• 1552 Citations
  • 20 h-Index
20012020
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Research Output 2001 2020

  • 1552 Citations
  • 20 h-Index
  • 45 Article
  • 2 Conference contribution
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Article
2020

Optimizing cell encapsulation condition in ECM-Collagen I hydrogels to support 3D neuronal cultures

Lam, D., Enright, H. A., Peters, S. K. G., Moya, M. L., Soscia, D. A., Cadena, J., Alvarado, J. A., Kulp, K. S., Wheeler, E. K. & Fischer, N. O., Jan 1 2020, In : Journal of Neuroscience Methods. 329, 108460.

Research output: Contribution to journalArticle

Open Access
Hydrogels
Collagen
Cell Survival
Gels
Neurons
2019

Extent of MHC clustering regulates selectivity and effectiveness of T cell responses

Anikeeva, N., Fischer, N. O., Blanchette, C. D. & Sykulev, Y., Jan 15 2019, In : Journal of Immunology. 202, 2, p. 591-597 7 p.

Research output: Contribution to journalArticle

Cluster Analysis
Ligands
T-Lymphocytes
Membranes
Cell Membrane
2 Citations (Scopus)

Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array

Lam, D., Enright, H. A., Cadena, J., Peters, S. K. G., Sales, A. P., Osburn, J. J., Soscia, D. A., Kulp, K. S., Wheeler, E. K. & Fischer, N. O., Dec 1 2019, In : Scientific Reports. 9, 1, 4159.

Research output: Contribution to journalArticle

Open Access
Coculture Techniques
Neuroglia
Extracellular Matrix
Electrodes
Neurons
2018
2 Citations (Scopus)

Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems

Belle, A. M., Enright, H. A., Sales, A. P., Kulp, K., Osburn, J., Kuhn, E. A., Fischer, N. O. & Wheeler, E. K., Dec 1 2018, In : Scientific Reports. 8, 1, 10820.

Research output: Contribution to journalArticle

Brain
Ketamine
Electrophysiology
Atropine
Neurons

Lipid composition dictates serum stability of reconstituted high-density lipoproteins: Implications for: In vivo applications

Gilmore, S. F., Carpenter, T. S., Ingólfsson, H. I., Peters, S. K. G., Henderson, P., Blanchette, C. D. & Fischer, N. O., Apr 28 2018, In : Nanoscale. 10, 16, p. 7420-7430 11 p.

Research output: Contribution to journalArticle

Lipoproteins
HDL Lipoproteins
Lipids
Lipid bilayers
Chemical analysis

Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale

Villanueva, J. T., Huang, Q., Fischer, N. O., Arya, G. & Sirbuly, D. J., Sep 27 2018, In : Journal of Physical Chemistry C. 122, 38, p. 22114-22124 11 p.

Research output: Contribution to journalArticle

Nanofibers
microbalances
Microscopic examination
Physical properties
Tin dioxide
1 Citation (Scopus)

Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles

Cleveland, T. E., He, W., Evans, A. C., Fischer, N. O., Lau, E. Y., Coleman, M. A. & Butler, P., Mar 1 2018, In : Protein Science. 27, 3, p. 780-789 10 p.

Research output: Contribution to journalArticle

Neutrons
Neutron scattering
X ray scattering
Detergents
X-Rays
2017
2 Citations (Scopus)

Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development

He, W., Felderman, M., Evans, A. C., Geng, J., Homan, D., Bourguet, F., Fischer, N. O., Li, Y., Lam, K., Noy, A., Xing, L., Cheng, R. H., Rasley, A., Blanchette, C. D., Kamrud, K., Wang, N., Gouvis, H., Peterson, T. C., Hubby, B. & Coleman, M. A., 2017, In : Journal of Biological Chemistry. 292, 36, p. 15121-15132 12 p.

Research output: Contribution to journalArticle

Chlamydia
Membrane Proteins
Vaccines
Proteins
Chlamydia muridarum
6 Citations (Scopus)

Controlled placement of multiple CNS cell populations to create complex neuronal cultures

Soscia, D., Belle, A., Fischer, N. O., Enright, H., Sales, A., Osburn, J., Benett, W., Mukerjee, E., Kulp, K., Pannu, S. & Wheeler, E., Nov 1 2017, In : PLoS One. 12, 11, e0188146.

Research output: Contribution to journalArticle

Cell culture
Neurons
Cells
Brain
neurons
5 Citations (Scopus)

Enhancement of antigen-specific CD4+ and CD8+ T cell responses using a self-assembled biologic nanolipoprotein particle vaccine

Weilhammer, D., Dunkle, A. D., Blanchette, C. D., Fischer, N. O., Corzett, M., Lehmann, D., Boone, T., Hoeprich, P., Driks, A. & Rasley, A., Mar 13 2017, In : Vaccine. 35, 11, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

CD8 Antigens
CD4 Antigens
ovalbumin
Ovalbumin
Vaccines
2016
6 Citations (Scopus)

Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake

Gilmore, S. F., Blanchette, C. D., Scharadin, T. M., Hura, G. L., Rasley, A., Corzett, M., Pan, C-X., Fischer, N. O. & Henderson, P., Aug 17 2016, In : ACS Applied Materials and Interfaces. 8, 32, p. 20549-20557 9 p.

Research output: Contribution to journalArticle

Lipids
Lipid bilayers
Size exclusion chromatography
Phospholipids
Degradation
9 Citations (Scopus)

Long-term non-invasive interrogation of human dorsal root ganglion neuronal cultures on an integrated microfluidic multielectrode array platform

Enright, H. A., Felix, S. H., Fischer, N. O., Mukerjee, E. V., Soscia, D., McNerney, M., Kulp, K., Zhang, J., Page, G., Miller, P., Ghetti, A., Wheeler, E. K. & Pannu, S., Sep 21 2016, In : Analyst. 141, 18, p. 5346-5357 12 p.

Research output: Contribution to journalArticle

Microfluidics
Spinal Ganglia
Neurons
drug
electrode
2014
2 Citations (Scopus)

Enhancing the efficacy of innate immune agonists: Could nanolipoprotein particles hold the key?

Fischer, N. O., Blanchette, C. & Rasley, A., 2014, In : Nanomedicine. 9, 3, p. 369-372 4 p.

Research output: Contribution to journalArticle

nanotechnology
infectious disease
contagious disease
particle
nanoparticle
21 Citations (Scopus)

Evaluation of Nanolipoprotein Particles (NLPs) as an in vivo delivery platform

Fischer, N. O., Weilhammer, D. R., Dunkle, A., Thomas, C., Hwang, M., Corzett, M., Lychak, C., Mayer, W., Urbin, S., Collette, N., Chang, J. C., Loots, G. G., Rasley, A. & Blanchette, C. D., Mar 27 2014, In : PLoS One. 9, 3, e93342.

Research output: Contribution to journalArticle

Cytotoxicity
Toxicity
Drug Stability
Nanosystems
Intranasal Administration
7 Citations (Scopus)

Fluorescence correlation spectroscopy at micromolar concentrations without optical nanoconfinement

Laurence, T. A., Ly, S., Bourguet, F., Fischer, N. O. & Coleman, M. A., Aug 14 2014, In : Journal of Physical Chemistry B. 118, 32, p. 9662-9667 6 p.

Research output: Contribution to journalArticle

Fluorescence
Spectroscopy
fluorescence
Detectors
spectroscopy
5 Citations (Scopus)

Nanoparticles and antigen delivery: Understanding the benefits and drawbacks of different delivery platforms

Fischer, N. O., Rasley, A. & Blanchette, C., 2014, In : Nanomedicine. 9, 4, p. 373-376 4 p.

Research output: Contribution to journalArticle

nanotechnology
vaccine
infectious disease
antigen
contagious disease
11 Citations (Scopus)

Quantifying interactions of a membrane protein embedded in a lipid nanodisc using fluorescence correlation spectroscopy

Ly, S., Bourguet, F., Fischer, N. O., Lau, E. Y., Coleman, M. A. & Laurence, T. A., Jan 21 2014, In : Biophysical Journal. 106, 2

Research output: Contribution to journalArticle

Fluorescence Spectrometry
Membrane Proteins
Lipids
Technology
Yersinia pestis
2013
35 Citations (Scopus)

Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens

Fischer, N. O., Rasley, A., Corzett, M., Hwang, M. H., Hoeprich, P. D. & Blanchette, C. D., Feb 13 2013, In : Journal of the American Chemical Society. 135, 6, p. 2044-2047 4 p.

Research output: Contribution to journalArticle

Antigens
Chelation
Vaccines
Antibodies
Yersinia pestis
8 Citations (Scopus)

Nanofiber near-field light-matter interactions for enhanced detection of molecular level displacements and dynamics

Yoon, I., Baker, S. E., Kim, K., Fischer, N. O., Heineck, D., Wang, Y., Esener, S. C. & Sirbuly, D. J., Apr 10 2013, In : Nano Letters. 13, 4, p. 1440-1445 6 p.

Research output: Contribution to journalArticle

Nanofibers
Nanoparticles
near fields
Light
Waveguides
18 Citations (Scopus)

The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge

Weilhammer, D. R., Blanchette, C. D., Fischer, N. O., Alam, S., Loots, G. G., Corzett, M., Thomas, C., Lychak, C., Dunkle, A. D., Ruitenberg, J. J., Ghanekar, S. A., Sant, A. J. & Rasley, A., Dec 2013, In : Biomaterials. 34, 38, p. 10305-10318 14 p.

Research output: Contribution to journalArticle

Lipids
Human Influenza
Cytokines
Oligodeoxyribonucleotides
Immune system
2012
28 Citations (Scopus)

Enhanced cellulose degradation using cellulase-nanosphere complexes

Blanchette, C., Lacayo, C. I., Fischer, N. O., Hwang, M. & Thelen, M. P., Aug 1 2012, In : PLoS One. 7, 8, e42116.

Research output: Contribution to journalArticle

nanospheres
Nanospheres
Cellulase
endo-1,4-beta-glucanase
Cellulose
2011
3 Citations (Scopus)

Identification and optimization of DNA aptamer binding regions using DNA microarrays.

Fischer, N. O. & Tarasow, T. M., 2011, In : Methods in molecular biology (Clifton, N.J.). 723, p. 57-66 10 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Biological Science Disciplines
Oligonucleotide Array Sequence Analysis
Immunoglobulin E
Technology
2010
24 Citations (Scopus)

Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent west nile encephalitis

Fischer, N. O., Infante, E., Ishikawa, T., Blanchette, C. D., Bourne, N., Hoeprich, P. D. & Mason, P. W., Jun 16 2010, In : Bioconjugate Chemistry. 21, 6, p. 1018-1022 5 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Vaccines
Encephalitis
Chelation
Nickel
12 Citations (Scopus)

Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III

Fischer, N. O., Blanchette, C. D., Segelke, B. W., Corzett, M., Chromy, B. A., Kuhn, E. A., Bench, G. & Hoeprich, P. D., Jul 19 2010, In : PLoS One. 5, 7, e11643.

Research output: Contribution to journalArticle

apolipophorin
Size exclusion chromatography
Apolipoproteins
Gel Chromatography
Atomic Force Microscopy
20 Citations (Scopus)

Kinetic analysis of his-tagged protein binding to nickel-chelating nanolipoprotein particles

Blanchette, C. D., Fischer, N. O., Corzett, M., Bench, G. & Hoeprich, P. D., Jul 21 2010, In : Bioconjugate Chemistry. 21, 7, p. 1321-1330 10 p.

Research output: Contribution to journalArticle

Chelation
Nickel
Protein Binding
Kinetics
Lipids
2009
15 Citations (Scopus)

Characterization and purification of polydisperse reconstituted lipoproteins and nanolipoprotein particles

Blanchette, C. D., Segelke, B. W., Fischer, N. O., Corzett, M. H., Kuhn, E. A., Cappuccio, J. A., Benner, W. H., Coleman, M. A., Chromy, B. A., Bench, G., Hoeprich, P. D. & Sulchek, T. A., Jul 2009, In : International Journal of Molecular Sciences. 10, 7, p. 2958-2971 14 p.

Research output: Contribution to journalArticle

Cholates
lipoproteins
Lipoproteins
Size exclusion chromatography
purification
28 Citations (Scopus)

Hydrogen production by a hyperthermophilic membrane-bound hydrogenase in water-soluble nanolipoprotein particles

Baker, S. E., Hopkins, R. C., Blanchette, C. D., Walsworth, V. L., Sumbad, R., Fischer, N. O., Kuhn, E. A., Coleman, M. A., Chromy, B. A., Létant, S. E., Hoeprich, P. D., Adams, M. W. W. & Henderson, P., Jun 10 2009, In : Journal of the American Chemical Society. 131, 22, p. 7508-7509 2 p.

Research output: Contribution to journalArticle

Hydrogenase
Hydrogen production
Hydrogen
Membranes
Water
31 Citations (Scopus)

Immobilization of his-tagged proteins on nickel-chelating nanolipoprotein particles

Fischer, N. O., Blanchette, C. D., Chromy, B. A., Kuhn, E. A., Segelke, B. W., Corzett, M., Bench, G., Mason, P. W. & Hoeprich, P. D., Mar 2009, In : Bioconjugate Chemistry. 20, 3, p. 460-465 6 p.

Research output: Contribution to journalArticle

Chelation
Nickel
Immobilization
Lipids
Proteins
2008
28 Citations (Scopus)

Biofunctional subwavelength optical waveguides for biodetection

Sirbuly, D. J., Fischer, N. O., Huang, S. C. J., Artyukhin, A. B., Tok, J. B. H., Bakajin, O. & Noy, A., Feb 2008, In : ACS Nano. 2, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

Lipid bilayers
Optical waveguides
optical waveguides
lipids
DNA
38 Citations (Scopus)

Massively parallel interrogation of aptamer sequence, structure and function

Fischer, N. O., Tok, J. B. H. & Tarasow, T. M., Jul 16 2008, In : PLoS One. 3, 7, e2720.

Research output: Contribution to journalArticle

Immunoglobulin E
fluorescence
immunoglobulin E
microarray technology
consensus sequence
63 Citations (Scopus)

Protein detection via direct enzymatic amplification of short DNA aptamers

Fischer, N. O., Tarasow, T. M. & Tok, J. B. H., Feb 1 2008, In : Analytical Biochemistry. 373, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Amplification
Polymerase chain reaction
Molecules
DNA
135 Citations (Scopus)

Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy

Samanta, B., Yan, H., Fischer, N. O., Shi, J., Jerry, D. J. & Rotello, V. M., 2008, In : Journal of Materials Chemistry. 18, 11, p. 1204-1208 5 p.

Research output: Contribution to journalArticle

toxicity
Toxicity
therapy
Magnetic fields
Nanoparticles
20 Citations (Scopus)

Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification

Schopf, E., Fischer, N. O., Chen, Y. & Tok, J. B. H., Nov 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 22, p. 5871-5874 4 p.

Research output: Contribution to journalArticle

Viral DNA
Microspheres
Amplification
Assays
69 Citations (Scopus)

Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin

Tok, J. B. H. & Fischer, N. O., 2008, In : Chemical Communications. 16, p. 1883-1885 3 p.

Research output: Contribution to journalArticle

Neurotoxins
2007
50 Citations (Scopus)

Aptasensors for biosecurity applications

Fischer, N. O., Tarasow, T. M. & Tok, J. B. H., Jun 2007, In : Current Opinion in Chemical Biology. 11, 3, p. 316-328 13 p.

Research output: Contribution to journalArticle

Nucleic Acids
Pathogens
Antibodies
Infection
In Vitro Techniques
24 Citations (Scopus)

Heightened sense for sensing: Recent advances in pathogen immunoassay sensing platforms

Fischer, N. O., Tarasow, T. M. & Tok, J. B. H., 2007, In : Analyst. 132, 3, p. 187-191 5 p.

Research output: Contribution to journalArticle

Biological warfare
Biological Warfare
Bioterrorism
immunoassay
Pathogens
2006
19 Citations (Scopus)

Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates

Bi, W., Bi, L., Cai, J., Liu, S., Peng, S., Fischer, N. O., Tok, J. B. H. & Wang, G., Sep 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 17, p. 4523-4527 5 p.

Research output: Contribution to journalArticle

Carbolines
Scavenging
Free Radicals
Assays
Myocardial Reperfusion Injury
52 Citations (Scopus)

Surface modification using cubic silsesquioxane ligands. facile synthesis of water-soluble metal oxide nanoparticles

Frankamp, B. L., Fischer, N. O., Hong, R., Srivastava, S. & Rotello, V. M., Feb 21 2006, In : Chemistry of Materials. 18, 4, p. 956-959 4 p.

Research output: Contribution to journalArticle

Oxides
Surface treatment
Metals
Ligands
Nanoparticles
2005
180 Citations (Scopus)

Surface PEGylation and ligand exchange chemistry of FePt nanoparticles for biological applications

Hong, R., Fischer, N. O., Emrick, T. & Rotello, V. M., Sep 6 2005, In : Chemistry of Materials. 17, 18, p. 4617-4621 5 p.

Research output: Contribution to journalArticle

Ligands
Nanoparticles
Sulfhydryl Compounds
Bearings (structural)
Water
2004
240 Citations (Scopus)

Control of Protein Structure and Function through Surface Recognition by Tailored Nanoparticle Scaffolds

Hong, R., Fischer, N. O., Verma, A., Goodman, C. M., Emrick, T. & Rotello, V. M., Jan 28 2004, In : Journal of the American Chemical Society. 126, 3, p. 739-743 5 p.

Research output: Contribution to journalArticle

Scaffolds
Nanoparticles
Ligands
Proteins
Denaturation
37 Citations (Scopus)

Highly efficient biocatalysts via covalent immobilization of Candida rugosa lipase on ethylene glycol-modified gold-silica nanocomposites

Drechsler, U., Fischer, N. O., Frankamp, B. L. & Rotello, V. M., Feb 3 2004, In : Advanced Materials. 16, 3, p. 271-274 4 p.

Research output: Contribution to journalArticle

Biocatalysts
Ethylene Glycol
Candida
Lipases
Ethylene glycol
10 Citations (Scopus)

Light-induced inhibition of chymotrypsin using photocleavable monolayers on gold nanoparticles

Fischer, N. O., Paulini, R., Drechsler, U. & Rotello, V. M., Dec 21 2004, In : Chemical Communications. 24, p. 2866-2867 2 p.

Research output: Contribution to journalArticle

Chymotrypsin
Gold
Monolayers
Irradiation
Nanoparticles
2003
96 Citations (Scopus)

Reversible "Irreversible" Inhibition of Chymotrypsin Using Nanoparticle Receptors

Fischer, N. O., Verma, A., Goodman, C. M., Simard, J. M. & Rotello, V. M., Nov 5 2003, In : Journal of the American Chemical Society. 125, 44, p. 13387-13391 5 p.

Research output: Contribution to journalArticle

Chymotrypsin
Nanoparticles
Surface active agents
Fluorescence
Surface-Active Agents
2002
169 Citations (Scopus)

Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors

Fischer, N. O., McIntosh, C. M., Simard, J. M. & Rotello, V. M., Apr 16 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 8, p. 5018-5023 6 p.

Research output: Contribution to journalArticle

Chymotrypsin
Gold
Nanoparticles
Galactosidases
Retinoic Acid Receptors
2001
21 Citations (Scopus)

HSV-2 disrupts gap junctional intercellular communication between mammalian cells in vitro

Fischer, N. O., Mbuy, G. N. K. & Woodruff, R. I., 2001, In : Journal of Virological Methods. 91, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Infection
Gap Junctions
Coloring Agents
Cercopithecus aethiops