Ralph W deVere White, MD

Professor

  • 12327 Citations
  • 58 h-Index
1973 …2020

Research output per year

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Research Output

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2020
2019
Open Access
2018

Bioengineered noncoding RNAs selectively change cellular miRNome profiles for cancer therapy

Ho, P. Y., Duan, Z., Batra, N., Jilek, J. L., Tu, M. J., Qiu, J. X., Hu, Z., Wun, T., Lara, P. N., deVere White, R. W., Chen, H. & Yu, A., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 494-506 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Changing Incidence of Metastatic Prostate Cancer by Race and Age, 1988–2015

Dall'Era, M., deVere White, R. W., Rodriguez, D. & Cress, R. D., Jan 1 2018, (Accepted/In press) In : European Urology Focus.

Research output: Contribution to journalArticle

4 Scopus citations

Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel

Wang, S., Scharadin, T. M., Zimmermann, M., Malfatti, M. A., Turteltaub, K. W., De Vere White, R., Pan, C. X. & Henderson, P. T., Dec 17 2018, In : Chemical Research in Toxicology. 31, 12, p. 1293-1304 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin

Wang, F., Zhang, H., Ma, A. H., Yu, W., Zimmermann, M., Yang, J., Hwang, S. H., Zhu, D., Lin, T. Y., Malfatti, M. A., Turteltaub, K. W., Henderson, P. T., Airhart, S., Hammock, B. D., Yuan, J., De Vere White, R. W. & Pan, C. X., Feb 1 2018, In : Molecular Cancer Therapeutics. 17, 2, p. 474-483 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

Wang, M., Yao, L. C., Cheng, M., Cai, D., Martinek, J., Pan, C-X., Shi, W., Ma, A. H., deVere White, R. W., Airhart, S., Liu, E. T., Banchereau, J., Brehm, M. A., Greiner, D. L., Shultz, L. D., Palucka, K. & Keck, J. G., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model

Long, Q., Lin, T-Y., Huang, Y., Li, X., Ma, A. H., Zhang, H., Carney, R., Airhart, S., Lam, K., deVere White, R. W., Pan, C-X. & Li, Y., Apr 1 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 789-799 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

A diagnostic microdosing approach to investigate platinum sensitivity in non-small cell lung cancer

Wang, S. S., Zimmermann, M., Zhang, H., Lin, T. Y., Malfatti, M. A., Haack, K., Turteltaub, K. W., Cimino, G. D., de Vere White, R., Pan, C. X. & Henderson, P. T., Aug 1 2017, In : International Journal of Cancer. 141, 3, p. 604-613 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models

Jian, C., Tu, M. J., Ho, P. Y., Duan, Z., Zhang, Q., Qiu, J. X., deVere White, R. W., Wun, T., Lara, P. N., Lam, K., Yu, A. X. & Yu, A., 2017, In : Oncotarget. 8, 19, p. 30742-30755 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells

Gheibi, P., Zeng, S., Son, K. J., Vu, T., Ma, A. H., Dall'Era, M. A., Yap, S. A., De Vere White, R. W., Pan, C. X. & Revzin, A., Dec 1 2017, In : Scientific Reports. 7, 1, 12277.

Research output: Contribution to journalArticle

8 Scopus citations

Microdose-induced drug-DNA adducts as biomarkers of chemotherapy resistance in humans and mice

Zimmermann, M., Wang, S. S., Zhang, H., Lin, T. Y., Malfatti, M. A., Haack, K., Ognibene, T., Yang, H., Airhart, S., Turteltaub, K. W., Cimino, G. D., Tepper, C. G., Drakaki, A., Chamie, K., De Vere White, R., Pan, C. X. & Henderson, P. T., Feb 1 2017, In : Molecular Cancer Therapeutics. 16, 2, p. 376-387 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: Implications for the use of mTOR inhibitors in advanced prostate cancer

D'Abronzo, L. S., Bose, S., Crapuchettes, M. E., Beggs, R. E., Vinall, R. L., Tepper, C. G., Siddiqui, S., Mudryj, M., Melgoza, F. U., Durbin-Johnson, B. P., deVere White, R. W. & Ghosh, P. M., Nov 16 2017, In : Oncogene. 36, 46, p. 6359-6373 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

The phosphatidylinositol 3-kinase pathway as a potential therapeutic target in bladder cancer

Zeng, S. X., Zhu, Y., Ma, A. H., Yu, W., Zhang, H., Lin, T-Y., Shi, W., Tepper, C. G., Henderson, P., Airhart, S., Guo, J. M., Xu, C. L., deVere White, R. W. & Pan, C-X., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6580-6591 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

TMPRSS2-ERG fusions unexpectedly identified in men initially diagnosed with nonprostatic malignancies

Lara, P. N., Heilmann, A. M., Elvin, J. A., Parikh, M., White, R. D. V., Gandour-Edwards, R., Evans, C. P., Pan, C. X., Schrock, A. B., Erlich, R., Ross, J. S., Stephens, P. J., McPherson, J., Miller, V. A. & Ali, S. M., Jan 1 2017, In : JCO Precision Oncology. 2017, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016
26 Scopus citations

Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy

Vinall, R. L., Tepper, C. G., Ripoll, A. A. Z., Gandour-Edwards, R. F., Durbin-Johnson, B. P., Yap, S., Ghosh, P. M. & deVere White, R. W., Mar 1 2016, In : Genes and Cancer. 7, 3-4, p. 86-97 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
10 Scopus citations

Diagnostic Microdosing Approach to Study Gemcitabine Resistance

Scharadin, T. M., Zhang, H., Zimmermann, M., Wang, S., Malfatti, M. A., Cimino, G. D., Turteltaub, K., De Vere White, R., Pan, C. X. & Henderson, P. T., Nov 21 2016, In : Chemical Research in Toxicology. 29, 11, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer

Pan, A., Zhang, H., Li, Y., Lin, T-Y., Wang, F., Lee, J. S., Cheng, M., Dall'Era, M., Li, T., deVere White, R. W., Pan, C-X. & Lam, K., Sep 19 2016, In : Nanotechnology. 27, 42, 425103.

Research output: Contribution to journalArticle

10 Scopus citations

Effect of neoadjuvant chemotherapy on renal function following radical cystectomy: Is there a meaningful impact?

Chandrasekar, T., Pugashetti, N., Durbin-Johnson, B., Era, M. A. D., Evans, C. P., White, R. W. D. & Yap, S. A., Jan 1 2016, In : Bladder Cancer. 2, 4, p. 441-448 8 p.

Research output: Contribution to journalArticle

Molecular dissection of induced platinum resistance through functional and gene expression analysis in a cell culture model of bladder cancer

Wang, S., Zhang, H., Scharadin, T. M., Zimmermann, M., Hu, B., Pan, A. W., Vinall, R. L., Lin, T-Y., Cimino, G., Chain, P., Vuyisich, M., Gleasner, C., McMurry, K., Malfatti, M., Turteltaub, K. W., deVere White, R. W., Pan, C-X. & Henderson, P., Jan 1 2016, In : PLoS One. 11, 1, e0146256.

Research output: Contribution to journalArticle

11 Scopus citations

Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer

Lin, T. Y., Li, Y., Liu, Q., Chen, J. L., Zhang, H., Lac, D., Zhang, H., Ferrara, K. W., Wachsmann-Hogiu, S., Li, T., Airhart, S., deVere White, R., Lam, K. S. & Pan, C. X., Oct 1 2016, In : Biomaterials. 104, p. 339-351 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Perioperative Outcomes following Neoadjuvant Chemotherapy and Radical Cystectomy-Is There Room for Improvement?

Pugashetti, N., Chandrasekar, T., Lurvey, R., Durbin-Johnson, B., Dall'Era, M., deVere White, R. W., Evans, C. P. & Yap, S., 2016, (Accepted/In press) In : Urology Practice.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Bioengineering novel chimeric microrna-34a for prodrug cancer therapy: High-yield expression and purification, and structural and functional characterization

Wang, W. P., Ho, P. Y., Chen, Q. X., Addepalli, B., Limbach, P. A., Li, M. M., Wu, W. J., Jilek, J. L., Qiu, J. X., Zhang, H. J., Li, T., Wun, T., deVere White, R. W., Lam, K. & Yu, A., Aug 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 131-141 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Bridging tumor genomics to patient outcomes through an integrated patient-derived xenograft platform

Gandara, D. R., Mack, P., Bult, C., Li, T., Lara, P. N., Riess, J., Astrow, S. H., Gandour-Edwards, R. F., Cooke, D. T., Yoneda, K. Y., Moore, E. H., Pan, C-X., Burich, R. A., David, E., Keck, J. G., Airhart, S., Goodwin, N., deVere White, R. W. & Liu, E. T., May 1 2015, In : Clinical Lung Cancer. 16, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development and characterization of bladder cancer patient- derived xenografts for molecularly guided targeted therapy

Pan, C. X., Zhang, H., Tepper, C. G., Lin, T. Y., Davis, R. R., Keck, J., Ghosh, P. M., Gill, P., Airhart, S., Bult, C., Gandara, D. R., Liu, E. & De Vere White, R. W., Aug 13 2015, In : PLoS One. 10, 8, e0134346.

Research output: Contribution to journalArticle

41 Scopus citations

MIR-124 and androgen receptor signaling inhibitors repress prostate cancer growth by downregulating androgen receptor splice variants, EZH2, and Src

Shi, X. B., Ma, A. H., Xue, L., Li, M., Nguyen, H. G., Yang, J. C., Tepper, C. G., Gandour-Edwards, R. F., Evans, C. P., Kung, H-J. & deVere White, R. W., Dec 15 2015, In : Cancer Research. 75, 24, p. 5309-5317 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2014

Legends in urology

deVere White, R. W., 2014, In : Canadian Journal of Urology. 21, 2, p. 7176-7178 3 p.

Research output: Contribution to journalArticle

MiR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C. J., Martiniez, A., Shi, X. B., Yang, J., Evans, C. P., Dobi, A., deVere White, R. W. & Kung, H-J., May 8 2014, In : Oncogene. 33, 19, p. 2495-2503 9 p.

Research output: Contribution to journalArticle

108 Scopus citations

No improvement noted in overall or cause-specific survival for men presenting with metastatic prostate cancer over a 20-year period

Wu, J. N., Fish, K. M., Evans, C. P., deVere White, R. W. & Dall'Era, M., Mar 15 2014, In : Cancer. 120, 6, p. 818-823 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model.

Nguyen, H. G., Yang, J. C., Kung, H-J., Shi, X. B., Tilki, D., Lara, P. N., deVere White, R. W., Gao, A. C. & Evans, C. P., 2014, In : Oncogene. 33, 36, p. 4521-4530 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

The role of microRNA in castration-resistant prostate cancer

Thieu, W., Tilki, D., deVere White, R. W. & Evans, C. P., 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 5, p. 517-523 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2 Scopus citations
2013

Functional p53 determines docetaxel sensitivity in prostate cancer cells

Liu, C., Zhu, Y., Lou, W., Nadiminty, N., Chen, X., Zhou, Q., Shi, X. B., deVere White, R. W. & Gao, A. C., Mar 2013, In : Prostate. 73, 4, p. 418-427 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Oncomir miR-125b Suppresses p14ARF to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer

Amir, S., Ma, A. H., Shi, X. B., Xue, L., Kung, H-J. & deVere White, R. W., Apr 9 2013, In : PLoS One. 8, 4, e61064.

Research output: Contribution to journalArticle

56 Scopus citations

Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells

Shi, X. B., Xue, L., Ma, A. H., Tepper, C. G., Gandour-Edwards, R. F., Kung, H-J. & deVere White, R. W., Aug 29 2013, In : Oncogene. 32, 35, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

118 Scopus citations

Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer

Lin, T. Y., Li, Y. P., Zhang, H., Luo, J. T., Goodwin, N., Gao, T., White, R. D. V., Lam, K. S. & Pan, C. X., Aug 2013, In : Nanomedicine. 8, 8, p. 1239-1251 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization

Mooso, B. A., Vinall, R. L., Tepper, C. G., Savoy, R. M., Cheung, J. P., Singh, S., Siddiqui, S., Wang, Y., Bedolla, R. G., Martinez, A., Mudryj, M., Kung, H-J., deVere White, R. W. & Ghosh, P. M., Dec 2012, In : Endocrine-Related Cancer. 19, 6, p. 759-777 19 p.

Research output: Contribution to journalArticle

20 Scopus citations
14 Scopus citations

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Jung, C. J., Iyengar, S., Blahnik, K. R., Jiang, X., Tahimic, C., Torok, N. J., deVere White, R. W., Farnham, P. J. & Zern, M. A., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 979-991 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach

Zhang, H., Aina, O. H., Lam, K., deVere White, R. W., Evans, C. P., Henderson, P., Lara, P. N., Wang, X., Bassuk, J. A. & Pan, C-X., Sep 2012, In : Urologic Oncology: Seminars and Original Investigations. 30, 5, p. 635-645 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Initiation of prostate cancer in mice by Tp53R270H: Evidence for an alternative molecular progression

Vinall, R. L., Chen, J. Q., Hubbard, N., Sulaimon, S. S., Shen, M. M., deVere White, R. W. & Borowsky, A. D., Nov 2012, In : DMM Disease Models and Mechanisms. 5, 6, p. 914-920 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
12 Scopus citations

MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth

Nadiminty, N., Tummala, R., Lou, W., Zhu, Y., Shi, X. B., Zou, J. X., Chen, H., Zhang, J., Chen, X., Luo, J., deVere White, R. W., Kung, H-J., Evans, C. P. & Gao, A. C., Mar 30 2012, In : PLoS One. 7, 3, e32832.

Research output: Contribution to journalArticle

112 Scopus citations

MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of myc expression in prostate cancer cells

Nadiminty, N., Tummala, R., Lou, W., Zhu, Y., Zhang, J., Chen, X., deVere White, R. W., Kung, H-J., Evans, C. P. & Gao, A. C., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1527-1537 11 p.

Research output: Contribution to journalArticle

134 Scopus citations

MiR-34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status

Vinall, R. L., Ripoll, A. Z., Wang, S., Pan, C-X. & deVere White, R. W., Jun 1 2012, In : International Journal of Cancer. 130, 11, p. 2526-2538 13 p.

Research output: Contribution to journalArticle

81 Scopus citations
22 Scopus citations