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1985 …2020

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2020

Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21

Nakamaru, K., Tomiyama, T., Kobayashi, S., Ikemune, M., Tsukuda, S., Ito, T., Tanaka, T., Yamaguchi, T., Ando, Y., Ikeura, T., Fukui, T., Nishio, A., Takaoka, M., Uchida, K., Leung, P. S. C., Gershwin, M. E. & Okazaki, K., Jan 1 2020, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Open Access

Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases

Bae, H. R., Leung, P. S. C., Hodge, D. L., Fenimore, J. M., Jeon, S. M., Thovarai, V., Dzutsev, A., Welcher, A. A., Boedigheimer, M., Damore, M. A., Choi, M. S., Fravell, R. A., Trinchieri, G., Gershwin, M. E. & Young, H. A., Jan 1 2020, (Accepted/In press) In : Journal of autoimmunity. 102436.

Research output: Contribution to journalArticle

2019

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology

Das, T., Bergen, I. M., Koudstaal, T., van Hulst, J. A. C., van Loo, G., Boonstra, A., Vanwolleghem, T., Leung, P. S., Gershwin, M. E., Hendriks, R. W. & Kool, M., Jan 1 2019, In : Journal of autoimmunity.

Research output: Contribution to journalArticle

Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

Sun, C., Xiao, X., Yan, L., Sheng, L., Wang, Q., Jiang, P., Lian, M., Li, Y., Wei, Y., Zhang, J., Chen, Y., Li, B., Li, Y., Huang, B., Li, Y., Peng, Y., Chen, X., Fang, J., Qiu, D., Hua, J. & 5 others, Tang, R., Leung, P. S., Gershwin, M. E., Miao, Q. & Ma, X., May 1 2019, In : Journal of autoimmunity. 99, p. 33-38 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Long-term Outcomes of Autologous Peripheral Blood Stem Cell Transplantation in Patients With Cirrhosis

Guo, C., Guo, G., Zhou, X., Chen, Y., Han, Z., Yang, C., Zhao, S., Su, H., Lian, Z., Leung, P. S., Gershwin, M. E., Zhou, X. & Han, Y., May 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 6, p. 1175-1182.e2

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Regional Differences in Food Allergies

Tang, R., Wang, Z. X., Ji, C. M., Leung, P. S., Woo, E., Chang, C., Wang, M., Liu, B., Wei, J. F. & Sun, J. L., Jan 1 2019, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalArticle

1 Scopus citations

The genetics of primary biliary cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Mar 1 2019, In : Current Opinion in Gastroenterology. 35, 2, p. 93-98 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice

Moritoki, Y., Tsuneyama, K., Nakamura, Y., Kikuchi, K., Shiota, A., Ohsugi, Y., Lian, Z. X., Zhang, W., Yang, G. X., Ueki, S., Takeda, M., Omokawa, A., Saga, T., Saga, A., Watanabe, D., Miura, M., Ueno, Y., Leung, P. S., Tanaka, A., Gershwin, M. E. & 1 others, Hirokawa, M., Nov 2 2018, In : Frontiers in Immunology. 9, NOV, 02534.

Research output: Contribution to journalArticle

4 Scopus citations

Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis

Hsueh, Y. H., Chen, H. W., Syu, B. J., Lin, C. I., Leung, P. S., Gershwin, M. E. & Chuang, Y. H., Dec 1 2018, In : Journal of Autoimmunity. 95, p. 159-170 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evolution of our understanding of PBC

Tanaka, A., Leung, P. S. & Gershwin, M. E., Jan 1 2018, (Accepted/In press) In : Best Practice and Research: Clinical Gastroenterology.

Research output: Contribution to journalArticle

8 Scopus citations

Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice

Hintermann, E., Bayer, M., Conti, C. B., Fuchs, S., Fausther, M., Leung, P. S., Aurrand-Lions, M., Taubert, R., Pfeilschifter, J. M., Friedrich-Rust, M., Schuppan, D., Dranoff, J. A., Gershwin, M. E., Manns, M. P., Imhof, B. A. & Christen, U., Jan 1 2018, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

5 Scopus citations

Microbiota and Food Allergy

Shu, S. A., Yuen, A. W. T., Woo, E., Chu, K. H., Kwan, H. S., Yang, G. X., Yang, Y. & Leung, P. S., Jan 1 2018, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalArticle

3 Scopus citations

Pathogen infections and primary biliary cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Jan 1 2018, (Accepted/In press) In : Clinical and Experimental Immunology.

Research output: Contribution to journalArticle

9 Scopus citations

Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis

Zhang, W., Zhang, R., Zhang, J., Sun, Y., Leung, P. S., Yang, G. X., Shuai, Z., Ridgway, W. M. & Gershwin, M. E., Aug 1 2018, In : Cellular and Molecular Immunology. 15, 8, p. 756-767 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

The critical role of chemokine (C-C motif) receptor 2-positive monocytes in autoimmune cholangitis

Reuveni, D., Gore, Y., Leung, P. S., Lichter, Y., Moshkovits, I., Kaminitz, A., Brazowski, E., Lefebvre, E., Vig, P., Varol, C., Halpern, Z., Shibolet, O., Gershwin, M. E. & Zigmond, E., Aug 15 2018, In : Frontiers in Immunology. 9, AUG, 1852.

Research output: Contribution to journalArticle

2 Scopus citations

The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7

Jiang, X., Lian, M., Li, Y., Zhang, W., Wang, Q., Wei, Y., Zhang, J., Chen, W., Xiao, X., Miao, Q., Bian, Z., Qiu, D., Fang, J., Ansari, A. A., Leung, P. S., Coppel, R. L., Tang, R., Gershwin, M. E. & Ma, X., Jan 1 2018, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

18 Scopus citations

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity

Bae, H. R., Hodge, D. L., Yang, G. X., Leung, P. S., Chodisetti, S. B., Valencia, J. C., Sanford, M., Fenimore, J. M., Rahman, Z. S. M., Tsuneyama, K., Norman, G. L., Gershwin, M. E. & Young, H. A., Apr 1 2018, In : Hepatology. 67, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

Tanaka, T., Zhang, W., Sun, Y., Shuai, Z., Chida, A. S., Kenny, T. P., Yang, G. X., Sanz, I., Ansari, A., Bowlus, C., Ippolito, G. C., Coppel, R. L., Okazaki, K., He, X., Leung, P. S. & Gershwin, M. E., Sep 1 2017, In : Hepatology. 66, 3, p. 885-895 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Common Variable Immunodeficiency and Liver Involvement

Song, J., Lleo, A., Yang, G. X., Zhang, W., Bowlus, C., Gershwin, M. E. & Leung, P. S., Aug 7 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-12 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

How the biliary tree maintains immune tolerance?

Zhang, H., Leung, P. S., Gershwin, M. E. & Ma, X., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

1 Scopus citations

Immunotherapy of Food Allergy: a Comprehensive Review

Wai, C. Y. Y., Leung, N. Y. H., Leung, P. S. & Chu, K. H., Sep 19 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-19 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

Leung, N. Y. H., Wai, C. Y. Y., Shu, S. A., Chang, C. C., Chu, K. H. & Leung, P. S., Oct 25 2017, (Accepted/In press) In : International Archives of Allergy and Immunology. p. 86-96 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Leung, N. Y. H., Wai, C. Y. Y., Ho, M. H. K., Liu, R., Lam, K., Wang, J. J., Shu, S. A., Chu, K. H. & Leung, P. S., Mar 1 2017, In : Cellular and Molecular Immunology. 14, 3, p. 308-318 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review

Yao, M., Wang, L., Leung, P. S., Li, Y., Liu, S., Wang, L., Guo, X., Zhou, G., Yan, Y., Guan, G., Chen, X., Bowlus, C., Liu, T., Jia, J., Gershwin, M. E., Ma, X., Zhao, J. & Lu, F., Nov 24 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-13 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis

Shuai, Z., Wang, J., Badamagunta, M., Choi, J., Yang, G., Zhang, W., Kenny, T. P., Guggenheim, K., Kurth, M. J., Ansari, A. A., Voss, J. C., Coppel, R. L., Invernizzi, P., Leung, P. S. & Gershwin, M. E., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

18 Scopus citations

The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1)

Guo, C. J., Leung, P. S., Zhang, W., Ma, X. & Gershwin, M. E., Jan 1 2017, (Accepted/In press) In : Autoimmunity Reviews.

Research output: Contribution to journalArticle

13 Scopus citations

The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

Tomiyama, T., Yang, G. X., Zhao, M., Zhang, W., Tanaka, H., Wang, J., Leung, P. S., Okazaki, K., He, X., Lu, Q., Coppel, R. L., Bowlus, C. & Gershwin, M. E., Mar 1 2017, In : Cellular and Molecular Immunology. 14, 3, p. 276-284 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis

Ray, J. L., Kopec, A. K., Joshi, N., Cline-Fedewa, H., Lash, L. H., Williams, K. J., Leung, P. S., Gershwin, M. E. & Luyendyk, J. P., Apr 1 2017, In : Toxicological Sciences. 156, 2, p. 428-437 10 p., kfw264.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance

Bae, H. R., Leung, P. S., Tsuneyama, K., Valencia, J. C., Hodge, D. L., Kim, S., Back, T., Karwan, M., Merchant, A. S., Baba, N., Feng, D., Park, O., Gao, B., Yang, G. X., Gershwin, M. E. & Young, H. A., Oct 1 2016, In : Hepatology. 64, 4, p. 1189-1201 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Arsenijevic, A., Milovanovic, M., Milovanovic, J., Stojanovic, B., Zdravkovic, N., Leung, P. S., Liu, F-T., Gershwin, M. E. & Lukic, M. L., Mar 21 2016, In : Scientific Reports. 6, 23348.

Research output: Contribution to journalArticle

13 Scopus citations
8 Scopus citations

T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy

Wai, C. Y. Y., Leung, N. Y. H., Leung, P. S. & Chu, K. H., Mar 1 2016, In : Clinical and Experimental Allergy. 46, 3, p. 491-503 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines, and acute toxicity

Vogel, C. F. A., William Chang, W. L., Kado, S., McCulloh, K., Vogel, H., Wu, D., Haarmann-Stemmann, T., Yang, G. X., Leung, P. S., Matsumura, F. & Gershwin, M. E., Jul 1 2016, In : Environmental Health Perspectives. 124, 7, p. 1071-1083 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Xenobiotics and loss of tolerance in primary biliary cholangitis

Wang, J., Yang, G., Dubrovsky, A. M., Choi, J. & Leung, P. S., Jan 7 2016, In : World Journal of Gastroenterology. 22, 1, p. 338-348 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Animal Models of Primary Biliary Cirrhosis

Katsumi, T., Tomita, K., Leung, P. S., Yang, G. X., Gershwin, M. E. & Ueno, Y., Jun 1 2015, In : Clinical Reviews in Allergy and Immunology. 48, 2-3, p. 142-153 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Anti-kelch-like 12 and anti-hexokinase 1: Novel autoantibodies in primary biliary cirrhosis

Norman, G. L., Yang, C. Y., Ostendorff, H. P., Shums, Z., Lim, M. J., Wang, J., Awad, A., Hirschfield, G. M., Milkiewicz, P., Bloch, D. B., Rothschild, K. J., Bowlus, C., Adamopoulos, I., Leung, P. S., Janssen, H. J., Cheung, A. C., Coltescu, C. & Gershwin, M. E., Feb 1 2015, In : Liver International. 35, 2, p. 642-651 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Environmental Basis of Autoimmunity

Floreani, A., Leung, P. S. & Gershwin, M. E., May 22 2015, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalArticle

38 Scopus citations

Extrahepatic Malignancies in Primary Biliary Cirrhosis: A Comparative Study at Two European Centers

Floreani, A., Spinazzè, A., Caballeria, L., Reig, A., Cazzagon, N., Franceschet, I., Buja, A., Furlan, P., Harada, K., Leung, P. S., Gershwin, M. E. & Pares, A., Jun 1 2015, In : Clinical Reviews in Allergy and Immunology. 48, 2-3, p. 254-262 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity

Lam, Y. F., Tong, K. K., Kwan, K. M., Tsuneyama, K., Shu, S. A., Leung, P. S. & Chu, K. H., Jun 25 2015, (Accepted/In press) In : International Archives of Allergy and Immunology. p. 29-40 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

IL-35 and Autoimmunity: a Comprehensive Perspective

Choi, J., Leung, P. S., Bowlus, C. & Gershwin, M. E., Dec 1 2015, In : Clinical Reviews in Allergy and Immunology. 49, 3, p. 327-332 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis

Tanaka, H., Yang, G. X., Tomiyama, T., Tsuneyama, K., Zhang, W., Leung, P. S., Coppel, R. L., Joh, T., Nadler, S. G., Ansari, A. A., Bowlus, C. & Gershwin, M. E., Jun 1 2015, In : Clinical and Experimental Immunology. 180, 3, p. 371-382 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Innate immunity drives the initiation of a murine model of primary biliary cirrhosis

Chang, C. H., Chen, Y. C., Zhang, W., Leung, P. S., Gershwin, M. E. & Chuang, Y. H., Mar 25 2015, In : PLoS One. 10, 3, e0121320.

Research output: Contribution to journalArticle

15 Scopus citations

The autoimmune basis of alopecia areata: A comprehensive review

Islam, N., Leung, P. S., Huntley, A. C. & Gershwin, M. E., 2015, In : Autoimmunity Reviews. 14, 2, p. 81-89 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

The significance of autoantibody changes over time in primary biliary cirrhosis

Tana, M. M., Shums, Z., Milo, J., Norman, G. L., Leung, P. S., Gershwin, M. E., Noureddin, M., Kleiner, D. E., Zhao, X., Heller, T. & Hoofnagle, J. H., Oct 1 2015, In : American Journal of Clinical Pathology. 144, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Animal models of primary biliary cirrhosis

Wang, J., Yang, G. X., Tsuneyama, K., Gershwin, M. E., Ridgway, W. M. & Leung, P. S., 2014, In : Seminars in Liver Disease. 34, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Common methodologies in the evaluation of food allergy: Pitfalls and prospects of food allergy prevalence studies

Shu, S. A., Chang, C. & Leung, P. S., 2014, In : Clinical Reviews in Allergy and Immunology. 46, 3, p. 198-210 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cross-talk between aryl hydrocarbon receptor and the inflammatory response: A role for nuclear factor-κB

Vogel, C. F. A., Khan, E. M., Leung, P. S., Gershwin, M. E., Chang, W. L. W., Wu, D., Haarmann-Stemmann, T., Hoffmann, A. & Denison, M. S., Jan 17 2014, In : Journal of Biological Chemistry. 289, 3, p. 1866-1875 10 p.

Research output: Contribution to journalArticle

128 Scopus citations

Current immunological and molecular biological perspectives on seafood allergy: A comprehensive review

Leung, N. Y. H., Wai, C. Y. Y., Shu, S., Wang, J., Kenny, T. P., Chu, K. H. & Leung, P. S., 2014, In : Clinical Reviews in Allergy and Immunology. 46, 3, p. 180-197 18 p.

Research output: Contribution to journalArticle

64 Scopus citations

Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice

Wang, J. J., Yang, G. X., Zhang, W., Lu, L., Tsuneyama, K., Kronenberg, M., Véla, J. L., Lopez-Hoyos, M., He, X., Ridgway, W. M., Leung, P. S. & Gershwin, M. E., Feb 2014, In : Clinical and Experimental Immunology. 175, 2, p. 192-201 10 p.

Research output: Contribution to journalArticle

37 Scopus citations