Konstantinos Zarbalis, PhD

Associate Professor

  • 1564 Citations
  • 17 h-Index
19962019
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Research Output 1996 2019

  • 1564 Citations
  • 17 h-Index
  • 28 Article
  • 1 Short survey
2019

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size

Le Duc, D., Giulivi, C., Hiatt, S. M., Napoli, E., Panoutsopoulos, A., Harlan De Crescenzo, A., Kotzaeridou, U., Syrbe, S., Anagnostou, E., Azage, M., Bend, R., Begtrup, A., Brown, N. J., Büttner, B., Cho, M. T., Cooper, G. M., Doering, J. H., Dubourg, C., Everman, D. B., Hildebrand, M. S. & 27 others, Santos, F. J. R., Kellam, B., Keller-Ramey, J., Lemke, J. R., Liu, S., Niyazov, D., Payne, K., Person, R., Quélin, C., Schnur, R. E., Smith, B. T., Strober, J., Walker, S., Wallis, M., Walsh, L., Yang, S., Yuen, R. K. C., Ziegler, A., Sticht, H., Pride, M. C., Orosco, L., Martínez-Cerdeño, V., Silverman, J. L., Crawley, J. N., Scherer, S. W., Zarbalis, K. S. & Jamra, R., Sep 1 2019, In : Brain : a journal of neurology. 142, 9, p. 2617-2630 14 p.

Research output: Contribution to journalArticle

Megalencephaly
Microcephaly
Wnt Signaling Pathway
Brain
Intellectual Disability
2018
9 Citations (Scopus)

Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy

Napoli, E., Song, G., Panoutsopoulos, A., Riyadh, M. A., Kaushik, G., Halmai, J., Levenson, R. M., Zarbalis, K. & Giulivi, C. R., Dec 1 2018, In : Scientific Reports. 8, 1, 11348.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Autophagy
Autistic Disorder
Brain
Energy Metabolism
2017
TNF Receptor-Associated Factor 6
Autophagy
Osteogenesis
Sarin
Regenerative Medicine
50 Citations (Scopus)

Germline Chd8 haploinsufficiency alters brain development in mouse

Gompers, A. L., Su-Feher, L., Ellegood, J., Copping, N. A., Riyadh, M. A., Stradleigh, T. W., Pride, M. C., Schaffler, M. D., Wade, A. A., Catta-Preta, R., Zdilar, I., Louis, S., Kaushik, G., Mannion, B. J., Plajzer-Frick, I., Afzal, V., Visel, A., Pennacchio, L. A., Dickel, D. E., Lerch, J. P. & 4 others, Crawley, J., Zarbalis, K., Silverman, J. L. & Nord, A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1062-1073 12 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Brain
Chromatin Assembly and Disassembly
Neuroimmunomodulation
cdc Genes
2 Citations (Scopus)

Lipid-based DNA/siRNA transfection agents disrupt neuronal bioenergetics and mitophagy

Napoli, E., Liu, S., Marsilio, I., Zarbalis, K. & Giulivi, C. R., Dec 1 2017, In : Biochemical Journal. 474, 23, p. 3887-3902 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Autophagy
Energy Metabolism
Small Interfering RNA
Transfection
2016
10 Citations (Scopus)

Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers

Kaushik, G., Huber, D. P., Aho, K., Finney, B., Bearden, S., Zarbalis, K. & Thomas, M. A., May 27 2016, In : Biochemical and Biophysical Research Communications. 474, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

Maternal Exposure
Psychotropic Drugs
Carbamazepine
Drinking Water
Fluoxetine
22 Citations (Scopus)

Prenatal neurogenesis in autism spectrum disorders

Kaushik, G. & Zarbalis, K., 2016, In : Frontiers in Chemistry. 4, MAR, 12.

Research output: Contribution to journalShort survey

Neurons
Pathology
Brain
Trajectories
Defects
2015
31 Citations (Scopus)

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis

Adamopoulos, I., Suzuki, E., Chao, C. C., Gorman, D., Adda, S., Maverakis, E. M., Zarbalis, K., Geissler, R., Asio, A., Blumenschein, W. M., Mcclanahan, T., De Malefyt, R. W., Gershwin, M. E. & Bowman, E. P., Jun 1 2015, In : Annals of the Rheumatic Diseases. 74, 6, p. 1284-1292 9 p.

Research output: Contribution to journalArticle

Gene transfer
Psoriatic Arthritis
Interleukin-17
Hyperplasia
Bone
32 Citations (Scopus)

The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice

Sohn, J., Orosco, L., Guo, F., Chung, S. H., Bannerman, P., Ko, E. M., Zarbalis, K., Deng, W. & Pleasure, D. E., 2015, In : Journal of Neuroscience. 35, 9, p. 3756-3763 8 p.

Research output: Contribution to journalArticle

Corpus Callosum
Lateral Ventricles
Astrocytes
Nestin
Stem Cells
2014
38 Citations (Scopus)

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

Orosco, L. A., Ross, A. P., Cates, S. L., Scott, S. E., Wu, D., Sohn, J., Pleasure, D. E., Pleasure, S. J., Adamopoulos, I. & Zarbalis, K., Sep 8 2014, In : Nature Communications. 5, 5692.

Research output: Contribution to journalArticle

Neurogenesis
pathology
Pathology
Autistic Disorder
mice
11 Citations (Scopus)

Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline

Choe, Y., Zarbalis, K. & Pleasure, S. J., Feb 6 2014, In : PLoS One. 9, 2, e86025.

Research output: Contribution to journalArticle

Catenins
Telencephalon
neural crest
Neural Crest
Stem cells
14 Citations (Scopus)

The emerging roles of ribosome biogenesis in craniofacial development

Ross, A. P. & Zarbalis, K., 2014, In : Frontiers in Physiology. 5 FEB, Article 26.

Research output: Contribution to journalArticle

Neural Crest
Ribosomes
Diamond-Blackfan Anemia
Mandibulofacial Dysostosis
Neurulation
2013
4 Citations (Scopus)

A Mutation in Mouse Pak1ip1 Causes Orofacial Clefting while Human PAK1IP1 Maps to 6p24 Translocation Breaking Points Associated with Orofacial Clefting

Ross, A. P., Mansilla, M. A., Choe, Y., Helminski, S., Sturm, R., Maute, R. L., May, S. R., Hozyasz, K. K., Wójcicki, P., Mostowska, A., Davidson, B., Adamopoulos, I., Pleasure, S. J., Murray, J. C. & Zarbalis, K., Jul 25 2013, In : PLoS One. 8, 7, e69333.

Research output: Contribution to journalArticle

Genes
mutation
Mutation
mice
genes
2012
28 Citations (Scopus)

Meningeal defects alter the tangential migration of cortical interneurons in Foxc1 hith/hith mice

Zarbalis, K., Choe, Y., Siegenthaler, J. A., Orosco, L. A. & Pleasure, S. J., Jan 17 2012, In : Neural Development. 7, 1, 2.

Research output: Contribution to journalArticle

Interneurons
Meninges
Prosencephalon
Chromatin Immunoprecipitation
Homozygote
19 Citations (Scopus)

PEDF is a novel oligodendrogenic Morphogen acting on the adult SVZ and corpus callosum

Sohn, J., Selvaraj, V., Wakayama, K., Orosco, L., Lee, E., Crawford, S. E., Guo, F., Lang, J., Horiuchi, M., Zarbalis, K., Ito, T., Deng, W. & Pleasure, D. E., Aug 29 2012, In : Journal of Neuroscience. 32, 35, p. 12152-12164 13 p.

Research output: Contribution to journalArticle

Corpus Callosum
Lateral Ventricles
Glial Fibrillary Acidic Protein
Green Fluorescent Proteins
Lysophosphatidylcholines
2011

Erratum: Retinoic acid from the meninges regulates cortical neuron generation (Cell (2009) 139 (597-609))

Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., Napoli, J. L., Peterson, A. S. & Pleasure, S. J., Aug 5 2011, In : Cell. 146, 3, p. 486 1 p.

Research output: Contribution to journalArticle

Meninges
Tretinoin
Neurons
2010
22 Citations (Scopus)

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice

Endoh-Yamagami, S., Karkar, K. M., May, S. R., Cobos, I., Thwin, M. T., Long, J. E., Ashique, A. M., Zarbalis, K., Rubenstein, J. L. R. & Peterson, A. S., Apr 1 2010, In : Developmental Biology. 340, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Interneurons
Mutation
Genes
Schizophrenia
2009
74 Citations (Scopus)

Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo

Wizenmann, A., Brunet, I., Lam, J. S. Y., Sonnier, L., Beurdeley, M., Zarbalis, K., Weisenhorn-Vogt, D., Weinl, C., Dwivedy, A., Joliot, A., Wurst, W., Holt, C. & Prochiantz, A., Nov 12 2009, In : Neuron. 64, 3, p. 355-366 12 p.

Research output: Contribution to journalArticle

Axons
Growth Cones
Membranes
Presynaptic Terminals
Mesencephalon
245 Citations (Scopus)

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., Napoli, J. L., Peterson, A. S. & Pleasure, S. J., Oct 30 2009, In : Cell. 139, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

Meninges
Tretinoin
Neurons
Phenotype
Prosencephalon
2007
76 Citations (Scopus)

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development

Zarbalis, K., Siegenthaler, J. A., Choe, Y., May, S. R., Peterson, A. S. & Pleasure, S. J., Aug 28 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 35, p. 14002-14007 6 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Skull
Alleles
Meninges
Cerebral Cortex
209 Citations (Scopus)

EphA-Ephrin-A-Mediated β Cell Communication Regulates Insulin Secretion from Pancreatic Islets

Konstantinova, I., Nikolova, G., Ohara-Imaizumi, M., Meda, P., Kučera, T., Zarbalis, K., Wurst, W., Nagamatsu, S. & Lammert, E., Apr 20 2007, In : Cell. 129, 2, p. 359-370 12 p.

Research output: Contribution to journalArticle

Ephrins
Islets of Langerhans
Cell Communication
Insulin
Communication
1 Citation (Scopus)

Erratum: The tumour-suppressor scribble dictates cell polarity during directed epithelial migration: Regulation of Rho GTPase recruitment to the leading edge (Oncogene (2007) 26, (2272-2282) DOI: 10.1038/sj.onc.1210639)

Dow, L. E., Kauffman, J. S., Caddy, J., Zarbalis, K., Peterson, A. S., Jane, S. M., Russell, S. M. & Humbert, P. O., Aug 16 2007, In : Oncogene. 26, 38, p. 5692 1 p.

Research output: Contribution to journalArticle

2005
318 Citations (Scopus)

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

May, S. R., Ashique, A. M., Karlen, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J., Ericson, J. & Peterson, A. S., Nov 15 2005, In : Developmental Biology. 287, 2, p. 378-389 12 p.

Research output: Contribution to journalArticle

Activator Appliances
Hedgehogs
Cilia
Signal Transduction
Organelles
2004
99 Citations (Scopus)

A focused and efficient genetic screening strategy in the mouse: Identification of mutations that disrupt cortical development

Zarbalis, K., May, S. R., Shen, Y., Ekker, M., Rubenstein, J. L. R. & Peterson, A. S., Aug 2004, In : PLoS Biology. 2, 8

Research output: Contribution to journalArticle

Genetic Testing
Interneurons
Cerebral Cortex
Screening
Alleles
54 Citations (Scopus)

Multiple Roles of Ephrins during the Formation of Thalamocortical Projections: Maps and More

Bolz, J., Uziel, D., Mühlfriedel, S., Güllmar, A., Peuckert, C., Zarbalis, K., Wurst, W., Torii, M. & Levitt, P., Apr 2004, In : Journal of Neurobiology. 59, 1, p. 82-94 13 p.

Research output: Contribution to journalArticle

Ephrins
Eph Family Receptors
Thalamus
Cerebral Cortex
Cues
2002
46 Citations (Scopus)

Miswiring of limbic thalamocortical projections in the absence of ephrin-A5

Uziel, D., Mühlfriedel, S., Zarbalis, K., Wurst, W., Levitt, P. & Bolz, J., Nov 1 2002, In : Journal of Neuroscience. 22, 21, p. 9352-9357 6 p.

Research output: Contribution to journalArticle

Ephrin-A5
Ephrins
Cues
Thalamic Nuclei
Lateral Thalamic Nuclei
2001
132 Citations (Scopus)

A role for the EphA family in the topographic targeting of vomeronasal axons

Knöll, B., Zarbalis, K., Wurst, W. & Drescher, U., 2001, In : Development. 128, 6, p. 895-906 12 p.

Research output: Contribution to journalArticle

Axons
Olfactory Bulb
Ephrin-A5
Laminin
Eph Family Receptors
2000
16 Citations (Scopus)

Expression domains of murine ephrin-A5 in the pituitary and hypothalamus

Zarbalis, K. & Wurst, W., May 1 2000, In : Mechanisms of Development. 93, 1-2, p. 165-168 4 p.

Research output: Contribution to journalArticle

Ephrin-A5
Ectoderm
Hypothalamus
Mesoderm
Ephrins
1996
2 Citations (Scopus)

Sequence analysis of the βB2-crystallin cDNA of hamster containing a domain conserved among vertebrates

Zarbalis, K., Chatterjee, B., Löster, J., Werner, T. & Graw, J., Sep 26 1996, In : Gene. 174, 1, p. 181-184 4 p.

Research output: Contribution to journalArticle

Crystallins
Cricetinae
Anura
Sequence Analysis
Vertebrates