Michael A Rogawski, MD; PhD

Professor

  • 17161 Citations
  • 72 h-Index
1973 …2020

Research output per year

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Research Output

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Article
2020

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity

González, E. A., Rindy, A. C., Guignet, M. A., Calsbeek, J. J., Bruun, D. A., Dhir, A., Andrew, P., Saito, N., Rowland, D. J., Harvey, D. J., Rogawski, M. A. & Lein, P. J., Jan 1 2020, (Accepted/In press) In : Archives of Toxicology.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

Senatorov, V. V., Friedman, A. R., Milikovsky, D. Z., Ofer, J., Saar-Ashkenazy, R., Charbash, A., Jahan, N., Chin, G., Mihaly, E., Lin, J. M., Ramsay, H. J., Moghbel, A., Preininger, M. K., Eddings, C. R., Harrison, H. V., Patel, R., Shen, Y., Ghanim, H., Sheng, H., Veksler, R. & 7 others, Sudmant, P. H., Becker, A., Hart, B., Rogawski, M. A., Dillin, A., Friedman, A. & Kaufer, D., Dec 4 2019, In : Science Translational Medicine. 11, 521, eaaw8283.

Research output: Contribution to journalArticle

15 Scopus citations
2018
3 Scopus citations

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Chen, C-Y., Di Lucente, J., Lin, Y. C., Lien, C. C., Rogawski, M. A., Maezawa, I. & Jin, L-W., Jan 1 2018, In : Neurobiology of Disease. 109, p. 25-32 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats

Dhir, A. & Rogawski, M. A., May 1 2018, In : Epilepsia. 59, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus

Zolkowska, D., Wu, C. Y. & Rogawski, M. A., Jan 1 2018, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

16 Scopus citations
2017

Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy

Lévesque, M., Herrington, R., Leclerc, L., Rogawski, M. A. & Avoli, M., Jul 15 2017, In : Neuropharmacology. 121, p. 12-19 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Data Descriptor: Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Dingledine, R., Coulter, D. A., Fritsch, B., Gorter, J. A., Lelutiu, N., McNamara, J., Nadler, J. V., Pitkänen, A., Rogawski, M. A., Skene, P., Sloviter, R. S., Wang, Y., Wadman, W. J., Wasterlain, C. & Roopra, A., May 9 2017, In : Scientific data. 4, 170061.

Research output: Contribution to journalArticle

22 Scopus citations

Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model

Ciarlone, S. L., Wang, X., Rogawski, M. A. & Weeber, E. J., Apr 1 2017, In : Neuropharmacology. 116, p. 142-150 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome

Wang, J. Y., Trivedi, A. M., Carrillo, N. R., Yang, J., Schneider, A., Giulivi, C. R., Adams, P., Tassone, F., Kim, K., Rivera, S. M., Lubarr, N., Wu, C. Y., Irwin, R. W., Brinton, R. D., Olichney, J. M., Rogawski, M. A. & Hagerman, R. J., Jul 13 2017, (Accepted/In press) In : Neurotherapeutics. p. 1-11 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye

Nik, A. M., Pressly, B., Singh, V., Antrobus, S., Hulsizer, S., Rogawski, M. A., Wulff, H. & Pessah, I. N., Jul 1 2017, In : Molecular Pharmacology. 92, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

2014 epilepsy Benchmarks Area III: Improve treatment options for controlling seizures and epilepsy-related conditions without side effects

Epilepsy Benchmark Stewards, 2016, In : Epilepsy Currents. 16, 3, p. 192-197 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Kazdoba, T. M., Hagerman, R. J., Zolkowska, D., Rogawski, M. A. & Crawley, J., Jan 1 2016, In : Psychopharmacology. 233, 2, p. 309-323 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mechanisms of action of Antiseizure Drugs and the Ketogenic diet

Rogawski, M. A., Löscher, W. & Rho, J. M., May 1 2016, In : Cold Spring Harbor perspectives in medicine. 6, 5, p. 28 1 p., a022780.

Research output: Contribution to journalArticle

70 Scopus citations
15 Scopus citations
2015

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for alzheimer's disease

Irwin, R. W., Solinsky, C. M., Loya, C. M., Salituro, F. G., Rodgers, K. E., Bauer, G., Rogawski, M. A. & Brinton, R. D., Jun 3 2015, In : PLoS One. 10, 6, e0128313.

Research output: Contribution to journalArticle

22 Scopus citations

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

Bruun, D. A., Cao, Z., Inceoglu, B., Vito, S. T., Austin, A. T., Hulsizer, S., Hammock, B. D., Tancredi, D. J., Rogawski, M. A., Pessah, I. N. & Lein, P. J., Aug 1 2015, In : Neuropharmacology. 95, p. 332-342 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects

Desai, R., Savechenkov, P. Y., Zolkowska, D., Ge, R. L., Rogawski, M. A., Bruzik, K. S., Forman, S. A., Raines, D. E. & Miller, K. W., Nov 15 2015, In : Journal of Physiology. 593, 22, p. 4943-4961 19 p.

Research output: Contribution to journalArticle

8 Scopus citations

Current understanding of the mechanism of action of the antiepileptic drug lacosamide

Rogawski, M. A., Tofighy, A., White, H. S., Matagne, A. & Wolff, C., Feb 1 2015, In : Epilepsy Research. 110, p. 189-205 17 p.

Research output: Contribution to journalArticle

91 Scopus citations

Is a separate monotherapy indication warranted for antiepileptic drugs?

Mintzer, S., French, J. A., Perucca, E., Cramer, J. A., Messenheimer, J. A., Blum, D. E., Rogawski, M. A. & Baulac, M., Dec 1 2015, In : The Lancet Neurology. 14, 12, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed K<inf>Ca</inf>2 Activator and Na<inf>V</inf> Blocker, is a Potent Novel Anticonvulsant

Coleman, N., Nguyen, H. M., Cao, Z., Brown, B. M., Jenkins, D. P., Zolkowska, D., Chen, Y. J., Tanaka, B. S., Goldin, A. L., Rogawski, M. A., Pessah, I. N. & Wulff, H., Jan 1 2015, In : Neurotherapeutics. 12, 1, p. 234-249 16 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

Zolkowska, D., Dhir, A., Krishnan, K., Covey, D. F. & Rogawski, M. A., 2014, In : Psychopharmacology. 231, 17, p. 3325-3332 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pediatric super-refractory status epilepticus treated with allopregnanolone

Broomall, E., Natale, J. E., Grimason, M., Goldstein, J., Smith, C. M., Chang, C. H., Kanes, S., Rogawski, M. A. & Wainwright, M. S., Dec 1 2014, In : Annals of Neurology. 76, 6, p. 911-915 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons

Chen, C-Y., Matt, L., Hell, J. W. & Rogawski, M. A., Sep 17 2014, In : PLoS One. 9, 9, A1249.

Research output: Contribution to journalArticle

21 Scopus citations

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

Vito, S. T., Austin, A. T., Banks, C. N., Inceoglu, B., Bruun, D. A., Zolkowska, D., Tancredi, D. J., Rogawski, M. A., Hammock, B. D. & Lein, P. J., Dec 1 2014, In : Toxicology and Applied Pharmacology. 281, 2, p. 185-194 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis

Fritsch, B., Reis, J., Gasior, M., Kaminski, R. M. & Rogawski, M. A., 2014, In : Journal of Neuroscience. 34, 17, p. 5765-5775 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

Kaminski, R. M., Rogawski, M. A. & Klitgaard, H., 2014, In : Neurotherapeutics. 11, 2, p. 385-400 16 p.

Research output: Contribution to journalArticle

65 Scopus citations
2013

AMPA receptors as a molecular target in epilepsy therapy

Rogawski, M. A., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 9-18 10 p.

Research output: Contribution to journalArticle

114 Scopus citations

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Galanopoulou, A. S., Kokaia, M., Loeb, J. A., Nehlig, A., Pitkänen, A., Rogawski, M. A., Staley, K. J., Whittemore, V. H. & Dudek, F. E., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 13-23 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

Inceoglu, B., Zolkowska, D., Yoo, H. J., Wagner, K. M., Yang, J., Hackett, E., Hwang, S. H., Lee, K. S. S., Rogawski, M. A., Morisseau, C. & Hammock, B. D., Dec 11 2013, In : PLoS One. 8, 12, e80922.

Research output: Contribution to journalArticle

38 Scopus citations

Glia and epilepsy: Excitability and inflammation

Devinsky, O., Vezzani, A., Najjar, S., De Lanerolle, N. C. & Rogawski, M. A., Mar 2013, In : Trends in Neurosciences. 36, 3, p. 174-184 11 p.

Research output: Contribution to journalArticle

355 Scopus citations

Issues related to development of new antiseizure treatments

Wilcox, K. S., Dixon-Salazar, T., Sills, G. J., Ben-Menachem, E., White, H. S., Porter, R. J., Dichter, M. A., Moshé, S. L., Noebels, J. L., Privitera, M. D. & Rogawski, M. A., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 24-34 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
9 Scopus citations

Neuroactive steroids for the treatment of status epilepticus

Rogawski, M. A., Loya, C. M., Reddy, K., Zolkowska, D. & Lossin, C., 2013, In : Epilepsia. 54, SUPPL. 6, p. 93-98 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

Rogawski, M. A. & Hanada, T., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 19-24 6 p.

Research output: Contribution to journalArticle

122 Scopus citations

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat

Bröer, S., Zolkowska, D., Gernert, M. & Rogawski, M. A., Nov 12 2013, In : Neuroscience. 252, p. 253-261 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Seizure protection by intrapulmonary delivery of midazolam in mice

Dhir, A., Zolkowska, D. & Rogawski, M. A., 2013, In : Neuropharmacology. 73, p. 425-431 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.

Rogawski, M. A., May 2013, In : Epilepsia. 54 Suppl 2, p. 33-40 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

French, J. A., Krauss, G. L., Biton, V., Squillacote, D., Yang, H., Laurenza, A., Kumar, D. & Rogawski, M. A., Aug 7 2012, In : Neurology. 79, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

284 Scopus citations

Altered fast and slow inactivation of the N440K Nav1.4 mutant in a periodic paralysis syndrome

Lossin, C., Nam, T. S., Shahangian, S., Rogawski, M. A., Choi, S. Y., Kim, M. K. & Sunwoo, I. N., Sep 4 2012, In : Neurology. 79, 10, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

Zolkowska, D., Banks, C. N., Dhir, A., Inceoglu, B., Sanborn, J. R., McCoy, M. R., Bruun, D. A., Hammock, B. D., Lein, P. J. & Rogawski, M. A., May 1 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 2, p. 435-446 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with allopregnanolone

Cao, Z., Hulsizer, S., Tassone, F., Tang, H. T., Hagerman, R. J., Rogawski, M. A., Hagerman, P. J. & Pessah, I. N., Jul 2012, In : Human Molecular Genetics. 21, 13, p. 2923-2935 13 p., dds118.

Research output: Contribution to journalArticle

57 Scopus citations

Compromised function in the Nav1.2 Dravet syndrome mutation R1312T

Lossin, C., Shi, X., Rogawski, M. A. & Hirose, S., Sep 2012, In : Neurobiology of Disease. 47, 3, p. 378-384 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

How theories evolved concerning the mechanism of action of barbiturates.

Löscher, W. & Rogawski, M. A., Dec 2012, In : Epilepsia. 53 Suppl 8, p. 12-25 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

Mechanisms of action of antiseizure drugs

Porter, R. J., Dhir, A., Macdonald, R. L. & Rogawski, M. A., 2012, In : Handbook of Clinical Neurology. 108, p. 664-681 18 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mechanisms of action of antiseizure drugs.

Porter, R. J., Dhir, A., Macdonald, R. L. & Rogawski, M. A., 2012, In : Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn. 108, p. 663-681 19 p.

Research output: Contribution to journalArticle

Propofol hemisuccinate suppresses cortical spreading depression

Dhir, A., Lossin, C. & Rogawski, M. A., Apr 11 2012, In : Neuroscience Letters. 514, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of neurosteroids in the anticonvulsant activity of midazolam

Dhir, A. & Rogawski, M. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2684-2691 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
31 Scopus citations
2011

11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis

Kaminski, R. M. & Rogawski, M. A., Jul 2011, In : Neuropharmacology. 61, 1-2, p. 133-137 5 p.

Research output: Contribution to journalArticle

16 Scopus citations