Ralph W deVere White, MD

Professor

  • 11865 Citations
  • 56 h-Index
1973 …2021
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Research Output 1973 2019

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Article
2019
Open Access
Methionine Adenosyltransferase
Drug therapy
methionine
Chemotherapy
bladder
2018
10 Citations (Scopus)

Bioengineered noncoding RNAs selectively change cellular miRNome profiles for cancer therapy

Ho, P. Y., Duan, Z., Batra, N., Jilek, J. L., Tu, M. J., Qiu, J. X., Hu, Z., Wun, T., Lara, P. N., deVere White, R. W., Chen, H. & Yu, A., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 494-506 13 p.

Research output: Contribution to journalArticle

Untranslated RNA
MicroRNAs
Neoplasms
Bioengineering
Lung
2 Citations (Scopus)

Changing Incidence of Metastatic Prostate Cancer by Race and Age, 1988–2015

Dall'Era, M., deVere White, R. W., Rodriguez, D. & Cress, R. D., Jan 1 2018, (Accepted/In press) In : European Urology Focus.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Prostate-Specific Antigen
Incidence
Hispanic Americans
Age Groups
1 Citation (Scopus)

Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel

Wang, S., Scharadin, T. M., Zimmermann, M., Malfatti, M. A., Turteltaub, K. W., deVere White, R. W., Pan, C-X. & Henderson, P., Dec 17 2018, In : Chemical Research in Toxicology. 31, 12, p. 1293-1304 12 p.

Research output: Contribution to journalArticle

oxaliplatin
DNA Adducts
Cytotoxicity
Platinum
Cells
11 Citations (Scopus)

COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin

Wang, F., Zhang, H., Ma, A. H., Yu, W., Zimmermann, M., Yang, J., Hwang, S. H., Zhu, D., Lin, T-Y., Malfatti, M., Turteltaub, K. W., Henderson, P., Airhart, S., Hammock, B. D., Yuan, J., deVere White, R. W. & Pan, C-X., Feb 1 2018, In : Molecular Cancer Therapeutics. 17, 2, p. 474-483 10 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cyclooxygenase 2
Cisplatin
gemcitabine
Platinum
40 Citations (Scopus)

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

Wang, M., Yao, L. C., Cheng, M., Cai, D., Martinek, J., Pan, C-X., Shi, W., Ma, A. H., deVere White, R. W., Airhart, S., Liu, E. T., Banchereau, J., Brehm, M. A., Greiner, D. L., Shultz, L. D., Palucka, K. & Keck, J. G., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

Immunotherapy
Tumors
Immune system
Neoplasms
Heterografts
5 Citations (Scopus)

Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model

Long, Q., Lin, T-Y., Huang, Y., Li, X., Ma, A. H., Zhang, H., Carney, R., Airhart, S., Lam, K., deVere White, R. W., Pan, C-X. & Li, Y., Apr 1 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 789-799 11 p.

Research output: Contribution to journalArticle

tanespimycin
Heterografts
Urinary Bladder Neoplasms
Tumors
Photodynamic therapy
Urinary Bladder Neoplasms
Recurrence
Drug Therapy
Survival
Logistic Models
Urinary Bladder Neoplasms
Drug Therapy
Muscles
Urinary Bladder
Cystectomy
2017
4 Citations (Scopus)

A diagnostic microdosing approach to investigate platinum sensitivity in non-small cell lung cancer

Wang, S. S., Zimmermann, M., Zhang, H., Lin, T-Y., Malfatti, M., Haack, K., Turteltaub, K. W., Cimino, G. D., deVere White, R. W., Pan, C-X. & Henderson, P., Aug 1 2017, In : International Journal of Cancer. 141, 3, p. 604-613 10 p.

Research output: Contribution to journalArticle

Carboplatin
Platinum
Non-Small Cell Lung Carcinoma
Mass Spectrometry
oxaliplatin
7 Citations (Scopus)

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models

Jian, C., Tu, M. J., Ho, P. Y., Duan, Z., Zhang, Q., Qiu, J. X., deVere White, R. W., Wun, T., Lara, P. N., Lam, K., Yu, A. X. & Yu, A., 2017, In : Oncotarget. 8, 19, p. 30742-30755 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
RNA
Neoplasm Metastasis
Lung
DNA
6 Citations (Scopus)

Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells

Gheibi, P., Zeng, S., Son, K. J., Vu, T., Ma, A. H., Dall'Era, M., Yap, S., deVere White, R. W., Pan, C-X. & Revzin, A., Dec 1 2017, In : Scientific Reports. 7, 1, 12277.

Research output: Contribution to journalArticle

Drug Resistance
Heterografts
Urinary Bladder Neoplasms
Neoplasms
Precision Medicine
10 Citations (Scopus)

Microdose-induced drug-DNA adducts as biomarkers of chemotherapy resistance in humans and mice

Zimmermann, M., Wang, S. S., Zhang, H., Lin, T-Y., Malfatti, M., Haack, K., Ognibene, T., Yang, H., Airhart, S., Turteltaub, K. W., Cimino, G. D., Tepper, C. G., Drakaki, A., Chamie, K., deVere White, R. W., Pan, C-X. & Henderson, P., Feb 1 2017, In : Molecular Cancer Therapeutics. 16, 2, p. 376-387 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Biomarkers
Drug Therapy
Pharmaceutical Preparations
Carboplatin
11 Citations (Scopus)

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: Implications for the use of mTOR inhibitors in advanced prostate cancer

D'Abronzo, L. S., Bose, S., Crapuchettes, M. E., Beggs, R. E., Vinall, R. L., Tepper, C. G., Siddiqui, S., Mudryj, M., Melgoza, F. U., Durbin-Johnson, B. P., deVere White, R. W. & Ghosh, P. M., Nov 16 2017, In : Oncogene. 36, 46, p. 6359-6373 15 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Androgen Receptors
Sirolimus
Prostatic Neoplasms
Phosphorylation
6 Citations (Scopus)

The phosphatidylinositol 3-kinase pathway as a potential therapeutic target in bladder cancer

Zeng, S. X., Zhu, Y., Ma, A. H., Yu, W., Zhang, H., Lin, T-Y., Shi, W., Tepper, C. G., Henderson, P., Airhart, S., Guo, J. M., Xu, C. L., deVere White, R. W. & Pan, C-X., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6580-6591 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Urinary Bladder Neoplasms
gemcitabine
Phosphatidylinositol 3-Kinases
Heterografts
2016
23 Citations (Scopus)
Castration
Prostatic Neoplasms
Clinical Trials
Prostate-Specific Antigen
Confidence Intervals
10 Citations (Scopus)

Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy

Vinall, R. L., Tepper, C. G., Ripoll, A. A. Z., Gandour-Edwards, R. F., Durbin-Johnson, B. P., Yap, S., Ghosh, P. M. & deVere White, R. W., Mar 1 2016, In : Genes and Cancer. 7, 3-4, p. 86-97 12 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Drug Therapy
Muscles
MicroRNAs
Survival Rate
8 Citations (Scopus)
Urinary Bladder Neoplasms
Registries
Young Adult
Survival
Neoplasms
3 Citations (Scopus)

Diagnostic Microdosing Approach to Study Gemcitabine Resistance

Scharadin, T. M., Zhang, H., Zimmermann, M., Wang, S., Malfatti, M. A., Cimino, G. D., Turteltaub, K. W., deVere White, R. W., Pan, C-X. & Henderson, P., Nov 21 2016, In : Chemical Research in Toxicology. 29, 11, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

gemcitabine
DNA
Cytotoxicity
Pharmaceutical Preparations
Chemotherapy
6 Citations (Scopus)
Paclitaxel
Drug delivery
Disulfides
Sodium sulfate
Heterografts

Effect of neoadjuvant chemotherapy on renal function following radical cystectomy: Is there a meaningful impact?

Chandrasekar, T., Pugashetti, N., Durbin-Johnson, B., Era, M. A. D., Evans, C. P., White, R. W. D. & Yap, S. A., Jan 1 2016, In : Bladder Cancer. 2, 4, p. 441-448 8 p.

Research output: Contribution to journalArticle

Cystectomy
Kidney
Drug Therapy
Urinary Bladder
Carcinoma
11 Citations (Scopus)

Molecular dissection of induced platinum resistance through functional and gene expression analysis in a cell culture model of bladder cancer

Wang, S., Zhang, H., Scharadin, T. M., Zimmermann, M., Hu, B., Pan, A. W., Vinall, R. L., Lin, T-Y., Cimino, G., Chain, P., Vuyisich, M., Gleasner, C., McMurry, K., Malfatti, M., Turteltaub, K. W., deVere White, R. W., Pan, C-X. & Henderson, P., Jan 1 2016, In : PLoS One. 11, 1, e0146256.

Research output: Contribution to journalArticle

oxaliplatin
Dissection
platinum
Platinum
Cell culture
28 Citations (Scopus)

Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer

Lin, T-Y., Li, Y., Liu, Q., Chen, J. L., Zhang, H., Lac, D., Zhang, H., Ferrara, K. W., Wachsmann-Hogiu, S., Li, T., Airhart, S., deVere White, R. W., Lam, K. & Pan, C-X., Oct 1 2016, In : Biomaterials. 104, p. 339-351 13 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Doxorubicin
Photodynamic therapy
Chemotherapy
Photochemotherapy
1 Citation (Scopus)

Perioperative Outcomes following Neoadjuvant Chemotherapy and Radical Cystectomy-Is There Room for Improvement?

Pugashetti, N., Chandrasekar, T., Lurvey, R., Durbin-Johnson, B., Dall'Era, M., deVere White, R. W., Evans, C. P. & Yap, S., 2016, (Accepted/In press) In : Urology Practice.

Research output: Contribution to journalArticle

Cystectomy
Drug Therapy
Logistic Models
Surgical Wound Infection
Venous Thromboembolism
2015
19 Citations (Scopus)

Bioengineering novel chimeric microrna-34a for prodrug cancer therapy: High-yield expression and purification, and structural and functional characterization

Wang, W. P., Ho, P. Y., Chen, Q. X., Addepalli, B., Limbach, P. A., Li, M. M., Wu, W. J., Jilek, J. L., Qiu, J. X., Zhang, H. J., Li, T., Wun, T., deVere White, R. W., Lam, K. & Yu, A., Aug 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 131-141 11 p.

Research output: Contribution to journalArticle

Bioengineering
Prodrugs
Transfer RNA
MicroRNAs
Neoplasms
9 Citations (Scopus)

Bridging tumor genomics to patient outcomes through an integrated patient-derived xenograft platform

Gandara, D. R., Mack, P., Bult, C., Li, T., Lara, P. N., Riess, J., Astrow, S. H., Gandour-Edwards, R. F., Cooke, D. T., Yoneda, K. Y., Moore, E. H., Pan, C-X., Burich, R. A., David, E., Keck, J. G., Airhart, S., Goodwin, N., deVere White, R. W. & Liu, E. T., May 1 2015, In : Clinical Lung Cancer. 16, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

Genomics
Heterografts
Neoplasms
Non-Small Cell Lung Carcinoma
Therapeutics
31 Citations (Scopus)

Development and characterization of bladder cancer patient- derived xenografts for molecularly guided targeted therapy

Pan, C. X., Zhang, H., Tepper, C. G., Lin, T. Y., Davis, R. R., Keck, J., Ghosh, P. M., Gill, P., Airhart, S., Bult, C., Gandara, D. R., Liu, E. & De Vere White, R. W., Aug 13 2015, In : PLoS One. 10, 8, e0134346.

Research output: Contribution to journalArticle

Heterografts
Urinary Bladder Neoplasms
therapeutics
drugs
Pharmaceutical Preparations
27 Citations (Scopus)

MIR-124 and androgen receptor signaling inhibitors repress prostate cancer growth by downregulating androgen receptor splice variants, EZH2, and Src

Shi, X. B., Ma, A. H., Xue, L., Li, M., Nguyen, H. G., Yang, J. C., Tepper, C. G., Gandour-Edwards, R. F., Evans, C. P., Kung, H-J. & deVere White, R. W., Dec 15 2015, In : Cancer Research. 75, 24, p. 5309-5317 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Down-Regulation
Growth
Neoplasms
2014

Legends in urology

deVere White, R. W., 2014, In : Canadian Journal of Urology. 21, 2, p. 7176-7178 3 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Urology
98 Citations (Scopus)

MiR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C. J., Martiniez, A., Shi, X. B., Yang, J., Evans, C. P., Dobi, A., deVere White, R. W. & Kung, H-J., May 8 2014, In : Oncogene. 33, 19, p. 2495-2503 9 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Epidermal Growth Factor
Genes
Neoplasms
Prostatic Neoplasms
68 Citations (Scopus)

No improvement noted in overall or cause-specific survival for men presenting with metastatic prostate cancer over a 20-year period

Wu, J. N., Fish, K. M., Evans, C. P., deVere White, R. W. & Dall'Era, M., Mar 15 2014, In : Cancer. 120, 6, p. 818-823 6 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Survival
Prostate-Specific Antigen
Mortality
Multivariate Analysis
78 Citations (Scopus)

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model.

Nguyen, H. G., Yang, J. C., Kung, H-J., Shi, X. B., Tilki, D., Lara, P. N., deVere White, R. W., Gao, A. C. & Evans, C. P., 2014, In : Oncogene. 33, 36, p. 4521-4530 10 p.

Research output: Contribution to journalArticle

Castration
Autophagy
Heterografts
Prostatic Neoplasms
Androgens
17 Citations (Scopus)

The role of microRNA in castration-resistant prostate cancer

Thieu, W., Tilki, D., deVere White, R. W. & Evans, C. P., 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 5, p. 517-523 7 p.

Research output: Contribution to journalArticle

Castration
MicroRNAs
Prostatic Neoplasms
Immunotherapy
Neoplasms
2 Citations (Scopus)
Medical Oncology
Castration
Urology
Prostatic Neoplasms
Patient Care
2013
66 Citations (Scopus)

Functional p53 determines docetaxel sensitivity in prostate cancer cells

Liu, C., Zhu, Y., Lou, W., Nadiminty, N., Chen, X., Zhou, Q., Shi, X. B., deVere White, R. W. & Gao, A. C., Mar 2013, In : Prostate. 73, 4, p. 418-427 10 p.

Research output: Contribution to journalArticle

docetaxel
Prostatic Neoplasms
Phosphorylation
Small Interfering RNA
54 Citations (Scopus)

Oncomir miR-125b Suppresses p14ARF to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer

Amir, S., Ma, A. H., Shi, X. B., Xue, L., Kung, H-J. & deVere White, R. W., Apr 9 2013, In : PLoS One. 8, 4, e61064.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p14ARF
prostatic neoplasms
Prostatic Neoplasms
apoptosis
Apoptosis
112 Citations (Scopus)

Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells

Shi, X. B., Xue, L., Ma, A. H., Tepper, C. G., Gandour-Edwards, R. F., Kung, H-J. & deVere White, R. W., Aug 29 2013, In : Oncogene. 32, 35, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Neoplasms
Down-Regulation
DNA Methylation
22 Citations (Scopus)

Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer

Lin, T-Y., Li, Y., Zhang, H., Luo, J., Goodwin, N., Gao, T., deVere White, R. W., Lam, K. & Pan, C-X., Aug 2013, In : Nanomedicine. 8, 8, p. 1239-1251 13 p.

Research output: Contribution to journalArticle

chemotherapy
Chemotherapy
Micelles
Urinary Bladder Neoplasms
tumor
2012
16 Citations (Scopus)

Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization

Mooso, B. A., Vinall, R. L., Tepper, C. G., Savoy, R. M., Cheung, J. P., Singh, S., Siddiqui, S., Wang, Y., Bedolla, R. G., Martinez, A., Mudryj, M., Kung, H-J., deVere White, R. W. & Ghosh, P. M., Dec 2012, In : Endocrine-Related Cancer. 19, 6, p. 759-777 19 p.

Research output: Contribution to journalArticle

Filamins
Androgens
Prostatic Neoplasms
Therapeutics
Genistein
14 Citations (Scopus)
bladder diseases
Urinary Bladder Diseases
Transitional Cell Carcinoma
MicroRNAs
microRNA
16 Citations (Scopus)

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Jung, C. J., Iyengar, S., Blahnik, K. R., Jiang, X., Tahimic, C., Torok, N. J., deVere White, R. W., Farnham, P. J. & Zern, M. A., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 979-991 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
MicroRNAs
Hepatocytes
Neoplasms
Embryonic Stem Cells
31 Citations (Scopus)

Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach

Zhang, H., Aina, O. H., Lam, K., deVere White, R. W., Evans, C. P., Henderson, P., Lara, P. N., Wang, X., Bassuk, J. A. & Pan, C-X., Sep 2012, In : Urologic Oncology: Seminars and Original Investigations. 30, 5, p. 635-645 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Ligands
Heterografts
Cell Line
Urinary Bladder
15 Citations (Scopus)

Initiation of prostate cancer in mice by Tp53R270H: Evidence for an alternative molecular progression

Vinall, R. L., Chen, J. Q., Hubbard, N., Sulaimon, S. S., Shen, M. M., deVere White, R. W. & Borowsky, A. D., Nov 2012, In : DMM Disease Models and Mechanisms. 5, 6, p. 914-920 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Mutation
Prostatic Intraepithelial Neoplasia
Androgens
Tumors
11 Citations (Scopus)
Endoscopy
bladder
Image acquisition
acquisition
cancer
106 Citations (Scopus)

MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth

Nadiminty, N., Tummala, R., Lou, W., Zhu, Y., Shi, X. B., Zou, J. X., Chen, H., Zhang, J., Chen, X., Luo, J., deVere White, R. W., Kung, H-J., Evans, C. P. & Gao, A. C., Mar 30 2012, In : PLoS One. 7, 3, e32832.

Research output: Contribution to journalArticle

prostatic neoplasms
MicroRNAs
microRNA
Tumors
Prostatic Neoplasms
128 Citations (Scopus)

MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of myc expression in prostate cancer cells

Nadiminty, N., Tummala, R., Lou, W., Zhu, Y., Zhang, J., Chen, X., deVere White, R. W., Kung, H-J., Evans, C. P. & Gao, A. C., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1527-1537 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
Cells
Castration
76 Citations (Scopus)

MiR-34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status

Vinall, R. L., Ripoll, A. Z., Wang, S., Pan, C-X. & deVere White, R. W., Jun 1 2012, In : International Journal of Cancer. 130, 11, p. 2526-2538 13 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cisplatin
Transitional Cell Carcinoma
Sirtuin 1
Drug Therapy
19 Citations (Scopus)
Micelles
Urinary Bladder Neoplasms
Imaging techniques
Dogs
Cells
27 Citations (Scopus)

Stem-like Cells in Bladder Cancer Cell Lines with Differential Sensitivity to Cisplatin

Falso, M. J. S., Buchholz, B. A. & deVere White, R. W., Mar 2012, In : Anticancer Research. 32, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cisplatin
Stem Cells
Cell Line
Aldehyde Dehydrogenase
21 Citations (Scopus)

Ten-year follow-up of neoadjuvant therapy with goserelin acetate and flutamide before radical prostatectomy for clinical T3 and T4 prostate cancer: Update on southwest oncology group study 9109

Berglund, R. K., Tangen, C. M., Powell, I. J., Lowe, B. A., Haas, G. P., Carroll, P. R., Canby-Hagino, E. D., deVere White, R. W., Hemstreet, G. P., Crawford, E. D., Thompson, I. M. & Klein, E. A., Mar 2012, In : Urology. 79, 3, p. 633-637 5 p.

Research output: Contribution to journalArticle

Goserelin
Flutamide
Neoadjuvant Therapy
Prostatectomy
Prostatic Neoplasms