• 6392 Citations
  • 41 h-Index
1993 …2020

Research output per year

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Research Output

2020

Controlling oxygen gradients within microfluidic devices to study angiogenesis

Lam, S. F., Chu, Y. E., Soetikno, A. G. & George, S. C., Jan 1 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 1055-1056 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model

Seiler, K. M., Bajinting, A., Alvarado, D. M., Traore, M. A., Binkley, M. M., Goo, W. H., Lanik, W. E., Ou, J., Ismail, U., Iticovici, M., King, C. R., VanDussen, K. L., Swietlicki, E. A., Gazit, V., Guo, J., Luke, C. J., Stappenbeck, T., Ciorba, M. A., George, S. C., Meacham, J. M. & 3 others, Rubin, D. C., Good, M. & Warner, B. W., Dec 1 2020, In : Scientific reports. 10, 1, 3842.

Research output: Contribution to journalArticle

Open Access
2019

A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis

Natividad-Diaz, S. L., Browne, S., Jha, A. K., Ma, Z., Hossainy, S., Kurokawa, Y. K., George, S. & Healy, K. E., Feb 1 2019, In : Biomaterials. 194, p. 73-83 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Randomly distributed K14 þ breast tumor cells polarize to the leading edge and guide collective migration in response to chemical and mechanical environmental cues

Hwang, P. Y., Brenot, A., King, A. C., Longmore, G. D. & George, S., Apr 15 2019, In : Cancer Research. 79, 8, p. 1899-1912 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogels

Gaetani, R., Aude, S., Demaddalena, L. L., Strassle, H., Dzieciatkowska, M., Wortham, M., Bender, R. H. F., Nguyen-Ngoc, K. V., Schmid-Schöenbein, G. W., George, S., Hughes, C. C. W., Sander, M., Hansen, K. C. & Christman, K. L., Dec 1 2018, In : Tissue Engineering - Part C: Methods. 24, 12, p. 697-708 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Microfluidic device to attain high spatial and temporal control of oxygen

Lam, S. F., Shirure, V. S., Chu, Y. E., Soetikno, A. G. & George, S., Dec 1 2018, In : PLoS One. 13, 12, e0209574.

Research output: Contribution to journalArticle

6 Scopus citations

Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes

Kurokawa, Y. K., Shang, M. R., Yin, R. T. & George, S., Mar 15 2018, In : Toxicology Letters. 285, p. 74-80 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

Shirure, V. S., Bi, Y., Curtis, M. B., Lezia, A., Goedegebuure, M. M., Goedegebuure, S. P., Aft, R., Fields, R. C. & George, S., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3687-3702 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2017

3D anastomosed microvascular network model with living capillary networks and endothelial cell-lined microfluidic channels

Wang, X., Phan, D. T. T., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 325-344 20 p. (Methods in Molecular Biology; vol. 1612).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Phan, D. T. T., Wang, X., Craver, B. M., Sobrino, A., Zhao, D., Chen, J. C., Lee, L. Y. N., George, S., Lee, A. P. & Hughes, C. C. W., Jan 1 2017, In : Lab on a Chip. 17, 3, p. 511-520 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

Phan, D. T. T., Bender, R. H. F., Andrejecsk, J. W., Sobrino, A., Hachey, S. J., George, S. & Hughes, C. C. W., Nov 1 2017, In : Experimental Biology and Medicine. 242, 17, p. 1669-1678 10 p.

Research output: Contribution to journalReview article

41 Scopus citations

Cancer-associated fibroblasts support vascular growth through mechanical force

Sewell-Loftin, M. K., Bayer, S. V. H., Crist, E., Hughes, T., Joison, S. M., Longmore, G. D. & George, S., Dec 1 2017, In : Scientific Reports. 7, 1, 12574.

Research output: Contribution to journalArticle

12 Scopus citations

Challenges and Opportunities: Building a Relationship Between a Department of Biomedical Engineering and a Medical School

behalf of the Council of Chairs of Biomedical Engineering, Mar 1 2017, In : Annals of Biomedical Engineering. 45, 3, p. 521-524 4 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms

Shirure, V. S. & George, S., Jan 1 2017, In : Lab on a Chip. 17, 4, p. 681-690 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Ensemble clustering of phosphoproteomic data identifies differences in protein interactions and cell-cell junction integrity of HER2-overexpressing cells

Schaberg, K. E., Shirure, V. S., Worley, E. A., George, S. & Naegle, K. M., Jun 1 2017, In : Integrative Biology (United Kingdom). 9, 6, p. 539-547 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Frequency domain phosphorescence lifetime Imaging measurements and applications by ISS FastFLIM and multi pulse excitation

Coskun, U. C., Lam, S., Sun, Y., Liao, S. C. J., George, S. & Barbieri, B., Jan 1 2017, Multiphoton Microscopy in the Biomedical Sciences XVII. Konig, K., So, P. T. C., Periasamy, A. & Xie, X. S. (eds.). SPIE, Vol. 10069. 1006918

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems

Kurokawa, Y. K., Yin, R. T., Shang, M. R., Shirure, V. S., Moya, M. L. & George, S., Aug 1 2017, In : Tissue Engineering - Part C: Methods. 23, 8, p. 474-484 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis

Shirure, V. S., Lezia, A., Tao, A., Alonzo, L. F. & George, S., Nov 1 2017, In : Angiogenesis. 20, 4, p. 493-504 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Tissue Engineering the Vascular Tree

Traore, M. A. & George, S., Dec 1 2017, In : Tissue Engineering - Part B: Reviews. 23, 6, p. 505-514 10 p.

Research output: Contribution to journalReview article

13 Scopus citations
2016

3D microtumors in vitro supported by perfused vascular networks

Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., Gratton, E., Lee, A. P., George, S. & Hughes, C. C. W., Aug 23 2016, In : Scientific Reports. 6, 31589.

Research output: Contribution to journalArticle

93 Scopus citations

An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

Wang, X., Phan, D. T. T., Zhao, D., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2016, In : Lab on a Chip. 16, 5, p. 868-876 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

Wang, X., Phan, D. T. T., Sobrino, A., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2016, In : Lab on a Chip. 16, 2, p. 282-290 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cellderived cardiomyocytes

Datta, R., Heylman, C., George, S. & Gratton, E., May 1 2016, In : Biomedical Optics Express. 7, 5, p. 1690-1701 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Fong, A. H., Romero-López, M., Heylman, C. M., Keating, M., Tran, D., Sobrino, A., Tran, A. Q., Pham, H. H., Fimbres, C., Gershon, P. D., Botvinick, E. L., George, S. & Hughes, C. C. W., Aug 1 2016, In : Tissue Engineering - Part A. 22, 15-16, p. 1016-1025 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening

Kurokawa, Y. K. & George, S., Jan 15 2016, In : Advanced Drug Delivery Reviews. 96, p. 225-233 9 p.

Research output: Contribution to journalReview article

26 Scopus citations
2015

Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components

Merna, N., Fung, K. M., Wang, J. J., King, C. R., Hansen, K. C., Christman, K. L. & George, S., Jan 1 2015, In : Tissue Engineering - Part A. 21, 15-16, p. 2195-2205 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Machine learning plus optical flow: A simple and sensitive method to detect cardioactive drugs

Lee, E. K., Kurokawa, Y. K., Tu, R., George, S. & Khine, M., Jul 3 2015, In : Scientific Reports. 5, 11817.

Research output: Contribution to journalArticle

15 Scopus citations

Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication

Alonzo, L. F., Moya, M. L., Shirure, V. S. & George, S., Jun 19 2015, In : Lab on a Chip. 15, 17, p. 3521-3529 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue

Wang, X., Phan, D., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2015, MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 740-742 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Supervised machine learning for classification of the electrophysiological effects of chronotropic drugs on human induced pluripotent stem cell-derived cardiomyocytes

Heylman, C., Datta, R., Sobrino, A., George, S. & Gratton, E., Dec 1 2015, In : PLoS One. 10, 12, e0144572.

Research output: Contribution to journalArticle

12 Scopus citations

Vessel network formation in response to intermittent hypoxia is frequency dependent

Ehsan, S. M. & George, S., Sep 1 2015, In : Journal of Bioscience and Bioengineering. 120, 3, p. 347-350 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Angiogenic sprouting is regulated by endothelial cell expression of Slug

Welch-Reardon, K. M., Ehsan, S. M., Wang, K., Wu, N., Newman, A. C., Romero-Lopez, M., Fong, A. H., George, S., Edwards, R. A. & Hughes, C. C. W., Jan 1 2014, In : Journal of Cell Science. 127, 9, p. 2017-2028 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Heylman, C., Sobrino, A., Shirure, V. S., Hughes, C. C. W. & George, S., Jan 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1240-1254 15 p.

Research output: Contribution to journalArticle

27 Scopus citations

A three-dimensional in vitro model of tumor cell intravasation

Ehsan, S. M., Welch-Reardon, K. M., Waterman, M. L., Hughes, C. C. W. & George, S., Jan 1 2014, In : Integrative Biology (United Kingdom). 6, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Electrical stimulation toward maturation of iPS cellderived cardiomyocytes in a 3-D tissue matrix

Simon, M. G., Lam, S., Tran, D. D., Alonzo, L. F., Flohn, N., George, S. & Lee, A. P., Jan 1 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 751-753 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Engineering anastomosis between biological perfused vessel networks and endothelial cell-lined microfluidic channels

Wang, X., Phan, D., George, S., Hughes, C. C. W. & Lee, A. P., Jan 1 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 748-750 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis

White, S. M., Pittman, C. R., Hingorani, R., Arora, R., Esipova, T. V., Vinogradov, S. A., Hughes, C. C. W., Choi, B. & George, S., Jan 1 2014, In : Tissue Engineering - Part A. 20, 17-18, p. 2316-2328 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Integrating in vitro organ-specific function with the microcirculation

Moya, M. L. & George, S., Feb 1 2014, In : Current Opinion in Chemical Engineering. 3, p. 102-111 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Label - free fluorescence lifetime imaging of microfluidic device based cardiac tissue model metabolism

Datta, R., Heylman, C., Tran, D., George, S. & Gratton, E., Jan 1 2014, Laser Science, LS 2014. Optical Society of America (OSA)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

Robertson, C., Heidari, A. E., Chen, Z. & George, S., Feb 7 2014, In : Journal of Biomechanics. 47, 3, p. 755-758 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Microfluidic device to culture 3D in vitro human capillary networks

Moya, M. L., Alonzo, L. F. & George, S., Jan 1 2014, Biomimetics and Stem Cells: Methods and Protocols. Humana Press Inc., p. 21-27 7 p. (Methods in Molecular Biology; vol. 1202).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Microfluidic platform to examine tumor angiogenesis and metastasis at high spatiotemporal resolution

Shirure, V. S. & George, S., Jan 1 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 181-183 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vascularizing engineered tissues for in vivo and in vitro applications

George, S., Jan 1 2014, Cardiac Regeneration and Repair: Biomaterials and Tissue Engineering. Elsevier Ltd., p. 283-298 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

Adenosine A1 and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury

Zhou, J., Alvarez-Elizondo, M. B., Botvinick, E. & George, S., Mar 1 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Age-stratified comparison of large and peripheral airway/alveolar nitric oxide levels in children and young adults

Gelb, A. F., Singh, D. H., Moridzadeh, R., Fraser, C., Tran, D., Verbanck, S. & George, S., Nov 1 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1222-1224 3 p.

Research output: Contribution to journalLetter

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

Hsu, Y. H., Moya, M. L., Hughes, C. C. W., George, S. & Lee, A. P., Aug 7 2013, In : Lab on a Chip. 13, 15, p. 2990-2998 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

An integrated in vitro model of perfused tumor and cardiac tissue

Moya, M., Tran, D. & George, S., Dec 20 2013, In : Stem Cell Research and Therapy. 4, SUPPL.1, S15.

Research output: Contribution to journalReview article

40 Scopus citations

Concise review: Maturation phases of human pluripotent stem cell-derived cardiomyocytes

Robertson, C., Tran, D. D. & George, S., May 1 2013, In : Stem Cells. 31, 5, p. 829-837 9 p.

Research output: Contribution to journalReview article

171 Scopus citations

Engineering a three-dimensional model of vascularized human tumor tissue

Ehsan, S. M., Alonzo, L. F., Waterman, M. L., Hughes, C. C. W. & George, S., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Full range physiological mass transport control in 3D tissue cultures

Hsu, Y. H., Moya, M. L., Abiri, P., Hughes, C. C. W., George, S. & Lee, A. P., Jan 7 2013, In : Lab on a Chip. 13, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

62 Scopus citations