• 4941 Citations
  • 38 h-Index
19952020

Research output per year

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Research Output

  • 4941 Citations
  • 38 h-Index
  • 77 Article
  • 3 Chapter
  • 2 Comment/debate
  • 2 Review article
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Article

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with Pbx-Meis1/Prep1

Knoepfler, P. S., Bergstrom, D. A., Uetsuki, T., Dac-Korytko, L., Sun, Y. H., Wright, W. E., Tapscott, S. J. & Kamps, M. P., Sep 15 1999, In : Nucleic Acids Research. 27, 18, p. 3752-3761 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Acting locally and globally: Myc's ever-expanding roles on chromatin

Varlakhanova, N. V. & Knoepfler, P. S., Oct 1 2009, In : Cancer Research. 69, 19, p. 7487-7490 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

Ota, S., Zhou, Z. Q., Keene, D. R., Knoepfler, P. S. & Hurlin, P. J., Apr 2007, In : Development. 134, 8, p. 1583-1592 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

An inhibitory switch derepressed by Pbx, Hox, and Meis/Prep1 partners regulates DNA-binding by Pbx1 and E2a-Pbx1 and is dispensable for myeloid immortalization by E2a-Pbx1

Calvo, K. R., Knoepfler, P. S., McGrath, S. & Kamps, M. P., Dec 23 1999, In : Oncogene. 18, 56, p. 8033-8043 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Arrestin' the hedgehog: Shh limits its own signaling via β-Arrestin1

Knoepfler, P. S., Nov 1 2010, In : Cell Cycle. 9, 21, p. 4260-4261 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Behavior of xeno-Transplanted undifferentiated human induced pluripotent stem cells is impacted by microenvironment without evidence of tumors

Martínez-Cerdeño, V., Barrilleaux, B. L., McDonough, A., Ariza, J., Yuen, B. T. K., Somanath, P., Le, C. T., Steward, C., Horton-Sparks, K. & Knoepfler, P. S., Oct 1 2017, In : Stem Cells and Development. 26, 19, p. 1409-1423 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes

Lu, Q., Knoepfler, P. S., Scheele, J., Wright, D. D. & Kamps, M. P., 1995, In : Molecular and Cellular Biology. 15, 7, p. 3786-3795 10 p.

Research output: Contribution to journalArticle

131 Scopus citations
10 Scopus citations
28 Scopus citations

C-myc and N-myc in the developing brain

Wey, A. & Knoepfler, P. S., May 2010, In : Aging. 2, 5, p. 261-262 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.

Wey, A. & Knoepfler, P. S., Jun 2010, In : Oncotarget. 1, 2, p. 120-130 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

Pshenichnaya, I., Schouwey, K., Armaro, M., Larue, L., Knoepfler, P. S., Eisenman, R. N., Trumpp, A., Delmas, V. & Beermann, F., May 2012, In : Pigment Cell and Melanoma Research. 25, 3, p. 312-325 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells

Somanath, P., Herndon Klein, R. & Knoepfler, P. S., Oct 1 2017, In : PLoS One. 12, 10, e0185627.

Research output: Contribution to journalArticle

5 Scopus citations

Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine

Knoepfler, P. S., May 2009, In : Stem Cells. 27, 5, p. 1050-1056 7 p.

Research output: Contribution to journalArticle

315 Scopus citations

Direct interaction of two homeoproteins, Homothorax and Extradenticle, is essential for EXD nuclear localization and function

Jaw, T. J., You, L. R., Knoepfler, P. S., Yao, L. C., Pai, C. Y., Tang, C. Y., Chang, L. P., Berthelsen, J., Blasi, F., Kamps, M. P. & Sun, Y. H., Mar 1 2000, In : Mechanisms of Development. 91, 1-2, p. 279-291 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

Division and apoptosis of E2f-deficient retinal progenitors

Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G. & Bremner, R., Dec 17 2009, In : Nature. 462, 7275, p. 925-929 5 p.

Research output: Contribution to journalArticle

106 Scopus citations

Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development

Bush, K. M., Yuen, B. T. K., Barrilleaux, B. L., Riggs, J. W., O'Geen, H., Cotterman, R. F. & Knoepfler, P. S., 2013, In : Epigenetics and Chromatin. 6, 1, 7.

Research output: Contribution to journalArticle

51 Scopus citations

Epigenetic mechanisms of tumorigenicity manifesting in stem cells

Tung, P. Y. & Knoepfler, P. S., Apr 30 2015, In : Oncogene. 34, 18, p. 2288-2296 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells

Somanath, P., Bush, K. M. & Knoepfler, P. S., Jan 1 2018, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

4 Scopus citations

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

Knoepfler, P. S., Mar 1 2015, In : Advanced Drug Delivery Reviews. 82, p. 192-196 5 p.

Research output: Contribution to journalArticle

49 Scopus citations
26 Scopus citations

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors

Orian, A., Grewal, S. S., Knoepfler, P. S., Edgar, B. A., Parkhurst, S. M. & Eisenman, R. N., 2005, In : Cold Spring Harbor Symposia on Quantitative Biology. 70, p. 299-307 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer

Klein, R. H., Tung, P. Y., Somanath, P., Fehling, H. J. & Knoepfler, P. S., Aug 1 2018, In : Stem Cell Research. 31, p. 83-94 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations

Swanson, K. A., Knoepfler, P. S., Huang, K., Kang, R. S., Cowley, S. M., Laherty, C. D., Eisenman, R. N. & Radhakrishnan, I., Aug 2004, In : Nature Structural and Molecular Biology. 11, 8, p. 738-746 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W. E., Ehninger, A., Knoepfler, P. S., Cheng, P. F., MacDonald, H. R., Eisenman, R. N., Bernstein, I. D. & Trumpp, A., Dec 4 2008, In : Cell Stem Cell. 3, 6, p. 611-624 14 p.

Research output: Contribution to journalArticle

170 Scopus citations

Histone H3.3 Mutations: A Variant Path to Cancer

Yuen, B. T. K. & Knoepfler, P. S., Nov 11 2013, In : Cancer Cell. 24, 5, p. 567-574 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

Yuen, B. T. K., Bush, K. M., Barrilleaux, B. L., Cotterman, R. & Knoepfler, P. S., 2014, In : Development (Cambridge). 141, 18, p. 3483-3494 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation

Knoepfler, P. S., Sykes, D. B., Pasillas, M. & Kamps, M. P., Sep 6 2001, In : Oncogene. 20, 39, p. 5440-5448 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes

Tung, P. Y., Varlakhanova, N. V. & Knoepfler, P. S., 2013, In : Stem Cells. 31, 11, p. 2330-2342 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Induced pluripotency and oncogenic transformation are related processes

Riggs, J. W., Barrilleaux, B. L., Varlakhanova, N., Bush, K. M., Chan, V. & Knoepfler, P. S., Jan 1 2013, In : Stem Cells and Development. 22, 1, p. 37-50 14 p.

Research output: Contribution to journalArticle

64 Scopus citations

Induced Pluripotent Stem Cells Show Metabolomic Differences to Embryonic Stem Cells in Polyunsaturated Phosphatidylcholines and Primary Metabolism

Meissen, J. K., Yuen, B. T. K., Kind, T., Riggs, J. W., Barupal, D. K., Knoepfler, P. S. & Fiehn, O., Oct 15 2012, In : PLoS One. 7, 10, e46770.

Research output: Contribution to journalArticle

49 Scopus citations

Inducing iPSCs to Escape the dish

Barrilleaux, B. & Knoepfler, P. S., Aug 5 2011, In : Cell Stem Cell. 9, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Journal club. A cell biologist looks at the risk and promise of a new insight into stem cells and cancer.

Knoepfler, P. S., Jan 22 2009, In : Nature. 457, 7228, p. 361 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Key action items for the stem cell field: Looking ahead to 2014

Knoepfler, P. S., Dec 1 2013, In : Stem Cells and Development. 22, SUPPL.1, p. 10-12 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells

Knoepfler, P. S., Sep 2012, In : Regenerative Medicine. 7, 5, p. 713-720 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

Knoepfler, P. S., Calvo, K. R., Chen, H., Antonarakis, S. E. & Kamps, M. P., Dec 23 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 26, p. 14553-14558 6 p.

Research output: Contribution to journalArticle

159 Scopus citations
76 Scopus citations

Miz-1 activates gene expression via a novel consensus DNA binding motif

Barrilleaux, B. L., Burow, D., Lockwood, S. H., Yu, A., Segal, D. & Knoepfler, P. S., Jul 1 2014, In : PLoS One. 9, 7, e101151.

Research output: Contribution to journalArticle

14 Scopus citations

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells

Varlakhanova, N., Cotterman, R., Bradnam, K., Korf, I. F. & Knoepfler, P. S., 2011, In : Epigenetics and Chromatin. 4, 1, 20.

Research output: Contribution to journalArticle

21 Scopus citations

Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain

Laskowski, A. I. & Knoepfler, P. S., Jun 14 2013, In : Biochemical and Biophysical Research Communications. 435, 4, p. 551-556 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myc goes global: New tricks for an old oncogene

Knoepfler, P. S., Jun 1 2007, In : Cancer Research. 67, 11, p. 5061-5063 3 p.

Research output: Contribution to journalArticle

97 Scopus citations

Myc influences global chromatin structure

Knoepfler, P. S., Zhang, X. Y., Cheng, P. F., Gafken, P. R., McMahon, S. B. & Eisenman, R. N., Jun 21 2006, In : EMBO Journal. 25, 12, p. 2723-2734 12 p.

Research output: Contribution to journalArticle

295 Scopus citations

Myc maintains embryonic stem cell pluripotency and self-renewal

Varlakhanova, N. V., Cotterman, R. F., deVries, W. N., Morgan, J., Donahue, L. R., Murray, S., Knowles, B. B. & Knoepfler, P. S., Jul 2010, In : Differentiation. 80, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

120 Scopus citations

Myc stimulates B lymphocyte differentiation and amplifies calcium signaling

Habib, T., Park, H., Tsang, M., De Alborán, I. M., Nicks, A., Wilson, L., Knoepfler, P. S., Andrews, S., Rawlings, D. J., Eisenman, R. N. & Iritani, B. M., Nov 19 2007, In : Journal of Cell Biology. 179, 4, p. 717-731 15 p.

Research output: Contribution to journalArticle

66 Scopus citations

My year as a stem-cell blogger

Knoepfler, P. S., Jul 28 2011, In : Nature. 475, 7357, p. 425 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes

Knoepfler, P. S. & Kenney, A. M., Jan 1 2006, In : Cell Cycle. 5, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells

Martinez-Cerdeno, V., Lemen, J. M., Chan, V., Wey, A., Lin, W., Dent, S. R. & Knoepfler, P. S., Jun 26 2012, In : PLoS One. 7, 6, e39456.

Research output: Contribution to journalArticle

30 Scopus citations

N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development

Zindy, F., Knoepfler, P. S., Xie, S., Sherr, C. J., Eisenman, R. N. & Roussel, M. F., Aug 1 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 31, p. 11579-11583 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

Frutos, E. D., Hernández, I. L., Vendrell, V., Neves, J., Gallozzi, M., Gutsche, K., Quintana, L., Sharpe, J., Knoepfler, P. S., Eisenman, R. N., Trumpp, A., Giráldez, F. & Schimmang, T., May 11 2011, In : Journal of Neuroscience. 31, 19, p. 7178-7189 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

N-myc coordinates retinal growth with eye size during mouse development

Martins, R. A. P., Zindy, F., Donovan, S., Zhang, J., Pounds, S., Wey, A., Knoepfler, P. S., Eisenman, R. N., Roussel, M. F. & Dyer, M. A., Jan 15 2008, In : Genes and Development. 22, 2, p. 179-193 15 p.

Research output: Contribution to journalArticle

34 Scopus citations