• 2787 Citations
  • 29 h-Index
1991 …2019

Research output per year

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Research Output

  • 2787 Citations
  • 29 h-Index
  • 60 Article
  • 1 Short survey
2019

Force-induced recruitment of cten along keratin network in epithelial cells

Cheah, J. S., Jacobs, K. A., Heinrich, V., Lo, S. H. & Yamada, S., Oct 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 40, p. 19799-19801 3 p.

Research output: Contribution to journalArticle

Open Access

Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases

Wu, Z. Y., Chiu, C. L., Lo, E., Lee, Y. R. J., Yamada, S. & Lo, S. H., Dec 1 2019, In : Cell Death and Disease. 10, 12, 871.

Research output: Contribution to journalArticle

Open Access

Tensin regulates pharyngeal pumping in Caenorhabditis elegans

Bruns, A. N. & Lo, S. H., Jan 1 2019, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation

Hong, S. Y., Shih, Y. P., Lo, A. & Lo, S. H., Jan 1 2018, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Cell Research.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process

Shih, Y. P., Yuan, S. Y. & Lo, S. H., Jul 10 2017, In : Cancer Letters. 398, p. 46-51 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tensins

Lo, S. H., May 8 2017, In : Current Biology. 27, 9, p. R331-R332

Research output: Contribution to journalShort survey

4 Scopus citations
2016

Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers

Hong, S. Y., Shih, Y. P., Sun, P., Hsieh, W. J., Lin, W. C. & Lo, S. H., 2016, In : Oncotarget. 7, 25, p. 38143-38153 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Δnp63α transcriptionally regulates the expression of CTEN that is associated with prostate cell adhesion

Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H. & Liao, Y. C., Jan 1 2016, In : PLoS One. 11, 1, e0147542.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Genetic association analyses highlight biological pathways underlying mitral valve prolapsed

Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F. N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., Le Tourneau, T., Chen, M. H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M., Hercberg, S., Roussel, R., Benjamin, E. J., Bonnet, F. & 19 others, Lo, S. H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R., Le Marec, H., Froguel, P., Ellinor, P. T., Vasan, R. S., Bruneval, P., Markwald, R. R., Norris, R. A., Milan, D. J., Slaugenhaupt, S. A., Levine, R. A., Schott, J. J., Hagege, A. A. & Jeunemaitre, X., Sep 29 2015, In : Nature Genetics. 47, 10, p. 1206-1211 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Tensin1 positively regulates RhoA activity through its interaction with DLC1

Shih, Y. P., Sun, P., Wang, A. & Lo, S. H., Dec 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 12, p. 3258-3265 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014
15 Scopus citations

Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration

Hung, S. Y., Shih, Y. P., Chen, M. & Lo, S. H., 2014, In : Molecular Carcinogenesis. 53, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R

Fujita, M., Ieguchi, K., Cedano-Prieto, D. M., Fong, A., Wilkerson, C., Chen, J. Q., Wu, M., Lo, S. H., Cheung, A. T. W., Wilson, M. D., Cardiff, R., Borowsky, A. D., Takada, Y. K. & Takada, Y., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19593-19603 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

CTEN prolongs signaling by egfr through reducing its ligand-induced degradation

Hong, S. Y., Shih, Y. P., Li, T., Carraway, K. L. & Lo, S. H., Aug 15 2013, In : Cancer Research. 73, 16, p. 5266-5276 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene

Chen, N. T., Kuwabara, Y., Conley, C., Liao, Y. C., Hong, S. Y., Chen, M., Shih, Y. P., Chen, H., Hsieh, F. & Lo, S. H., May 15 2013, In : Gene. 520, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure

Zimmer, C. C., Shi, L., Shih, Y., Li, J., Jin, L-W., Lo, S. H. & Liu, G., Sep 2012, In : Science China Chemistry. 55, 9, p. 1922-1930 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nanogratings of fibronectin provide an effective biochemical cue for regulating focal adhesion and cellular structure

Shi, L., Li, J. R., Shih, Y. P., Lo, S. H. & Liu, G., Aug 2012, In : Nano Research. 5, 8, p. 565-575 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes

Li, J. R., Shi, L., Deng, Z., Lo, S. H. & Liu, G., Jul 31 2012, In : Biochemistry. 51, 30, p. 5876-5893 18 p.

Research output: Contribution to journalArticle

20 Scopus citations

Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells

Shih, Y. P., Takada, Y. & Lo, S. H., Jan 2012, In : Molecular Cancer Research. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer

Albasri, A., Al-Ghamdi, S., Fadhil, W., Aleskandarany, M., Liao, Y. C., Jackson, D., Lobo, D. N., Lo, S. H., Kumari, R., Durrant, L., Watson, S., Kindle, K. B. & Ilyas, M., Jun 30 2011, In : Oncogene. 30, 26, p. 2997-3002 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Autophagy blockade sensitizes prostate cancer cells towards src family kinase inhibitors

Wu, Z., Chang, P. C., Yang, J. C., Chu, C. Y., Wang, L. Y., Chen, N. T., Ma, A. H., Desai, S. J., Lo, S. H., Evans, C. P., Lam, K. & Kung, H-J., 2010, In : Genes and Cancer. 1, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

DLC1 negatively regulates angiogenesis in a paracrine fashion

Shih, Y. P., Liao, Y. C., Lin, Y. & Lo, S. H., Nov 1 2010, In : Cancer Research. 70, 21, p. 8270-8275 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

Lin, Y., Chen, N. T., Shih, Y. P., Liao, Y. C., Xue, L. & Lo, S. H., May 20 2010, In : Oncogene. 29, 20, p. 3010-3016 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Cell tracing dyes significantly change single cell mechanics

Lulevich, V., Shih, Y. P., Lo, S. H. & Liu, G., May 7 2009, In : Journal of Physical Chemistry B. 113, 18, p. 6511-6519 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation

Hsieh, S. C., Chen, N. T. & Lo, S. H., Jun 2009, In : Molecular Carcinogenesis. 48, 6, p. 545-552 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through β-catenin

Liao, Y. C., Chen, N. T., Shih, Y. P., Dong, Y. & Lo, S. H., Jun 1 2009, In : Cancer Research. 69, 11, p. 4563-4566 4 p.

Research output: Contribution to journalArticle

37 Scopus citations
2008

Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver

Liao, Y. C. & Lo, S. H., 2008, In : International Journal of Biochemistry and Cell Biology. 40, 5, p. 843-847 5 p.

Research output: Contribution to journalArticle

89 Scopus citations

Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function

Liao, Y. C., Shih, Y. P. & Lo, S. H., Oct 1 2008, In : Cancer Research. 68, 19, p. 7718-7722 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y. C., Trusk, P., Lyass, A., Rechavi, G., Spector, N. L., Lo, S. H. & 3 others, Schmitt, F., Bacus, S. S. & Yarden, Y., Aug 2007, In : Nature Cell Biology. 9, 8, p. 961-969 9 p.

Research output: Contribution to journalArticle

125 Scopus citations

Association of the tensin N-terminal protein-tyrosine phosphatase domain with the α isoform of protein phosphatase-1 in focal adhesions

Eto, M., Kirkbride, J., Elliott, E., Lo, S. H. & Brautigan, D. L., Jun 15 2007, In : Journal of Biological Chemistry. 282, 24, p. 17806-17815 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reverse interactomics: From peptides to proteins and to functions

Lo, S. H., Feb 2007, In : ACS Chemical Biology. 2, 2, p. 93-95 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
114 Scopus citations
2006

An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells

Hu, L. Y., Tepper, C. G., Lo, S. H. & Lin, W. C., 2006, In : Gene Expression. 13, 3, p. 179-189 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Focal adhesions: What's new inside

Lo, S. H., Jun 15 2006, In : Developmental Biology. 294, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer

You, Z., Shi, X. B., DuRaine, G., Haudenschild, D. R., Tepper, C. G., Lo, S. H., Gandour-Edwards, R. F., deVere White, R. W. & Reddi, A. H., Jan 1 2006, In : Cancer Research. 66, 1, p. 175-183 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Cleavage of cten by caspase-3 during apoptosis

Lo, S. S., Lo, S. H. & Lo, S. H., Jun 16 2005, In : Oncogene. 24, 26, p. 4311-4314 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inactivation of tensin3 in mice results in growth retardation and postnatal lethality

Chiang, M. K., Liao, Y. C., Kuwabara, Y. & Lo, S. H., Mar 15 2005, In : Developmental Biology. 279, 2, p. 368-377 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

The N-terminal half of talin2 is sufficient for mouse development and survival

Chen, N. T. & Lo, S. H., Nov 18 2005, In : Biochemical and Biophysical Research Communications. 337, 2, p. 670-676 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3

Cui, Y., Liao, Y. C. & Lo, S. H., Apr 2004, In : Molecular Cancer Research. 2, 4, p. 225-232 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Tensin

Lo, S. H., Jan 2004, In : International Journal of Biochemistry and Cell Biology. 36, 1, p. 31-34 4 p.

Research output: Contribution to journalArticle

141 Scopus citations
2003

Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2

Chen, H. & Lo, S. H., Mar 15 2003, In : Biochemical Journal. 370, 3, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
2002

Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer

Lo, S. H. & Lo, T. B., Aug 1 2002, In : Cancer Research. 62, 15, p. 4217-4221 5 p.

Research output: Contribution to journalArticle

65 Scopus citations
48 Scopus citations

Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration

Chen, H., Duncan, I. C., Bozorgchami, H. & Lo, S. H., Jan 22 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 2, p. 733-738 6 p.

Research output: Contribution to journalArticle

80 Scopus citations
2001

A role of tensin in skeletal-muscle regeneration

Ishii, A. & Lo, S. H., Jun 15 2001, In : Biochemical Journal. 356, 3, p. 737-745 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Quantitative analysis of angiogenesis using confocal laser scanning microscopy

Guo, L., Burke, P., Lo, S. H., Gandour-Edwards, R. F. & Lau, D. H., 2001, In : Angiogenesis. 4, 3, p. 187-191 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2000

Molecular characterization of human tensin

Chen, H., Ishii, A., Wong, W. K., Chen, L. B. & Lo, S. H., Oct 15 2000, In : Biochemical Journal. 351, 2, p. 403-411 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
1999

Inhibition of focal contact formation in cells transformed by p 185(neu)

Lo, S. S., Lo, S. H., Wang, S. C. & Hung, M. C., 1999, In : Molecular Carcinogenesis. 25, 2, p. 150-154 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment of ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445

Tikoo, A., Cutler, H., Lo, S. H., Chen, L. B. & Maruta, H., Sep 1999, In : Cancer Journal from Scientific American. 5, 5, p. 293-300 8 p.

Research output: Contribution to journalArticle

23 Scopus citations