Natalie J Torok, MD

Professor

  • 2316 Citations
  • 24 h-Index
1991 …2020

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Research Output

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Article
2020

Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population

Mikami, K., Endo, T., Sawada, N., Igarashi, G., Kimura, M., Hasegawa, T., Iino, C., Tomita, H., Sawada, K., Nakaji, S., Matsuzaka, M., Torok, N. J. & Fukuda, S., Feb 2020, In : Cytokine. 126, 154927.

Research output: Contribution to journalArticle

2019

Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation

Zhao, P., Han, S. N., Arumugam, S., Yousaf, M. N., Qin, Y., Jiang, J. X., Torok, N. J., Chen, Y., Mankash, M. S., Liu, J., Li, J., Iwakiri, Y. & Ouyang, X., Oct 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 4, p. G387-G397

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations
2018

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

Ouyang, X., Han, S. N., Zhang, J. Y., Nemeth, B. T., Pacher, P., Feng, D., Bataller, R., Cabezas, J., Stärkel, P., Caballeria, J., Pongratz, R. L. P., Cai, S. Y., Schnabl, B., Hoque, R., Chen, Y., Yang, W. H., Martinez, I. G., Wang, F. S., Gao, B., Torok, N. J. & 2 others, Kibbey, R. G. & Mehal, W. Z., Feb 6 2018, In : Cell Metabolism. 27, 2, p. 339-350.e3

Research output: Contribution to journalArticle

10 Scopus citations

High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease

Tepper, C. G., Dang, J. H. T., Stewart, S. L., Fang, D. M., Wong, K. A., Liu, S. Y., Davis, R. R., Dao, D. Y., Gregg, J. P., Török, N. J. & Chen, M. S., Apr 1 2018, In : Cancer. 124, p. 1583-1589 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis

Zhou, Z., Xu, M. J., Cai, Y., Wang, W., Jiang, X., Varga, Z. V., Feng, D., Pacher, P., Kunos, G., Torok, N. J. & Gao, B., Mar 1 2018, In : CMGH. 5, 3, p. 399-413 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease

Matsumoto, M., Zhang, J., Zhang, X., Liu, J., Jiang, X., Yamaguchi, K., Taruno, A., Katsuyama, M., Iwata, K., Ibi, M., Cui, W., Matsuno, K., Marunaka, Y., Itoh, Y., Torok, N. J. & Yabe-Nishimura, C., Feb 1 2018, In : Free Radical Biology and Medicine. 115, p. 412-420 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

Sasaki, Y., Dehnad, A., Fish, S., Sato, A., Jiang, X., Tian, J., Schröder, K., Brandes, R. & Torok, N. J., Apr 6 2017, In : Scientific Reports. 7, 46144.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury

Haque, A., Gheibi, P., Stybayeva, G., Gao, Y., Torok, N. J. & Revzin, A., Oct 31 2016, In : Scientific Reports. 6, 36077.

Research output: Contribution to journalArticle

7 Scopus citations

Galectin-3 regulates inflammasome activation in cholestatic liver injury

Tian, J., Yang, G., Chen, H. Y., Hsu, D. K., Tomilov, A., Olson, K. A., Dehnad, A., Fish, S. R., Cortopassi, G. A., Zhao, B., Liu, F-T., Gershwin, M. E., Torok, N. J. & Jiang, X., Dec 1 2016, In : FASEB Journal. 30, 12, p. 4202-4213 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation

Serizawa, N., Tian, J., Fukada, H., Baghy, K., Scott, F., Chen, X., Kiss, Z., Olson, K. A., Hsu, D., Liu, F-T., Torok, N. J., Zhao, B. & Jiang, X., Oct 1 2015, In : Laboratory Investigation. 95, 10, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, X., Sasaki, Y., Chao, T. I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., Szyndralewiez, C., Schröder, K., Shah, A., Brandes, R. P., Haj, F. & Torok, N. J., Aug 1 2015, In : Gastroenterology. 149, 2, p. 468-480.e10

Research output: Contribution to journalArticle

59 Scopus citations

Role of intestinal myofibroblasts in HIV-associated intestinal collagen deposition and immune reconstitution following combination antiretroviral therapy

Asmuth, D. M., Pinchuk, I. V., Wu, J., Vargas, G., Chen, X., Mann, S., Albanese, A., Ma, Z. M., Saroufeem, R. M. G., Melcher, G. P., Troia-Cancio, P., Torok, N. J., Miller, C. J. & Powell, D. W., May 15 2015, In : AIDS (London, England). 29, 8, p. 877-888 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014

Torok, N. J., Dranoff, J. A., Schuppan, D. & Friedman, S. L., Aug 1 2015, In : Hepatology. 62, 2, p. 627-634 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Vascular adhesion protein 1 in nonalcoholic steatohepatitis: A novel biomarker?

Torok, N. J., Oct 1 2015, In : Hepatology. 62, 4, p. 1313-1315 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

MLK3 as a regulator of disease progression in non-alcoholic steatohepatitis

Jiang, X. & Torok, N. J., 2014, In : Liver International. 34, 8, p. 1131-1132 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice

Jiang, X., Chen, X., Fukada, H., Serizawa, N., Devaraj, S. & Torok, N. J., Oct 2013, In : Hepatology. 58, 4, p. 1339-1348 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

Medici, V., Shibata, N. M., Kharbanda, K. K., LaSalle, J. M., Woods, R., Liu, S., Engelberg, J. A., Devaraj, S., Torok, N. J., Jiang, X., Havel, P. J., Lönnerdal, B., Kim, K. & Halsted, C. H., Feb 2013, In : Hepatology. 57, 2, p. 555-565 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo

Jiang, X., Chen, X., Hsu, D. K., Baghy, K., Serizawa, N., Scott, F., Takada, Y., Takada, Y., Fukada, H., Chen, J., Devaraj, S., Adamson, R., Liu, F-T. & Torok, N. J., Feb 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 4, p. 439-446 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Jung, C. J., Iyengar, S., Blahnik, K. R., Jiang, X., Tahimic, C., Torok, N. J., deVere White, R. W., Farnham, P. J. & Zern, M. A., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 979-991 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S. & Torok, N. J., Jul 15 2012, In : Free Radical Biology and Medicine. 53, 2, p. 289-296 8 p.

Research output: Contribution to journalArticle

142 Scopus citations
2011

Leptin: The missing link between obesity and heart disease?

Devaraj, S. & Torok, N. J., Aug 2011, In : Atherosclerosis. 217, 2, p. 322-323 2 p.

Research output: Contribution to journalArticle

4 Scopus citations
88 Scopus citations

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

Cui, W., Matsuno, K., Iwata, K., Ibi, M., Matsumoto, M., Zhang, J., Zhu, K., Katsuyama, M., Torok, N. J. & Yabe-Nishimura, C., Sep 2 2011, In : Hepatology. 54, 3, p. 949-958 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
2010

Genomic variants associated with primary biliary cirrhosis

Selmi, C. F., Torok, N. J., Affronti, A. & Gershwin, M. E., Jan 26 2010, In : Genome Medicine. 2, 1, 5.

Research output: Contribution to journalArticle

6 Scopus citations

Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease

Medici, V., Ali, M. R., Seo, S., Aoki, C. A., Rossaro, L., Kim, K., Fuller, W. D., Vidovszky, T. J., Smith, W., Jiang, X., Maganti, K., Havel, P. J., Kamboj, A., Ramsamooj, R. & Torok, N. J., Dec 2010, In : Obesity. 18, 12, p. 2268-2273 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
164 Scopus citations

Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in Vivo

Jiang, X., Venugopal, S., Serizawa, N., Chen, X., Scott, F., Li, Y., Adamson, R., Devaraj, S., Shah, V., Gershwin, M. E., Friedman, S. L. & Torok, N. J., Oct 2010, In : Gastroenterology. 139, 4

Research output: Contribution to journalArticle

80 Scopus citations
2009

Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition

Sohail, M. A., Hashmi, A. Z., Hakim, W., Watanabe, A., Zipprich, A., Groszmann, R. J., Dranoff, J. A., Torok, N. J. & Mehal, W. Z., 2009, In : Hepatology. 49, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

Jiang, X., Mikami, K., Venugopal, S., Li, Y. & Torok, N. J., Jul 2009, In : Journal of Hepatology. 51, 1, p. 139-148 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Minocycline in the treatment of patients with primary sclerosing cholangitis: Results of a pilot study

Silveira, M. G., Torok, N. J., Gossard, A. A., Keach, J. C., Jorgensenrn, R. A., Petzrn, J. L. & Lindor, K. D., Jan 2009, In : American Journal of Gastroenterology. 104, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

78 Scopus citations
2008

Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: Evidence for an adipose tissue-vascular loop

Devaraj, S., Torok, N. J., Dasu, M. R., Samols, D. & Jialal, I., Jul 1 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 7, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a rho guanosine triphosphatase-dependent mechanism

Jiang, X., Mikami, K., Shah, V. H. & Torok, N. J., Nov 2008, In : Hepatology. 48, 5, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Nonalcoholic steatohepatitis and the metabolic syndrome

Jiang, X. & Torok, N. J., Mar 1 2008, In : Metabolic Syndrome and Related Disorders. 6, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Recent advances in the pathogenesis and diagnosis of liver fibrosis

Torok, N. J., May 2008, In : Journal of Gastroenterology. 43, 5, p. 315-321 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Apoptotic cell death takes its toll

Torok, N. J., Nov 2007, In : Hepatology. 46, 5, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

De novo nonalcoholic fatty liver disease after liver transplantation

Seo, S., Maganti, K., Khehra, M., Ramsamooj, R., Tsodikov, A., Bowlus, C., McVicar, J., Zern, M. A. & Torok, N. J., Jun 2007, In : Liver Transplantation. 13, 6, p. 844-847 4 p.

Research output: Contribution to journalArticle

118 Scopus citations

Increasing adherence to therapy for recurrent hepatitis C after liver transplantation by starting at lower drug doses and adding growth factors

Rahim, N., Prosser, C., Bowlus, C., Torok, N. J., Troppmann, C., Ramsamooj, R., O'Brien, M. & Rossaro, L., May 2007, In : Practical Gastroenterology. 31, 5, p. 24-33 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2006

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S. S., Jiang, X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A. & Torok, N. J., Mar 2006, In : Hepatology. 43, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

171 Scopus citations

Review

Seo, S., Torok, N. J. & Zern, M. A., Oct 2006, In : Gastroenterology and Hepatology. 2, 10

Research output: Contribution to journalArticle

2003

Apoptotic body engulfment by a human stellate cell line is profibrogenic

Canbay, A., Taimr, P., Torok, N. J., Higuchi, H., Friedman, S. & Gores, G. J., May 1 2003, In : Laboratory Investigation. 83, 5, p. 655-663 9 p.

Research output: Contribution to journalArticle

275 Scopus citations
2002

Nitric oxide inhibits apoptosis downstream of cytochrome c release by nitrosylating caspase 9

Torok, N. J., Higuchi, H., Bronk, S. & Gores, G. J., Mar 15 2002, In : Cancer Research. 62, 6, p. 1648-1653 6 p.

Research output: Contribution to journalArticle

130 Scopus citations
2001

Alterations in vesicle transport and cell polarity in rat hepatocytes subjected to mechanical or chemical cholestasis

Torok, N. J., Larusso, E. M. & McNiven, M. A., 2001, In : Gastroenterology. 121, 5, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cholangiocarcinoma

Torok, N. J. & Gores, G. J., 2001, In : Seminars in Gastrointestinal Disease. 12, 2, p. 125-132 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
1998

Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes

Yoon, Y., Torok, N. J., Krueger, E., Oswald, B. & McNiven, M. A., Apr 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 274, 4 37-4

Research output: Contribution to journalArticle

46 Scopus citations
1997

Vesicle movement in rat hepatocytes is reduced by ethanol exposure: Alterations in microtubule-based motor enzymes

Torok, N. J., Marks, D., Hsiao, K., Oswald, B. J. & McNiven, M. A., 1997, In : Gastroenterology. 113, 6, p. 1938-1948 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
1996

Upregulation of molecular motor-encoding genes during hepatocyte growth factor-and epidermal growth factor-induced cell motility

Torok, N. J., Urrutia, R., Nakamura, T. & McNiven, M. A., Jun 1996, In : Journal of Cellular Physiology. 167, 3, p. 422-433 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
1991

Expression of transforming growth factor-beta 1 in human non-Hodgkin's lymphoma xenografts

Nagy, P., Torok, N. J., Ladånyi, A. & Kopper, L., Aug 21 1991, In : Journal of the National Cancer Institute. 83, 16, p. 1174-1175 2 p.

Research output: Contribution to journalArticle

3 Scopus citations