• 2187 Citations
  • 24 h-Index
1991 …2020
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Research Output 1991 2020

2020

Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population

Mikami, K., Endo, T., Sawada, N., Igarashi, G., Kimura, M., Hasegawa, T., Iino, C., Tomita, H., Sawada, K., Nakaji, S., Matsuzaka, M., Torok, N. J. & Fukuda, S., Feb 2020, In : Cytokine. 126, 154927.

Research output: Contribution to journalArticle

Vascular Stiffness
Adiponectin
Leptin
Liver
Stiffness
2019

Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation

Zhao, P., Han, S. N., Arumugam, S., Yousaf, M. N., Qin, Y., Jiang, J. X., Torok, N. J., Chen, Y., Mankash, M. S., Liu, J., Li, J., Iwakiri, Y. & Ouyang, X., Oct 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 4, p. G387-G397

Research output: Contribution to journalArticle

Digoxin
Fatty Liver
Transcriptional Activation
Liver
Hypoxia-Inducible Factor 1

Macrophage Nourishment in Nonalcoholic Steatohepatitis: A Novel Role for Ketone Bodies

Torok, N. J., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalComment/debate

Ketone Bodies
Macrophages
Non-alcoholic Fatty Liver Disease
2018
7 Citations (Scopus)

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

Ouyang, X., Han, S. N., Zhang, J. Y., Nemeth, B. T., Pacher, P., Feng, D., Bataller, R., Cabezas, J., Stärkel, P., Caballeria, J., Pongratz, R. L. P., Cai, S. Y., Schnabl, B., Hoque, R., Chen, Y., Yang, W. H., Martinez, I. G., Wang, F. S., Gao, B., Torok, N. J. & 2 others, Kibbey, R. G. & Mehal, W. Z., Feb 6 2018, In : Cell Metabolism. 27, 2, p. 339-350.e3

Research output: Contribution to journalArticle

Pyruvate Kinase
Digoxin
Fatty Liver
Transcriptional Activation
Inflammation
1 Citation (Scopus)

Erratum: Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis (Cell Metabolism (2018) 27(2) (339–350.e3)(S1550413118300561)(10.1016/j.cmet.2018.01.007))

Ouyang, X., Han, S. N., Zhang, J. Y., Dioletis, E., Nemeth, B. T., Pacher, P., Feng, D., Bataller, R., Cabezas, J., Stärkel, P., Caballeria, J., LePine Pongratz, R., Cai, S. Y., Schnabl, B., Hoque, R., Chen, Y., Yang, W. H., Garcia-Martinez, I., Wang, F. S., Gao, B. & 3 others, Torok, N. J., Kibbey, R. G. & Mehal, W. Z., May 1 2018, In : Cell Metabolism. 27, 5, 1 p.

Research output: Contribution to journalComment/debate

Pyruvate Kinase
Digoxin
Fatty Liver
Transcriptional Activation
Names
4 Citations (Scopus)

High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease

Tepper, C. G., Dang, J. H. T., Stewart, S. L., Fang, D. M., Wong, K. A., Liu, S. Y., Davis, R. R., Dao, D. Y., Gregg, J., Torok, N. J. & Chen, M. S., Apr 1 2018, In : Cancer. 124, p. 1583-1589 7 p.

Research output: Contribution to journalArticle

Phospholipases
Single Nucleotide Polymorphism
Liver Diseases
Chronic Disease
Hepatocellular Carcinoma
16 Citations (Scopus)

Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis

Zhou, Z., Xu, M. J., Cai, Y., Wang, W., Jiang, X., Varga, Z. V., Feng, D., Pacher, P., Kunos, G., Torok, N. J. & Gao, B., Mar 1 2018, In : CMGH. 5, 3, p. 399-413 15 p.

Research output: Contribution to journalArticle

High Fat Diet
Fatty Liver
Cell Communication
Liver Cirrhosis
Hepatic Stellate Cells
2 Citations (Scopus)

P300, A New Player in Mechanosensitivity and Activation of Cancer-Associated Fibroblasts

Torok, N. J., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2025-2026 2 p.

Research output: Contribution to journalEditorial

Cancer-Associated Fibroblasts
5 Citations (Scopus)

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease

Matsumoto, M., Zhang, J., Zhang, X., Liu, J., Jiang, X., Yamaguchi, K., Taruno, A., Katsuyama, M., Iwata, K., Ibi, M., Cui, W., Matsuno, K., Marunaka, Y., Itoh, Y., Torok, N. J. & Yabe-Nishimura, C., Feb 1 2018, In : Free Radical Biology and Medicine. 115, p. 412-420 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Liver
Liver Diseases
Protein Isoforms
Endothelial cells
2017
3 Citations (Scopus)

NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

Sasaki, Y., Dehnad, A., Fish, S., Sato, A., Jiang, X., Tian, J., Schröder, K., Brandes, R. & Torok, N. J., Apr 6 2017, In : Scientific Reports. 7, 46144.

Research output: Contribution to journalArticle

CC Chemokines
Alcoholic Liver Diseases
Chemokine CCL2
Chemokine Receptors
NADPH Oxidase
1 Citation (Scopus)

TRIF as a Novel Modulator of Liver Inflammation and Fibrosis

Torok, N. J., May 1 2017, In : CMGH. 3, 3, p. 299-300 2 p.

Research output: Contribution to journalEditorial

Liver Cirrhosis
Inflammation
2016
6 Citations (Scopus)

Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury

Haque, A., Gheibi, P., Stybayeva, G., Gao, Y., Torok, N. J. & Revzin, A., Oct 31 2016, In : Scientific Reports. 6, 36077.

Research output: Contribution to journalArticle

Microfluidics
Coculture Techniques
Stem Cells
Hepatocytes
Liver
22 Citations (Scopus)

Dysregulation of redox pathways in liver fibrosis

Torok, N. J., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 4, p. G667-G674

Research output: Contribution to journalReview article

Liver Cirrhosis
Oxidation-Reduction
Fibrosis
Antioxidants
Liver
1 Citation (Scopus)

Extracellular vesicles and ceramide: New mediators for macrophage chemotaxis?

Torok, N. J., Feb 1 2016, In : Journal of Lipid Research. 57, 2, p. 157-158 2 p.

Research output: Contribution to journalComment/debate

Macrophages
Ceramides
9 Citations (Scopus)

Galectin-3 regulates inflammasome activation in cholestatic liver injury

Tian, J., Yang, G., Chen, H. Y., Hsu, D. K., Tomilov, A., Olson, K. A., Dehnad, A., Fish, S. R., Cortopassi, G. A., Zhao, B., Liu, F-T., Gershwin, M. E., Torok, N. J. & Jiang, X., Dec 1 2016, In : FASEB Journal. 30, 12, p. 4202-4213 12 p.

Research output: Contribution to journalArticle

Inflammasomes
Galectin 3
Liver
Cholangitis
Chemical activation

Metabolic Syndrome Post-Liver Transplant: Can We Predict?

Marsano, J. G. & Torok, N. J., Aug 1 2016, In : Metabolic Syndrome and Related Disorders. 14, 6, p. 289-290 2 p.

Research output: Contribution to journalEditorial

Transplants
Liver
2015
18 Citations (Scopus)

Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation

Serizawa, N., Tian, J., Fukada, H., Baghy, K., Scott, F., Chen, X., Kiss, Z., Olson, K. A., Hsu, D., Liu, F-T., Torok, N. J., Zhao, B. & Jiang, X., Oct 1 2015, In : Laboratory Investigation. 95, 10, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Galectin 3
Hepatocellular Carcinoma
Cell Movement
Lectins
Small Interfering RNA
52 Citations (Scopus)

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, X., Sasaki, Y., Chao, T. I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., Szyndralewiez, C., Schröder, K., Shah, A., Brandes, R. P., Haj, F. & Torok, N. J., Aug 1 2015, In : Gastroenterology. 149, 2, p. 468-480.e10

Research output: Contribution to journalArticle

Fatty Liver
NADP
Insulin Resistance
Hepatocytes
Oxidoreductases
9 Citations (Scopus)

Role of intestinal myofibroblasts in HIV-associated intestinal collagen deposition and immune reconstitution following combination antiretroviral therapy

Asmuth, D., Pinchuk, I. V., Wu, J., Vargas, G., Chen, X., Mann, S. K., Albanese, A., Ma, Z. M., Saroufeem, R., Melcher, G. P., Troia-Cancio, P., Torok, N. J., Miller, C. J. & Powell, D. W., May 15 2015, In : AIDS (London, England). 29, 8, p. 877-888 12 p.

Research output: Contribution to journalArticle

Myofibroblasts
Collagen
HIV
Thromboplastin
Intercellular Signaling Peptides and Proteins
36 Citations (Scopus)

Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014

Torok, N. J., Dranoff, J. A., Schuppan, D. & Friedman, S. L., Aug 1 2015, In : Hepatology. 62, 2, p. 627-634 8 p.

Research output: Contribution to journalArticle

Clinical Trials
Liver Cirrhosis
Pharmaceutical Preparations
Drug Design
Drug Discovery
16 Citations (Scopus)

Update on alcoholic hepatitis

Torok, N. J., Nov 2 2015, In : Biomolecules. 5, 4, p. 2978-2986 9 p.

Research output: Contribution to journalReview article

Alcoholic Hepatitis
Liver
Dysbiosis
Hepatic Stellate Cells
Alcoholic Liver Diseases
1 Citation (Scopus)

Vascular adhesion protein 1 in nonalcoholic steatohepatitis: A novel biomarker?

Torok, N. J., Oct 1 2015, In : Hepatology. 62, 4, p. 1313-1315 3 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Cell Adhesion Molecules
Blood Vessels
Biomarkers
Proteins
2014
2 Citations (Scopus)

MLK3 as a regulator of disease progression in non-alcoholic steatohepatitis

Jiang, X. & Torok, N. J., 2014, In : Liver International. 34, 8, p. 1131-1132 2 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 8
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Fatty Liver
Disease Progression
2013
26 Citations (Scopus)

Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice

Jiang, X., Chen, X., Fukada, H., Serizawa, N., Devaraj, S. & Torok, N. J., Oct 2013, In : Hepatology. 58, 4, p. 1339-1348 10 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Sirtuin 1
Choline
Amino Acids
Adenoviridae
20 Citations (Scopus)

Liver Injury and the Activation of the Hepatic Myofibroblasts

Jiang, X. & Torok, N. J., Sep 1 2013, In : Current Pathobiology Reports. 1, 3, p. 215-223 9 p.

Research output: Contribution to journalReview article

Open Access
Myofibroblasts
Hepatic Stellate Cells
Liver
Wounds and Injuries
Extracellular Matrix
41 Citations (Scopus)

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

Medici, V., Shibata, N. M., Kharbanda, K. K., LaSalle, J. M., Woods, R., Liu, S., Engelberg, J. A., Devaraj, S., Torok, N. J., Jiang, X., Havel, P. J., Lönnerdal, B., Kim, K. & Halsted, C. H., Feb 2013, In : Hepatology. 57, 2, p. 555-565 11 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
DNA Methylation
Methionine
S-Adenosylhomocysteine
Liver Diseases
2012
36 Citations (Scopus)

Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo

Jiang, X., Chen, X., Hsu, D. K., Baghy, K., Serizawa, N., Scott, F., Takada, Y., Takada, Y., Fukada, H., Chen, J., Devaraj, S., Adamson, R., Liu, F-T. & Torok, N. J., Feb 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 4, p. 439-446 8 p.

Research output: Contribution to journalArticle

Galectin 3
Phagocytosis
Liver Cirrhosis
Hepatic Stellate Cells
Cytophagocytosis
16 Citations (Scopus)

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Jung, C. J., Iyengar, S., Blahnik, K. R., Jiang, X., Tahimic, C., Torok, N. J., deVere White, R. W., Farnham, P. J. & Zern, M. A., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 979-991 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
MicroRNAs
Hepatocytes
Neoplasms
Embryonic Stem Cells
136 Citations (Scopus)

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S. & Torok, N. J., Jul 15 2012, In : Free Radical Biology and Medicine. 53, 2, p. 289-296 8 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Liver Cirrhosis
Liver
Hepatocytes
Reactive Oxygen Species
2 Citations (Scopus)

The role of Galectin-3 in stellate cell activation and liver fibrosis

Jiang, X., Chen, X., Fukada, H., Hsu, D. K., Liu, F-T. & Torok, N. J., Dec 18 2012, ACS Symposium Series. American Chemical Society, Vol. 1115. p. 391-395 5 p. (ACS Symposium Series; vol. 1115).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Galectin 3
Liver
Chemical activation
Integrins
Kupffer Cells
2011
4 Citations (Scopus)

Leptin: The missing link between obesity and heart disease?

Devaraj, S. & Torok, N. J., Aug 2011, In : Atherosclerosis. 217, 2, p. 322-323 2 p.

Research output: Contribution to journalArticle

Caveolin 1
Leptin
Coronary Artery Disease
Heart Diseases
Atherosclerosis
86 Citations (Scopus)
Microbiota
Ribosomal DNA
HIV
T-Lymphocytes
16S Ribosomal RNA
74 Citations (Scopus)

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

Cui, W., Matsuno, K., Iwata, K., Ibi, M., Matsumoto, M., Zhang, J., Zhu, K., Katsuyama, M., Torok, N. J. & Yabe-Nishimura, C., Sep 2 2011, In : Hepatology. 54, 3, p. 949-958 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Bile Ducts
NADP
Liver Cirrhosis
Ligation
2010
6 Citations (Scopus)

Genomic variants associated with primary biliary cirrhosis

Selmi, C., Torok, N. J., Affronti, A. & Gershwin, M. E., Jan 26 2010, In : Genome Medicine. 2, 1, 5.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Keto Acids
Genome-Wide Association Study
Genetic Polymorphisms
Genetic Predisposition to Disease
21 Citations (Scopus)

Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease

Medici, V., Ali, M. R., Seo, S., Aoki, C. A., Rossaro, L., Kim, K., Fuller, W. D., Vidovszky, T. J., Smith, W., Jiang, X., Maganti, K., Havel, P. J., Kamboj, A., Ramsamooj, R. & Torok, N. J., Dec 2010, In : Obesity. 18, 12, p. 2268-2273 6 p.

Research output: Contribution to journalArticle

Leptin Receptors
Leptin
Insulin Resistance
Fasting
Fibrosis
155 Citations (Scopus)
Hepatic Stellate Cells
MicroRNAs
Liver Cirrhosis
Down-Regulation
Extracellular Matrix
79 Citations (Scopus)

Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in Vivo

Jiang, X., Venugopal, S., Serizawa, N., Chen, X., Scott, F., Li, Y., Adamson, R., Devaraj, S., Shah, V., Gershwin, M. E., Friedman, S. L. & Torok, N. J., Oct 2010, In : Gastroenterology. 139, 4

Research output: Contribution to journalArticle

Hepatic Stellate Cells
NADP
Oxidoreductases
Phagocytosis
Liver
2009
52 Citations (Scopus)

Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition

Sohail, M. A., Hashmi, A. Z., Hakim, W., Watanabe, A., Zipprich, A., Groszmann, R. J., Dranoff, J. A., Torok, N. J. & Mehal, W. Z., 2009, In : Hepatology. 49, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Stress Fibers
Adenosine
Actins
Purinergic P1 Receptors
83 Citations (Scopus)

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

Jiang, X., Mikami, K., Venugopal, S., Li, Y. & Torok, N. J., Jul 2009, In : Journal of Hepatology. 51, 1, p. 139-148 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Phagocytosis
Apoptosis
Phosphatidylinositol 3-Kinases
Cell Survival
73 Citations (Scopus)

Minocycline in the treatment of patients with primary sclerosing cholangitis: Results of a pilot study

Silveira, M. G., Torok, N. J., Gossard, A. A., Keach, J. C., Jorgensenrn, R. A., Petzrn, J. L. & Lindor, K. D., Jan 2009, In : American Journal of Gastroenterology. 104, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Minocycline
Therapeutics
Anti-Inflammatory Agents
Enzyme Activation
2008
98 Citations (Scopus)

Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: Evidence for an adipose tissue-vascular loop

Devaraj, S., Torok, N. J., Dasu, M. R., Samols, D. & Jialal, I., Jul 1 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 7, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

Adiponectin
C-Reactive Protein
Blood Vessels
Adipose Tissue
Endothelial Cells
49 Citations (Scopus)

Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a rho guanosine triphosphatase-dependent mechanism

Jiang, X., Mikami, K., Shah, V. H. & Torok, N. J., Nov 2008, In : Hepatology. 48, 5, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Guanosine
Leptin
Phagocytosis
Fatty Liver
37 Citations (Scopus)

Nonalcoholic steatohepatitis and the metabolic syndrome

Jiang, X. & Torok, N. J., Mar 1 2008, In : Metabolic Syndrome and Related Disorders. 6, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Fibrosis
Obesity
End Stage Liver Disease
Lipid Peroxidation
Insulin Resistance
51 Citations (Scopus)

Recent advances in the pathogenesis and diagnosis of liver fibrosis

Torok, N. J., May 2008, In : Journal of Gastroenterology. 43, 5, p. 315-321 7 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Extracellular Matrix Proteins
Aspartate Aminotransferases
Alanine Transaminase
Liver Cirrhosis
2007
10 Citations (Scopus)

Apoptotic cell death takes its toll

Torok, N. J., Nov 2007, In : Hepatology. 46, 5, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Calcium Signaling
Oligodeoxyribonucleotides
Liver Cirrhosis
Cell Death

Cryoglobulins and cryoglobulins secondary to hepatitis C virus infection

Seo, S. & Torok, N. J., 2007, Autoantibodies. Elsevier Inc., p. 437-442 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cryoglobulins
Cryoglobulinemia
Virus Diseases
Viruses
Hepacivirus
113 Citations (Scopus)

De novo nonalcoholic fatty liver disease after liver transplantation

Seo, S., Maganti, K., Khehra, M., Ramsamooj, R., Tsodikov, A., Bowlus, C., McVicar, J., Zern, M. A. & Torok, N. J., Jun 2007, In : Liver Transplantation. 13, 6, p. 844-847 4 p.

Research output: Contribution to journalArticle

Liver Transplantation
Liver
Transplants
Biopsy
Non-alcoholic Fatty Liver Disease
2 Citations (Scopus)

Increasing adherence to therapy for recurrent hepatitis C after liver transplantation by starting at lower drug doses and adding growth factors

Rahim, N., Prosser, C., Bowlus, C., Torok, N. J., Troppmann, C., Ramsamooj, R., O'Brien, M. & Rossaro, L., May 2007, In : Practical Gastroenterology. 31, 5, p. 24-33 10 p.

Research output: Contribution to journalArticle

Hepatitis C
Liver Transplantation
Intercellular Signaling Peptides and Proteins
Interferons
Pharmaceutical Preparations
2006
162 Citations (Scopus)

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S. S., Jiang, X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A. & Torok, N. J., Mar 2006, In : Hepatology. 43, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
NADPH Oxidase
Phagocytosis
Liver Cirrhosis
Procollagen

Review

Seo, S., Torok, N. J. & Zern, M. A., Oct 2006, In : Gastroenterology and Hepatology. 2, 10

Research output: Contribution to journalArticle