Xiaosong Jiang, MD; PhD

Associate Adjunct Professor

  • 1066 Citations
  • 16 h-Index
20062019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2006 2019

  • 1066 Citations
  • 16 h-Index
  • 22 Article
  • 1 Conference contribution
  • 1 Review article
Filter
Article
2019

Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation

Zhao, P., Han, S. N., Arumugam, S., Yousaf, M. N., Qin, Y., Jiang, J. X., Torok, N. J., Chen, Y., Mankash, M. S., Liu, J., Li, J., Iwakiri, Y. & Ouyang, X., Oct 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 4, p. G387-G397

Research output: Contribution to journalArticle

Digoxin
Fatty Liver
Transcriptional Activation
Liver
Hypoxia-Inducible Factor 1
2018
16 Citations (Scopus)

Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis

Zhou, Z., Xu, M. J., Cai, Y., Wang, W., Jiang, X., Varga, Z. V., Feng, D., Pacher, P., Kunos, G., Torok, N. J. & Gao, B., Mar 1 2018, In : CMGH. 5, 3, p. 399-413 15 p.

Research output: Contribution to journalArticle

High Fat Diet
Fatty Liver
Cell Communication
Liver Cirrhosis
Hepatic Stellate Cells
5 Citations (Scopus)

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease

Matsumoto, M., Zhang, J., Zhang, X., Liu, J., Jiang, X., Yamaguchi, K., Taruno, A., Katsuyama, M., Iwata, K., Ibi, M., Cui, W., Matsuno, K., Marunaka, Y., Itoh, Y., Torok, N. J. & Yabe-Nishimura, C., Feb 1 2018, In : Free Radical Biology and Medicine. 115, p. 412-420 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Liver
Liver Diseases
Protein Isoforms
Endothelial cells
2017
3 Citations (Scopus)

NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

Sasaki, Y., Dehnad, A., Fish, S., Sato, A., Jiang, X., Tian, J., Schröder, K., Brandes, R. & Torok, N. J., Apr 6 2017, In : Scientific Reports. 7, 46144.

Research output: Contribution to journalArticle

CC Chemokines
Alcoholic Liver Diseases
Chemokine CCL2
Chemokine Receptors
NADPH Oxidase
2016
9 Citations (Scopus)

Galectin-3 regulates inflammasome activation in cholestatic liver injury

Tian, J., Yang, G., Chen, H. Y., Hsu, D. K., Tomilov, A., Olson, K. A., Dehnad, A., Fish, S. R., Cortopassi, G. A., Zhao, B., Liu, F-T., Gershwin, M. E., Torok, N. J. & Jiang, X., Dec 1 2016, In : FASEB Journal. 30, 12, p. 4202-4213 12 p.

Research output: Contribution to journalArticle

Inflammasomes
Galectin 3
Liver
Cholangitis
Chemical activation
2015
18 Citations (Scopus)

Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation

Serizawa, N., Tian, J., Fukada, H., Baghy, K., Scott, F., Chen, X., Kiss, Z., Olson, K. A., Hsu, D., Liu, F-T., Torok, N. J., Zhao, B. & Jiang, X., Oct 1 2015, In : Laboratory Investigation. 95, 10, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Galectin 3
Hepatocellular Carcinoma
Cell Movement
Lectins
Small Interfering RNA
52 Citations (Scopus)

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, X., Sasaki, Y., Chao, T. I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., Szyndralewiez, C., Schröder, K., Shah, A., Brandes, R. P., Haj, F. & Torok, N. J., Aug 1 2015, In : Gastroenterology. 149, 2, p. 468-480.e10

Research output: Contribution to journalArticle

Fatty Liver
NADP
Insulin Resistance
Hepatocytes
Oxidoreductases
46 Citations (Scopus)

The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals

Tian, J., Feng, Y., Fu, H., Xie, H. Q., Jiang, X. & Zhao, B., Jun 16 2015, In : Environmental Science and Technology. 49, 16, p. 9518-9531 14 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
hydrocarbon
Molecules
ligand
Dioxins
2014
2 Citations (Scopus)

MLK3 as a regulator of disease progression in non-alcoholic steatohepatitis

Jiang, X. & Torok, N. J., 2014, In : Liver International. 34, 8, p. 1131-1132 2 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 8
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Fatty Liver
Disease Progression
2013
26 Citations (Scopus)

Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice

Jiang, X., Chen, X., Fukada, H., Serizawa, N., Devaraj, S. & Torok, N. J., Oct 2013, In : Hepatology. 58, 4, p. 1339-1348 10 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Sirtuin 1
Choline
Amino Acids
Adenoviridae
41 Citations (Scopus)

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

Medici, V., Shibata, N. M., Kharbanda, K. K., LaSalle, J. M., Woods, R., Liu, S., Engelberg, J. A., Devaraj, S., Torok, N. J., Jiang, X., Havel, P. J., Lönnerdal, B., Kim, K. & Halsted, C. H., Feb 2013, In : Hepatology. 57, 2, p. 555-565 11 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
DNA Methylation
Methionine
S-Adenosylhomocysteine
Liver Diseases
2012
36 Citations (Scopus)

Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo

Jiang, X., Chen, X., Hsu, D. K., Baghy, K., Serizawa, N., Scott, F., Takada, Y., Takada, Y., Fukada, H., Chen, J., Devaraj, S., Adamson, R., Liu, F-T. & Torok, N. J., Feb 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 4, p. 439-446 8 p.

Research output: Contribution to journalArticle

Galectin 3
Phagocytosis
Liver Cirrhosis
Hepatic Stellate Cells
Cytophagocytosis
16 Citations (Scopus)

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Jung, C. J., Iyengar, S., Blahnik, K. R., Jiang, X., Tahimic, C., Torok, N. J., deVere White, R. W., Farnham, P. J. & Zern, M. A., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 979-991 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
MicroRNAs
Hepatocytes
Neoplasms
Embryonic Stem Cells
136 Citations (Scopus)

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S. & Torok, N. J., Jul 15 2012, In : Free Radical Biology and Medicine. 53, 2, p. 289-296 8 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Liver Cirrhosis
Liver
Hepatocytes
Reactive Oxygen Species
2011
52 Citations (Scopus)

Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation

Jung, C. J., Iyengar, S., Blahnik, K. R., Ajuha, T. P., Jiang, X., Farnham, P. J. & Zern, M. A., Nov 28 2011, In : PLoS One. 6, 11, e27740.

Research output: Contribution to journalArticle

embryonic stem cells
hepatoma
Stem cells
Epigenomics
epigenetics
2010
21 Citations (Scopus)

Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease

Medici, V., Ali, M. R., Seo, S., Aoki, C. A., Rossaro, L., Kim, K., Fuller, W. D., Vidovszky, T. J., Smith, W., Jiang, X., Maganti, K., Havel, P. J., Kamboj, A., Ramsamooj, R. & Torok, N. J., Dec 2010, In : Obesity. 18, 12, p. 2268-2273 6 p.

Research output: Contribution to journalArticle

Leptin Receptors
Leptin
Insulin Resistance
Fasting
Fibrosis
155 Citations (Scopus)
Hepatic Stellate Cells
MicroRNAs
Liver Cirrhosis
Down-Regulation
Extracellular Matrix
79 Citations (Scopus)

Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in Vivo

Jiang, X., Venugopal, S., Serizawa, N., Chen, X., Scott, F., Li, Y., Adamson, R., Devaraj, S., Shah, V., Gershwin, M. E., Friedman, S. L. & Torok, N. J., Oct 2010, In : Gastroenterology. 139, 4

Research output: Contribution to journalArticle

Hepatic Stellate Cells
NADP
Oxidoreductases
Phagocytosis
Liver
2009
83 Citations (Scopus)

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

Jiang, X., Mikami, K., Venugopal, S., Li, Y. & Torok, N. J., Jul 2009, In : Journal of Hepatology. 51, 1, p. 139-148 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Phagocytosis
Apoptosis
Phosphatidylinositol 3-Kinases
Cell Survival
2008
49 Citations (Scopus)

Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a rho guanosine triphosphatase-dependent mechanism

Jiang, X., Mikami, K., Shah, V. H. & Torok, N. J., Nov 2008, In : Hepatology. 48, 5, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Guanosine
Leptin
Phagocytosis
Fatty Liver
37 Citations (Scopus)

Nonalcoholic steatohepatitis and the metabolic syndrome

Jiang, X. & Torok, N. J., Mar 1 2008, In : Metabolic Syndrome and Related Disorders. 6, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Fibrosis
Obesity
End Stage Liver Disease
Lipid Peroxidation
Insulin Resistance
2006
162 Citations (Scopus)

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S. S., Jiang, X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A. & Torok, N. J., Mar 2006, In : Hepatology. 43, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
NADPH Oxidase
Phagocytosis
Liver Cirrhosis
Procollagen