Vladimir Yarov-Yarovoy, PhD; MS

Associate Professor

  • 6031 Citations
  • 35 h-Index
19962020

Research output per year

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Research Output

  • 6031 Citations
  • 35 h-Index
  • 77 Article
  • 1 Editorial
  • 1 Short survey
  • 1 Review article
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Article
1996

Inhibition of the mitochondrial K(ATP) channel by long-chain acyl-CoA esters and activation by guanine nucleotides

Paucek, P., Yarov-Yarovoy, V., Sun, X. & Garlid, K. D., 1996, In : Journal of Biological Chemistry. 271, 50, p. 32084-32088 5 p.

Research output: Contribution to journalArticle

83 Scopus citations

The mitochondrial KATP channel as a receptor for potassium channel openers

Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Sun, X. & Schindler, P. A., Apr 12 1996, In : Journal of Biological Chemistry. 271, 15, p. 8796-8799 4 p.

Research output: Contribution to journalArticle

367 Scopus citations
1997

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels: Possible mechanism of cardioprotection

Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Murray, H. N., Darbenzio, R. B., D'Alonzo, A. J., Lodge, N. J., Smith, M. A. & Grover, G. J., 1997, In : Circulation Research. 81, 6, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

925 Scopus citations

The nucleotide regulatory sites on the mitochondrial K(ATP) channel face the cytosol

Yarov-Yarovoy, V., Paucek, P., Jabůrek, M. & Garlid, K. D., Aug 22 1997, In : Biochimica et Biophysica Acta - Bioenergetics. 1321, 2, p. 128-136 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
1998

State-dependent inhibition of the mitochondrial K(ATP) channel by glyburide and 5-hydroxydecanoate

Jabůrek, M., Yarov-Yarovoy, V., Paucek, P. & Garlid, K. D., May 29 1998, In : Journal of Biological Chemistry. 273, 22, p. 13578-13582 5 p.

Research output: Contribution to journalArticle

224 Scopus citations
2001

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na+ channel α subunit

Yarov-Yarovoy, V., Brown, J., Sharp, E. M., Clare, J. J., Scheuer, T. & Catterall, W. A., Jan 5 2001, In : Journal of Biological Chemistry. 276, 1, p. 20-27 8 p.

Research output: Contribution to journalArticle

200 Scopus citations
2002

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel α subunit in voltage-dependent gating and drug block

Yarov-Yarovoy, V., McPhee, J. C., Idsvoog, D., Pate, C., Scheuer, T. & Catterall, W. A., Sep 20 2002, In : Journal of Biological Chemistry. 277, 38, p. 35393-35401 9 p.

Research output: Contribution to journalArticle

175 Scopus citations
2003

Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels

Liu, G., Yarov-Yarovoy, V., Nobbs, M., Clare, J. J., Scheuer, T. & Catterall, W. A., Mar 2003, In : Neuropharmacology. 44, 3, p. 413-422 10 p.

Research output: Contribution to journalArticle

86 Scopus citations
2004

A gating hinge in Na+ channels: A molecular switch for electrical signaling

Zhao, Y., Yarov-Yarovoy, V., Scheuer, T. & Catterall, W. A., Mar 25 2004, In : Neuron. 41, 6, p. 859-865 7 p.

Research output: Contribution to journalArticle

115 Scopus citations
2005

Overview of molecular relationships in the voltage-gated ion channel superfamily

Yu, F. H., Yarov-Yarovoy, V., Gutman, G. A. & Catterall, W. A., Dec 2005, In : Pharmacological Reviews. 57, 4, p. 387-395 9 p.

Research output: Contribution to journalArticle

306 Scopus citations
2006

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain

Hulme, J. T., Yarov-Yarovoy, V., Lin, T. W. C., Scheuer, T. & Catterall, W. A., Oct 2006, In : Journal of Physiology. 576, 1, p. 87-102 16 p.

Research output: Contribution to journalArticle

127 Scopus citations

Multipass membrane protein structure prediction using Rosetta

Yarov-Yarovoy, V., Schonbrun, J. & Baker, D., Mar 1 2006, In : Proteins: Structure, Function and Genetics. 62, 4, p. 1010-1025 16 p.

Research output: Contribution to journalArticle

244 Scopus citations

Structure and function of the voltage sensor of sodium channels probed by a β-scorpion toxin

Cestèle, S., Yarov-Yarovoy, V., Qu, Y., Sampieri, F., Scheuer, T. & Catterall, W. A., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 21332-21344 13 p.

Research output: Contribution to journalArticle

110 Scopus citations
187 Scopus citations
2007

Closing In on the Resting State of the Shaker K+ Channel

Pathak, M. M., Yarov-Yarovoy, V., Agarwal, G., Roux, B., Barth, P., Kohout, S., Tombola, F. & Isacoff, E. Y., Oct 4 2007, In : Neuron. 56, 1, p. 124-140 17 p.

Research output: Contribution to journalArticle

232 Scopus citations

Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose

Aprikian, P., Tchesnokova, V., Kidd, B., Yakovenko, O., Yarov-Yarovoy, V., Trinchina, E., Vogel, V., Thomas, W. & Sokurenko, E., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23437-23446 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Voltage-gated ion channels and gating modifier toxins

Catterall, W. A., Cestèle, S., Yarov-Yarovoy, V., Yu, F. H., Konoki, K. & Scheuer, T., Feb 2007, In : Toxicon. 49, 2, p. 124-141 18 p.

Research output: Contribution to journalArticle

426 Scopus citations
2008

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

DeCaen, P. G., Yarov-Yarovoy, V., Zhao, Y., Scheuer, T. & Catterall, W. A., Sep 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 39, p. 15142-15147 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2009

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function

Lees-Miller, J. P., Subbotina, J. O., Guo, J., Yarov-Yarovoy, V., Noskov, S. Y. & Duff, H. J., 2009, In : Biophysical Journal. 96, 9, p. 3600-3610 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Sequential formation of ion pairs during activation of a sodium channel voltage sensor

DeCaen, P. G., Yarov-Yarovoy, V., Sharp, E. M., Scheuer, T. & Catterall, W. A., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22498-22503 6 p.

Research output: Contribution to journalArticle

104 Scopus citations
2010

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

Khalili-Araghi, F., Jogini, V., Yarov-Yarovoy, V., Tajkhorshid, E., Roux, B. & Schulten, K., May 19 2010, In : Biophysical Journal. 98, 10, p. 2189-2198 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

Helical motion of an S4 voltage sensor revealed by gating pore currents

Catterall, W. A. & Yarov-Yarovoy, V., 2010, In : Channels. 4, 2, p. 75-77 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations

Subbotina, J., Yarov-Yarovoy, V., Lees-Miller, J., Durdagi, S., Guo, J., Duff, H. J. & Noskov, S. Y., Nov 1 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 14, p. 2922-2934 13 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Allosteric catch bond properties of the fimh adhesin from Salmonella enterica serovar typhimurium

Kisiela, D. I., Kramer, J. J., Tchesnokova, V., Aprikian, P., Yarov-Yarovoy, V., Clegg, S. & Sokurenko, E. V., Nov 4 2011, In : Journal of Biological Chemistry. 286, 44, p. 38136-38147 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
18 Scopus citations

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states

Kelly, E. J., Nakano, M., Rohatgi, P., Yarov-Yarovoy, V. & Rettie, A. E., Apr 2011, In : Molecular Interventions. 11, 2, p. 124-132 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor

DeCaen, P. G., Yarov-Yarovoy, V., Scheuer, T. & Catterall, W. A., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. 18825-18830 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor

Wang, J., Yarov-Yarovoy, V., Kahn, R., Gordon, D., Gurevitz, M., Scheuer, T. & Catterall, W. A., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15426-15431 6 p.

Research output: Contribution to journalArticle

95 Scopus citations

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment

Kufareva, I., Rueda, M., Katritch, V., Stevens, R. C., Abagyan, R., Yoshikawa, Y., Furuya, T., Lee, H., Roy, A., Grime, J., Rebehmed, J., Zhang, Y., Roumen, L., de Esch, I. J. P., Leurs, R., de Graaf, C., Li, Y., Hou, T., Mysinger, M. M., Weiss, D. R. & 90 others, Irwin, J. J., Shoichet, B. K., McRobb, F. M., Capuano, B., Crosby, I. T., Chalmers, D. K., Yuriev, E., Wang, Q., Mach, R. H., Reichert, D. E., Chuang, G. Y., Rognan, D., Simms, J., Sexton, P., Wootten, D., Latek, D., Ghoshdastider, U., Filipek, S., LenServer, Kirkpatrick, A., Trzaskowski, B., Griffith, A., Kim, S. K., Abrol, R., Goddard, W. A., Vaidehi, N., Lam, A., Bhattacharya, S., Li, H., Balaraman, G., Niesen, M., Pal, S., Solovyev, V., Vorobjev, Y., Bakulina, N., Beuming, T., Costanzi, S., Shi, L., Higgs, C., Salam, N., Lupyan, D., Sherman, W., Ding, F., Kota, P., Ramachandran, S., Dokholyan, N. V., Carlsson, J., Coleman, R. G., Fan, H., Schlessinger, A., Irwin, J. J., Sali, A., Shoichet, B. K., Tikhonova, I., Pogozheva, I., Lomize, A., Hall, N. E., Muddassa, M., Zhang, Y., Nim Pae, A., Lee, J., Lopez, L., Obiol-Pardo, C., Selent, J., Mahboob, S., Werner, T., Bret Church, W., Brylinski, M., Ando, T., Guerler, A., Zhou, H., Skolnick, J., Xhaard, H., Jurkowski, W., Elofsson, A., Murad, A. K., Drwal, M., Dupree, T. B., Griffith, R., Ostopovici-Halip, L., Bologa, C., Chen, K. M., Sun, J., Barth, P., Yarov-Yarovoy, V., Baker, D., Vroling, B., Sanders, M. P. A., Nabuurs, S. B. & Nikiforovich, G. V., Aug 10 2011, In : Structure. 19, 8, p. 1108-1126 19 p.

Research output: Contribution to journalArticle

229 Scopus citations

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

Zhang, J. Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. & Catterall, W. A., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33641-33651 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2012

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

Vargas, E., Yarov-Yarovoy, V., Khalili-Araghi, F., Catterall, W. A., Klein, M. L., Tarek, M., Lindahl, E., Schulten, K., Perozo, E., Bezanilla, F. & Roux, B., Dec 2012, In : Journal of General Physiology. 140, 6, p. 587-594 8 p.

Research output: Contribution to journalArticle

123 Scopus citations

Catalytic residues and a predicted structure of tetrahydrobiopterin- dependent alkylglycerol mono-oxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Apr 1 2012, In : Biochemical Journal. 443, 1, p. 279-286 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin

Maselli, R. A., Fernandez, J. M., Arredondo, J., Navarro, C., Ngo, M., Beeson, D., Cagney, Ó., Williams, D. C., Wollmann, R. L., Yarov-Yarovoy, V. & Ferns, M. J., Jul 2012, In : Human Genetics. 131, 7, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na+ channels

Zhang, J. Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. & Catterall, W. A., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30719-30728 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Na+/K+-ATPase E960 and phospholemman F28 are critical for their functional interaction.

Khafaga, M., Bossuyt, J. B. C., Mamikonian, L., Li, J. C., Lee, L. L., Yarov-Yarovoy, V., Despa, S. & Bers, D. M., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20756-20761 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

Cui, Y., Yang, F., Cao, X., Yarov-Yarovoy, V., Wang, K. & Zheng, J., Apr 2012, In : Journal of General Physiology. 139, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Structural basis for gating charge movement in the voltage sensor of a sodium channel

Yarov-Yarovoy, V., DeCaen, P. G., Westenbroek, R. E., Pan, C. Y., Scheuer, T., Baker, D. & Catterall, W. A., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2

Research output: Contribution to journalArticle

145 Scopus citations
2013

Adenylyl cyclase subtype-specific compartmentalization: Differential regulation of L-Type Ca2+ current in ventricular myocytes

Timofeyev, V., Myers, R. E., Kim, H. J., Woltz, R. L., Sirish, P., Heiserman, J. P., Li, N., Singapuri, A., Tang, T., Yarov-Yarovoy, V., Yamoah, E. N., Hammond, H. K. & Chiamvimonvat, N., Jun 7 2013, In : Circulation Research. 112, 12, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Channels: Sticking to nooks and crannies

Wulff, H. & Yarov-Yarovoy, V., Aug 2013, In : Nature Chemical Biology. 9, 8, p. 473-474 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

First insights into structure-function relationships of alkylglycerol monooxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Jun 2013, In : Pteridines. 24, 1, p. 99-103 5 p.

Research output: Contribution to journalArticle

The bipolar assembly domain of the mitotic motor kinesin-5

Acar, S., Carlson, D. B., Budamagunta, M. S., Yarov-Yarovoy, V., Correia, J. J., Niñonuevo, M. R., Jia, W., Tao, L., Leary, J. A., Voss, J. C., Evans, J. E. & Scholey, J. M., 2013, In : Nature Communications. 4, 1343.

Research output: Contribution to journalArticle

34 Scopus citations
2014

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Tilleya, D. C., Euma, K. S., Fletcher-Taylor, S., Austina, D. C., Dupré, C., Patrón, L. A., Garcia, R. L., Lam, K., Yarov-Yarovoy, V., Cohenc, B. E. & Sack, J. T., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4789-E4796

Research output: Contribution to journalArticle

22 Scopus citations

Computational models for predictive cardiac ion channel pharmacology

Yarov-Yarovoy, V., Allen, T. W. & Clancy, C. E., Feb 4 2014, In : Drug Discovery Today: Disease Models. 14, p. 3-10 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca 2+-activated K+ (SK2) channel

Rafizadeh, S., Zhang, Z., Woltz, R. L., Kim, H. J., Myers, R. E., Lu, L., Tuteja, D., Singapuri, A., Bigdeli, A. A. Z., Harchache, S. B., Knowlton, A. A., Yarov-Yarovoy, V., Yamoah, E. N. & Chiamvimonvat, N., Jul 8 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9989-9994 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

Boiteux, C., Vorobyov, I., French, R. J., French, C., Yarov-Yarovoy, V. & Allen, T. W., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13057-13062 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
2015

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

Yang, S., Yang, F., Wei, N., Hong, J., Li, B., Luo, L., Rong, M., Yarov-Yarovoy, V., Zheng, J., Wang, K. & Lai, R., Sep 30 2015, In : Nature Communications. 6, 8297.

Research output: Contribution to journalArticle

49 Scopus citations

A polybasic plasma membrane binding motif in the I-II linker stabilizes voltage-gated Ca<inf>V</inf>1.2 calcium channel function

Kaur, G., Pinggera, A., Ortner, N. J., Lieb, A., Sinnegger-Brauns, M. J., Yarov-Yarovoy, V., Obermair, G. J., Flucher, B. E. & Striessnig, J., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 21086-21100 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of an additional splice acceptor site introduced into CYP4B1 in hominoidae during evolution

Schmidt, E. M., Wiek, C., Parkinson, O. T., Roellecke, K., Freund, M., Gombert, M., Lottmann, N., Steward, C. A., Kramm, C. M., Yarov-Yarovoy, V., Rettie, A. E. & Hanenberg, H., Sep 10 2015, In : PLoS One. 10, 9, e0137110.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

Wiek, C., Schmidt, E. M., Roellecke, K., Freund, M., Nakano, M., Kelly, E. J., Kaisers, W., Yarov-Yarovoy, V., Kramm, C. M., Rettie, A. E. & Hanenberg, H., Jan 1 2015, In : Biochemical Journal. 465, p. 103-114 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels

Tuluc, P., Yarov-Yarovoy, V., Benedetti, B. & Flucher, B. E., May 28 2015, (Accepted/In press) In : Structure.

Research output: Contribution to journalArticle

20 Scopus citations