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells

Zhang, Y., Yan, W. & Chen, X., Dec 27 2013, In : PLoS One. 8, 12, e85624.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
kidney cells
Cysts
Genes
Proto-Oncogene Proteins c-met
20 Citations (Scopus)

Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality

Cho, S. J., Rossi, A., Jung, Y. S., Yan, W., Liu, G., Zhang, J., Zhang, M. & Chen, X., Jun 4 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9362-9367 6 p.

Research output: Contribution to journalArticle

Cell Aging
Cell Survival
Protein Biosynthesis
Radiation
Apoptosis
25 Citations (Scopus)

Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63

Jung, Y. S., Qian, Y., Yan, W. & Chen, X., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1178-1187 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Keratinocytes
Proteins
Cell proliferation
Post Translational Protein Processing
27 Citations (Scopus)

Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability

Cho, S. J., Jung, Y. S. & Chen, X., Aug 7 2013, In : PLoS One. 8, 8, e71724.

Research output: Contribution to journalArticle

Poly C
RNA Stability
binding proteins
Carrier Proteins
Heterogeneous-Nuclear Ribonucleoproteins
13 Citations (Scopus)

PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition

Zhang, Y., Yan, W., Jung, Y. S. & Chen, X., Jun 21 2013, In : PLoS One. 8, 6, e66464.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Morphogenesis
breasts
morphogenesis
Breast
9 Citations (Scopus)

Regulation of Mdm2 mRNA stability by RNA-binding protein RNPC1

Zhang, J., Xu, E. & Chen, X., 2013, In : Oncotarget. 4, 8, p. 1121-1122 2 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-mdm2
RNA-Binding Proteins
RNA Stability
18 Citations (Scopus)

RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability

Yin, T., Cho, S. J. & Chen, X., Aug 16 2013, In : Journal of Biological Chemistry. 288, 33, p. 23680-23686 7 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 15
RNA-Binding Proteins
RNA Stability
Messenger RNA
Cell growth
45 Citations (Scopus)

Senescence regulation by the p53 protein family.

Qian, Y. & Chen, X., 2013, In : Methods in molecular biology (Clifton, N.J.). 965, p. 37-61 25 p.

Research output: Contribution to journalArticle

Cell Aging
Proteins
Neoplasms
Protein Isoforms
Apoptosis
8 Citations (Scopus)

TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function

Zhang, J., Xu, E. & Chen, X., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7727-7737 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Protein Stability
HSP90 Heat-Shock Proteins
Histone Deacetylases
Proteins
31 Citations (Scopus)

The p53-estrogen receptor loop in cancer

Berger, C., Qian, Y. & Chen, X., Sep 2013, In : Current Molecular Medicine. 13, 8, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Neoplasms
Genes
Genomic Instability
2012
6 Citations (Scopus)

DEC1 and MIC-1: Newplayers of p53-dependent cell fate decision

Qian, Y., Jung, Y. S. & Chen, X., Oct 1 2012, In : Cell Cycle. 11, 19, p. 3525-3526 2 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells

Hertwig, F., Meyer, K., Braun, S., Ek, S., Spang, R., Pfenninger, C. V., Artner, I., Prost, G., Chen, X., Biegel, J. A., Judkins, A. R., Englund, E. & Nuber, U. A., Jul 1 2012, In : Cancer Research. 72, 13, p. 3381-3392 12 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Neural Stem Cells
Brain Neoplasms
Stem Cells
Rhabdoid Tumor
4 Citations (Scopus)

Development and characterization of 5 canine B-cell lymphoma cell lines

Zwingenberger, A., Vernau, W., Shi, C., Yan, W., Chen, X., Gordon, I. K. & Kent, M. S., May 2012, In : Leukemia Research. 36, 5, p. 601-606 6 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Canidae
Cell Line
Lymphoma
Translational Medical Research
24 Citations (Scopus)
Growth Differentiation Factor 15
Chondrocytes
Cell Survival
Cell Death
Embryonic Structures