• 7050 Citations
  • 46 h-Index
19952020

Research output per year

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Research Output

  • 7050 Citations
  • 46 h-Index
  • 88 Article
  • 3 Comment/debate
  • 3 Editorial
  • 3 Review article
2020

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes

Drum, B. M., Yuan, C., de la Mata, A., Grainger, N. & Santana, L. F., Mar 1 2020, In : American journal of physiology. Cell physiology. 318, 3, p. C598-C604

Research output: Contribution to journalArticle

Open Access

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle

O’Dwyer, S. C., Palacio, S., Matsumoto, C., Guarina, L., Klug, N. R., Tajada, S., Rosati, B., McKinnon, D., Trimmer, J. S. & Santana, L. F., Feb 18 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 7, p. 3858-3866 9 p.

Research output: Contribution to journalArticle

Open Access
2019

Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

Syed, A. U., Reddy, G. R., Ghosh, D., Prada, M. P., Nystoriak, M. A., Morotti, S., Grandi, E., Sirish, P., Chiamvimonvat, N., Hell, J. W., Santana, L. F., Xiang, Y. K., Nieves-Cintrón, M. & Navedo, M. F., Jun 4 2019, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A Gs-coupled purinergic receptor boosts ca 2+ influx and vascular contractility during diabetic hyperglycemia

Prada, M. P., Syed, A. U., Buonarati, O. R., Reddy, G. R., Nystoriak, M. A., Ghosh, D., Simó, S., Sato, D., Sasse, K. C., Ward, S. M., Santana, L. F., Xiang, Y. K., Hell, J. W., Nieves-Cintrón, M. & Navedo, M. F., Mar 1 2019, In : eLife. 8, e42214.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A stochastic model of ion channel cluster formation in the plasma membrane

Sato, D., Hernández-Hernández, G., Matsumoto, C., Tajada, S., Moreno, C. M., Dixon, R. E., O'Dwyer, S., Navedo, M. F., Trimmer, J. S., Clancy, C. E., Binder, M. D. & Santana, L. F., Sep 2 2019, In : The Journal of general physiology. 151, 9, p. 1116-1134 19 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

Dong, J. X., Lee, Y., Kirmiz, M., Palacio, S., Dumitras, C., Moreno, C. M., Sando, R., Santana, L. F., Südhof, T. C., Gong, B., Murray, K. D. & Trimmer, J. S., Sep 2019, In : eLife. 8, e48750.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity

Tiscione, S. A., Vivas, O., Ginsburg, K. S., Bers, D. M., Ory, D. S., Santana, L. F., Dixon, R. E. & Dickson, E. J., Dec 2 2019, In : The Journal of cell biology. 218, 12, p. 4141-4156 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

KV2.1 mediates spatial and functional coupling of l-type calcium channels and ryanodine receptors in mammalian neurons

Vierra, N. C., Kirmiz, M., van der List, D., Santana, L. F. & Trimmer, J. S., Oct 2019, In : eLife. 8, e49953.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018
6 Scopus citations

BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes

De La Mata, A., Tajada, S., O'Dwyer, S., Matsumoto, C., Dickson, R. E., Hariharan, N., Moreno, C. M. & Santana, L. F., Jan 1 2018, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

10 Scopus citations
5 Scopus citations

Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins

Donelson Smith, F., Omar, M. H., Nygren, P. J., Soughayer, J., Hoshi, N., Lau, H. T., Snyder, C. G., Branon, T. C., Ghosh, D., Langeberg, L. K., Ting, A. Y., Santana, L. F., Ong, S. E., Navedo, M. F. & Scott, J. D., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. E11465-E11474

Research output: Contribution to journalArticle

8 Scopus citations
2017

A new mutation in FIG4 causes a severe form of CMT4J involving TRPV4 in the pathogenic cascade

Gentil, B. J., O'Ferrall, E., Chalk, C., Santana, L. F., Durham, H. D. & Massie, R., Jan 1 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 9, p. 789-799 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

Tajada, S., Moreno, C. M., Samantha, O., Woods, S., Sato, D., Navedo, M. F. & Santana, L. F., Jun 1 2017, In : Journal of General Physiology. 149, 6, p. 639-659 21 p.

Research output: Contribution to journalArticle

17 Scopus citations

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes

Nieves-Cintrón, M., Syed, A. U., Buonarati, O. R., Rigor, R. R., Nystoriak, M. A., Ghosh, D., Sasse, K. C., Ward, S. M., Santana, L. F., Hell, J. W. & Navedo, M. F., Dec 1 2017, In : Scientific Reports. 7, 1, 14058.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve

Li, L., Li, J., Drum, B. M., Chen, Y., Yin, H., Guo, X., Luckey, S. W., Gilbert, M. L., Stanley McKnight, G., Scott, J. D., Santana, L. F. & Liu, Q., 2017, In : Cardiovascular Research. 113, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Proximal clustering between BK and Cav1.3 channels promotes functional coupling and BK channel activation at low voltage

Vivas, O., Moreno, C. M., Santana, L. F. & Hille, B., Jun 30 2017, In : eLife. 6, e28029.

Research output: Contribution to journalArticle

15 Scopus citations
2016

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

Nieves-Cintrón, M., Hirenallur-Shanthappa, D., Nygren, P. J., Hinke, S. A., Dell'Acqua, M. L., Langeberg, L. K., Navedo, M., Santana, L. F. & Scott, J. D., Jul 1 2016, In : Cellular Signalling. 28, 7, p. 733-740 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ca2+ entry into neurons is facilitated by cooperative gating of clustered Cav1.3 channels

Moreno, C. M., Dickson, R. E., Tajada, S., Yuan, C., Opitz-Araya, X., Binder, M. D. & Santana, L. F., May 17 2016, In : eLife. 5, MAY2016, e15744.

Research output: Contribution to journalArticle

27 Scopus citations

Calcium Channels in Vascular Smooth Muscle

Ghosh, D., Syed, A. U., Prada, M. P., Nystoriak, M. A., Santana, L. F., Nieves-Cintrón, M. & Navedo, M. F., 2016, (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

8 Scopus citations

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

Drum, B. M. L., Yuan, C., Li, L., Liu, Q., Wordeman, L. & Santana, L. F., Apr 1 2016, In : Journal of Molecular and Cellular Cardiology. 93, p. 32-43 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Hehnly, H., Canton, D., Bucko, P., Langeberg, L. K., Ogier, L., Gelman, I., Santana, L. F., Wordeman, L. & Scott, J. D., Sep 25 2015, In : eLife. 4, September, e09384.

Research output: Contribution to journalArticle

24 Scopus citations

Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

Dickson, R. E., Moreno, C. M., Yuan, C., Opitz-Araya, X., Binder, M. D., Navedo, M. F. & Santana, L. F., Feb 25 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

26 Scopus citations

The long and winding road home: How junctin and triadin find their way to the junctional SR

Drum, B. M. L. & Santana, L. F., 2015, In : Journal of Molecular and Cellular Cardiology. 81, p. 15-17 3 p.

Research output: Contribution to journalEditorial

2014

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus

Nystoriak, M. A., Nieves-Cintrón, M., Nygren, P. J., Hinke, S. A., Nichols, C. B., Chen, C. Y., Puglisi, J. L., Izu, L. T., Bers, D. M., Dell'acqua, M. L., Scott, J. D., Santana, L. F. & Navedo, M. F., Feb 14 2014, In : Circulation Research. 114, 4, p. 607-615 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

Sonkusare, S. K., Dalsgaard, T., Bonev, A. D., Hill-Eubanks, D. C., Kotlikoff, M. I., Scott, J. D., Santana, L. F. & Nelson, M. T., Jul 8 2014, In : Science Signaling. 333, ra66.

Research output: Contribution to journalArticle

83 Scopus citations

Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)

Drum, B. M. L., Dickson, R. E., Yuan, C., Cheng, E. P. & Santana, L. F., 2014, In : Journal of Molecular and Cellular Cardiology. 66, p. 63-71 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery

Guan, X., Mack, D. L., Moreno, C. M., Strande, J. L., Mathieu, J., Shi, Y., Markert, C. D., Wang, Z., Liu, G., Lawlor, M. W., Moorefield, E. C., Jones, T. N., Fugate, J. A., Furth, M. E., Murry, C. E., Ruohola-Baker, H., Zhang, Y., Santana, L. F. & Childers, M. K., Mar 2014, In : Stem Cell Research. 12, 2, p. 467-480 14 p.

Research output: Contribution to journalArticle

51 Scopus citations

Local control of TRPV4 channels by akap150-targeted PKC in arterial smooth muscle

Mercado, J., Baylie, R., Navedo, M. F., Yuan, C., Scott, J. D., Nelson, M. T., Brayden, J. E. & Santana, L. F., 2014, In : Journal of General Physiology. 143, 5, p. 559-575 17 p.

Research output: Contribution to journalArticle

46 Scopus citations

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure

Zhang, C., Chen, B., Guo, A., Zhu, Y., Miller, J. D., Gao, S., Yuan, C., Kutschke, W., Zimmerman, K., Weiss, R. M., Wehrens, X. H. T., Hong, J., Johnson, F. L., Santana, L. F., Anderson, M. E. & Song, L. S., Apr 29 2014, In : Circulation. 129, 17, p. 1742-1750 9 p.

Research output: Contribution to journalArticle

65 Scopus citations
2013

A ca2+- and PKC-driven regulatory network in airway smooth muscle

Dickson, R. E. & Santana, L. F., Feb 2013, In : Journal of General Physiology. 141, 2, p. 161-164 4 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

CaV1.2 sparklets in heart and vascular smooth muscle

Navedo, M. F. & Santana, L. F., May 2013, In : Journal of Molecular and Cellular Cardiology. 58, 1, p. 67-96 30 p.

Research output: Contribution to journalArticle

26 Scopus citations

Down-regulation of CaV1.2 channels during hypertension: How fewer CaV1.2 channels allow more Ca2+ into hypertensive arterial smooth muscle

Tajada, S., Cidad, P., Colinas, O., Santana, L. F., López-López, J. R. & Pérez-García, M. T., Dec 2013, In : Journal of Physiology. 591, 24, p. 6175-6191 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α

Gulia, J., Navedo, M. F., Gui, P., Chao, J. T., Mercado, J. L., Santana, L. F. & Davis, M. J., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5

Research output: Contribution to journalArticle

10 Scopus citations
2012

Adding accessories for hypertension: α2δ-1 subunits upregulate CaV1.2 channels in arterial myocytes in a model of genetic hypertension

Santana, L. F. & Mercado, J. L., Oct 2012, In : Hypertension. 60, 4, p. 894-895 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Anchored phosphatases modulate glucose homeostasis

Hinke, S. A., Navedo, M. F., Ulman, A., Whiting, J. L., Nygren, P. J., Tian, G., Jimenez-Caliani, A. J., Langeberg, L. K., Cirulli, V., Tengholm, A., Dell'Acqua, M. L., Santana, L. F. & Scott, J. D., Oct 17 2012, In : EMBO Journal. 31, 20, p. 3991-4004 14 p.

Research output: Contribution to journalArticle

40 Scopus citations
60 Scopus citations

Cardiomyocyte-specific expression of lamin A improves cardiac function in Lmna-/- mice

Frock, R. L., Chen, S. C., Da, D. F., Frett, E., Lau, C., Brown, C., Pak, D. N., Wang, Y., Muchir, A., Worman, H. J., Santana, L. F., Ladiges, W. C., Rabinovitch, P. S. & Kennedy, B. K., Aug 15 2012, In : PLoS One. 7, 8, e42918.

Research output: Contribution to journalArticle

20 Scopus citations

Erratum: Anchored phosphatases modulate glucose homeostasis (EMBO Journal (2012) 31 (3991-4004) DOI: 10.1038/emboj.2012.244)

Hinke, S. A., Navedo, M. F., Ulman, A., Whiting, J. L., Nygren, P. J., Tian, G., Jimenez-Caliani, A. J., Langeberg, L. K., Cirulli, V., Tengholm, A., Dell'Acqua, M. L., Fernando Santana, L. & Scott, J. D., Nov 28 2012, In : EMBO Journal. 31, 23, p. 4481 1 p.

Research output: Contribution to journalArticle

L-Type Ca 2+ Channel Function During Timothy Syndrome

Dickson, R. E., Cheng, E. P., Mercado, J. L. & Santana, L. F., Apr 2012, In : Trends in Cardiovascular Medicine. 22, 3, p. 72-76 5 p.

Research output: Contribution to journalReview article

17 Scopus citations
2011

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

Means, C. K., Lygren, B., Langeberg, L. K., Jain, A., Dickson, R. E., Vega, A. L., Gold, M. G., Petrosyan, S., Taylor, S. S., Murphy, A. N., Ha, T., Santana, L. F., Tasken, K. & Scott, J. D., Nov 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 48

Research output: Contribution to journalArticle

82 Scopus citations

Dynamic changes in sarcoplasmic reticulum structure in ventricular myocytes

Vega, A. L., Yuan, C., Votaw, V. S. & Santana, L. F., 2011, In : Journal of Biomedicine and Biotechnology. 2011, 382586.

Research output: Contribution to journalArticle

13 Scopus citations

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and gαq overexpression-induced heart failure

Dai, D. F., Johnson, S. C., Villarin, J. J., Chin, M. T., Nieves-Cintrón, M., Chen, T., Marcinek, D. J., Dorn, G. W., Kang, Y. J., Prolla, T. A., Santana, L. F. & Rabinovitch, P. S., Apr 1 2011, In : Circulation Research. 108, 7, p. 837-846 10 p.

Research output: Contribution to journalArticle

271 Scopus citations

Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy

Dai, D. F., Chen, T., Szeto, H., Nieves-Cintrón, M., Kutyavin, V., Santana, L. F. & Rabinovitch, P. S., Jun 28 2011, In : Journal of the American College of Cardiology. 58, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

209 Scopus citations
17 Scopus citations

Restoration of normal L-type Ca2+ channel function during timothy syndrome by ablation of an anchoring protein

Cheng, E. P., Yuan, C., Navedo, M. F., Dixon, R. E., Nieves-Cintrón, M., Scott, J. D. & Santana, L. F., Jul 22 2011, In : Circulation Research. 109, 3, p. 255-261 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Single cell transcriptional profiling of adult mouse cardiomyocytes.

Flynn, J. M., Santana, L. F. & Melov, S., 2011, In : Journal of visualized experiments : JoVE. 58

Research output: Contribution to journalArticle

9 Scopus citations
2010

A-kinase anchoring proteins: getting to the heart of the matter.

Scott, J. D. & Santana, L. F., Mar 16 2010, In : Circulation. 121, 10, p. 1264-1271 8 p.

Research output: Contribution to journalReview article

54 Scopus citations
55 Scopus citations

Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X

Lai, Y., Oslund, R. C., Bollinger, J. G., Henderson, W. R., Santana, L. F., Altemeier, W. A., Gelb, M. H. & Hallstrand, T. S., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41491-41500 10 p.

Research output: Contribution to journalArticle

44 Scopus citations