Lin Zhang, MD; PhD

Professor

  • 3227 Citations
  • 24 h-Index
1994 …2020

Research output per year

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Research Output

  • 3227 Citations
  • 24 h-Index
  • 47 Article
  • 1 Chapter
2020

Parkin is the most common causative gene in a cohort of mainland Chinese patients with sporadic early-onset Parkinson's disease

Jiang, Y., Yu, M., Chen, J., Zhou, H., Sun, W., Sun, Y., Li, F., Wei, L., Pinkhardt, E. H., Zhang, L., Yuan, Y. & Wang, Z., Sep 1 2020, In : Brain and Behavior. 10, 9, e01765.

Research output: Contribution to journalArticle

Open Access
2019

Clinimetric Properties of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale

Hall, D. A., Stebbins, G. T., Jacquemont, S., Berry-Kravis, E., Goetz, C. G., Hagerman, R. J., Zhang, L. & Leehey, M. A., Jan 1 2019, (Accepted/In press) In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Congnitive deficits and associated ERP N400 abnormalities in FXTAS with parkinsonism

Wang, X. H., Yang, J. C., Soohoo, R., Cotter, D., Yuan, M., Xia, J., Yaqub, S., Doty, J., Niu, Y. Q., Tassone, F., Hagerman, R. J., Zhang, L. & Olichney, J. M., Sep 18 2018, In : Frontiers in Genetics. 9, SEP, 327.

Research output: Contribution to journalArticle

2017
3 Scopus citations
9 Scopus citations
2016

A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia

Trenkwalder, C., Berg, D., Rascol, O., Eggert, K., Ceballos-Baumann, A., Corvol, J. C., Storch, A., Zhang, L., Azulay, J. P., Broussolle, E., Defebvre, L., Geny, C., Gostkowski, M., Stocchi, F., Tranchant, C., Derkinderen, P., Durif, F., Espay, A. J., Feigin, A., Houeto, J. L. & 13 others, Schwarz, J., Di Paolo, T., Feuerbach, D., Hockey, H. U., Jaeger, J., Jakab, A., Johns, D., Linazasoro, G., Maruff, P., Rozenberg, I., Sovago, J., Weiss, M. & Gomez-Mancilla, B., Jul 1 2016, In : Movement Disorders. 31, 7, p. 1049-1054 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Optimal Cutoff Scores for Alzheimer's Disease Using the Chinese Version of Mini-Mental State Examination among Chinese Population Living in Rural Areas

Yang, Z., Holt, H. K., Fan, J. H., Ma, L., Liu, Y., Chen, W., Como, P., Zhang, L. & Qiao, Y. L., Dec 1 2016, In : American Journal of Alzheimer's Disease and other Dementias. 31, 8, p. 650-657 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Target selection recommendations based on impact of deep brain stimulation surgeries on nonmotor symptoms of Parkinson’s disease

Wang, X. H., Zhang, L., Sperry, L., Olichney, J. M., Tomaszewski Farias, S. E., Shahlaie, K., Malhado-Chang, N. O., Liu, Y., Wang, S. P. & Wang, C., Dec 20 2015, In : Chinese Medical Journal. 128, 24, p. 3371-3380 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

The natural progression of Parkinson’s disease in a small cohort with 15 drug‑naïve patients

Liu, Y., Fan, J. H., Gao, X., Ma, L., Qiao, Y. L. & Zhang, L., 2015, In : Chinese Medical Journal. 128, 13, p. 1761-1764 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

A randomized clinical trial of high-dosage coenzyme Q10 in early parkinson disease no evidence of benefit

The Parkinson Study Group QE3 Investigators, 2014, In : JAMA Neurology. 75, 1, p. 543-552 10 p.

Research output: Contribution to journalArticle

158 Scopus citations

Case report: Dystonia in a fragile X carrier

Zhang, L., Sukharev, D., Schneider, A., Olichney, J. M., Seritan, A. & Hagerman, R. J., 2014, In : Movement Disorders. 29, 7

Research output: Contribution to journalArticle

1 Scopus citations

Memantine for fragile x-associated tremor/ataxia syndrome: A randomized, double-blind, placebo-controlled trial

Seritan, A. L., Nguyen, D. V., Mu, Y., Tassone, F., Bourgeois, J. A., Schneider, A., Cogswell, J. B., Cook, K. R., Leehey, M. A., Grigsby, J., Olichney, J. M., Adams, P. E., Legg, W., Zhang, L., Hagerman, P. J. & Hagerman, R. J., 2014, In : Journal of Clinical Psychiatry. 75, 3, p. 264-271 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Parkinsonism in fragile X-associated tremor/ataxia syndrome (FXTAS): Revisited

Niu, Y. Q., Yang, J. C., Hall, D. A., Leehey, M. A., Tassone, F., Olichney, J. M., Hagerman, R. J. & Zhang, L., 2014, In : Parkinsonism and Related Disorders. 20, 4, p. 456-459 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Perceived and performance-based executive dysfunction in Parkinsons disease

Lanni, K. E., Ross, J. M., Higginson, C. I., Dressler, E. M., Sigvardt, K. A., Zhang, L., Malhado-Chang, N. O. & Disbrow, E. A., Apr 21 2014, In : Journal of Clinical and Experimental Neuropsychology. 36, 4, p. 342-355 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Resting state functional connectivity is associated with cognitive dysfunction in non-demented people with Parkinson's disease

Disbrow, E. A., Carmichael, O., He, J., Lanni, K. E., Dressler, E. M., Zhang, L., Malhado-Chang, N. O. & Sigvardt, K. A., 2014, In : Journal of Parkinson's Disease. 4, 3, p. 453-465 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

Altered N400 Congruity Effects in Parkinson's Disease without Dementia

Kutas, M., Iragui, V. J., Niu, Y. Q., D'Avanzo, T. J., Yang, J. C., Salmon, D. P., Zhang, L. & Olichney, J. M., Oct 2013, Cognitive Electrophysiology of Attention: Signals of the Mind. Elsevier Inc., p. 254-267 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Extrapyramidal signs by dementia severity in alzheimer disease and dementia with lewy bodies

Kaur, B., Harvey, D. J., DeCarli, C., Zhang, L., Sabbagh, M. N. & Olichney, J. M., Jul 2013, In : Alzheimer Disease and Associated Disorders. 27, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fragile X-associated tremor/ataxia syndrome (FXTAS) in grey zone carriers

Liu, Y., Winarni, T., Zhang, L., Tassone, F. & Hagerman, R. J., Jul 2013, In : Clinical Genetics. 84, 1, p. 74-77 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Movement activation and inhibition in Parkinson's disease: A functional imaging study

Disbrow, E. A., Sigvardt, K. A., Franz, E. A., Turner, R. S., Russo, K. A., Hinkley, L. B., Herron, T. J., Ventura, M. I., Zhang, L. & Malhado-Chang, N. O., 2013, In : Journal of Parkinson's Disease. 3, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Screening for parkinson syndrome in a Chinese rural population: Re-examination of a historic questionnaire

Liu, Y., Fan, J. H., Chen, W., Nie, Z. Y., Qiao, Y. L. & Zhang, L., Mar 5 2013, In : Chinese Medical Journal. 126, 5, p. 819-822 4 p.

Research output: Contribution to journalArticle

2012

Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease

Disbrow, E. A., Russo, K. A., Higginson, C. I., Yund, E. W., Ventura, M. I., Zhang, L., Malhado-Chang, N. O., Woods, D. L. & Sigvardt, K. A., May 3 2012, In : Brain Research. 1452, p. 151-164 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Fragile X-associated tremor/ataxia syndrome

Han, W. W., Zhang, L., Jiang, H. & Tang, B. S., Feb 10 2011, In : Chinese Journal of Medical Genetics. 28, 1, p. 52-55 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sleep apnea in fragile X premutation carriers with and without FXTAS

Hamlin, A., Liu, Y., Nguyen, D. V., Tassone, F., Zhang, L. & Hagerman, R. J., Dec 2011, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 156, 8, p. 923-928 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2010

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers

Adams, P. E., Adams, J. S., Nguyen, D. V., Hessl, D. R., Brunberg, J. A., Tassone, F., Zhang, W., Koldewyn, K., Rivera, S. M., Grigsby, J., Zhang, L., DeCarli, C., Hagerman, P. J. & Hagerman, R. J., Apr 2010, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153, 3, p. 775-785 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2009

Development of Parkinsonism following exposure to aripiprazole: Two case reports

Lua, L. L. & Zhang, L., 2009, In : Journal of Medical Case Reports. 3, 6448.

Research output: Contribution to journalArticle

5 Scopus citations

FMR1 premutation in females diagnosed with multiple sclerosis

Zhang, L., Coffey, S., Lua, L. L., Greco, C. M., Schafer, J. A., Brunberg, J. A., Borodyanskaya, M., Agius, M. A., Apperson, M. L., Leehey, M., Tartaglia, N., Tassone, F., Hagerman, P. J. & Hagerman, R. J., Jul 2009, In : Journal of Neurology, Neurosurgery and Psychiatry. 80, 7, p. 812-814 3 p.

Research output: Contribution to journalArticle

22 Scopus citations

Subclinical cortical reorganization: A preclinical imaging marker for recessively inherited PD?

Zhang, L., Mar 24 2009, In : Neurology. 72, 12, p. 1036-1037 2 p.

Research output: Contribution to journalArticle

2008

FMR1 CGG repeat length predicts motor dysfunction in premutation carriers

Leehey, M. A., Berry-Kravis, E., Goetz, C. G., Zhang, L., Hall, D. A., Li, L., Rice, C. D., Lara, R., Cogswell, J., Reynolds, A., Gane, L., Jacquemont, S., Tassone, F., Grigsby, J., Hagerman, R. J. & Hagerman, P. J., Apr 2008, In : Neurology. 70, 16 PART 2, p. 1397-1402 6 p.

Research output: Contribution to journalArticle

122 Scopus citations

Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems

Hagerman, R. J., Hall, D. A., Coffey, S., Leehey, M., Bourgeois, J., Gould, J., Zhang, L., Seritan, A., Berry-Kravis, E., Olichney, J. M., Miller, J. W., Fong, A. L., Carpenter, R., Bodine, C., Gane, L. W., Rainin, E., Hagerman, H. & Hagerman, P. J., 2008, In : Clinical Interventions in Aging. 3, 2, p. 251-262 12 p.

Research output: Contribution to journalArticle

104 Scopus citations
2007

Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome

Bourgeois, J. A., Cogswell, J. B., Hessl, D. R., Zhang, L., Ono, M. Y., Tassone, F., Farzin, F., Brunberg, J. A., Grigsby, J. & Hagerman, R. J., Jul 2007, In : General Hospital Psychiatry. 29, 4, p. 349-356 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Fragile X-associated tremor/ataxia syndrome: Clinical features, genetics, and testing guidelines

Berry-Kravis, E., Abrams, L., Coffey, S. M., Hall, D. A., Greco, C., Gane, L. W., Grigsby, J., Bourgeois, J. A., Finucane, B., Jacquemont, S., Brunberg, J. A., Zhang, L., Lin, J., Tassone, F., Hagerman, P. J., Hagerman, R. J. & Leehey, M. A., Oct 31 2007, In : Movement Disorders. 22, 14, p. 2018-2030 13 p.

Research output: Contribution to journalArticle

234 Scopus citations

Neuropathic features in fragile X premutation carriers

Berry-Kravis, E., Goetz, C. G., Leehey, M. A., Hagerman, R. J., Zhang, L., Li, L., Nguyen, D., Hall, D. A., Tartaglia, N., Cogswell, J., Tassone, F. & Hagerman, P. J., Jan 1 2007, In : American Journal of Medical Genetics, Part A. 143, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Neuropathy as a presenting feature in fragile X-associated tremor/ataxia syndrome

Hagerman, R. J., Coffey, S. M., Maselli, R. A., Soontarapornchai, K., Brunberg, J. A., Leehey, M. A., Zhang, L., Gane, L. W., Fenton-Farrell, G., Tassone, F. & Hagerman, P. J., Oct 1 2007, In : American Journal of Medical Genetics, Part A. 143, 19, p. 2256-2260 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Progression of tremor and ataxia in male carriers of the FMR1 premutation

Leehey, M. A., Berry-Kravis, E., Min, S. J., Hall, D. A., Rice, C. D., Zhang, L., Grigsby, J., Greco, C. M., Reynolds, A., Lara, R., Cogswell, J., Jacquemont, S., Hessl, D. R., Tassone, F., Hagerman, R. J. & Hagerman, P. J., Jan 15 2007, In : Movement Disorders. 22, 2, p. 203-206 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS)

Adams, J. S., Adams, P. E., Nguyen, D., Brunberg, J. A., Tassone, F., Zhang, W., Koldewyn, K., Rivera, S. M., Grigsby, J., Zhang, L., DeCarli, C., Hagerman, P. J. & Hagerman, R. J., Aug 2007, In : Neurology. 69, 9, p. 851-859 9 p.

Research output: Contribution to journalArticle

130 Scopus citations
2006
44 Scopus citations

Dietary factors and smoking as risk factors for PD in a rural population in China: A nested case-control study

Ma, L., Zhang, L., Gao, X. H., Chen, W., Wu, Y. P., Wang, Y., Li, X. F., Como, P., Kieburtz, K. & Qiao, Y. L., Apr 2006, In : Acta Neurologica Scandinavica. 113, 4, p. 278-281 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome

Cohen, S., Masyn, K., Adams, J., Hessl, D. R., Rivera, S., Tassone, F., Brunberg, J. A., DeCarli, C., Zhang, L., Cogswell, J., Loesch, D., Leehey, M., Grigsby, J., Hagerman, P. J. & Hagerman, R. J., Oct 2006, In : Neurology. 67, 8, p. 1426-1431 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Prevalence of dementia in rural China: Impact of age, gender and education

Zhou, D. F., Wu, C. S., Qi, H., Fan, J. H., Sun, X. D., Como, P., Qiao, Y. L., Zhang, L. & Kieburtz, K., Oct 2006, In : Acta Neurologica Scandinavica. 114, 4, p. 273-280 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
2005

Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS)

Hall, D. A., Berry-Kravis, E., Jacquemont, S., Rice, C. D., Cogswell, J., Zhang, L., Hagerman, R. J., Hagerman, P. J. & Leehey, M. A., Jul 26 2005, In : Neurology. 65, 2 SUPPL. 1, p. 299-301 3 p.

Research output: Contribution to journalArticle

88 Scopus citations

The prevalence of PD in a nutritionally deficient rural population in China

Zhang, L., Nie, Z. Y., Liu, Y., Chen, W., Xin, S. M., Sun, X. D., Fan, J. H., Liu, Y. H., Gao, X. H., Lu, L. Q., Como, P., McDermott, M. P., Qiao, Y. L. & Kieburtz, K., Jul 2005, In : Acta Neurologica Scandinavica. 112, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

Aging in Individuals with the FMR1 Mutation

Jacquemont, S., Farzin, F., Hall, D., Leehey, M., Tassone, F., Gane, L., Zhang, L., Grigsby, J., Jardini, T., Lewin, F., Berry-Kravis, E., Hagerman, P. J. & Hagerman, R. J., Mar 2004, In : American Journal on Mental Retardation. 109, 2

Research output: Contribution to journalArticle

118 Scopus citations

Fragile-X-Associated Tremor/Ataxia Syndrome (FXTAS) in Females with the FMR1 Premutation

Hagerman, R. J., Leavitt, B. R., Farzin, F., Jacquemont, S., Greco, C. M., Brunberg, J. A., Tassone, F., Hessl, D. R., Harris, S. W., Zhang, L., Jardini, T., Gane, L. W., Ferranti, J. A., Ruiz, L., Leehey, M. A., Grigsby, J. & Hagerman, P. J., May 2004, In : American Journal of Human Genetics. 74, 5, p. 1051-1056 6 p.

Research output: Contribution to journalArticle

266 Scopus citations

Penetrance of the Fragile X-Associated Tremor/Ataxia Syndrome in a Premutation Carrier Population

Jacquemont, S., Hagerman, R. J., Leehey, M. A., Hall, D. A., Levine, R. A., Brunberg, J. A., Zhang, L., Jardini, T., Gane, L. W., Harris, S. W., Herman, K., Grigsby, J., Greco, C. M., Berry-Kravis, E., Tassone, F. & Hagerman, P. J., Jan 28 2004, In : Journal of the American Medical Association. 291, 4, p. 460-469 10 p.

Research output: Contribution to journalArticle

463 Scopus citations
2003

Fragile X premutation tremor/ataxia syndrome: Molecular, clinical, and neuroimaging correlates

Jacquemont, S., Hagerman, R. J., Leehey, M., Grigsby, J., Zhang, L., Brunberg, J. A., Greco, C., Des Portes, V., Jardini, T., Levine, R., Berry-Kravis, E., Brown, W. T., Schaeffer, S., Kissel, J., Tassone, F. & Hagerman, P. J., Apr 1 2003, In : American Journal of Human Genetics. 72, 4, p. 869-878 10 p.

Research output: Contribution to journalArticle

560 Scopus citations

Relationship between blood pressure and Alzheimer's disease in Linxian County, China

Wu, C., Zhou, D., Wen, C., Zhang, L., Como, P. & Qiao, Y., Jan 24 2003, In : Life Sciences. 72, 10, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

66 Scopus citations
1994
18 Scopus citations