Michael A Rogawski, MD; PhD

Professor

  • 16757 Citations
  • 72 h-Index
1973 …2020

Research output per year

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Research Output

2020

Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

for the National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) Epilepsy Research Benchmark Stewards, Jan 1 2020, In : Epilepsy Currents. 20, 1_suppl, p. 23S-30S

Research output: Contribution to journalReview article

Open Access

Mechanisms of action of currently used antiseizure drugs

Sills, G. J. & Rogawski, M. A., May 15 2020, In : Neuropharmacology. 168, 107966.

Research output: Contribution to journalReview article

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity

González, E. A., Rindy, A. C., Guignet, M. A., Calsbeek, J. J., Bruun, D. A., Dhir, A., Andrew, P., Saito, N., Rowland, D. J., Harvey, D. J., Rogawski, M. A. & Lein, P. J., Jan 1 2020, (Accepted/In press) In : Archives of Toxicology.

Research output: Contribution to journalArticle

2019

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

Senatorov, V. V., Friedman, A. R., Milikovsky, D. Z., Ofer, J., Saar-Ashkenazy, R., Charbash, A., Jahan, N., Chin, G., Mihaly, E., Lin, J. M., Ramsay, H. J., Moghbel, A., Preininger, M. K., Eddings, C. R., Harrison, H. V., Patel, R., Shen, Y., Ghanim, H., Sheng, H., Veksler, R. & 7 others, Sudmant, P. H., Becker, A., Hart, B., Rogawski, M. A., Dillin, A., Friedman, A. & Kaufer, D., Dec 4 2019, In : Science Translational Medicine. 11, 521, eaaw8283.

Research output: Contribution to journalArticle

5 Scopus citations

Diazepam buccal film for the treatment of acute seizures

Rogawski, M. A. & Heller, A. H., Jan 1 2019, (Accepted/In press) In : Epilepsy and Behavior. 106537.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication

Guignet, M., Dhakal, K., Flannery, B. M., Hobson, B. A., Zolkowska, D., Dhir, A., Bruun, D. A., Li, S., Wahab, A., Harvey, D. J., Silverman, J. L., Rogawski, M. A. & Lein, P. J., Jan 1 2019, In : Neurobiology of Disease.

Research output: Contribution to journalReview article

4 Scopus citations

Reduced efficacy and risk of seizure aggravation when cannabidiol is used without clobazam

Rogawski, M. A., Jan 1 2019, (Accepted/In press) In : Epilepsy and Behavior. 106506.

Research output: Contribution to journalEditorial

1 Scopus citations
2018
2 Scopus citations

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein, P., Dingledine, R., Aronica, E., Bernard, C., Blümcke, I., Boison, D., Brodie, M. J., Brooks-Kayal, A. R., Engel, J., Forcelli, P. A., Hirsch, L. J., Kaminski, R. M., Klitgaard, H., Kobow, K., Lowenstein, D. H., Pearl, P. L., Pitkänen, A., Puhakka, N., Rogawski, M. A., Schmidt, D. & 6 others, Sillanpää, M., Sloviter, R. S., Steinhäuser, C., Vezzani, A., Walker, M. C. & Löscher, W., Jan 1 2018, In : Epilepsia. 59, 1, p. 37-66 30 p.

Research output: Contribution to journalReview article

48 Scopus citations

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Chen, C-Y., Di Lucente, J., Lin, Y. C., Lien, C. C., Rogawski, M. A., Maezawa, I. & Jin, L-W., Jan 1 2018, In : Neurobiology of Disease. 109, p. 25-32 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats

Dhir, A. & Rogawski, M. A., May 1 2018, In : Epilepsia. 59, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus

Zolkowska, D., Wu, C. Y. & Rogawski, M. A., Jan 1 2018, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy

Lévesque, M., Herrington, R., Leclerc, L., Rogawski, M. A. & Avoli, M., Jul 15 2017, In : Neuropharmacology. 121, p. 12-19 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Data Descriptor: Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Dingledine, R., Coulter, D. A., Fritsch, B., Gorter, J. A., Lelutiu, N., McNamara, J., Nadler, J. V., Pitkänen, A., Rogawski, M. A., Skene, P., Sloviter, R. S., Wang, Y., Wadman, W. J., Wasterlain, C. & Roopra, A., May 9 2017, In : Scientific data. 4, 170061.

Research output: Contribution to journalArticle

21 Scopus citations

Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model

Ciarlone, S. L., Wang, X., Rogawski, M. A. & Weeber, E. J., Apr 1 2017, In : Neuropharmacology. 116, p. 142-150 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome

Wang, J. Y., Trivedi, A. M., Carrillo, N. R., Yang, J., Schneider, A., Giulivi, C. R., Adams, P., Tassone, F., Kim, K., Rivera, S. M., Lubarr, N., Wu, C. Y., Irwin, R. W., Brinton, R. D., Olichney, J. M., Rogawski, M. A. & Hagerman, R. J., Jul 13 2017, (Accepted/In press) In : Neurotherapeutics. p. 1-11 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye

Nik, A. M., Pressly, B., Singh, V., Antrobus, S., Hulsizer, S., Rogawski, M. A., Wulff, H. & Pessah, I. N., Jul 1 2017, In : Molecular Pharmacology. 92, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

2014 epilepsy Benchmarks Area III: Improve treatment options for controlling seizures and epilepsy-related conditions without side effects

Epilepsy Benchmark Stewards, 2016, In : Epilepsy Currents. 16, 3, p. 192-197 6 p.

Research output: Contribution to journalArticle

A New SV2A Ligand for Epilepsy

Rogawski, M. A., Oct 20 2016, In : Cell. 167, 3, p. 587 1 p.

Research output: Contribution to journalShort survey

8 Scopus citations

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Kazdoba, T. M., Hagerman, R. J., Zolkowska, D., Rogawski, M. A. & Crawley, J., Jan 1 2016, In : Psychopharmacology. 233, 2, p. 309-323 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanisms of action of Antiseizure Drugs and the Ketogenic diet

Rogawski, M. A., Löscher, W. & Rho, J. M., May 1 2016, In : Cold Spring Harbor perspectives in medicine. 6, 5, p. 28 1 p., a022780.

Research output: Contribution to journalArticle

56 Scopus citations
14 Scopus citations
2015

A fatty acid in the MCT ketogenic diet for epilepsy treatment blocks AMPA receptors

Rogawski, M. A., Dec 21 2015, In : Brain. 139, 2, p. 306-309 4 p.

Research output: Contribution to journalComment/debate

9 Scopus citations

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for alzheimer's disease

Irwin, R. W., Solinsky, C. M., Loya, C. M., Salituro, F. G., Rodgers, K. E., Bauer, G., Rogawski, M. A. & Brinton, R. D., Jun 3 2015, In : PLoS One. 10, 6, e0128313.

Research output: Contribution to journalArticle

21 Scopus citations

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

Bruun, D. A., Cao, Z., Inceoglu, B., Vito, S. T., Austin, A. T., Hulsizer, S., Hammock, B. D., Tancredi, D. J., Rogawski, M. A., Pessah, I. N. & Lein, P. J., Aug 1 2015, In : Neuropharmacology. 95, p. 332-342 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects

Desai, R., Savechenkov, P. Y., Zolkowska, D., Ge, R. L., Rogawski, M. A., Bruzik, K. S., Forman, S. A., Raines, D. E. & Miller, K. W., Nov 15 2015, In : Journal of Physiology. 593, 22, p. 4943-4961 19 p.

Research output: Contribution to journalArticle

8 Scopus citations

Current understanding of the mechanism of action of the antiepileptic drug lacosamide

Rogawski, M. A., Tofighy, A., White, H. S., Matagne, A. & Wolff, C., Feb 1 2015, In : Epilepsy Research. 110, p. 189-205 17 p.

Research output: Contribution to journalArticle

79 Scopus citations

Is a separate monotherapy indication warranted for antiepileptic drugs?

Mintzer, S., French, J. A., Perucca, E., Cramer, J. A., Messenheimer, J. A., Blum, D. E., Rogawski, M. A. & Baulac, M., Dec 1 2015, In : The Lancet Neurology. 14, 12, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanisms of action of antiepileptic drugs

Rogawski, M. A. & Cavazos, J. E., Jan 16 2015, Wyllie's Treatment of Epilepsy: Principles and Practice: Sixth Edition. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed K<inf>Ca</inf>2 Activator and Na<inf>V</inf> Blocker, is a Potent Novel Anticonvulsant

Coleman, N., Nguyen, H. M., Cao, Z., Brown, B. M., Jenkins, D. P., Zolkowska, D., Chen, Y-J., Tanaka, B. S., Goldin, A. L., Rogawski, M. A., Pessah, I. N. & Wulff, H., Jan 1 2015, In : Neurotherapeutics. 12, 1, p. 234-249 16 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

Zolkowska, D., Dhir, A., Krishnan, K., Covey, D. F. & Rogawski, M. A., 2014, In : Psychopharmacology. 231, 17, p. 3325-3332 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pediatric super-refractory status epilepticus treated with allopregnanolone

Broomall, E., Natale, J. E., Grimason, M., Goldstein, J., Smith, C. M., Chang, C. H., Kanes, S., Rogawski, M. A. & Wainwright, M. S., Dec 1 2014, In : Annals of Neurology. 76, 6, p. 911-915 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons

Chen, C-Y., Matt, L., Hell, J. W. & Rogawski, M. A., Sep 17 2014, In : PLoS One. 9, 9, A1249.

Research output: Contribution to journalArticle

20 Scopus citations

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

Vito, S. T., Austin, A. T., Banks, C. N., Inceoglu, B., Bruun, D. A., Zolkowska, D., Tancredi, D. J., Rogawski, M. A., Hammock, B. D. & Lein, P. J., Dec 1 2014, In : Toxicology and Applied Pharmacology. 281, 2, p. 185-194 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis

Fritsch, B., Reis, J., Gasior, M., Kaminski, R. M. & Rogawski, M. A., 2014, In : Journal of Neuroscience. 34, 17, p. 5765-5775 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tetramethylenedisulfotetramine

Banks, C. N., Yang, D., Lein, P. J. & Rogawski, M. A., Jan 1 2014, Encyclopedia of Toxicology: Third Edition. Elsevier, p. 509-511 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

Kaminski, R. M., Rogawski, M. A. & Klitgaard, H., 2014, In : Neurotherapeutics. 11, 2, p. 385-400 16 p.

Research output: Contribution to journalArticle

59 Scopus citations
2013

AMPA receptors as a molecular target in epilepsy therapy

Rogawski, M. A., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 9-18 10 p.

Research output: Contribution to journalArticle

106 Scopus citations

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Galanopoulou, A. S., Kokaia, M., Loeb, J. A., Nehlig, A., Pitkänen, A., Rogawski, M. A., Staley, K. J., Whittemore, V. H. & Dudek, F. E., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 13-23 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

Inceoglu, B., Zolkowska, D., Yoo, H. J., Wagner, K. M., Yang, J., Hackett, E., Hwang, S. H., Lee, K. S. S., Rogawski, M. A., Morisseau, C. & Hammock, B. D., Dec 11 2013, In : PLoS One. 8, 12, e80922.

Research output: Contribution to journalArticle

35 Scopus citations

Glia and epilepsy: Excitability and inflammation

Devinsky, O., Vezzani, A., Najjar, S., De Lanerolle, N. C. & Rogawski, M. A., Mar 2013, In : Trends in Neurosciences. 36, 3, p. 174-184 11 p.

Research output: Contribution to journalArticle

330 Scopus citations

Issues related to development of new antiseizure treatments

Wilcox, K. S., Dixon-Salazar, T., Sills, G. J., Ben-Menachem, E., White, H. S., Porter, R. J., Dichter, M. A., Moshé, S. L., Noebels, J. L., Privitera, M. D. & Rogawski, M. A., Aug 2013, In : Epilepsia. 54, SUPPL.4, p. 24-34 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
8 Scopus citations

Neuroactive steroids for the treatment of status epilepticus

Rogawski, M. A., Loya, C. M., Reddy, K., Zolkowska, D. & Lossin, C., 2013, In : Epilepsia. 54, SUPPL. 6, p. 93-98 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

Rogawski, M. A. & Hanada, T., Apr 2013, In : Acta Neurologica Scandinavica. 127, SUPPL.197, p. 19-24 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat

Bröer, S., Zolkowska, D., Gernert, M. & Rogawski, M. A., Nov 12 2013, In : Neuroscience. 252, p. 253-261 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Seizure protection by intrapulmonary delivery of midazolam in mice

Dhir, A., Zolkowska, D. & Rogawski, M. A., 2013, In : Neuropharmacology. 73, p. 425-431 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.

Rogawski, M. A., May 2013, In : Epilepsia. 54 Suppl 2, p. 33-40 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

French, J. A., Krauss, G. L., Biton, V., Squillacote, D., Yang, H., Laurenza, A., Kumar, D. & Rogawski, M. A., Aug 7 2012, In : Neurology. 79, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

269 Scopus citations

Altered fast and slow inactivation of the N440K Nav1.4 mutant in a periodic paralysis syndrome

Lossin, C., Nam, T. S., Shahangian, S., Rogawski, M. A., Choi, S. Y., Kim, M. K. & Sunwoo, I. N., Sep 4 2012, In : Neurology. 79, 10, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

15 Scopus citations