• 9001 Citations
  • 54 h-Index
1985 …2020

Research output per year

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Research Output

2020

Animal Models of Autoimmune Liver Diseases: a Comprehensive Review

Liu, S. P., Bian, Z. H., Zhao, Z. B., Wang, J., Zhang, W., Leung, P. S. C., Li, L. & Lian, Z. X., Jan 1 2020, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalReview article

Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21

Nakamaru, K., Tomiyama, T., Kobayashi, S., Ikemune, M., Tsukuda, S., Ito, T., Tanaka, T., Yamaguchi, T., Ando, Y., Ikeura, T., Fukui, T., Nishio, A., Takaoka, M., Uchida, K., Leung, P. S. C., Gershwin, M. E. & Okazaki, K., Jan 1 2020, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Open Access

Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases

Bae, H. R., Leung, P. S. C., Hodge, D. L., Fenimore, J. M., Jeon, S. M., Thovarai, V., Dzutsev, A., Welcher, A. A., Boedigheimer, M., Damore, M. A., Choi, M. S., Fravell, R. A., Trinchieri, G., Gershwin, M. E. & Young, H. A., Jan 1 2020, (Accepted/In press) In : Journal of autoimmunity. 102436.

Research output: Contribution to journalArticle

Overcoming shellfish allergy: How far have we come?

Wai, C. Y. Y., Leung, N. Y. H., Chu, K. H., Leung, P. S. C., Leung, A. S. Y., Wong, G. W. K. & Leung, T. F., Mar 2 2020, In : International journal of molecular sciences. 21, 6, 2234.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Recurrence of disease following organ transplantation in autoimmune liver disease and systemic lupus erythematosus

Tanaka, A., Kono, H., Leung, P. S. C. & Eric Gershwin, M., Jan 2020, In : Cellular Immunology. 347, 104021.

Research output: Contribution to journalReview article

Open Access

The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review

Lleo, A., Leung, P. S. C., Hirschfield, G. M. & Gershwin, E. M., Jan 1 2020, In : Seminars in Liver Disease. 40, 1, p. 34-48 15 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review

Song, J., Li, Y., Bowlus, C., Yang, G. X., Leung, P. S. & Gershwin, M. E., Jan 1 2019, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalReview article

4 Scopus citations

Clinical Management of Primary Biliary Cholangitis—Strategies and Evolving Trends

Gao, L., Wang, L., Woo, E., He, X., Yang, G. X., Bowlus, C., Leung, P. S. C. & Gershwin, M. E., Jan 1 2019, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalReview article

2 Scopus citations

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology

Das, T., Bergen, I. M., Koudstaal, T., van Hulst, J. A. C., van Loo, G., Boonstra, A., Vanwolleghem, T., Leung, P. S., Gershwin, M. E., Hendriks, R. W. & Kool, M., Jan 1 2019, In : Journal of autoimmunity.

Research output: Contribution to journalArticle

Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

Sun, C., Xiao, X., Yan, L., Sheng, L., Wang, Q., Jiang, P., Lian, M., Li, Y., Wei, Y., Zhang, J., Chen, Y., Li, B., Li, Y., Huang, B., Li, Y., Peng, Y., Chen, X., Fang, J., Qiu, D., Hua, J. & 5 others, Tang, R., Leung, P. S., Gershwin, M. E., Miao, Q. & Ma, X., May 1 2019, In : Journal of autoimmunity. 99, p. 33-38 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Long-term Outcomes of Autologous Peripheral Blood Stem Cell Transplantation in Patients With Cirrhosis

Guo, C., Guo, G., Zhou, X., Chen, Y., Han, Z., Yang, C., Zhao, S., Su, H., Lian, Z., Leung, P. S., Gershwin, M. E., Zhou, X. & Han, Y., May 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 6, p. 1175-1182.e2

Research output: Contribution to journalArticle

Mimotope-based allergen-specific immunotherapy: ready for prime time?

Leung, N. Y. H., Wai, C. Y. Y., Chu, K. H. & Leung, P. S., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Immunology.

Research output: Contribution to journalLetter

1 Scopus citations
Open Access
1 Scopus citations

Principles of Allergen Immunotherapy and Its Clinical Application in China: Contrasts and Comparisons with the USA

Guan, K., Liu, B., Wang, M., Li, Z., Chang, C., Cui, L., Wang, R. Q., Wen, L. P., Leung, P. S., Wei, J. F. & Sun, J. L., Aug 15 2019, In : Clinical Reviews in Allergy and Immunology. 57, 1, p. 128-143 16 p.

Research output: Contribution to journalReview article

Proteomics in primary biliary cholangitis

Li, Y., Tang, R., Leung, P. S., Gershwin, M. E. & Ma, X., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 163-173 11 p. (Methods in Molecular Biology; vol. 1981).

Research output: Chapter in Book/Report/Conference proceedingChapter

Regional Differences in Food Allergies

Tang, R., Wang, Z. X., Ji, C. M., Leung, P. S., Woo, E., Chang, C., Wang, M., Liu, B., Wei, J. F. & Sun, J. L., Jan 1 2019, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalArticle

1 Scopus citations

The genetics of primary biliary cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Mar 1 2019, In : Current Opinion in Gastroenterology. 35, 2, p. 93-98 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice

Moritoki, Y., Tsuneyama, K., Nakamura, Y., Kikuchi, K., Shiota, A., Ohsugi, Y., Lian, Z. X., Zhang, W., Yang, G. X., Ueki, S., Takeda, M., Omokawa, A., Saga, T., Saga, A., Watanabe, D., Miura, M., Ueno, Y., Leung, P. S., Tanaka, A., Gershwin, M. E. & 1 others, Hirokawa, M., Nov 2 2018, In : Frontiers in Immunology. 9, NOV, 02534.

Research output: Contribution to journalArticle

4 Scopus citations

Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis

Hsueh, Y. H., Chen, H. W., Syu, B. J., Lin, C. I., Leung, P. S., Gershwin, M. E. & Chuang, Y. H., Dec 1 2018, In : Journal of Autoimmunity. 95, p. 159-170 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Environmental basis of primary biliary cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Jan 1 2018, In : Experimental Biology and Medicine. 243, 2, p. 184-189 6 p.

Research output: Contribution to journalReview article

7 Scopus citations

Etiopathogenesis of autoimmune hepatitis

Floreani, A., Restrepo-Jiménez, P., Secchi, M. F., De Martin, S., Leung, P. S., Krawitt, E., Bowlus, C., Gershwin, M. E. & Anaya, J. M., Dec 1 2018, In : Journal of Autoimmunity. 95, p. 133-143 11 p.

Research output: Contribution to journalReview article

17 Scopus citations

Evolution of our understanding of PBC

Tanaka, A., Leung, P. S. & Gershwin, M. E., Jan 1 2018, (Accepted/In press) In : Best Practice and Research: Clinical Gastroenterology.

Research output: Contribution to journalArticle

8 Scopus citations

Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice

Hintermann, E., Bayer, M., Conti, C. B., Fuchs, S., Fausther, M., Leung, P. S., Aurrand-Lions, M., Taubert, R., Pfeilschifter, J. M., Friedrich-Rust, M., Schuppan, D., Dranoff, J. A., Gershwin, M. E., Manns, M. P., Imhof, B. A. & Christen, U., Jan 1 2018, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

5 Scopus citations

Microbiota and Food Allergy

Shu, S. A., Yuen, A. W. T., Woo, E., Chu, K. H., Kwan, H. S., Yang, G. X., Yang, Y. & Leung, P. S., Jan 1 2018, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular mimicry and autoimmunity

Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S., Ansari, A. A., Gershwin, M. E. & Anaya, J. M., Dec 1 2018, In : Journal of Autoimmunity. 95, p. 100-123 24 p.

Research output: Contribution to journalReview article

39 Scopus citations

Pathogen infections and primary biliary cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Jan 1 2018, (Accepted/In press) In : Clinical and Experimental Immunology.

Research output: Contribution to journalArticle

9 Scopus citations

Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis

Zhang, W., Zhang, R., Zhang, J., Sun, Y., Leung, P. S., Yang, G. X., Shuai, Z., Ridgway, W. M. & Gershwin, M. E., Aug 1 2018, In : Cellular and Molecular Immunology. 15, 8, p. 756-767 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

The critical role of chemokine (C-C motif) receptor 2-positive monocytes in autoimmune cholangitis

Reuveni, D., Gore, Y., Leung, P. S., Lichter, Y., Moshkovits, I., Kaminitz, A., Brazowski, E., Lefebvre, E., Vig, P., Varol, C., Halpern, Z., Shibolet, O., Gershwin, M. E. & Zigmond, E., Aug 15 2018, In : Frontiers in Immunology. 9, AUG, 1852.

Research output: Contribution to journalArticle

2 Scopus citations

The Genetics and Epigenetics of Primary Biliary Cholangitis

Tanaka, A., Leung, P. S. & Gershwin, M. E., Aug 1 2018, In : Clinics in Liver Disease. 22, 3, p. 443-455 13 p.

Research output: Contribution to journalReview article

8 Scopus citations

The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7

Jiang, X., Lian, M., Li, Y., Zhang, W., Wang, Q., Wei, Y., Zhang, J., Chen, W., Xiao, X., Miao, Q., Bian, Z., Qiu, D., Fang, J., Ansari, A. A., Leung, P. S., Coppel, R. L., Tang, R., Gershwin, M. E. & Ma, X., Jan 1 2018, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

18 Scopus citations

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity

Bae, H. R., Hodge, D. L., Yang, G. X., Leung, P. S., Chodisetti, S. B., Valencia, J. C., Sanford, M., Fenimore, J. M., Rahman, Z. S. M., Tsuneyama, K., Norman, G. L., Gershwin, M. E. & Young, H. A., Apr 1 2018, In : Hepatology. 67, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The molecular basis of immune regulation in autoimmunity

Yang, S. H., Gao, C. Y., Li, L., Chang, C., Leung, P. S., Gershwin, M. E. & Lian, Z. X., Jan 1 2018, In : Clinical Science. 132, 1, p. 43-67 25 p.

Research output: Contribution to journalReview article

4 Scopus citations

Therapeutic and immunological interventions in primary biliary cholangitis: From mouse models to humans

Tanaka, A., Leung, P. S., Young, H. A. & Gershwin, M. E., Jan 1 2018, In : Archives of Medical Science. 14, 4, p. 930-940 11 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2017

Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

Tanaka, T., Zhang, W., Sun, Y., Shuai, Z., Chida, A. S., Kenny, T. P., Yang, G. X., Sanz, I., Ansari, A., Bowlus, C., Ippolito, G. C., Coppel, R. L., Okazaki, K., He, X., Leung, P. S. & Gershwin, M. E., Sep 1 2017, In : Hepatology. 66, 3, p. 885-895 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases

Li, Y., Tang, R., Leung, P. S., Gershwin, M. E. & Ma, X., Sep 1 2017, In : Autoimmunity Reviews. 16, 9, p. 885-896 12 p.

Research output: Contribution to journalReview article

49 Scopus citations

Common Variable Immunodeficiency and Liver Involvement

Song, J., Lleo, A., Yang, G. X., Zhang, W., Bowlus, C., Gershwin, M. E. & Leung, P. S., Aug 7 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-12 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

How the biliary tree maintains immune tolerance?

Zhang, H., Leung, P. S., Gershwin, M. E. & Ma, X., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

1 Scopus citations

Immunotherapy of Food Allergy: a Comprehensive Review

Wai, C. Y. Y., Leung, N. Y. H., Leung, P. S. & Chu, K. H., Sep 19 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-19 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

Leung, N. Y. H., Wai, C. Y. Y., Shu, S. A., Chang, C. C., Chu, K. H. & Leung, P. S., Oct 25 2017, (Accepted/In press) In : International Archives of Allergy and Immunology. p. 86-96 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Leung, N. Y. H., Wai, C. Y. Y., Ho, M. H. K., Liu, R., Lam, K., Wang, J. J., Shu, S. A., Chu, K. H. & Leung, P. S., Mar 1 2017, In : Cellular and Molecular Immunology. 14, 3, p. 308-318 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review

Yao, M., Wang, L., Leung, P. S., Li, Y., Liu, S., Wang, L., Guo, X., Zhou, G., Yan, Y., Guan, G., Chen, X., Bowlus, C., Liu, T., Jia, J., Gershwin, M. E., Ma, X., Zhao, J. & Lu, F., Nov 24 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-13 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis

Shuai, Z., Wang, J., Badamagunta, M., Choi, J., Yang, G., Zhang, W., Kenny, T. P., Guggenheim, K., Kurth, M. J., Ansari, A. A., Voss, J. C., Coppel, R. L., Invernizzi, P., Leung, P. S. & Gershwin, M. E., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

18 Scopus citations

The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1)

Guo, C. J., Leung, P. S., Zhang, W., Ma, X. & Gershwin, M. E., Jan 1 2017, (Accepted/In press) In : Autoimmunity Reviews.

Research output: Contribution to journalArticle

13 Scopus citations

The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

Tomiyama, T., Yang, G. X., Zhao, M., Zhang, W., Tanaka, H., Wang, J., Leung, P. S., Okazaki, K., He, X., Lu, Q., Coppel, R. L., Bowlus, C. & Gershwin, M. E., Mar 1 2017, In : Cellular and Molecular Immunology. 14, 3, p. 276-284 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis

Ray, J. L., Kopec, A. K., Joshi, N., Cline-Fedewa, H., Lash, L. H., Williams, K. J., Leung, P. S., Gershwin, M. E. & Luyendyk, J. P., Apr 1 2017, In : Toxicological Sciences. 156, 2, p. 428-437 10 p., kfw264.

Research output: Contribution to journalArticle

2 Scopus citations
2016

A contemporary perspective on the molecular characteristics of mitochondrial autoantigens and diagnosis in primary biliary cholangitis

Leung, P. S., Choi, J., Yang, G., Woo, E., Kenny, T. P. & Gershwin, M. E., Jun 2 2016, In : Expert Review of Molecular Diagnostics. 16, 6, p. 697-705 9 p.

Research output: Contribution to journalReview article

16 Scopus citations

Adaptive immunity in the liver

Shuai, Z., Leung, M. W. Y., He, X., Zhang, W., Yang, G., Leung, P. S. & Gershwin, M. E., May 1 2016, In : Cellular and Molecular Immunology. 13, 3, p. 354-368 15 p.

Research output: Contribution to journalReview article

29 Scopus citations

Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC)

Sun, Y., Zhang, W., Evans, J. F., Floreani, A., Zou, Z., Nishio, Y., Qi, R., Leung, P. S., Bowlus, C. & Gershwin, M. E., Aug 1 2016, In : Autoimmunity Reviews. 15, 8, p. 795-800 6 p.

Research output: Contribution to journalReview article

19 Scopus citations

Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis

Choi, J., Selmi, C. F., Leung, P. S. C., Kenny, T. P., Roskams, T. & Gershwin, M. E., Jun 2 2016, In : Expert Review of Clinical Immunology. 12, 6, p. 661-672 12 p.

Research output: Contribution to journalReview article

25 Scopus citations

Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance

Bae, H. R., Leung, P. S., Tsuneyama, K., Valencia, J. C., Hodge, D. L., Kim, S., Back, T., Karwan, M., Merchant, A. S., Baba, N., Feng, D., Park, O., Gao, B., Yang, G. X., Gershwin, M. E. & Young, H. A., Oct 1 2016, In : Hepatology. 64, 4, p. 1189-1201 13 p.

Research output: Contribution to journalArticle

41 Scopus citations