Maryam Afkarian

Associate Professor

  • 2741 Citations
  • 17 h-Index
19952019

Research output per year

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Research Output

  • 2741 Citations
  • 17 h-Index
  • 33 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
2019

Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study

SEARCH for Diabetes in Youth Study Group, Jan 1 2019, In : The Lancet Child and Adolescent Health. 3, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Preventing Early Renal Loss in Diabetes (PERL) study: A randomized double-blinded trial of allopurinoldrationale, design, and baseline data

PERL Study Group, Aug 1 2019, In : Diabetes Care. 42, 8, p. 1454-1463 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

The NASA twins study: A multidimensional analysis of a year-long human spaceflight

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A. & 62 others, Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. & Turek, F. W., Jan 1 2019, In : Science. 364, 6436, eaau8650.

Research output: Contribution to journalArticle

77 Scopus citations

Urinary Renin in Patients and Mice With Diabetic Kidney Disease

Tang, J., Wysocki, J., Ye, M., Vallés, P. G., Rein, J., Shirazi, M., Bader, M., Gomez, R. A., Sequeira-Lopez, M. L. S., Afkarian, M. & Batlle, D., Jul 1 2019, In : Hypertension (Dallas, Tex. : 1979). 74, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Erratum: Urine complement proteins and the risk of kidney disease progression and mortality in type 2 diabetes (Diabetes Care (2018) 41 (2361-2369) DOI: 10.2337/dc18-0699)

Vaisar, T., Durbin-Johnson, B., Whitlock, K., Babenko, I., Mehrotra, R., Rocke, D. M. & Afkarian, M., Nov 1 2018, In : Diabetes Care. 42, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access

The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes

for the SEARCH for Diabetes in Youth Study Group, Jan 1 2018, (Accepted/In press) In : Journal of Diabetes and its Complications.

Research output: Contribution to journalArticle

Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes

Vaisar, T., Durbin-Johnson, B., Whitlock, K., Babenko, I., Mehrotra, R., Rocke, D. M. & Afkarian, M., Nov 1 2018, In : Diabetes Care. 41, 11, p. 2361-2369 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Absolute rates of heart failure, coronary heart disease, and stroke in chronic kidney disease: An analysis of 3 community-based cohort studies

Bansal, N., Katz, R., Robinson-Cohen, C., Odden, M. C., Dalrymple, L., Shlipak, M. G., Sarnak, M. J., Siscovick, D. S., Zelnick, L., Psaty, B. M., Kestenbaum, B., Correa, A., Afkarian, M., Young, B. & De Boer, I. H., Mar 1 2017, In : JAMA Cardiology. 2, 3, p. 314-318 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood

SEARCH for Diabetes in Youth Research Group, Feb 28 2017, In : JAMA - Journal of the American Medical Association. 317, 8, p. 825-835 11 p.

Research output: Contribution to journalArticle

143 Scopus citations

Identification, confirmation, and replication of novel urinary microrna biomarkers in lupus nephritis and diabetic nephropathy

Cardenas-Gonzalez, M., Srivastava, A., Pavkovic, M., Bijol, V., Rennke, H. G., Stillman, I. E., Zhang, X., Parikh, S., Rovin, B. H., Afkarian, M., De Boer, I. H., Himmelfarb, J., Waikar, S. S. & Vaidya, V. S., Sep 1 2017, In : Clinical Chemistry. 63, 9, p. 1515-1526 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Immunity and inflammation in diabetic kidney disease: Translating mechanisms to biomarkers and treatment targets

Pichler, R., Afkarian, M., Dieter, B. P. & Tuttle, K. R., Apr 7 2017, In : American Journal of Physiology - Renal Physiology. 312, 4, p. F716-F731

Research output: Contribution to journalReview article

40 Scopus citations

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Hallan, S., Afkarian, M., Zelnick, L. R., Kestenbaum, B., Sharma, S., Saito, R., Darshi, M., Barding, G., Raftery, D., Ju, W., Kretzler, M., Sharma, K. & de Boer, I. H., Dec 1 2017, In : EBioMedicine. 26, p. 68-77 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease

Wysocki, J., Goodling, A., Burgaya, M., Whitlock, K., Ruzinski, J., Batlle, D. & Afkarian, M., Aug 2 2017, In : American Journal of Physiology - Renal Physiology. 313, 2, p. F487-F494

Research output: Contribution to journalArticle

10 Scopus citations

Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes

Nandi-Munshi, D., Afkarian, M., Whitlock, K. B., Crandell, J. L., Bell, R. A., D'Agostino, R., Saydah, S., Mottl, A. K., Dabelea, D., Black, M. H., Mayer-Davis, E. J. & Pihoker, C., Jul 1 2017, In : Hormone Research in Paediatrics. 87, 6, p. 385-395 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

An optimized method for protein extraction from OCT-embedded human kidney tissue for protein quantification by LC-MS/MS proteomics

Vrana, M., Goodling, A., Afkarian, M. & Prasad, B., Oct 1 2016, In : Drug Metabolism and Disposition. 44, 10, p. 1692-1696 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical manifestations of kidney disease among US adults with diabetes, 1988-2014

Afkarian, M., Zelnick, L. R., Hall, Y. N., Heagerty, P. J., Tuttle, K., Weiss, N. S. & De Boer, I. H., Aug 9 2016, In : JAMA - Journal of the American Medical Association. 316, 6, p. 602-610 9 p.

Research output: Contribution to journalArticle

185 Scopus citations

Diabetes, kidney disease, and cardiovascular outcomes in the jackson heart study

Afkarian, M., Katz, R., Bansal, N., Correa, A., Kestenbaum, B., Himmelfarb, J., De Boer, I. H. & Young, B., Jan 1 2016, In : Clinical Journal of the American Society of Nephrology. 11, 8, p. 1384-1391 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Impaired glucose and insulin homeostasis in moderate-severe CKD

De Boer, I. H., Zelnick, L., Afkarian, M., Ayers, E., Curtin, L., Himmelfarb, J., Ikizler, T. A., Kahn, S. E., Kestenbaum, B. & Utzschneider, K., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 9, p. 2861-2871 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: The Jackson Heart Study

Bansal, N., Katz, R., Himmelfarb, J., Afkarian, M., Kestenbaum, B., De Boer, I. H. & Young, B., Jan 1 2016, In : Nephrology Dialysis Transplantation. 31, 12, p. 2057-2064 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease

Dieter, B. P., McPherson, S. M., Afkarian, M., de Boer, I. H., Mehrotra, R., Short, R., Barbosa-Leiker, C., Alicic, R. Z., Meek, R. L. & Tuttle, K. R., Nov 1 2016, In : Journal of Diabetes and its Complications. 30, 8, p. 1467-1472 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

The surging tide of diabetes: Implications for nephrology

De Boer, I. H., Afkarian, M. & Tuttle, K. R., Mar 1 2016, In : American Journal of Kidney Diseases. 67, 3, p. 364-366 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects

Shao, B., De Boer, I., Tang, C., Mayer, P. S., Zelnick, L., Afkarian, M., Heinecke, J. W. & Himmelfarb, J., Jan 1 2015, In : Journal of Proteome Research. 14, 7, p. 2792-2806 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

Diabetic kidney disease in children and adolescents

Afkarian, M., Jan 1 2015, In : Pediatric Nephrology. 30, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes

Afkarian, M., Zelnick, L. R., Ruzinski, J., Kestenbaum, B., Himmelfarb, J., De Boer, I. H. & Mehrotra, R., Nov 1 2015, In : Journal of Diabetes and its Complications. 29, 8, p. 1024-1031 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Renal outcomes in patients with type 1 diabetes and macroalbuminuria

De Boer, I. H., Afkarian, M., Rue, T. C., Cleary, P. A., Lachin, J. M., Molitch, M. E., Steffes, M. W., Sun, W. & Zinman, B., Jan 1 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2342-2350 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease

Afkarian, M., Hirsch, I. B., Tuttle, K. R., Greenbaum, C., Himmelfarb, J. & De Boer, I. H., Jan 1 2014, In : Physiological Reports. 2, 5, e12010.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Albuminuria according to status of autoimmunity and insulin sensitivity among youth with type 1 and type 2 diabetes

Mottl, A. K., Lauer, A., Dabelea, D., Maahs, D. M., D'Agostino, R. B., Dolan, L. M., Gilliam, L. K., Lawrence, J. M., Rodriguez, B., Marcovina, S. M., Imperatore, G., Shankar, R. K., Afkarian, M., Reynolds, K., Liese, A. D., Mauer, M. & Mayer-Davis, E. J., Nov 1 2013, In : Diabetes Care. 36, 11, p. 3633-3638 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Diabetic kidney disease

Pichler, R. H., De Boer, I. H., Diaz, M. F. P. & Afkarian, M., Nov 1 2013, Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer New York, p. 547-560 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kidney disease and increased mortality risk in type 2 diabetes

Afkarian, M., Sachs, M. C., Kestenbaum, B., Hirsch, I. B., Tuttle, K. R., Himmelfarb, J. & Boer, I. H. D., Jan 31 2013, In : Journal of the American Society of Nephrology. 24, 2, p. 302-308 7 p.

Research output: Contribution to journalArticle

359 Scopus citations
2010

Optimizing a proteomics platform for urine biomarker discovery

Afkarian, M., Bhasin, M., Dillon, S. T., Guerrero, M. C., Nelson, R. G., Knowler, W. C., Thadhani, R. & Libermann, T. A., Oct 1 2010, In : Molecular and Cellular Proteomics. 9, 10, p. 2195-2204 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2009

Klotho variants and chronic hemodialysis mortality

Friedman, D. J., Afkarian, M., Tamez, H., Bhan, I., Isakova, T., Wolf, M., Ankers, E., Ye, J., Tonelli, M., Zoccali, C., Kuro-o, M., Moe, O., Karumanchi, S. A. & Thadhani, R., Nov 1 2009, In : Journal of Bone and Mineral Research. 24, 11, p. 1847-1855 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2002

Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human

Asnagli, H., Afkarian, M. & Murphy, K. M., May 1 2002, In : Journal of Immunology. 168, 9, p. 4268-4271 4 p.

Research output: Contribution to journalArticle

72 Scopus citations

Dicarbon monofluoride: A solid host for containment of volatiles

Afkarian, M., Sedy, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L. & Murphy, K. M., Jan 1 2002, In : Inorganic Materials. 38, 3, p. 278-282 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

Nguyen, A. C., Burack, W. R., Stock, J. L., Kortum, R., Chaika, O. V., Afkarian, M., Muller, W. J., Murphy, K. M., Morrison, D. K., Lewis, R. E., McNeish, J. & Shaw, A. S., May 6 2002, In : Molecular and Cellular Biology. 22, 9, p. 3035-3045 11 p.

Research output: Contribution to journalArticle

210 Scopus citations

T-bet is a STATI-induced regulator for IL-12R expression in naïve CD4+ T cells

Afkarian, M., Sedy, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L. & Murphy, K. M., Jan 1 2002, In : Nature Immunology. 3, 6, p. 549-557 9 p.

Research output: Contribution to journalArticle

685 Scopus citations
2000

Signaling and transcription in T helper development

Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M. & Murphy, T. L., Jun 27 2000, In : Annual Review of Immunology. 18, p. 451-494 44 p.

Research output: Contribution to journalReview article

511 Scopus citations
1995

A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells

Malarkannan, S., Afkarian, M. & Shastri, N., Dec 1 1995, In : Journal of Experimental Medicine. 182, 6, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

61 Scopus citations