Michael A Rogawski, MD; PhD

Professor

  • 15917 Citations
  • 71 h-Index
1973 …2019
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Research Output 1973 2019

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Article
2018
Pregnanolone
Metabolomics
gamma-Aminobutyric Acid
Neurodegenerative Diseases
Mitochondria
3 Citations (Scopus)

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Chen, C-Y., Di Lucente, J., Lin, Y. C., Lien, C. C., Rogawski, M. A., Maezawa, I. & Jin, L-W., Jan 1 2018, In : Neurobiology of Disease. 109, p. 25-32 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Solitary Nucleus
Synaptic Transmission
GABA-A Receptor Agonists
Inhibitory Postsynaptic Potentials

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats

Dhir, A. & Rogawski, M. A., May 1 2018, In : Epilepsia. 59, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

Diazepam
Seizures
Jugular Veins
Intravenous Infusions
Half-Life
4 Citations (Scopus)

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus

Zolkowska, D., Wu, C. Y. & Rogawski, M. A., Jan 1 2018, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

Pregnanolone
Status Epilepticus
tetramethylenedisulfotetramine
Intramuscular Injections
Steroids
2017
5 Citations (Scopus)

Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy

Lévesque, M., Herrington, R., Leclerc, L., Rogawski, M. A. & Avoli, M., Jul 15 2017, In : Neuropharmacology. 121, p. 12-19 8 p.

Research output: Contribution to journalArticle

Pregnanolone
Temporal Lobe Epilepsy
Animal Models
Pilocarpine
Status Epilepticus
12 Citations (Scopus)

Data Descriptor: Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Dingledine, R., Coulter, D. A., Fritsch, B., Gorter, J. A., Lelutiu, N., McNamara, J., Nadler, J. V., Pitkänen, A., Rogawski, M. A., Skene, P., Sloviter, R. S., Wang, Y., Wadman, W. J., Wasterlain, C. & Roopra, A., May 9 2017, In : Scientific data. 4, 170061.

Research output: Contribution to journalArticle

Epilepsy
epilepsy
Descriptors
Rats
Cell
2 Citations (Scopus)

Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model

Ciarlone, S. L., Wang, X., Rogawski, M. A. & Weeber, E. J., Apr 1 2017, In : Neuropharmacology. 116, p. 142-150 9 p.

Research output: Contribution to journalArticle

Angelman Syndrome
Neurotransmitter Agents
Seizures
GABA-A Receptors
Neuronal Plasticity
8 Citations (Scopus)

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome

Wang, J. Y., Trivedi, A. M., Carrillo, N. R., Yang, J., Schneider, A., Giulivi, C. R., Adams, P., Tassone, F., Kim, K., Rivera, S. M., Lubarr, N., Wu, C. Y., Irwin, R. W., Brinton, R. D., Olichney, J. M., Rogawski, M. A. & Hagerman, R. J., Jul 13 2017, (Accepted/In press) In : Neurotherapeutics. p. 1-11 11 p.

Research output: Contribution to journalArticle

Pregnanolone
Magnetic Resonance Imaging
Therapeutics
Hippocampus
Corpus Callosum
5 Citations (Scopus)

Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye

Nik, A. M., Pressly, B., Singh, V., Antrobus, S., Hulsizer, S., Rogawski, M. A., Wulff, H. & Pessah, I. N., Jul 1 2017, In : Molecular Pharmacology. 92, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Membrane Potentials
Coloring Agents
Null Lymphocytes
gamma-Aminobutyric Acid
2016
2 Citations (Scopus)

2014 epilepsy Benchmarks Area III: Improve treatment options for controlling seizures and epilepsy-related conditions without side effects

Epilepsy Benchmark Stewards, 2016, In : Epilepsy Currents. 16, 3, p. 192-197 6 p.

Research output: Contribution to journalArticle

Benchmarking
Epilepsy
Seizures
15 Citations (Scopus)

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Kazdoba, T. M., Hagerman, R. J., Zolkowska, D., Rogawski, M. A. & Crawley, J., Jan 1 2016, In : Psychopharmacology. 233, 2, p. 309-323 15 p.

Research output: Contribution to journalArticle

Autistic Disorder
Steroids
GABA-A Receptors
Grooming
Synaptic Transmission
37 Citations (Scopus)

Mechanisms of action of Antiseizure Drugs and the Ketogenic diet

Rogawski, M. A., Löscher, W. & Rho, J. M., May 1 2016, In : Cold Spring Harbor perspectives in medicine. 6, 5, p. 28 1 p., a022780.

Research output: Contribution to journalArticle

Ketogenic Diet
Nutrition
GABA Plasma Membrane Transport Proteins
Seizures
Ion Channels
10 Citations (Scopus)
tetramethylenedisulfotetramine
fluorophosphate
Seizures
GABA Receptors
Cholinesterase Inhibitors
2015
15 Citations (Scopus)

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for alzheimer's disease

Irwin, R. W., Solinsky, C. M., Loya, C. M., Salituro, F. G., Rodgers, K. E., Bauer, G., Rogawski, M. A. & Brinton, R. D., Jun 3 2015, In : PLoS One. 10, 6, e0128313.

Research output: Contribution to journalArticle

Pharmacodynamics
Pregnanolone
Pharmacokinetics
pharmacology
Alzheimer disease
9 Citations (Scopus)

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

Bruun, D. A., Cao, Z., Inceoglu, B., Vito, S. T., Austin, A. T., Hulsizer, S., Hammock, B. D., Tancredi, D. J., Rogawski, M. A., Pessah, I. N. & Lein, P. J., Aug 1 2015, In : Neuropharmacology. 95, p. 332-342 11 p.

Research output: Contribution to journalArticle

tetramethylenedisulfotetramine
Pregnanolone
Diazepam
Seizures
Calcium
6 Citations (Scopus)

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects

Desai, R., Savechenkov, P. Y., Zolkowska, D., Ge, R. L., Rogawski, M. A., Bruzik, K. S., Forman, S. A., Raines, D. E. & Miller, K. W., Nov 15 2015, In : Journal of Physiology. 593, 22, p. 4943-4961 19 p.

Research output: Contribution to journalArticle

Convulsants
GABA-A Receptors
Anticonvulsants
Anesthetics
gamma-Aminobutyric Acid
60 Citations (Scopus)

Current understanding of the mechanism of action of the antiepileptic drug lacosamide

Rogawski, M. A., Tofighy, A., White, H. S., Matagne, A. & Wolff, C., Feb 1 2015, In : Epilepsy Research. 110, p. 189-205 17 p.

Research output: Contribution to journalArticle

Anticonvulsants
Seizures
Sodium Channels
Electroshock
Status Epilepticus
23 Citations (Scopus)

Is a separate monotherapy indication warranted for antiepileptic drugs?

Mintzer, S., French, J. A., Perucca, E., Cramer, J. A., Messenheimer, J. A., Blum, D. E., Rogawski, M. A. & Baulac, M., Dec 1 2015, In : The Lancet Neurology. 14, 12, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Anticonvulsants
Epilepsy
Drug Labeling
Clinical Ethics
Drug Approval
18 Citations (Scopus)

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed K<inf>Ca</inf>2 Activator and Na<inf>V</inf> Blocker, is a Potent Novel Anticonvulsant

Coleman, N., Nguyen, H. M., Cao, Z., Brown, B. M., Jenkins, D. P., Zolkowska, D., Chen, Y-J., Tanaka, B. S., Goldin, A. L., Rogawski, M. A., Pessah, I. N. & Wulff, H., Jan 1 2015, In : Neurotherapeutics. 12, 1, p. 234-249 16 p.

Research output: Contribution to journalArticle

Riluzole
Anticonvulsants
Seizures
Voltage-Gated Sodium Channel Blockers
Calcium-Activated Potassium Channels
2014
4 Citations (Scopus)

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

Zolkowska, D., Dhir, A., Krishnan, K., Covey, D. F. & Rogawski, M. A., 2014, In : Psychopharmacology. 231, 17, p. 3325-3332 8 p.

Research output: Contribution to journalArticle

Etiocholanolone
Androsterone
Anticonvulsants
Neurotransmitter Agents
Pentylenetetrazole
46 Citations (Scopus)

Pediatric super-refractory status epilepticus treated with allopregnanolone

Broomall, E., Natale, J. E., Grimason, M., Goldstein, J., Smith, C. M., Chang, C. H., Kanes, S., Rogawski, M. A. & Wainwright, M. S., Dec 1 2014, In : Annals of Neurology. 76, 6, p. 911-915 5 p.

Research output: Contribution to journalArticle

Pregnanolone
Status Epilepticus
Pediatrics
GABA-A Receptors
Benzodiazepines
15 Citations (Scopus)

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons

Chen, C-Y., Matt, L., Hell, J. W. & Rogawski, M. A., Sep 17 2014, In : PLoS One. 9, 9, A1249.

Research output: Contribution to journalArticle

AMPA Receptors
Neurons
neurons
receptors
Kainic Acid
13 Citations (Scopus)

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

Vito, S. T., Austin, A. T., Banks, C. N., Inceoglu, B., Bruun, D. A., Zolkowska, D., Tancredi, D. J., Rogawski, M. A., Hammock, B. D. & Lein, P. J., Dec 1 2014, In : Toxicology and Applied Pharmacology. 281, 2, p. 185-194 10 p.

Research output: Contribution to journalArticle

tetramethylenedisulfotetramine
Epoxide Hydrolases
Diazepam
Seizures
Convulsants
13 Citations (Scopus)

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis

Fritsch, B., Reis, J., Gasior, M., Kaminski, R. M. & Rogawski, M. A., 2014, In : Journal of Neuroscience. 34, 17, p. 5765-5775 11 p.

Research output: Contribution to journalArticle

Epilepsy
Seizures
Hippocampus
Gluk1 kainate receptor
Pentylenetetrazole
46 Citations (Scopus)

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

Kaminski, R. M., Rogawski, M. A. & Klitgaard, H., 2014, In : Neurotherapeutics. 11, 2, p. 385-400 16 p.

Research output: Contribution to journalArticle

rimonabant
Sirolimus
Pharmaceutical Preparations
Epilepsy
Seizures
2013
94 Citations (Scopus)

AMPA receptors as a molecular target in epilepsy therapy

Rogawski, M. A., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 9-18 10 p.

Research output: Contribution to journalArticle

AMPA Receptors
Epilepsy
N-Methyl-D-Aspartate Receptors
Neuronal Plasticity
Seizures
33 Citations (Scopus)

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Galanopoulou, A. S., Kokaia, M., Loeb, J. A., Nehlig, A., Pitkänen, A., Rogawski, M. A., Staley, K. J., Whittemore, V. H. & Dudek, F. E., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 13-23 11 p.

Research output: Contribution to journalArticle

Epilepsy
Animal Models
Seizures
Comorbidity
Therapeutics
31 Citations (Scopus)

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

Inceoglu, B., Zolkowska, D., Yoo, H. J., Wagner, K. M., Yang, J., Hackett, E., Hwang, S. H., Lee, K. S. S., Rogawski, M. A., Morisseau, C. & Hammock, B. D., Dec 11 2013, In : PLoS One. 8, 12, e80922.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
gamma-aminobutyric acid
seizures
epoxides
286 Citations (Scopus)

Glia and epilepsy: Excitability and inflammation

Devinsky, O., Vezzani, A., Najjar, S., De Lanerolle, N. C. & Rogawski, M. A., Mar 2013, In : Trends in Neurosciences. 36, 3, p. 174-184 11 p.

Research output: Contribution to journalArticle

Neuroglia
Epilepsy
Inflammation
Seizures
Microglia
42 Citations (Scopus)

Issues related to development of new antiseizure treatments

Wilcox, K. S., Dixon-Salazar, T., Sills, G. J., Ben-Menachem, E., White, H. S., Porter, R. J., Dichter, M. A., Moshé, S. L., Noebels, J. L., Privitera, M. D. & Rogawski, M. A., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 24-34 11 p.

Research output: Contribution to journalArticle

Epilepsy
Seizures
National Institute of Neurological Disorders and Stroke
Group Processes
Drug Industry
8 Citations (Scopus)
Convection
Type A Botulinum Toxins
Neurotoxins
Amygdala
Synaptic Transmission
59 Citations (Scopus)

Neuroactive steroids for the treatment of status epilepticus

Rogawski, M. A., Loya, C. M., Reddy, K., Zolkowska, D. & Lossin, C., 2013, In : Epilepsia. 54, SUPPL. 6, p. 93-98 6 p.

Research output: Contribution to journalArticle

Status Epilepticus
Pregnanolone
GABA-A Receptors
Steroids
Benzodiazepines
98 Citations (Scopus)

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

Rogawski, M. A. & Hanada, T., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 19-24 6 p.

Research output: Contribution to journalArticle

AMPA Receptors
Pharmacology
Biological Availability
Allosteric Site
Cytochrome P-450 CYP3A
9 Citations (Scopus)

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat

Bröer, S., Zolkowska, D., Gernert, M. & Rogawski, M. A., Nov 12 2013, In : Neuroscience. 252, p. 253-261 9 p.

Research output: Contribution to journalArticle

Seizures
Neurotoxins
Pentylenetetrazole
Synapses
rimabotulinumtoxinB
4 Citations (Scopus)

Seizure protection by intrapulmonary delivery of midazolam in mice

Dhir, A., Zolkowska, D. & Rogawski, M. A., 2013, In : Neuropharmacology. 73, p. 425-431 7 p.

Research output: Contribution to journalArticle

Midazolam
Seizures
Pentylenetetrazole
Righting Reflex
Anticonvulsants
34 Citations (Scopus)

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.

Rogawski, M. A., May 2013, In : Epilepsia. 54 Suppl 2, p. 33-40 8 p.

Research output: Contribution to journalArticle

Anticonvulsants
Epilepsy
Seizures
Ion Channels
Pharmaceutical Preparations
2012
244 Citations (Scopus)

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

French, J. A., Krauss, G. L., Biton, V., Squillacote, D., Yang, H., Laurenza, A., Kumar, D. & Rogawski, M. A., Aug 7 2012, In : Neurology. 79, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

Seizures
Placebos
Anticonvulsants
Maintenance
Isoxazoles
14 Citations (Scopus)

Altered fast and slow inactivation of the N440K Nav1.4 mutant in a periodic paralysis syndrome

Lossin, C., Nam, T. S., Shahangian, S., Rogawski, M. A., Choi, S. Y., Kim, M. K. & Sunwoo, I. N., Sep 4 2012, In : Neurology. 79, 10, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

Paralysis
Hyperkalemic Periodic Paralysis
Myotonic Disorders
Mutation
Skeletal Muscle
26 Citations (Scopus)

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

Zolkowska, D., Banks, C. N., Dhir, A., Inceoglu, B., Sanborn, J. R., McCoy, M. R., Bruun, D. A., Hammock, B. D., Lein, P. J. & Rogawski, M. A., May 1 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 2, p. 435-446 12 p.

Research output: Contribution to journalArticle

tetramethylenedisulfotetramine
Seizures
Convulsants
Antidotes
Pentylenetetrazole
52 Citations (Scopus)

Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with allopregnanolone

Cao, Z., Hulsizer, S., Tassone, F., Tang, H. T., Hagerman, R. J., Rogawski, M. A., Hagerman, P. J. & Pessah, I. N., Jul 2012, In : Human Molecular Genetics. 21, 13, p. 2923-2935 13 p., dds118.

Research output: Contribution to journalArticle

Pregnanolone
Intellectual Disability
Neurons
Glutamic Acid
Astrocytes
16 Citations (Scopus)

Compromised function in the Nav1.2 Dravet syndrome mutation R1312T

Lossin, C., Shi, X., Rogawski, M. A. & Hirose, S., Sep 2012, In : Neurobiology of Disease. 47, 3, p. 378-384 7 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Epilepsy
Mutation
Voltage-Gated Sodium Channels
Sodium Channels
66 Citations (Scopus)

How theories evolved concerning the mechanism of action of barbiturates.

Löscher, W. & Rogawski, M. A., Dec 2012, In : Epilepsia. 53 Suppl 8, p. 12-25 14 p.

Research output: Contribution to journalArticle

Barbiturates
GABA-A Receptors
Phenobarbital
Pentobarbital
Calcium Channels
29 Citations (Scopus)

Mechanisms of action of antiseizure drugs

Porter, R. J., Dhir, A., Macdonald, R. L. & Rogawski, M. A., 2012, In : Handbook of Clinical Neurology. 108, p. 664-681 18 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Seizures
Ionotropic Glutamate Receptors
Sodium Channels
Potassium Channels

Mechanisms of action of antiseizure drugs.

Porter, R. J., Dhir, A., Macdonald, R. L. & Rogawski, M. A., 2012, In : Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn. 108, p. 663-681 19 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Biological Models
Anticonvulsants
Seizures
18 Citations (Scopus)

Propofol hemisuccinate suppresses cortical spreading depression

Dhir, A., Lossin, C. & Rogawski, M. A., Apr 11 2012, In : Neuroscience Letters. 514, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

Cortical Spreading Depression
Propofol
Migraine Disorders
Dizocilpine Maleate
Prodrugs
17 Citations (Scopus)

Role of neurosteroids in the anticonvulsant activity of midazolam

Dhir, A. & Rogawski, M. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2684-2691 8 p.

Research output: Contribution to journalArticle

Midazolam
Anticonvulsants
Neurotransmitter Agents
Benzodiazepines
Finasteride
26 Citations (Scopus)
tetramethylenedisulfotetramine
GABA-A Receptors
Neurons
Modulation
Pregnanolone
2011
15 Citations (Scopus)

11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis

Kaminski, R. M. & Rogawski, M. A., Jul 2011, In : Neuropharmacology. 61, 1-2, p. 133-137 5 p.

Research output: Contribution to journalArticle

Steroid 11-beta-Hydroxylase
Mixed Function Oxygenases
Neurotransmitter Agents
Seizures
Finasteride

A new policy for disclosure of competing interests

Rogawski, M. A., Jan 2011, In : Epilepsy Currents. 11, 1, p. 7-8 2 p.

Research output: Contribution to journalArticle

Disclosure
7 Citations (Scopus)

Disclosure of clinical trial results when product development is abandoned

Rogawski, M. A. & Federo, H. J., Sep 28 2011, In : Science Translational Medicine. 3, 102, 102cm29.

Research output: Contribution to journalArticle

Disclosure
Clinical Trials
United States Dept. of Health and Human Services
Equipment and Supplies
Translational Medical Research