• 8363 Citations
  • 40 h-Index
1986 …2020

Research output per year

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Research Output

  • 8363 Citations
  • 40 h-Index
  • 90 Article
  • 2 Review article
2020

A novel bioengineered miR-127 prodrug suppresses the growth and metastatic potential of triple-negative breast cancer cells

Umeh-Garcia, M., Simion, C., Ho, P. Y., Batra, N., Berg, A. L., Carraway, K. L., Yu, A. & Sweeney, C., Feb 1 2020, In : Cancer Research. 80, 3, p. 418-429 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer

Saldana, M., VanderVorst, K., Berg, A. L., Lee, H. & Carraway, K. L., Jan 1 2019, In : Endocrine-Related Cancer. 26, 1, p. R1-R14

Research output: Contribution to journalReview article

10 Scopus citations

Wnt/PCP signaling contribution to carcinoma collective cell migration and metastasis

VanderVorst, K., Dreyer, C. A., Konopelski, S. E., Lee, H., Ho, H-Y. H. & Carraway, K. L., Apr 15 2019, In : Cancer Research. 79, 8, p. 1719-1729 11 p.

Research output: Contribution to journalReview article

8 Scopus citations
2018

Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer

Rowson-Hodel, A. R., Wald, J. H., Hatakeyama, J., O'Neal, W. K., Stonebraker, J. R., VanderVorst, K., Saldana, M. J., Borowsky, A. D., Sweeney, C. A. & Carraway, K. L., Jan 11 2018, In : Oncogene. 37, 2, p. 197-207 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Single-Molecule Fluorescence Detection of the Epidermal Growth Factor Receptor in Membrane Discs

Quinn, S. D., Srinivasan, S., Gordon, J. B., He, W., Carraway, K. L., Coleman, M. A. & Schlau-Cohen, G. S., Jan 1 2018, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy

VanderVorst, K., Hatakeyama, J., Berg, A., Lee, H. & Carraway, K. L., 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

7 Scopus citations

Replication study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Reproducibility Project: Cancer Biology, Jun 27 2017, In : eLife. 6, e26030.

Research output: Contribution to journalArticle

10 Scopus citations

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination

Wald, J. H., Hatakeyama, J., Printsev, I., Cuevas, A., Fry, W. H. D., Saldana, M. J., Vandervorst, K., Rowson-Hodel, A., Angelastro, J. M., Sweeney, C. A. & Carraway, K. L., Sep 7 2017, In : Oncogene. 36, 36, p. 5158-5167 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system

Scharadin, T. M., He, W., Yiannakou, Y., Tomilov, A., Saldana, M., Cortopassi, G. A., Carraway, K. L., Coleman, M. A. & Henderson, P., Jun 1 2017, In : PLoS One. 12, 6, 0177761.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells

Rowson-Hodel, A. R., Berg, A. L., Wald, J. H., Hatakeyama, J., VanderVorst, K., Curiel, D. A., Leon, L. J., Sweeney, C. A. & Carraway, K. L., May 28 2016, In : Cancer Letters. 375, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

LRIG1 opposes epithelial-To-mesenchymal transition and inhibits invasion of basal-like breast cancer cells

Yokdang, N., Hatakeyama, J., Wald, J. H., Simion, C., Tellez, J. D., Chang, D. Z., Swamynathan, M. M., Chen, M., Murphy, W. J., Carraway, K. L. & Sweeney, C. A., Jun 2 2016, In : Oncogene. 35, 22, p. 2932-2947 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Membrane Protein Quantity Control at the Endoplasmic Reticulum

Printsev, I., Curiel, D. & Carraway, K. L., Oct 14 2016, (Accepted/In press) In : Journal of Membrane Biology. p. 1-14 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer

Amir, S., Simion, C., Umeh-Garcia, M., Krig, S., Moss, T., Carraway, K. L. & Sweeney, C. A., May 10 2016, In : British Journal of Cancer. 114, 10, p. 1125-1134 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Hatakeyama, J., Wald, J. H., Rafidi, H., Cuevas, A., Sweeney, C. A. & Carraway, K. L., Jun 28 2016, In : Science Signaling. 9, 434, ra65.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Cell-free expression of functional receptor tyrosine kinases

He, W., Scharadin, T. M., Saldana, M., Gellner, C., Hoang-Phou, S., Takanishi, C., Hura, G. L., Tainer, J. A., Carraway, K. L., Henderson, P. & Coleman, M. A., Aug 14 2015, In : Scientific Reports. 5, 12896.

Research output: Contribution to journalArticle

15 Scopus citations

Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer

Savoy, R. M., Chen, L., Siddiqui, S., Melgoza, F. U., Durbin-Johnson, B., Drake, C., Jathal, M. K., Bose, S., Steele, T. M., Mooso, B. A., D'Abronzo, L. S., Fry, W. H., Carraway, K. L., Mudryj, M. & Ghosh, P. M., Jun 1 2015, In : Endocrine-Related Cancer. 22, 3, p. 369-386 18 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Novel sorafenib-based structural analogues: In-vitro anticancer evaluation of t-MTUCB and t-AUCMB

Wecksler, A. T., Hwang, S. H., Wettersten, H. I., Gilda, J. E., Patton, A., Leon, L. J., Carraway, K. L., Gomes, A. V., Baar, K., Weiss, R. H. & Hammock, B. D., 2014, In : Anti-Cancer Drugs. 25, 4, p. 433-446 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination

Printsev, I., Yen, L., Sweeney, C. A. & Carraway, K. L., Mar 21 2014, In : Journal of Biological Chemistry. 289, 12, p. 8570-8578 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Vangl1 and Vangl2: Planar cell polarity components with a developing role in cancer

Hatakeyama, J., Wald, J. H., Printsev, I., Ho, H-Y. H. & Carraway, K. L., Oct 1 2014, In : Endocrine-Related Cancer. 21, 5, p. 345-356 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013
31 Scopus citations

A Cell-Permeant Amiloride Derivative Induces Caspase-Independent, AIF-Mediated Programmed Necrotic Death of Breast Cancer Cells

Leon, L. J., Pasupuleti, N., Gorin, F. A. & Carraway, K. L., Apr 30 2013, In : PLoS One. 8, 4, e63038.

Research output: Contribution to journalArticle

17 Scopus citations

CTEN prolongs signaling by egfr through reducing its ligand-induced degradation

Hong, S. Y., Shih, Y. P., Li, T., Carraway, K. L. & Lo, S. H., Aug 15 2013, In : Cancer Research. 73, 16, p. 5266-5276 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
22 Scopus citations
2012

Galectin-3 regulates intracellular trafficking of EGFR through alix and promotes keratinocyte migration

Liu, W., Hsu, D. K., Chen, H. Y., Yang, R. Y., Carraway, K. L., Isseroff, R. R. & Liu, F-T., Dec 2012, In : Journal of Investigative Dermatology. 132, 12, p. 2828-2837 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2011

Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer

Krig, S. R., Frietze, S., Simion, C., Miller, J. K., Fry, W. H. D., Rafidi, H., Kotelawala, L., Qi, L., Griffith, O. L., Gray, J. W., Carraway, K. L. & Sweeney, C. A., Oct 2011, In : Molecular Cancer Research. 9, 10, p. 1406-1417 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

MUC1 and MUC4: Switching the emphasis from large to small

Albrecht, H. & Carraway, K. L., Jun 1 2011, In : Cancer Biotherapy and Radiopharmaceuticals. 26, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum

Fry, W. H. D., Simion, C., Sweeney, C. A. & Carraway, K. L., Jul 2011, In : Molecular and Cellular Biology. 31, 14, p. 3009-3018 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2010

Diacylglycerol kinase δ and protein kinase Cα modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8

Cai, J., Crotty, T. M., Reichert, E., Carraway, K. L., Stafforini, D. M. & Topham, M. K., Mar 5 2010, In : Journal of Biological Chemistry. 285, 10, p. 6952-6959 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

Harley, W., Floyd, C., Dunn, T., Zhang, X. D., Chen, T. Y., Hegde, M., Palandoken, H., Nantz, M. H., Leon, L., Carraway, K. L., Lyeth, B. & Gorin, F. A., Dec 6 2010, In : Brain Research. 1363, p. 159-169 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

E3 ubiquitin ligases in ErbB receptor quantity control

Carraway, K. L., Dec 2010, In : Seminars in Cell and Developmental Biology. 21, 9, p. 936-943 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells

Chen, L., Siddiqui, S., Bose, S., Mooso, B., Asuncion, A., Bedolla, R. G., Vinall, R. L., Tepper, C. G., Gandour-Edwards, R. F., Shi, X., Lu, X. H., Siddiqui, J., Chinnaiyan, A. M., Mehra, R., deVere White, R. W., Carraway, K. L. & Ghosh, P. M., Jul 15 2010, In : Cancer Research. 70, 14, p. 5994-6003 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors

Ingalla, E. Q., Miller, J. K., Wald, J. H., Workman, H. C., Kaur, R. P., Yen, L., Fry, W. H. D., Borowsky, A. D., Young, L. J. T., Sweeney, C. A. & Carraway, K. L., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28691-28697 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2009

Mechanisms of ErbB receptor negative regulation and relevance in cancer

Fry, W. H. D., Kotelawala, L., Sweeney, C. A. & Carraway, K. L., Feb 15 2009, In : Experimental Cell Research. 315, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

The membrane mucin Muc4 inhibits apoptosis Induced by Multiple insults via ErbB2-dependent and ErbB2-independent mechanisms

Workman, H. C., Sweeney, C. A. & Carraway, K. L., Apr 1 2009, In : Cancer Research. 69, 7, p. 2845-2852 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells

Workman, H. C., Miller, J. K., Ingalla, E. Q., Kaur, R. P., Yamamoto, D. I., Beckett, L. A., Young, L. J. T., Cardiff, R. D., Borowsky, A. D., Carraway, K. L., Sweeney, C. & Carraway, K. L., Sep 18 2009, In : Breast Cancer Research. 11, 5, R70.

Research output: Contribution to journalArticle

31 Scopus citations
2008

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

Stutz, M. A., Shattuck, D. L., Laederich, M. B., Carraway, K. L. & Sweeney, C. A., Sep 25 2008, In : Oncogene. 27, 43, p. 5741-5752 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells

Shattuck, D. L., Miller, J. K., Carraway, K. L. & Sweeney, C. A., Mar 1 2008, In : Cancer Research. 68, 5, p. 1471-1477 7 p.

Research output: Contribution to journalArticle

290 Scopus citations

Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer

Miller, J. K., Shattuck, D. L., Ingalla, E. Q., Yen, L., Borowsky, A. D., Young, L. J. T., Cardiff, R., Carraway, K. L. & Sweeney, C. A., Oct 15 2008, In : Cancer Research. 68, 20, p. 8286-8294 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
2007
65 Scopus citations

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

Shattuck, D. L., Miller, J. K., Laederich, M., Funes, M., Petersen, H., Carraway, K. L. & Sweeney, C. A., Mar 2007, In : Molecular and Cellular Biology. 27, 5, p. 1934-1946 13 p.

Research output: Contribution to journalArticle

97 Scopus citations

Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Cao, Z., Wu, X., Yen, L., Sweeney, C. A. & Carraway, K. L., Mar 2007, In : Molecular and Cellular Biology. 27, 6, p. 2180-2188 9 p.

Research output: Contribution to journalArticle

91 Scopus citations
2006

Co-opted integrin signaling in ErbB2-induced mammary tumor progression

Carraway, K. L. & Sweeney, C. A., Aug 2006, In : Cancer Cell. 10, 2, p. 93-95 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

ErbB receptor negative regulatory mechanisms: Implications in cancer

Sweeney, C. A., Miller, J. K., Shattuck, D. L. & Carraway, K. L., Jan 2006, In : Journal of Mammary Gland Biology and Neoplasia. 11, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification of 14-3-3ε substrates from embryonic murine brain

Ballif, B. A., Cao, Z., Schwartz, D., Carraway, K. L. & Gygi, S. P., Sep 2006, In : Journal of Proteome Research. 5, 9, p. 2372-2379 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth

Yen, L., Cao, Z., Wu, X., Ingalla, E. R. Q., Baron, C., Young, L. J. T., Gregg, J., Cardiff, R., Borowsky, A. D., Sweeney, C. A. & Carraway, K. L., Dec 1 2006, In : Cancer Research. 66, 23, p. 11279-11286 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3

Funes, M., Miller, J. K., Lai, C., Carraway, K. L. & Sweeney, C. A., Jul 14 2006, In : Journal of Biological Chemistry. 281, 28, p. 19310-19319 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
2004

Erratum: The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases (The Journal of Biological Chemistry (2004) 279 (47050-47056))

Laederich, M. B., Funes-Duran, M., Yen, L., Ingalla, E., Wu, X., Carraway, K. L. & Sweeney, C., Dec 10 2004, In : Journal of Biological Chemistry. 279, 50, p. 52806 1 p.

Research output: Contribution to journalArticle

Negative regulation of ErbB family receptor tyrosine kinases

Sweeney, C. A. & Carraway, K. L., Jan 26 2004, In : British Journal of Cancer. 90, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8

Wu, X., Yen, L., Irwin, L., Sweeney, C. A. & Carraway, K. L., Sep 2004, In : Molecular and Cellular Biology. 24, 17, p. 7748-7757 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

Laederich, M. B., Funes-Duran, M., Yen, L., Ingalla, E., Wu, X., Carraway, K. L. & Sweeney, C. A., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47050-47056 7 p.

Research output: Contribution to journalArticle

164 Scopus citations