Leonard M Hjelmeland, PhD

Professor Emeritus

  • 6223 Citations
  • 40 h-Index
1974 …2016

Research output per year

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Research Output

  • 6223 Citations
  • 40 h-Index
  • 121 Article
  • 1 Conference contribution
2016
1 Scopus citations

GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration

Hunter, A. A., McBride, Z., Anderson, R., Bordbari, M. H., Ying, G. S., Kim, E. S., Park, S. S. C., Telander, D. G., Dunaief, J. L., Hjelmeland, L. M. & Morse, L. S., Mar 3 2016, In : Current Eye Research. 41, 3, p. 410-416 7 p.

Research output: Contribution to journalArticle

2015

Localization of complement factor H gene expression and protein distribution in the mouse outer retina

McBride, Z., Oltjen, S. L., Radu, R. A., Estep, J., Nguyen, A. T., Gong, Q. & Hjelmeland, L. M., Feb 5 2015, In : Molecular Vision. 21, p. 110-123 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye

McBride, Z., Forward, K. I., Nguyen, A. T., Bordbari, M. H., Oltjen, S. L. & Hjelmeland, L. M., Nov 5 2014, In : Molecular Vision. 20, p. 1569-1578 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

Dark matters in AMD genetics: Epigenetics and stochasticity

Hjelmeland, L. M., Mar 2011, In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1622-1631 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
7 Scopus citations
2010

Quantification of retinal pigment epithelial phenotypic variation using laser scanning cytometry

Hjelmeland, L. M., Fujikawa, A., Oltjen, S. L., McBride, Z. & Braunschweig, D., 2010, In : Molecular Vision. 16, p. 1108-1121 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

A strong genetic determinant of hyperoxia-related retinal degeneration on mouse chromosome 6

McBride, Z., Oltjen, S. L., LaVail, M. M. & Hjelmeland, L. M., Jan 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 405-411 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2006

Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse

Alizadeh, P., McBride, Z., Oltjen, S. L. & Hjelmeland, L. M., Sep 2006, In : Experimental Eye Research. 83, 3, p. 679-687 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

Changes in the spatial expression of genes with aging in the mouse RPE/choroid

Ogawa, T., Boylan, S. A., Oltjen, S. L. & Hjelmeland, L. M., Jun 1 2005, In : Molecular Vision. 11, p. 380-386 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mosaicism of the retinal pigment epithelium: Seeing the small picture

Burke, J. M. & Hjelmeland, L. M., Aug 2005, In : Molecular Interventions. 5, 4, p. 241-249 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions

Tian, J., Ishibashi, K., Honda, S., Boylan, S. A., Hjelmeland, L. M. & Handa, J. T., Nov 2005, In : British Journal of Ophthalmology. 89, 11, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2004

Age-related changes in the transcriptional profile of mouse RPE/choroid

Ida, H., Boylan, S. A., Weigel, A. L. & Hjelmeland, L. M., Jan 2004, In : Physiological Genomics. 15, p. 258-262 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

EST analysis of mouse retina and RPE/choroid cDNA libraries

Ida, H., Boylan, S. A., Weigel, A. L., McBride, Z., Chao, A., Gao, J., Buchoff, P., Wistow, G. & Hjelmeland, L. M., Jul 6 2004, In : Molecular Vision. 10, p. 439-444 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human retinal pigment epithelium

Miyamura, N., Ogawa, T., Boylan, S., Morse, L. S., Handa, J. T. & Hjelmeland, L. M., May 2004, In : Investigative Ophthalmology and Visual Science. 45, 5, p. 1562-1565 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the D-galactose-treated mouse

Ida, H., Ishibashi, K., Reiser, K., Hjelmeland, L. M. & Handa, J. T., Jul 2004, In : Investigative Ophthalmology and Visual Science. 45, 7, p. 2348-2354 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
2003

Acute hyperoxia-induced transcriptional response in the mouse RPE/choroid

Weigel, A. L., Ida, H., Boylan, S. A. & Hjelmeland, L. M., Sep 1 2003, In : Free Radical Biology and Medicine. 35, 5, p. 465-474 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human RPE cells express the FGFR2IIIc and FGFR3IIIc splice variants and FGF9 as a potential high affinity ligand

Alizadeh, M., Miyamura, N., Handa, J. T. & Hjelmeland, L. M., Feb 1 2003, In : Experimental Eye Research. 76, 2, p. 249-256 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells

Philp, N. J., Wang, D., Yoon, H. & Hjelmeland, L. M., Apr 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 4, p. 1716-1721 6 p.

Research output: Contribution to journalArticle

116 Scopus citations
2002

Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells

Weigel, A. L., Handa, J. T. & Hjelmeland, L. M., Nov 15 2002, In : Free Radical Biology and Medicine. 33, 10, p. 1419-1432 14 p.

Research output: Contribution to journalArticle

80 Scopus citations
27 Scopus citations
2001

Age and topographic variation of insulin-like growth factor-binding protein 2 in the human RPE

Miyamura, N., Mishima, K., Honda, S., Aotaki-Keen, A. E., Morse, L. S., Handa, J. T. & Hjelmeland, L. M., 2001, In : Investigative Ophthalmology and Visual Science. 42, 7, p. 1626-1630 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

An optimized protocol for first strand cDNA synthesis from laser capture microdissected tissue

Boylan, S., Honda, S., Hjelmeland, L. M. & Handa, J. T., 2001, In : Laboratory Investigation. 81, 8, p. 1167-1169 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Density-dependent expression of FGF-2 in response to oxidative stress in RPE cells in vitro

Wada, M., Gelfman, C. M., Matsunaga, H., Alizadeh, M., Morse, L. S., Handa, J. T. & Hjelmeland, L. M., 2001, In : Current Eye Research. 23, 3, p. 226-231 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells

Alizadeh, M., Wada, M., Gelfman, C. M., Handa, J. T. & Hjelmeland, L. M., 2001, In : Investigative Ophthalmology and Visual Science. 42, 11, p. 2706-2713 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Induction of an aging mRNA retinal pigment epithelial cell phenotype by matrix-containing advanced glycation end products in vitro

Honda, S., Farboud, B., Hjelmeland, L. M. & Handa, J. T., 2001, In : Investigative Ophthalmology and Visual Science. 42, 10, p. 2419-2425 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Induction of telomere shortening and replicative senescence by cryopreservation

Honda, S., Weigel, A., Hjelmeland, L. M. & Handa, J. T., 2001, In : Biochemical and Biophysical Research Communications. 282, 2, p. 493-498 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
43 Scopus citations

The use of hyperoxia to induce chronic mild oxidative stress in RPE cell in vitro

Honda, S., Hjelmeland, L. M. & Handa, J. T., 2001, In : Molecular Vision. 7, p. 63-70 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2000

Expression and splicing of FGF receptor mRNAs during APRE-19 cell differentiation in vitro

Alizadeh, M., Gelfman, C. M., Bench, S. R. & Hjelmeland, L. M., 2000, In : Investigative Ophthalmology and Visual Science. 41, 8, p. 2357-2362 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Expression of a recombinant human RGR opsin in Lentivirus-transduced cultured cells

Yang, M., Wang, X. G., Timothy Stout, J., Chen, P., Hjelmeland, L. M., Appukuttan, B. & Fong, H. K. W., 2000, In : Molecular Vision. 6, 32, p. 237-242 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1999

Angiogenic factors in human proliferative sickle cell retinopathy

Cao, J., Mathews, M. K., McLeod, D. S., Merges, C., Hjelmeland, L. M. & Lutty, G. A., 1999, In : British Journal of Ophthalmology. 83, 7, p. 838-846 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
70 Scopus citations

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age

Handa, J. T., Verzijl, N., Matsunaga, H., Aotaki-Keen, A., Lutty, G. A., Te Koppele, J. M., Miyata, T. & Hjelmeland, L. M., 1999, In : Investigative Ophthalmology and Visual Science. 40, 3, p. 775-779 5 p.

Research output: Contribution to journalArticle

168 Scopus citations

Senescence-associated β-galactosidase histochemistry for the primate eye

Mishima, K., Handa, J. T., Aotaki-Keen, A., Lutty, G. A., Morse, L. S. & Hjelmeland, L. M., 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1590-1593 4 p.

Research output: Contribution to journalArticle

90 Scopus citations

Senescence of the retinal pigmented epithelium

Hjelmeland, L. M., 1999, In : Investigative Ophthalmology and Visual Science. 40, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Senescence of the retinal pigment epithelium.

Hjelmeland, L. M., Cristofolo, V. J., Funk, W., Rakoczy, E. & Katz, M. L., Nov 3 1999, In : Molecular Vision. 5, p. 33 1 p.

Research output: Contribution to journalArticle

52 Scopus citations

The mRNA phenotype of a human RPE cell line at replicative senescence.

Matsunaga, H., Handa, J. T., Gelfman, C. M. & Hjelmeland, L. M., Dec 29 1999, In : Molecular vision [electronic resource]. 5, p. 39 1 p.

Research output: Contribution to journalArticle

24 Scopus citations

β-Galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells

Matsunaga, H., Handa, J. T., Aotaki-Keen, A., Sherwood, S. W., West, M. D. & Hjelmeland, L. M., 1999, In : Investigative Ophthalmology and Visual Science. 40, 1, p. 197-202 6 p.

Research output: Contribution to journalArticle

69 Scopus citations
1998

Differentiation of retinal pigment epithelial cells in vitro uncovers silencer activity in the FGF-5 gene promoter

Gelfman, C. M., Kelleher, C. M. & Hjelmeland, L. M., Aug 1998, In : Experimental Eye Research. 67, 2, p. 151-162 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Histologic localization of indocyanine green dye in aging primate and human ocular tissues with clinical angiographic correlation

Chang, A. A., Morse, L. S., Handa, J. T., Morales, R. B., Tucker, R. P., Hjelmeland, L. M. & Yannuzzi, L. A., Jun 1 1998, In : Ophthalmology. 105, 6, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The advanced glycation endproduct pentosidine induces the expression of PDGF-B in human retinal pigment epithelial cells

Handa, J. T., Reiser, K. M., Matsunaga, H. & Hjelmeland, L. M., Apr 1998, In : Experimental Eye Research. 66, 4, p. 411-419 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Use of the ARPE-19 cell line as a model of RPE polarity: Basolateral secretion of FGF5

Dunn, K. C., Marmorstein, A. D., Bonilha, V. L., Rodriguez-Boulan, E., Giordano, F. & Hjelmeland, L. M., Dec 1998, In : Investigative Ophthalmology and Visual Science. 39, 13, p. 2744-2749 6 p.

Research output: Contribution to journalArticle

101 Scopus citations
1997

Apolipoprotein E in the subretinal fluid of rhegmatogenous and exudative retinal detachments

Schneeberger, S. A., Iwahashi, C. K., Hjelmeland, L. M., Davis, P. A. & Morse, L. S., 1997, In : Retina. 17, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Expression of FGF5 in choroidal neovascular membranes associated with ARMD

Kitaoka, T., Morse, L. S., Schneeberger, S., Ishigooka, H. & Hjelmeland, L. M., 1997, In : Current Eye Research. 16, 4, p. 396-399 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Expression of fibroblast growth factor-5 by bovine choroidal endothelial cells in vitro

Keithahn, M. A. Z., Aotaki-Keen, A. E., Schneeberger, S. A., Hjelmeland, L. M. & Morse, L. S., Sep 1997, In : Investigative Ophthalmology and Visual Science. 38, 10, p. 2073-2080 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pentosidine induces PDGF-B chain expression in ARPE-19 RPE cells

Handa, J. T., Reiser, K. M. & Hjelmeland, L. M., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

26 Scopus citations