Vladimir Yarov-Yarovoy, PhD; MS

Associate Professor

  • 5970 Citations
  • 35 h-Index
19962020

Research output per year

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Research Output

  • 5970 Citations
  • 35 h-Index
  • 76 Article
  • 1 Editorial
  • 1 Short survey
  • 1 Review article
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Article
2020

A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm

Yang, P. C., Demarco, K. R., Aghasafari, P., Jeng, M. T., Dawson, J. R. D., Bekker, S., Noskov, S. Y., Yarov-Yarovoy, V., Vorobyov, I. & Clancy, C. E., Jan 1 2020, (Accepted/In press) In : Circulation research. p. 947-964 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells

Perez-Flores, M. C., Lee, J. H., Park, S., Zhang, X. D., Sihn, C. R., Ledford, H. A., Wang, W., Kim, H. J., Timofeyev, V., Yarov-Yarovoy, V., Chiamvimonvat, N., Rabbitt, R. D. & Yamoah, E. N., Jan 1 2020, In : Science Advances. 6, 15, eaba1104.

Research output: Contribution to journalArticle

Open Access

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking

Rudell, J. C., Borges, L. S., Yarov-Yarovoy, V. & Ferns, M., Mar 24 2020, In : Frontiers in Molecular Neuroscience. 13, 48.

Research output: Contribution to journalArticle

Open Access

Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels

Craig, R. A., Garrison, C. E., Nguyen, P. T., Yarov-Yarovoy, V. & Du Bois, J., Feb 5 2020, In : ACS Chemical Neuroscience. 11, 3, p. 418-426 9 p.

Research output: Contribution to journalArticle

α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav1.2

Turner, M., Anderson, D. E., Bartels, P., Nieves-Cintron, M., Coleman, A. M., Henderson, P. B., Man, K. N. M., Tseng, P. Y., Yarov-Yarovoy, V., Bers, D. M., Navedo, M. F., Horne, M. C., Ames, J. B. & Hell, J. W., Jan 1 2020, (Accepted/In press) In : EMBO Journal. e102622.

Research output: Contribution to journalArticle

2019

A distinct structural mechanism underlies TRPV1 activation by piperine

Dong, Y., Yin, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

Ng, L. C. T., Vien, T. N., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15540-15549 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
3 Scopus citations

Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein

Heeney, D. D., Yarov-Yarovoy, V. & Marco, M. L., Nov 1 2019, In : MicrobiologyOpen. 8, 11, e827.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
12 Scopus citations

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

Yin, Y., Dong, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : British Journal of Pharmacology. 176, 17, p. 3364-3377 14 p.

Research output: Contribution to journalArticle

The trials and tribulations of structure assisted design of KCa channel activators

Shim, H., Brown, B. M., Singh, L., Singh, V., Fettinger, J. C., Yarov-Yarovoy, V. & Wulff, H., Jan 1 2019, In : Frontiers in Pharmacology. 10, SEP, 972.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Yang, F., Xiao, X., Lee, B. H., Vu, S., Yang, W., Yarov-Yarovoy, V. & Zheng, J., Dec 1 2018, In : Nature Communications. 9, 1, 2879.

Research output: Contribution to journalArticle

14 Scopus citations
2017

A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel

Tang, C., Zhou, X., Nguyen, P. T., Zhang, Y., Hu, Z., Zhang, C., Yarov-Yarovoy, V., DeCaen, P. G., Liang, S. & Liu, Z., Jul 1 2017, In : FASEB Journal. 31, 7, p. 3167-3178 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

Tanaka, B. S., Nguyen, P. T., Zhou, E. Y., Yang, Y., Yarov-Yarovoy, V., Dib-Hajj, S. D. & Waxman, S. G., Jun 2 2017, In : Journal of Biological Chemistry. 292, 22, p. 9262-9272 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
33 Scopus citations

Structural determinants for the selectivity of the positive KCa3.1 gating modulator 5-methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)

Brown, B. M., Shim, H., Zhang, M., Yarov-Yarovoy, V. & Wulff, H., Oct 1 2017, In : Molecular Pharmacology. 92, 4, p. 469-480 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structural insights into the atomistic mechanisms of action of small molecule inhibitors targeting the KCa3.1 channel pore

Nguyen, H. M., Singh, V., Pressly, B., Jenkins, D. P., Wulff, H. & Yarov-Yarovoy, V., Apr 1 2017, In : Molecular Pharmacology. 91, 4, p. 392-402 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Activity-dependent palmitoylation controls synDIG1 stability, localization, and function

Kaur, I., Yarov-Yarovoy, V., Kirk, L. M., Plambeck, K. E., Barragan, E. V., Ontiveros, E. S. & Diaz, E. D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7562-7568 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

A large and phylogenetically diverse class of type 1 opsins lacking a canonical retinal binding site

Becker, E. A., Yao, A. I., Seitzer, P. M., Kind, T., Wang, T., Eigenheer, R., Shao, K. S. Y., Yarov-Yarovoy, V. & Facciotti, M. T., Jun 1 2016, In : PLoS One. 11, 6, e0156543.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of calmodulin regulation of different isoforms of Kv7.4 K+ channels

Sihn, C. R., Kim, H. J., Woltz, R. L., Yarov-Yarovoy, V., Yang, P. C., Xu, J., Clancy, C. E., Zhang, X. D., Chiamvimonvat, N. & Yamoah, E. N., Jan 29 2016, In : Journal of Biological Chemistry. 291, 5, p. 2499-2509 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Potassium channels in the heart: Structure, function and regulation

Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Chen-Izu, Y., Chiamvimonvat, N., Colecraft, H. M., Delisle, B. P., Heijman, J., Navedo, M. F., Noskov, S., Proenza, C., Vandenberg, J. I. & Yarov-Yarovoy, V., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

26 Scopus citations
25 Scopus citations
2015

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

Yang, S., Yang, F., Wei, N., Hong, J., Li, B., Luo, L., Rong, M., Yarov-Yarovoy, V., Zheng, J., Wang, K. & Lai, R., Sep 30 2015, In : Nature Communications. 6, 8297.

Research output: Contribution to journalArticle

46 Scopus citations

A polybasic plasma membrane binding motif in the I-II linker stabilizes voltage-gated Ca<inf>V</inf>1.2 calcium channel function

Kaur, G., Pinggera, A., Ortner, N. J., Lieb, A., Sinnegger-Brauns, M. J., Yarov-Yarovoy, V., Obermair, G. J., Flucher, B. E. & Striessnig, J., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 21086-21100 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of an additional splice acceptor site introduced into CYP4B1 in hominoidae during evolution

Schmidt, E. M., Wiek, C., Parkinson, O. T., Roellecke, K., Freund, M., Gombert, M., Lottmann, N., Steward, C. A., Kramm, C. M., Yarov-Yarovoy, V., Rettie, A. E. & Hanenberg, H., Sep 10 2015, In : PLoS One. 10, 9, e0137110.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

Wiek, C., Schmidt, E. M., Roellecke, K., Freund, M., Nakano, M., Kelly, E. J., Kaisers, W., Yarov-Yarovoy, V., Kramm, C. M., Rettie, A. E. & Hanenberg, H., Jan 1 2015, In : Biochemical Journal. 465, p. 103-114 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels

Tuluc, P., Yarov-Yarovoy, V., Benedetti, B. & Flucher, B. E., May 28 2015, (Accepted/In press) In : Structure.

Research output: Contribution to journalArticle

19 Scopus citations

Na+ channel function, regulation, structure, trafficking and sequestration

Chen-Izu, Y., Shaw, R. M., Pitt, G. S., Yarov-Yarovoy, V., Sack, J. T., Abriel, H., Aldrich, R. W., Belardinelli, L., Cannell, M. B., Catterall, W. A., Chazin, W. J., Chiamvimonvat, N., Deschenes, I., Grandi, E., Hund, T. J., Izu, L. T., Maier, L. S., Maltsev, V. A., Marionneau, C., Mohler, P. J. & 5 others, Rajamani, S., Rasmusson, R. L., Sobie, E. A., Clancy, C. E. & Bers, D. M., Mar 15 2015, In : Journal of Physiology. 593, 6, p. 1347-1360 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

Yang, F., Xiao, X., Cheng, W., Yang, W., Yu, P., Song, Z., Yarov-Yarovoy, V. & Zheng, J., Jul 20 2015, In : Nature Chemical Biology. 11, 7, p. 518-524 7 p.

Research output: Contribution to journalArticle

118 Scopus citations

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

Gupta, K., Zamanian, M., Bae, C., Milescu, M., Krepkiy, D., Tilley, D. C., Sack, J. T., Yarov-Yarovoy, V., Kim, J. I. & Swartz, K. J., May 7 2015, In : eLife. 4, MAY, e06774.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Tilleya, D. C., Euma, K. S., Fletcher-Taylor, S., Austina, D. C., Dupré, C., Patrón, L. A., Garcia, R. L., Lam, K., Yarov-Yarovoy, V., Cohenc, B. E. & Sack, J. T., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4789-E4796

Research output: Contribution to journalArticle

21 Scopus citations

Computational models for predictive cardiac ion channel pharmacology

Yarov-Yarovoy, V., Allen, T. W. & Clancy, C. E., Feb 4 2014, In : Drug Discovery Today: Disease Models. 14, p. 3-10 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca 2+-activated K+ (SK2) channel

Rafizadeh, S., Zhang, Z., Woltz, R. L., Kim, H. J., Myers, R. E., Lu, L., Tuteja, D., Singapuri, A., Bigdeli, A. A. Z., Harchache, S. B., Knowlton, A. A., Yarov-Yarovoy, V., Yamoah, E. N. & Chiamvimonvat, N., Jul 8 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9989-9994 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

Boiteux, C., Vorobyov, I., French, R. J., French, C., Yarov-Yarovoy, V. & Allen, T. W., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13057-13062 6 p.

Research output: Contribution to journalArticle

52 Scopus citations
2013

Adenylyl cyclase subtype-specific compartmentalization: Differential regulation of L-Type Ca2+ current in ventricular myocytes

Timofeyev, V., Myers, R. E., Kim, H. J., Woltz, R. L., Sirish, P., Heiserman, J. P., Li, N., Singapuri, A., Tang, T., Yarov-Yarovoy, V., Yamoah, E. N., Hammond, H. K. & Chiamvimonvat, N., Jun 7 2013, In : Circulation Research. 112, 12, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Channels: Sticking to nooks and crannies

Wulff, H. & Yarov-Yarovoy, V., Aug 2013, In : Nature Chemical Biology. 9, 8, p. 473-474 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

First insights into structure-function relationships of alkylglycerol monooxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Jun 2013, In : Pteridines. 24, 1, p. 99-103 5 p.

Research output: Contribution to journalArticle

The bipolar assembly domain of the mitotic motor kinesin-5

Acar, S., Carlson, D. B., Budamagunta, M. S., Yarov-Yarovoy, V., Correia, J. J., Niñonuevo, M. R., Jia, W., Tao, L., Leary, J. A., Voss, J. C., Evans, J. E. & Scholey, J. M., 2013, In : Nature Communications. 4, 1343.

Research output: Contribution to journalArticle

33 Scopus citations
2012

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

Vargas, E., Yarov-Yarovoy, V., Khalili-Araghi, F., Catterall, W. A., Klein, M. L., Tarek, M., Lindahl, E., Schulten, K., Perozo, E., Bezanilla, F. & Roux, B., Dec 2012, In : Journal of General Physiology. 140, 6, p. 587-594 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Catalytic residues and a predicted structure of tetrahydrobiopterin- dependent alkylglycerol mono-oxygenase

Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R., Apr 1 2012, In : Biochemical Journal. 443, 1, p. 279-286 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin

Maselli, R. A., Fernandez, J. M., Arredondo, J., Navarro, C., Ngo, M., Beeson, D., Cagney, Ó., Williams, D. C., Wollmann, R. L., Yarov-Yarovoy, V. & Ferns, M. J., Jul 2012, In : Human Genetics. 131, 7, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na+ channels

Zhang, J. Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. & Catterall, W. A., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30719-30728 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Na+/K+-ATPase E960 and phospholemman F28 are critical for their functional interaction.

Khafaga, M., Bossuyt, J. B. C., Mamikonian, L., Li, J. C., Lee, L. L., Yarov-Yarovoy, V., Despa, S. & Bers, D. M., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20756-20761 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

Cui, Y., Yang, F., Cao, X., Yarov-Yarovoy, V., Wang, K. & Zheng, J., Apr 2012, In : Journal of General Physiology. 139, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Structural basis for gating charge movement in the voltage sensor of a sodium channel

Yarov-Yarovoy, V., DeCaen, P. G., Westenbroek, R. E., Pan, C. Y., Scheuer, T., Baker, D. & Catterall, W. A., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2

Research output: Contribution to journalArticle

144 Scopus citations
2011

Allosteric catch bond properties of the fimh adhesin from Salmonella enterica serovar typhimurium

Kisiela, D. I., Kramer, J. J., Tchesnokova, V., Aprikian, P., Yarov-Yarovoy, V., Clegg, S. & Sokurenko, E. V., Nov 4 2011, In : Journal of Biological Chemistry. 286, 44, p. 38136-38147 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
18 Scopus citations

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states

Kelly, E. J., Nakano, M., Rohatgi, P., Yarov-Yarovoy, V. & Rettie, A. E., Apr 2011, In : Molecular Interventions. 11, 2, p. 124-132 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor

DeCaen, P. G., Yarov-Yarovoy, V., Scheuer, T. & Catterall, W. A., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. 18825-18830 6 p.

Research output: Contribution to journalArticle

55 Scopus citations