• 6453 Citations
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1993 …2020

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Article
2020

Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

Weng, K. C., Kurokawa, Y. K., Hajek, B. S., Paladin, J. A., Shirure, V. S. & George, S. C., Jan 2020, In : Tissue Engineering - Part C: Methods. 26, 1, p. 44-55 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model

Seiler, K. M., Bajinting, A., Alvarado, D. M., Traore, M. A., Binkley, M. M., Goo, W. H., Lanik, W. E., Ou, J., Ismail, U., Iticovici, M., King, C. R., VanDussen, K. L., Swietlicki, E. A., Gazit, V., Guo, J., Luke, C. J., Stappenbeck, T., Ciorba, M. A., George, S. C., Meacham, J. M. & 3 others, Rubin, D. C., Good, M. & Warner, B. W., Dec 1 2020, In : Scientific reports. 10, 1, 3842.

Research output: Contribution to journalArticle

Open Access
2019

A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis

Natividad-Diaz, S. L., Browne, S., Jha, A. K., Ma, Z., Hossainy, S., Kurokawa, Y. K., George, S. & Healy, K. E., Feb 1 2019, In : Biomaterials. 194, p. 73-83 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Randomly distributed K14 þ breast tumor cells polarize to the leading edge and guide collective migration in response to chemical and mechanical environmental cues

Hwang, P. Y., Brenot, A., King, A. C., Longmore, G. D. & George, S., Apr 15 2019, In : Cancer Research. 79, 8, p. 1899-1912 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogels

Gaetani, R., Aude, S., Demaddalena, L. L., Strassle, H., Dzieciatkowska, M., Wortham, M., Bender, R. H. F., Nguyen-Ngoc, K. V., Schmid-Schöenbein, G. W., George, S., Hughes, C. C. W., Sander, M., Hansen, K. C. & Christman, K. L., Dec 1 2018, In : Tissue Engineering - Part C: Methods. 24, 12, p. 697-708 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Microfluidic device to attain high spatial and temporal control of oxygen

Lam, S. F., Shirure, V. S., Chu, Y. E., Soetikno, A. G. & George, S., Dec 1 2018, In : PLoS One. 13, 12, e0209574.

Research output: Contribution to journalArticle

6 Scopus citations

Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes

Kurokawa, Y. K., Shang, M. R., Yin, R. T. & George, S., Mar 15 2018, In : Toxicology Letters. 285, p. 74-80 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

Shirure, V. S., Bi, Y., Curtis, M. B., Lezia, A., Goedegebuure, M. M., Goedegebuure, S. P., Aft, R., Fields, R. C. & George, S., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3687-3702 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Phan, D. T. T., Wang, X., Craver, B. M., Sobrino, A., Zhao, D., Chen, J. C., Lee, L. Y. N., George, S., Lee, A. P. & Hughes, C. C. W., Jan 1 2017, In : Lab on a Chip. 17, 3, p. 511-520 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Cancer-associated fibroblasts support vascular growth through mechanical force

Sewell-Loftin, M. K., Bayer, S. V. H., Crist, E., Hughes, T., Joison, S. M., Longmore, G. D. & George, S., Dec 1 2017, In : Scientific Reports. 7, 1, 12574.

Research output: Contribution to journalArticle

13 Scopus citations

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms

Shirure, V. S. & George, S., Jan 1 2017, In : Lab on a Chip. 17, 4, p. 681-690 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ensemble clustering of phosphoproteomic data identifies differences in protein interactions and cell-cell junction integrity of HER2-overexpressing cells

Schaberg, K. E., Shirure, V. S., Worley, E. A., George, S. & Naegle, K. M., Jun 1 2017, In : Integrative Biology (United Kingdom). 9, 6, p. 539-547 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems

Kurokawa, Y. K., Yin, R. T., Shang, M. R., Shirure, V. S., Moya, M. L. & George, S., Aug 1 2017, In : Tissue Engineering - Part C: Methods. 23, 8, p. 474-484 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis

Shirure, V. S., Lezia, A., Tao, A., Alonzo, L. F. & George, S., Nov 1 2017, In : Angiogenesis. 20, 4, p. 493-504 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

3D microtumors in vitro supported by perfused vascular networks

Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., Gratton, E., Lee, A. P., George, S. & Hughes, C. C. W., Aug 23 2016, In : Scientific Reports. 6, 31589.

Research output: Contribution to journalArticle

97 Scopus citations

An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

Wang, X., Phan, D. T. T., Zhao, D., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2016, In : Lab on a Chip. 16, 5, p. 868-876 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

Wang, X., Phan, D. T. T., Sobrino, A., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2016, In : Lab on a Chip. 16, 2, p. 282-290 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cellderived cardiomyocytes

Datta, R., Heylman, C., George, S. & Gratton, E., May 1 2016, In : Biomedical Optics Express. 7, 5, p. 1690-1701 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Fong, A. H., Romero-López, M., Heylman, C. M., Keating, M., Tran, D., Sobrino, A., Tran, A. Q., Pham, H. H., Fimbres, C., Gershon, P. D., Botvinick, E. L., George, S. & Hughes, C. C. W., Aug 1 2016, In : Tissue Engineering - Part A. 22, 15-16, p. 1016-1025 10 p.

Research output: Contribution to journalArticle

54 Scopus citations
2015

Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components

Merna, N., Fung, K. M., Wang, J. J., King, C. R., Hansen, K. C., Christman, K. L. & George, S., Jan 1 2015, In : Tissue Engineering - Part A. 21, 15-16, p. 2195-2205 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Machine learning plus optical flow: A simple and sensitive method to detect cardioactive drugs

Lee, E. K., Kurokawa, Y. K., Tu, R., George, S. & Khine, M., Jul 3 2015, In : Scientific Reports. 5, 11817.

Research output: Contribution to journalArticle

15 Scopus citations

Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication

Alonzo, L. F., Moya, M. L., Shirure, V. S. & George, S., Jun 19 2015, In : Lab on a Chip. 15, 17, p. 3521-3529 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Supervised machine learning for classification of the electrophysiological effects of chronotropic drugs on human induced pluripotent stem cell-derived cardiomyocytes

Heylman, C., Datta, R., Sobrino, A., George, S. & Gratton, E., Dec 1 2015, In : PLoS One. 10, 12, e0144572.

Research output: Contribution to journalArticle

12 Scopus citations

Vessel network formation in response to intermittent hypoxia is frequency dependent

Ehsan, S. M. & George, S., Sep 1 2015, In : Journal of Bioscience and Bioengineering. 120, 3, p. 347-350 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Angiogenic sprouting is regulated by endothelial cell expression of Slug

Welch-Reardon, K. M., Ehsan, S. M., Wang, K., Wu, N., Newman, A. C., Romero-Lopez, M., Fong, A. H., George, S., Edwards, R. A. & Hughes, C. C. W., Jan 1 2014, In : Journal of Cell Science. 127, 9, p. 2017-2028 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Heylman, C., Sobrino, A., Shirure, V. S., Hughes, C. C. W. & George, S., Jan 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1240-1254 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

A three-dimensional in vitro model of tumor cell intravasation

Ehsan, S. M., Welch-Reardon, K. M., Waterman, M. L., Hughes, C. C. W. & George, S., Jan 1 2014, In : Integrative Biology (United Kingdom). 6, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

98 Scopus citations

Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis

White, S. M., Pittman, C. R., Hingorani, R., Arora, R., Esipova, T. V., Vinogradov, S. A., Hughes, C. C. W., Choi, B. & George, S., Jan 1 2014, In : Tissue Engineering - Part A. 20, 17-18, p. 2316-2328 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Integrating in vitro organ-specific function with the microcirculation

Moya, M. L. & George, S., Feb 1 2014, In : Current Opinion in Chemical Engineering. 3, p. 102-111 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

Robertson, C., Heidari, A. E., Chen, Z. & George, S., Feb 7 2014, In : Journal of Biomechanics. 47, 3, p. 755-758 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Adenosine A1 and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury

Zhou, J., Alvarez-Elizondo, M. B., Botvinick, E. & George, S., Mar 1 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

Hsu, Y. H., Moya, M. L., Hughes, C. C. W., George, S. & Lee, A. P., Aug 7 2013, In : Lab on a Chip. 13, 15, p. 2990-2998 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Full range physiological mass transport control in 3D tissue cultures

Hsu, Y. H., Moya, M. L., Abiri, P., Hughes, C. C. W., George, S. & Lee, A. P., Jan 7 2013, In : Lab on a Chip. 13, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Grand challenges in interfacing engineering with life sciences and medicine

He, B., Baird, R., Butera, R., Datta, A., George, S., Hecht, B., Hero, A., Lazzi, G., Lee, R. C., Liang, J., Neuman, M., Peng, G. C. Y., Perreault, E. J., Ramasubramanian, M., Wang, M. D., Wikswo, J., Yang, G. Z. & Zhang, Y. T., Oct 1 2013, In : IEEE Transactions on Biomedical Engineering. 60, 3, p. 589-598 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

In vitro perfused human capillary networks

Moya, M. L., Hsu, Y. H., Lee, A. P., Christopher, C. W. H. & George, S., Sep 1 2013, In : Tissue Engineering - Part C: Methods. 19, 9, p. 730-737 8 p.

Research output: Contribution to journalArticle

198 Scopus citations

Multiscale analysis of collagen microstructure with generalized image correlation spectroscopy and the detection of tissue prestress

Robertson, C., Ikemura, K., Krasieva, T. B. & George, S., Aug 1 2013, In : Biomaterials. 34, 26, p. 6127-6132 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nonsteady state oxygen transport in engineered tissue: Implications for design

Ehsan, S. M. & George, S., Jun 1 2013, In : Tissue Engineering - Part A. 19, 11-12, p. 1433-1442 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Optical imaging predicts mechanical properties during decellularization of cardiac tissue

Merna, N., Robertson, C., La, A. & George, S., Oct 1 2013, In : Tissue Engineering - Part C: Methods. 19, 10, p. 802-809 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children

Shi, Y., Aledia, A. S., Galant, S. P. & George, S., Mar 1 2013, In : Journal of Allergy and Clinical Immunology. 131, 3, p. 718-723 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
2012

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: Implications for hereditary hemorrhagic telangiectasia type II

Kim, J. H., Peacock, M. R., George, S. & Hughes, C. C. W., Sep 1 2012, In : Angiogenesis. 15, 3, p. 497-509 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cut points for Asthma Control Tests in Mexican children in Orange County, California

Shi, Y., Tatavoosian, A. V., Aledia, A. S., George, S. & Galant, S. P., Aug 1 2012, In : Annals of Allergy, Asthma and Immunology. 109, 2, p. 108-113 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

In moderate-to-severe asthma patients monitoring exhaled nitric oxide during exacerbation is not a good predictor of spirometric response to oral corticosteroid

Gelb, A. F., Moridzadeh, R., Singh, D. H., Fraser, C. & George, S., Jun 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 6, p. 1491-1498 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Local small airway epithelial injury induces global smooth muscle contraction and airway constriction

Zhou, J., Alvarez-Elizondo, M. B., Botvinick, E. & George, S., Feb 1 2012, In : Journal of Applied Physiology. 112, 4, p. 627-637 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues

White, S. M., Hingorani, R., Arora, R. P. S., Hughes, C. C. W., George, S. & Choi, B., Sep 1 2012, In : Tissue Engineering - Part C: Methods. 18, 9, p. 697-709 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Relating small airways to asthma control by using impulse oscillometry in children

Shi, Y., Aledia, A. S., Tatavoosian, A. V., Vijayalakshmi, S., Galant, S. P. & George, S., Mar 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 3, p. 671-678 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

Theory and practical recommendations for autocorrelation-based image correlation spectroscopy

Robertson, C. & George, S., Aug 1 2012, In : Journal of Biomedical Optics. 17, 8, 080801.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Airway gas exchange and exhaled biomarkers

George, S. & Hlastala, M. P., Oct 1 2011, In : Comprehensive Physiology. 1, 4, p. 1837-1859 23 p.

Research output: Contribution to journalArticle

6 Scopus citations

Automated computation of functional vascular density using laser speckle imaging in a rodent window chamber model

White, S. M., George, S. & Choi, B., Jul 1 2011, In : Microvascular Research. 82, 1, p. 92-95 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Increased nitric oxide concentrations in the small airway of older normal subjects

Gelb, A. F., George, S., Camacho, F., Fraser, C., Taylor, C. F. & Shakkottai, S., Feb 1 2011, In : Chest. 139, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography

Robertson, C., Lee, S. W., Ahn, Y. C., Mahon, S., Chen, Z., Brenner, M. & George, S., Oct 1 2011, In : Journal of Biomedical Optics. 16, 10, 106011.

Research output: Contribution to journalArticle

11 Scopus citations