Vladimir Yarov-Yarovoy, PhD; MS

Associate Professor

  • 5629 Citations
  • 34 h-Index
19962019
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Research Output 1996 2019

  • 5629 Citations
  • 34 h-Index
  • 69 Article
  • 1 Editorial
  • 1 Short survey
  • 1 Review article
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Article
2019

A distinct structural mechanism underlies TRPV1 activation by piperine

Dong, Y., Yin, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

piperine
Chemical activation
S 6
Capsaicin
Piper nigrum

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

Ng, L. C. T., Vien, T. N., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15540-15549 10 p.

Research output: Contribution to journalArticle

Open Access
Ion Channels
TRPP Cation Channels
Transient Receptor Potential Channels
Membranes
Membrane Potentials
1 Citation (Scopus)

Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4

Rudell, J. B., Maselli, R. A., Yarov-Yarovoy, V. & Ferns, M. J., Aug 15 2019, In : Human molecular genetics. 28, 16, p. 2648-2658 11 p.

Research output: Contribution to journalArticle

Open Access
Agrin
Lipoprotein Receptors
Heparan Sulfate Proteoglycans
Protein Isoforms
Mutation
1 Citation (Scopus)
Sodium Channels
Anti-Arrhythmia Agents
Drug Interactions
Molecular Dynamics Simulation
Local Anesthetics

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

Yin, Y., Dong, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : British Journal of Pharmacology. 176, 17, p. 3364-3377 14 p.

Research output: Contribution to journalArticle

Ginger
Capsicum
Capsaicin
Hydrogen
Nociception
2018
9 Citations (Scopus)

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Yang, F., Xiao, X., Lee, B. H., Vu, S., Yang, W., Yarov-Yarovoy, V. & Zheng, J., Dec 1 2018, In : Nature Communications. 9, 1, 2879.

Research output: Contribution to journalArticle

Capsaicin
Ion Channels
Chemical activation
activation
Structural Models
2017
2 Citations (Scopus)

A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel

Tang, C., Zhou, X., Nguyen, P. T., Zhang, Y., Hu, Z., Zhang, C., Yarov-Yarovoy, V., DeCaen, P. G., Liang, S. & Liu, Z., Jul 1 2017, In : FASEB Journal. 31, 7, p. 3167-3178 12 p.

Research output: Contribution to journalArticle

Toxoids
Sodium Channels
Bacillus
Sensors
Electric potential
6 Citations (Scopus)

Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

Tanaka, B. S., Nguyen, P. T., Zhou, E. Y., Yang, Y., Yarov-Yarovoy, V., Dib-Hajj, S. D. & Waxman, S. G., Jun 2 2017, In : Journal of Biological Chemistry. 292, 22, p. 9262-9272 11 p.

Research output: Contribution to journalArticle

NAV1.7 Voltage-Gated Sodium Channel
Extremities
Aspartic Acid
Pain
Mutation
23 Citations (Scopus)
Rod Cell Outer Segment
Retinal Rod Photoreceptor Cells
Light Signal Transduction
GTP-Binding Proteins
Light
6 Citations (Scopus)

Structural determinants for the selectivity of the positive KCa3.1 gating modulator 5-methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)

Brown, B. M., Shim, H., Zhang, M., Yarov-Yarovoy, V. & Wulff, H., Oct 1 2017, In : Molecular Pharmacology. 92, 4, p. 469-480 12 p.

Research output: Contribution to journalArticle

Calmodulin
Oxazoles
Hydrogen
Benzothiazoles
5-methylnaphtho(2,1-d)oxazol-2-amine
10 Citations (Scopus)

Structural insights into the atomistic mechanisms of action of small molecule inhibitors targeting the KCa3.1 channel pore

Nguyen, H. M., Singh, V., Pressly, B., Jenkins, D. P., Wulff, H. & Yarov-Yarovoy, V., Apr 1 2017, In : Molecular Pharmacology. 91, 4, p. 392-402 11 p.

Research output: Contribution to journalArticle

Nifedipine
Pyrans
Drug Design
Ions
Calcium-Activated Potassium Channels
2016
11 Citations (Scopus)

Activity-dependent palmitoylation controls synDIG1 stability, localization, and function

Kaur, I., Yarov-Yarovoy, V., Kirk, L. M., Plambeck, K. E., Barragan, E. V., Ontiveros, E. S. & Diaz, E. D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7562-7568 7 p.

Research output: Contribution to journalArticle

Lipoylation
Synapses
Neurons
AMPA Receptors
Site-Directed Mutagenesis
5 Citations (Scopus)

A large and phylogenetically diverse class of type 1 opsins lacking a canonical retinal binding site

Becker, E. A., Yao, A. I., Seitzer, P. M., Kind, T., Wang, T., Eigenheer, R., Shao, K. S. Y., Yarov-Yarovoy, V. & Facciotti, M. T., Jun 1 2016, In : PLoS One. 11, 6, e0156543.

Research output: Contribution to journalArticle

Opsins
opsin
binding sites
Binding Sites
Light
6 Citations (Scopus)

Mechanisms of calmodulin regulation of different isoforms of Kv7.4 K+ channels

Sihn, C. R., Kim, H. J., Woltz, R. L., Yarov-Yarovoy, V., Yang, P. C., Xu, J., Clancy, C. E., Zhang, X. D., Chiamvimonvat, N. & Yamoah, E. N., Jan 29 2016, In : Journal of Biological Chemistry. 291, 5, p. 2499-2509 11 p.

Research output: Contribution to journalArticle

Calmodulin
Protein Isoforms
Audition
Missense Mutation
Hearing Loss
20 Citations (Scopus)

Potassium channels in the heart: Structure, function and regulation

Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Chen-Izu, Y., Chiamvimonvat, N., Colecraft, H. M., Delisle, B. P., Heijman, J., Navedo, M. F., Noskov, S., Proenza, C., Vandenberg, J. I. & Yarov-Yarovoy, V., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Potassium Channels
Cardiac Arrhythmias
Cardiac Electrophysiology
Voltage-Gated Potassium Channels
Excitation Contraction Coupling
17 Citations (Scopus)
Capsaicin
Ion Channels
Ligands
Binding Sites
Ligand-Gated Ion Channels
2015
35 Citations (Scopus)

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

Yang, S., Yang, F., Wei, N., Hong, J., Li, B., Luo, L., Rong, M., Yarov-Yarovoy, V., Zheng, J., Wang, K. & Lai, R., Sep 30 2015, In : Nature Communications. 6, 8297.

Research output: Contribution to journalArticle

Nociceptors
pain
machinery
Machinery
Hot Temperature
10 Citations (Scopus)

A polybasic plasma membrane binding motif in the I-II linker stabilizes voltage-gated Ca<inf>V</inf>1.2 calcium channel function

Kaur, G., Pinggera, A., Ortner, N. J., Lieb, A., Sinnegger-Brauns, M. J., Yarov-Yarovoy, V., Obermair, G. J., Flucher, B. E. & Striessnig, J., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 21086-21100 15 p.

Research output: Contribution to journalArticle

Cell membranes
Cell Membrane
Electric potential
Type C Phospholipases
Arginine
10 Citations (Scopus)

Characterization of an additional splice acceptor site introduced into CYP4B1 in hominoidae during evolution

Schmidt, E. M., Wiek, C., Parkinson, O. T., Roellecke, K., Freund, M., Gombert, M., Lottmann, N., Steward, C. A., Kramm, C. M., Yarov-Yarovoy, V., Rettie, A. E. & Hanenberg, H., Sep 10 2015, In : PLoS One. 10, 9, e0137110.

Research output: Contribution to journalArticle

RNA Splice Sites
serine
Serine
Pongidae
Hominidae
21 Citations (Scopus)

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

Wiek, C., Schmidt, E. M., Roellecke, K., Freund, M., Nakano, M., Kelly, E. J., Kaisers, W., Yarov-Yarovoy, V., Kramm, C. M., Rettie, A. E. & Hanenberg, H., Jan 1 2015, In : Biochemical Journal. 465, p. 103-114 12 p.

Research output: Contribution to journalArticle

Amino Acids
Processing
Rabbits
Enzymes
Proteins
15 Citations (Scopus)

Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels

Tuluc, P., Yarov-Yarovoy, V., Benedetti, B. & Flucher, B. E., May 28 2015, (Accepted/In press) In : Structure.

Research output: Contribution to journalArticle

Calcium Channels
Site-Directed Mutagenesis
Sodium Channels
Electrophysiology
Potassium Channels
33 Citations (Scopus)

Na+ channel function, regulation, structure, trafficking and sequestration

Chen-Izu, Y., Shaw, R. M., Pitt, G. S., Yarov-Yarovoy, V., Sack, J. T., Abriel, H., Aldrich, R. W., Belardinelli, L., Cannell, M. B., Catterall, W. A., Chazin, W. J., Chiamvimonvat, N., Deschenes, I., Grandi, E., Hund, T. J., Izu, L. T., Maier, L. S., Maltsev, V. A., Marionneau, C., Mohler, P. J. & 5 others, Rajamani, S., Rasmusson, R. L., Sobie, E. A., Clancy, C. E. & Bers, D. M., Mar 15 2015, In : Journal of Physiology. 593, 6, p. 1347-1360 14 p.

Research output: Contribution to journalArticle

Excitation Contraction Coupling
Systems Analysis
Cardiac Arrhythmias
Sodium
99 Citations (Scopus)

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

Yang, F., Xiao, X., Cheng, W., Yang, W., Yu, P., Song, Z., Yarov-Yarovoy, V. & Zheng, J., Jul 20 2015, In : Nature Chemical Biology. 11, 7, p. 518-524 7 p.

Research output: Contribution to journalArticle

Capsaicin
Ion Channels
Amides
Head
Electrons
22 Citations (Scopus)

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

Gupta, K., Zamanian, M., Bae, C., Milescu, M., Krepkiy, D., Tilley, D. C., Sack, J. T., Yarov-Yarovoy, V., Kim, J. I. & Swartz, K. J., May 7 2015, In : eLife. 4, MAY, e06774.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Ion Channels
Membranes
Electric potential
Sensors
2014
18 Citations (Scopus)

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Tilleya, D. C., Euma, K. S., Fletcher-Taylor, S., Austina, D. C., Dupré, C., Patrón, L. A., Garcia, R. L., Lam, K., Yarov-Yarovoy, V., Cohenc, B. E. & Sack, J. T., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4789-E4796

Research output: Contribution to journalArticle

Ion Channels
Voltage-Gated Potassium Channels
Cystine
Alkynes
Sulfhydryl Compounds
6 Citations (Scopus)

Computational models for predictive cardiac ion channel pharmacology

Yarov-Yarovoy, V., Allen, T. W. & Clancy, C. E., Feb 4 2014, In : Drug Discovery Today: Disease Models. 14, p. 3-10 8 p.

Research output: Contribution to journalArticle

Ion Channels
Pharmacology
Biological Science Disciplines
Anti-Arrhythmia Agents
Pharmaceutical Preparations
28 Citations (Scopus)

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca 2+-activated K+ (SK2) channel

Rafizadeh, S., Zhang, Z., Woltz, R. L., Kim, H. J., Myers, R. E., Lu, L., Tuteja, D., Singapuri, A., Bigdeli, A. A. Z., Harchache, S. B., Knowlton, A. A., Yarov-Yarovoy, V., Yamoah, E. N. & Chiamvimonvat, N., Jul 8 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9989-9994 6 p.

Research output: Contribution to journalArticle

Filamins
Cytoskeletal Proteins
Cardiac Myocytes
Action Potentials
Membranes
50 Citations (Scopus)

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

Boiteux, C., Vorobyov, I., French, R. J., French, C., Yarov-Yarovoy, V. & Allen, T. W., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13057-13062 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Local Anesthetics
Anticonvulsants
Anesthetics
Sodium Channels
2013
38 Citations (Scopus)

Adenylyl cyclase subtype-specific compartmentalization: Differential regulation of L-Type Ca2+ current in ventricular myocytes

Timofeyev, V., Myers, R. E., Kim, H. J., Woltz, R. L., Sirish, P., Heiserman, J. P., Li, N., Singapuri, A., Tang, T., Yarov-Yarovoy, V., Yamoah, E. N., Hammond, H. K. & Chiamvimonvat, N., Jun 7 2013, In : Circulation Research. 112, 12, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Muscle Cells
Protein Isoforms
Adrenergic Receptors
Caveolin 3
2 Citations (Scopus)

Channels: Sticking to nooks and crannies

Wulff, H. & Yarov-Yarovoy, V., Aug 2013, In : Nature Chemical Biology. 9, 8, p. 473-474 2 p.

Research output: Contribution to journalArticle

First insights into structure-function relationships of alkylglycerol monooxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Jun 2013, In : Pteridines. 24, 1, p. 99-103 5 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Enzymes
Glutamic Acid
Fatty Acids
Aromatic Amino Acids
31 Citations (Scopus)

The bipolar assembly domain of the mitotic motor kinesin-5

Acar, S., Carlson, D. B., Budamagunta, M. S., Yarov-Yarovoy, V., Correia, J. J., Niñonuevo, M. R., Jia, W., Tao, L., Leary, J. A., Voss, J. C., Evans, J. E. & Scholey, J. M., 2013, In : Nature Communications. 4, 1343.

Research output: Contribution to journalArticle

Kinesin
spindles
assembly
Spindle Apparatus
bipolarity
2012
108 Citations (Scopus)

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

Vargas, E., Yarov-Yarovoy, V., Khalili-Araghi, F., Catterall, W. A., Klein, M. L., Tarek, M., Lindahl, E., Schulten, K., Perozo, E., Bezanilla, F. & Roux, B., Dec 2012, In : Journal of General Physiology. 140, 6, p. 587-594 8 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Ion Channels
X-Rays
14 Citations (Scopus)

Catalytic residues and a predicted structure of tetrahydrobiopterin- dependent alkylglycerol mono-oxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Apr 1 2012, In : Biochemical Journal. 443, 1, p. 279-286 8 p.

Research output: Contribution to journalArticle

Oxygenases
long-chain-aldehyde dehydrogenase
glyceryl-ether monooxygenase
Mixed Function Oxygenases
Membranes
57 Citations (Scopus)

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin

Maselli, R. A., Fernandez, J. M., Arredondo, J., Navarro, C., Ngo, M., Beeson, D., Cagney, Ó., Williams, D. C., Wollmann, R. L., Yarov-Yarovoy, V. & Ferns, M. J., Jul 2012, In : Human Genetics. 131, 7, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Agrin
Mutation
Dystroglycans
Neuromuscular Junction
40 Citations (Scopus)

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na+ channels

Zhang, J. Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. & Catterall, W. A., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30719-30728 10 p.

Research output: Contribution to journalArticle

Scorpions
S 6
Amino Acids
Electric potential
Sensors
10 Citations (Scopus)

Na+/K+-ATPase E960 and phospholemman F28 are critical for their functional interaction.

Khafaga, M., Bossuyt, J. B. C., Mamikonian, L., Li, J. C., Lee, L. L., Yarov-Yarovoy, V., Despa, S. & Bers, D. M., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20756-20761 6 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
sodium-translocating ATPase
phospholemman
Phosphorylation
HEK293 Cells
56 Citations (Scopus)

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

Cui, Y., Yang, F., Cao, X., Yarov-Yarovoy, V., Wang, K. & Zheng, J., Apr 2012, In : Journal of General Physiology. 139, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

Capsaicin
Hot Temperature
Mutation
TRPV Cation Channels
Potassium Channels
131 Citations (Scopus)

Structural basis for gating charge movement in the voltage sensor of a sodium channel

Yarov-Yarovoy, V., DeCaen, P. G., Westenbroek, R. E., Pan, C. Y., Scheuer, T., Baker, D. & Catterall, W. A., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2

Research output: Contribution to journalArticle

Sodium Channels
Structural Models
Ion Channel Gating
S 6
Hydrogen Bonding
2011
15 Citations (Scopus)

Allosteric catch bond properties of the fimh adhesin from Salmonella enterica serovar typhimurium

Kisiela, D. I., Kramer, J. J., Tchesnokova, V., Aprikian, P., Yarov-Yarovoy, V., Clegg, S. & Sokurenko, E. V., Nov 4 2011, In : Journal of Biological Chemistry. 286, 44, p. 38136-38147 12 p.

Research output: Contribution to journalArticle

Salmonella enterica
Salmonella typhimurium
Lectins
Mannose
Fimbriae Proteins
16 Citations (Scopus)
Epidermal Growth Factor Receptor
Adrenergic Receptors
Transcriptional Activation
Cell Proliferation
Matrix Metalloproteinase 7
30 Citations (Scopus)

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states

Kelly, E. J., Nakano, M., Rohatgi, P., Yarov-Yarovoy, V. & Rettie, A. E., Apr 2011, In : Molecular Interventions. 11, 2, p. 124-132 9 p.

Research output: Contribution to journalArticle

Orphaned Children
Cytochromes
Lamellar Ichthyosis
Genes
Mutation
50 Citations (Scopus)

Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor

DeCaen, P. G., Yarov-Yarovoy, V., Scheuer, T. & Catterall, W. A., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. 18825-18830 6 p.

Research output: Contribution to journalArticle

Disulfides
Ion Channels
Action Potentials
Cysteine
94 Citations (Scopus)

Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor

Wang, J., Yarov-Yarovoy, V., Kahn, R., Gordon, D., Gurevitz, M., Scheuer, T. & Catterall, W. A., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15426-15431 6 p.

Research output: Contribution to journalArticle

Charybdotoxin
Scorpions
S 6
Amino Acids
Membrane Potentials
223 Citations (Scopus)

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment

Kufareva, I., Rueda, M., Katritch, V., Stevens, R. C., Abagyan, R., Yoshikawa, Y., Furuya, T., Lee, H., Roy, A., Grime, J., Rebehmed, J., Zhang, Y., Roumen, L., de Esch, I. J. P., Leurs, R., de Graaf, C., Li, Y., Hou, T., Mysinger, M. M., Weiss, D. R. & 90 others, Irwin, J. J., Shoichet, B. K., McRobb, F. M., Capuano, B., Crosby, I. T., Chalmers, D. K., Yuriev, E., Wang, Q., Mach, R. H., Reichert, D. E., Chuang, G. Y., Rognan, D., Simms, J., Sexton, P., Wootten, D., Latek, D., Ghoshdastider, U., Filipek, S., LenServer, Kirkpatrick, A., Trzaskowski, B., Griffith, A., Kim, S. K., Abrol, R., Goddard, W. A., Vaidehi, N., Lam, A., Bhattacharya, S., Li, H., Balaraman, G., Niesen, M., Pal, S., Solovyev, V., Vorobjev, Y., Bakulina, N., Beuming, T., Costanzi, S., Shi, L., Higgs, C., Salam, N., Lupyan, D., Sherman, W., Ding, F., Kota, P., Ramachandran, S., Dokholyan, N. V., Carlsson, J., Coleman, R. G., Fan, H., Schlessinger, A., Irwin, J. J., Sali, A., Shoichet, B. K., Tikhonova, I., Pogozheva, I., Lomize, A., Hall, N. E., Muddassa, M., Zhang, Y., Nim Pae, A., Lee, J., Lopez, L., Obiol-Pardo, C., Selent, J., Mahboob, S., Werner, T., Bret Church, W., Brylinski, M., Ando, T., Guerler, A., Zhou, H., Skolnick, J., Xhaard, H., Jurkowski, W., Elofsson, A., Murad, A. K., Drwal, M., Dupree, T. B., Griffith, R., Ostopovici-Halip, L., Bologa, C., Chen, K. M., Sun, J., Barth, P., Yarov-Yarovoy, V., Baker, D., Vroling, B., Sanders, M. P. A., Nabuurs, S. B. & Nikiforovich, G. V., Aug 10 2011, In : Structure. 19, 8, p. 1108-1126 19 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
CXCR4 Receptors
Ligands
Cyclic Peptides
Quantitative Structure-Activity Relationship
53 Citations (Scopus)

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

Zhang, J. Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. & Catterall, W. A., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33641-33651 11 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Scorpions
Sodium Channels
Amino Acids
Electric potential
2010
102 Citations (Scopus)

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

Khalili-Araghi, F., Jogini, V., Yarov-Yarovoy, V., Tajkhorshid, E., Roux, B. & Schulten, K., May 19 2010, In : Biophysical Journal. 98, 10, p. 2189-2198 10 p.

Research output: Contribution to journalArticle

Potassium Channels
Molecular Dynamics Simulation
Arginine
Kv1.2 Potassium Channel
Shaker Superfamily of Potassium Channels
4 Citations (Scopus)

Helical motion of an S4 voltage sensor revealed by gating pore currents

Catterall, W. A. & Yarov-Yarovoy, V., 2010, In : Channels. 4, 2, p. 75-77 3 p.

Research output: Contribution to journalArticle

Ion Channel Gating
Mutation
Sensors
Electric potential
Ion Channels
46 Citations (Scopus)

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations

Subbotina, J., Yarov-Yarovoy, V., Lees-Miller, J., Durdagi, S., Guo, J., Duff, H. J. & Noskov, S. Y., Nov 1 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 14, p. 2922-2934 13 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Molecular Dynamics Simulation
Molecular dynamics
Membranes
Voltage-Gated Potassium Channels
2009
31 Citations (Scopus)

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function

Lees-Miller, J. P., Subbotina, J. O., Guo, J., Yarov-Yarovoy, V., Noskov, S. Y. & Duff, H. J., 2009, In : Biophysical Journal. 96, 9, p. 3600-3610 11 p.

Research output: Contribution to journalArticle

Potassium Channels
Mutation
Cyclic Nucleotides
Molecular Dynamics Simulation
Hydrogen Bonding