• 11318 Citations
  • 62 h-Index
1993 …2020

Research output per year

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Research Output

  • 11318 Citations
  • 62 h-Index
  • 148 Article
  • 6 Review article
  • 2 Chapter
  • 1 Editorial
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Article
2020

NOD1/NOD2 and rip2 regulate endoplasmic reticulum stress-induced inflammation during chlamydia infection

Pham, O. H., Lee, B., Labuda, J., Keestra-Gounder, A. M., Byndloss, M. X., Tsolis, R. M. & McSorley, S. J., May 1 2020, In : mBio. 11, 3, e00979-20.

Research output: Contribution to journalArticle

Open Access
2019

Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP

Byndloss, M. X., Tsai, A. Y., Walker, G. T., Miller, C. N., Young, B. M., English, B. C., Seyffert, N., Kerrinnes, T., de Jong, M. F., Atluri, V., Winter, M. G., Celli, J. & Tsolis, R. M., Jul 23 2019, In : mBio. 10, 4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition

Litvak, Y., Mon, K. K. Z., Nguyen, H., Chanthavixay, G., Liou, M., Velazquez, E. M., Kutter, L., Alcantara, M. A., Byndloss, M. X., Tiffany, C. R., Walker, G. T., Faber, F., Zhu, Y., Bronner, D. N., Byndloss, A. J., Tsolis, R. M., Zhou, H. & Baumler, A. J., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 128-139.e5

Research output: Contribution to journalArticle

15 Scopus citations
2018

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens

Yokoyama, C. C., Baldridge, M. T., Leung, D. W., Zhao, G., Desai, C., Liu, T. C., Diaz-Ochoa, V. E., Huynh, J. P., Kimmey, J. M., Sennott, E. L., Hole, C. R., Idol, R. A., Park, S., Storek, K. M., Wang, C., Hwang, S., Milam, A. V., Chen, E., Kerrinnes, T., Starnbach, M. N. & 12 others, Handley, S. A., Mysorekar, I. U., Allen, P. M., Monack, D. M., Dinauer, M. C., Doering, T. L., Tsolis, R. M., Dworkin, J. E., Stallings, C. L., Amarasinghe, G. K., Micchelli, C. A. & Virgina, H. W., Jan 1 2018, In : Journal of Biological Chemistry. 293, 16, p. 6022-6038 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Malaria parasite-mediated alteration of macrophage function and increased iron availability predispose to disseminated nontyphoidal Salmonella infection

Lokken, K. L., Stull-Lane, A. R., Poels, K. & Tsolis, R. M., Sep 1 2018, In : Infection and Immunity. 86, 9, e00301-18.

Research output: Contribution to journalArticle

8 Scopus citations

Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus

Kerrinnes, T., Winter, M. G., Young, B. M., Diaz-Ochoa, V. E., Winter, S. E. & Tsolis, R. M., Mar 1 2018, In : Infection and Immunity. 86, 3, e00458-17.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Byndloss, M. X., Olsan, E. E., Rivera-Chávez, F., Tiffany, C. R., Cevallos, S. A., Lokken, K. L., Torres, T. P., Byndloss, A. J., Faber, F., Gao, Y., Litvak, Y., Lopez, C. A., Xu, G., Napoli, E., Giulivi, C., Tsolis, R. M., Revzin, A., Lebrilla, C. B. & Bäumler, A. J., Aug 11 2017, In : Science. 357, 6351, p. 570-575 6 p.

Research output: Contribution to journalArticle

216 Scopus citations

NOD1 and NOD2: Beyond Peptidoglycan Sensing

Keestra-Gounder, A. M. & Tsolis, R. M., 2017, (Accepted/In press) In : Trends in Immunology.

Research output: Contribution to journalArticle

28 Scopus citations

Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells

Carden, S. E., Walker, G. T., Honeycutt, J., Lugo, K., Pham, T., Jacobson, A., Bouley, D., Idoyaga, J., Tsolis, R. M. & Monack, D., Feb 8 2017, In : Cell Host and Microbe. 21, 2, p. 182-194 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria

Pham, O. H., O’Donnell, H., Al-Shamkhani, A., Kerrinnes, T., Tsolis, R. M. & Mcsorley, S. J., Aug 1 2017, In : PLoS Pathogens. 13, 8, e1006566.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Chronic bacterial pathogens: Mechanisms of persistence

Byndloss, M. X. & Tsolis, R. M., 2016, In : Microbiology spectrum. 4, 2, VMBF-0020-2015.

Research output: Contribution to journalArticle

14 Scopus citations

Energy taxis toward host-derived nitrate supports a salmonella pathogenicity island 1-independent mechanism of invasion

Rivera-Chávez, F., Lopez, C. A., Zhang, L. F., García-Pastor, L., Chávez-Arroyo, A., Lokken, K. L., Tsolis, R. M., Winter, S. E. & Baumler, A. J., Jul 1 2016, In : mBio. 7, 4, e00960-16.

Research output: Contribution to journalArticle

21 Scopus citations

Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

Faber, F., Tran, L., Byndloss, M. X., Lopez, C. A., Velazquez, E. M., Kerrinnes, T., Nuccio, S. P., Wangdi, T., Fiehn, O., Tsolis, R. M. & Baumler, A. J., Jun 30 2016, In : Nature. 534, 7609, p. 697-699 3 p.

Research output: Contribution to journalArticle

75 Scopus citations

Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium

Costa, L. F., Mol, J. P. S., Silva, A. P. C., Macêdo, A. A., Silva, T. M. A., Alves, G. E. S., Winter, S., Winter, M. G., Velazquez, E. M., Byndloss, M. X., Baumler, A. J., Tsolis, R. M., Paixão, T. A. & Santos, R. L., Dec 1 2016, In : International Journal of Medical Microbiology. 306, 8, p. 604-610 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of multicellular behavior in epidemic african nontyphoidal salmonella enterica serovar typhimurium ST313 strain D23580

Singletary, L. A., Karlinsey, J. E., Libby, S. J., Mooney, J. P., Lokken, K. L., Tsolis, R. M., Byndloss, M. X., Hirao, L. A., Gaulke, C. A., Crawford, R. W., Dandekar, S., Kingsley, R. A., Msefula, C. L., Heyderman, R. S. & Fang, F. C., Mar 1 2016, In : mBio. 7, 2, e02265-15.

Research output: Contribution to journalArticle

26 Scopus citations

NOD1 and NOD2: New functions linking endoplasmic reticulum stress and inflammation

Byndloss, M. X., Keestra-Gounder, A. M., Baumler, A. J. & Tsolis, R. M., Jul 1 2016, In : DNA and Cell Biology. 35, 7, p. 311-313 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

NOD1 and NOD2 signalling links ER stress with inflammation

Keestra-Gounder, A. M., Byndloss, M. X., Seyffert, N., Young, B. M., Chávez-Arroyo, A., Tsai, A. Y., Cevallos, S. A., Winter, M. G., Pham, O. H., Tiffany, C. R., De Jong, M. F., Kerrinnes, T., Ravindran, R., Luciw, P. A., Mcsorley, S. J., Baumler, A. J. & Tsolis, R. M., Apr 21 2016, In : Nature. 532, 7599, p. 394-397 4 p.

Research output: Contribution to journalArticle

184 Scopus citations

Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration

Lopez, C. A., Miller, B. M., Rivera-Chávez, F., Velazquez, E. M., Byndloss, M. X., Chávez-Arroyo, A., Lokken, K. L., Tsolis, R. M., Winter, S. E. & Baumler, A. J., Sep 16 2016, In : Science. 353, 6305, p. 1249-1253 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Bacteria, the endoplasmic reticulum and the unfolded protein response: Friends or foes?

Celli, J. & Tsolis, R. M., Feb 16 2015, In : Nature Reviews Microbiology. 13, 2, p. 71-82 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection

Mooney, J. P., Lokken, K. L., Byndloss, M. X., George, M. D., Velazquez, E. M., Faber, F., Butler, B. P., Walker, G. T., Ali, M. M., Potts, R., Tiffany, C., Ahmer, B. M. M., Luckhart, S. & Tsolis, R. M., Oct 5 2015, In : Scientific Reports. 5, 14603.

Research output: Contribution to journalArticle

30 Scopus citations

Mast cells and histamine alter intestinal permeability during malaria parasite infection

Potts, R. A., Tiffany, C. M., Pakpour, N., Lokken, K. L., Tiffany, C. R., Cheung, K., Tsolis, R. M. & Luckhart, S., Aug 9 2015, (Accepted/In press) In : Immunobiology.

Research output: Contribution to journalArticle

11 Scopus citations

Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

Keestra-Gounder, A. M., Tsolis, R. M. & Baumler, A. J., Mar 16 2015, In : Nature Reviews Microbiology. 13, 4, p. 206-216 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Phospholipase A1 modulates the cell envelope phospholipid content of brucella melitensis, contributing to polymyxin resistance and pathogenicity

Kerrinnes, T., Young, B. M., Leon, C., Roux, C. M., Tran, L., Atluri, V. L., Winter, M. G. & Tsolis, R. M., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6717-6724 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

The flagellar regulator TviA reduces pyroptosis by Salmonella enterica serovar Typhi

Winter, S. E., Winter, M. G., Atluri, V., Poon, V., Romão, E. L., Tsolis, R. M. & Baumler, A. J., 2015, In : Infection and Immunity. 83, 4, p. 1546-1555 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria

Mooney, J. P., Lee, S. J., Lokken, K. L., Nanton, M. R., Nuccio, S. P., Mcsorley, S. J. & Tsolis, R. M., Sep 14 2015, In : PLoS Neglected Tropical Diseases. 9, 9, e0004027.

Research output: Contribution to journalArticle

11 Scopus citations
2014

A Protein-Conjugate Approach to Develop a Monoclonal Antibody-Based Antigen Detection Test for the Diagnosis of Human Brucellosis

Patra, K. P., Saito, M., Atluri, V. L., Rolán, H. G., Young, B., Kerrinnes, T., Smits, H., Ricaldi, J. N., Gotuzzo, E., Gilman, R. H., Tsolis, R. M. & Vinetz, J. M., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2926.

Research output: Contribution to journalArticle

10 Scopus citations

Brucella melitensis T cell epitope recognition in humans with brucellosis in Peru

Cannella, A. P., Arlehamn, C. S. L., Sidney, J., Patra, K. P., Torres, K., Tsolis, R. M., Liang, L., Felgner, P. L., Saito, M., Gotuzzo, E., Gilman, R. H., Sette, A. & Vinetz, J. M., Jan 2014, In : Infection and Immunity. 82, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Comparative phylogenomics and evolution of the brucellae reveal a path to virulence

Wattam, A. R., Foster, J. T., Mane, S. P., Beckstrom-Sternberg, S. M., Beckstrom-Sternberg, J. M., Dickerman, A. W., Keim, P., Pearson, T., Shukla, M., Ward, D. V., Williams, K. P., Sobral, B. W., Tsolis, R. M., Whatmore, A. M. & O'Callaghan, D., Mar 2014, In : Journal of Bacteriology. 196, 5, p. 920-930 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Early transcriptional responses of bovine chorioallantoic membrane explants to wild type, ΔvirB2 or ΔbtpB Brucella abortus infection

Mol, J. P. S., Costa, E. A., Carvalho, A. F., Sun, Y. H., Tsolis, R. M., Paixão, T. A. & Santos, R. L., Sep 26 2014, In : PLoS One. 9, 9, e108606.

Research output: Contribution to journalArticle

7 Scopus citations

Hypoferremia of infection: A double-edged sword?

Lokken, K. L., Tsolis, R. M. & Baumler, A. J., 2014, In : Nature Medicine. 20, 4, p. 335-337 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Indirect ELISA for diagnosis of Brucella ovis infection in rams

França, S. A., Mol, J. P. S., Costa, E. A., Silva, A. P. C., Xavier, M. N., Tsolis, R. M., Reis, J. K. P., Paixão, T. A. & Santos, R. L., 2014, In : Arquivo Brasileiro de Medicina Veterinaria e Zootecnia. 66, 6, p. 1695-1702 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function

Lokken, K. L., Mooney, J. P., Butler, B. P., Xavier, M. N., Chau, J. Y., Schaltenberg, N., Begum, R. H., Müller, W., Luckhart, S. & Tsolis, R. M., 2014, In : PLoS Pathogens. 10, 5, e1004049.

Research output: Contribution to journalArticle

47 Scopus citations

Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar typhimurium colitis

Spees, A. M., Kingsbury, D. D., Wangdi, T., Xavier, M. N., Tsolis, R. M. & Baumler, A. J., 2014, In : Infection and Immunity. 82, 4, p. 1692-1697 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection

Mooney, J. P., Butler, B. P., Lokken, K. L., Xavier, M. N., Chau, J. Y., Schaltenberg, N., Dandekar, S., George, M. D., Santos, R. L., Luckhart, S. & Tsolis, R. M., Nov 25 2014, In : Mucosal Immunology. 7, 6, p. 1302-1311 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

The predicted ABC transporter AbcEDCBA is required for type IV secretion system expression and lysosomal evasion by Brucella ovis

Silva, T. M. A., Mol, J. P. S., Winter, M. G., Atluri, V., Xavier, M. N., Pires, S. F., Paixão, T. A., Andrade, H. M., Santos, R. L. & Tsolis, R. M., Dec 4 2014, In : PLoS One. 9, 12, e114532.

Research output: Contribution to journalArticle

13 Scopus citations

The quest for a true One Health perspective of brucellosis

Godfroid, J., De bolle, X., Roop, R. M., O'Callaghan, D., Tsolis, R. M., Baldwin, C., Santos, R. L., McGiven, J., Olsen, S., Nymo, I. H., Larsen, A., Al Dahouk, S. & Letesson, J. J., Aug 1 2014, In : OIE Revue Scientifique et Technique. 33, 2, p. 521-538 18 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

CD4+ T Cell-derived IL-10 Promotes Brucella abortus Persistence via Modulation of Macrophage Function

Xavier, M. N., Winter, M. G., Spees, A. M., Nguyen, K., Atluri, V. L., Silva, T. M. A., Baumler, A. J., Müller, W., Santos, R. L. & Tsolis, R. M., Jun 2013, In : PLoS Pathogens. 9, 6, e1003454.

Research output: Contribution to journalArticle

48 Scopus citations

Host-derived nitrate boosts growth of E. coli in the inflamed gut

Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., Popova, I. E., Parikh, S. J., Adams, L. G., Tsolis, R. M., Stewart, V. J. & Baumler, A. J., Feb 8 2013, In : Science. 339, 6120, p. 708-711 4 p.

Research output: Contribution to journalArticle

399 Scopus citations

Innate immune recognition of flagellin limits systemic persistence of Brucella

Terwagne, M., Ferooz, J., Rolán, H. G., Sun, Y. H., Atluri, V., Xavier, M. N., Franchi, L., Núñez, G., Legrand, T., Flavell, R. A., De Bolle, X., Letesson, J. J. & Tsolis, R. M., Jun 2013, In : Cellular Microbiology. 15, 6, p. 942-960 19 p.

Research output: Contribution to journalArticle

20 Scopus citations

Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi

Crawford, R. W., Wangdi, T., Spees, A. M., Xavier, M. N., Tsolis, R. M. & Baumler, A. J., Jul 16 2013, In : mBio. 4, 4

Research output: Contribution to journalArticle

32 Scopus citations

Malaria-associated l-arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against nontyphoidal salmonella bacteremia

Chau, J. Y., Tiffany, C. M., Nimishakavi, S., Lawrence, J. A., Pakpour, N., Mooney, J. P., Lokken, K. L., Caughey, G. H., Tsolis, R. M. & Luckhart, S., 2013, In : Infection and Immunity. 81, 10, p. 3515-3526 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

Keestra, A. M., Winter, M. G., Auburger, J. J., Fräßle, S. P., Xavier, M. N., Winter, S. E., Kim, A., Poon, V., Ravesloot, M. M., Waldenmaier, J. F. T., Tsolis, R. M., Eigenheer, R. A. & Baumler, A. J., Apr 11 2013, In : Nature. 496, 7444, p. 233-237 5 p.

Research output: Contribution to journalArticle

133 Scopus citations

PPARγ-mediated increase in glucose availability sustains chronic brucella abortus infection in alternatively activated macrophages

Xavier, M. N., Winter, M. G., Spees, A. M., Den Hartigh, A. B., Nguyen, K., Roux, C. M., Silva, T. M. A., Atluri, V. L., Kerrinnes, T., Keestra, A. M., Monack, D. M., Luciw, P. A., Eigenheer, R. A., Baumler, A. J., Santos, R. L. & Tsolis, R. M., Aug 14 2013, In : Cell Host and Microbe. 14, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation

Rivera-Chávez, F., Winter, S. E., Lopez, C. A., Xavier, M. N., Winter, M. G., Nuccio, S. P., Russell, J. M., Laughlin, R. C., Lawhon, S. D., Sterzenbach, T., Bevins, C. L., Tsolis, R. M., Harshey, R., Adams, L. G. & Baumler, A. J., Apr 2013, In : PLoS Pathogens. 9, 4, e1003267.

Research output: Contribution to journalArticle

86 Scopus citations

Sensing of bacterial type IV secretion via the unfolded protein response

de Jong, M. F., Starr, T., Winter, M. G., den Hartigh, A. B., Child, R., Knodler, L. A., van Dijl, J. M., Celli, J. & Tsolis, R. M., 2013, In : mBio. 4, 1

Research output: Contribution to journalArticle

58 Scopus citations

Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration

Spees, A. M., Wangdi, T., Lopez, C. A., Kingsbury, D. D., Xavier, M. N., Winter, S. E., Tsolis, R. M. & Baumler, A. J., Jul 2 2013, In : mBio. 4, 4

Research output: Contribution to journalArticle

89 Scopus citations
2012

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development.

Cannella, A. P., Tsolis, R. M., Liang, L., Felgner, P. L., Saito, M., Sette, A., Gotuzzo, E. & Vinetz, J. M., 2012, In : Frontiers in cellular and infection microbiology. 2, p. 1 1 p.

Research output: Contribution to journalArticle

18 Scopus citations

Brucellosis and type IV secretion

De Jong, M. F. & Tsolis, R. M., Jan 2012, In : Future Microbiology. 7, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
13 Scopus citations

Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets

Chu, H., Pazgier, M., Jung, G., Nuccio, S. P., Castillo, P. A., De Jong, M. F., Winter, M. G., Winter, S. E., Wehkamp, J., Shen, B., Salzman, N. H., Underwood, M., Tsolis, R. M., Young, G. M., Lu, W., Lehrer, R. I., Baumler, A. J. & Bevins, C. L., Jul 27 2012, In : Science. 337, 6093, p. 477-481 5 p.

Research output: Contribution to journalArticle

214 Scopus citations