Jonathan Widdicombe, PhD

Professor Emeritus

  • 6597 Citations
  • 45 h-Index
1974 …2019

Research output per year

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Research Output

  • 6597 Citations
  • 45 h-Index
  • 161 Article
  • 7 Chapter
  • 1 Conference contribution
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Article
2019

Early studies of airway submucosal glands

Widdicombe, J., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L990-L998

Research output: Contribution to journalArticle

2015

Airway gland structure and function

Widdicombe, J. & Wine, J. J., Sep 2 2015, In : Physiological Reviews. 95, 4, p. 1241-1319 79 p.

Research output: Contribution to journalArticle

64 Scopus citations
2013

Distribution and size of mucous glands in the ferret tracheobronchial tree

Hajighasemi-Ossareh, M., Borthwell, R. M., Stevens, J. E., Finkbeiner, W. E. & Widdicombe, J., Nov 2013, In : Anatomical Record. 296, 11, p. 1768-1774 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

A simple device to illustrate the Einthoven triangle

Jin, B. E., Wulff, H., Widdicombe, J., Zheng, J., Bers, D. M. & Puglisi, J. L., Dec 2012, In : American Journal of Physiology - Advances in Physiology Education. 36, 4, p. 319-324 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chloride secretion by cultures of pig tracheal gland cells

Widdicombe, J., Borthwell, R. M., Hajighasemi-Ossareh, M., Lachowicz-Scroggins, M. E., Finkbeiner, W. E., Stevens, J. E. & Modlin, S., May 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 10

Research output: Contribution to journalArticle

1 Scopus citations

Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells

Rajagopal, M., Kathpalia, P. P., Widdicombe, J. & Pao, A. C., Aug 15 2012, In : American Journal of Physiology - Renal Physiology. 303, 4

Research output: Contribution to journalArticle

14 Scopus citations
2011

Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells

Finkbeiner, W. E., Zlock, L. T., Morikawa, M., Lao, A. Y., Dasari, V. & Widdicombe, J., Oct 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4

Research output: Contribution to journalArticle

15 Scopus citations

Quantitative real-time PCR for rhinovirus, and its use in determining the relationship between TCID50 and the number of viral particles

Sachs, L. A., Schnurr, D., Yagi, S., Lachowicz-Scroggins, M. E. & Widdicombe, J., Jan 2011, In : Journal of Virological Methods. 171, 1, p. 212-218 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010
31 Scopus citations

Cultures of human tracheal gland cells of mucous or serous phenotype

Finkbeiner, W. E., Zlock, L. T., Mehdi, I. & Widdicombe, J., May 2010, In : In Vitro Cellular and Developmental Biology - Animal. 46, 5, p. 450-456 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection

Lachowicz-Scroggins, M. E., Boushey, H. A., Finkbeiner, W. E. & Widdicombe, J., Dec 1 2010, In : American Journal of Respiratory Cell and Molecular Biology. 43, 6, p. 652-661 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Transgenic animals may help resolve a sticky situation in cystic fibrosis

Widdicombe, J., Sep 1 2010, In : Journal of Clinical Investigation. 120, 9, p. 3093-3096 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects

Lopez-Souza, N., Favoreto, S., Wong, H., Ward, T., Yagi, S., Schnurr, D., Finkbeiner, W. E., Dolganov, G. M., Widdicombe, J., Boushey, H. A. & Avila, P. C., Jun 2009, In : Journal of Allergy and Clinical Immunology. 123, 6

Research output: Contribution to journalArticle

140 Scopus citations
2008
9 Scopus citations
2007

Basolateral Cl channels in primary airway epithelial cultures

Fischer, H., Illek, B., Finkbeiner, W. E. & Widdicombe, J., Jun 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 6

Research output: Contribution to journalArticle

32 Scopus citations
2006

Differentiated structure and function of primary cultures of monkey oviductal epithelium

Rajagopal, M., Tollner, T. L., Finkbeiner, W. E., Cherr, G. N. & Widdicombe, J., Sep 2006, In : In Vitro Cellular and Developmental Biology - Animal. 42, 8-9, p. 248-254 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
47 Scopus citations

Mechanisms of acid and base secretion by the airway epithelium

Fischer, H. & Widdicombe, J., May 2006, In : Journal of Membrane Biology. 211, 3, p. 139-150 12 p.

Research output: Contribution to journalArticle

109 Scopus citations
2005

Are Drosophila a useful model for understanding the toxicity of inhaled oxidative pollutants: A review

Wilson, M., Widdicombe, J., Gohil, K., Burtis, K. C., Reznick, A. Z., Cross, C. E. & Eiserich, J. P., Dec 1 2005, In : Inhalation Toxicology. 17, 13, p. 765-774 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function

Widdicombe, J., Sachs, L. A., Morrow, J. L. & Finkbeiner, W. E., 2005, In : BioTechniques. 39, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia

Moody, M., Pennington, C., Schultz, C., Caldwell, R., Dinkel, C., Rossi, M. W., McNamara, S., Widdicombe, J., Gabriel, S. & Traynor-Kaplan, A. E., Sep 2005, In : American Journal of Physiology - Cell Physiology. 289, 3 58-3

Research output: Contribution to journalArticle

17 Scopus citations
2004
14 Scopus citations

A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells

Fischer, H., Machen, T. E., Widdicombe, J., Carlson, T. J. S., King, S. R., Chow, J. W. S. & Illek, B., Aug 2004, In : Journal of Ethnopharmacology. 93, 2-3, p. 351-357 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
10 Scopus citations

Resistance of differentiated human airway epithelium to infection by rhinovirus

Lopez-Souza, N., Dolganov, G., Dubin, R., Sachs, L. A., Sassina, L., Sporer, H., Yagi, S., Schnurr, D., Boushey, H. A. & Widdicombe, J., Feb 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 2 30-2

Research output: Contribution to journalArticle

84 Scopus citations

Secretion of lactoferrin and lysozyme by cultures of human airway epithelium

Dubin, R. F., Robinson, S. K. & Widdicombe, J., Apr 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 4 30-4

Research output: Contribution to journalArticle

53 Scopus citations
2003

Effects of growth surface on differentiation of cultures of human tracheal epithelium

Widdicombe, J., Sachs, L. A. & Finkbeiner, W. E., Jan 2003, In : In Vitro Cellular and Developmental Biology - Animal. 39, 1-2, p. 51-55 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Effects of media on differentiation of cultured human tracheal epithelium

Sachs, L. A., Finkbeiner, W. E. & Widdicombe, J., Jan 2003, In : In Vitro Cellular and Developmental Biology - Animal. 39, 1-2, p. 56-62 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Measurement of nasal potential difference in mild asthmatics

Chung, N. C., Illek, B., Widdicombe, J. & Fischer, H., May 1 2003, In : Chest. 123, 5, p. 1467-1471 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Polarized cultures of human airway epithelium from nasal scrapings and bronchial brushings

Lopez-Souza, N., Avila, P. C. & Widdicombe, J., Jul 2003, In : In Vitro Cellular and Developmental Biology - Animal. 39, 7, p. 266-269 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

Acid secretion and proton conductance in human airway epithelium

Fischer, H., Widdicombe, J. & Illek, B., 2002, In : American Journal of Physiology - Cell Physiology. 282, 4 51-4

Research output: Contribution to journalArticle

75 Scopus citations
178 Scopus citations

Alveolarepithel typ I ist aktiv an alveolärer flüssigkeits-resorption beteiligt

Translated title of the contribution: Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasisJohnson, M. D., Widdicombe, J., Allen, L., Barbry, P., Dobbs, L. G. & Kohstall, M., 2002, In : Pneumologie. 56, 7, p. 457 1 p.

Research output: Contribution to journalArticle

Distribution and numbers of mucous glands in the horse trachea

Widdicombe, J. & Pecson, I. S., Sep 2002, In : Equine Veterinary Journal. 34, 6, p. 630-633 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Estimate of the subepithelial hydrostatic pressure that drives inflammatory transudate into the airway lumen

Serikov, V. B., Jang, Y. J. & Widdicombe, J., 2002, In : Journal of Applied Physiology. 92, 4, p. 1702-1708 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of the depth and composition of airway surface liquid

Widdicombe, J., Oct 1 2002, In : Journal of Anatomy. 201, 4, p. 313-318 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Volume of airway surface liquid in health and disease [1]

Widdicombe, J., Jun 1 2002, In : American Journal of Respiratory and Critical Care Medicine. 165, 11, p. 1566 1 p.

Research output: Contribution to journalArticle

14 Scopus citations
2001
9 Scopus citations

Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit

Widdicombe, J., Chen, L. L. K., Sporer, H., Choi, H. K., Pecson, I. S. & Bastacky, S. J., 2001, In : Journal of Anatomy. 198, 2, p. 207-221 15 p.

Research output: Contribution to journalArticle

51 Scopus citations
2000

A comparative study of mammalian tracheal mucous glands

Choi, H. K., Finkbeiner, W. E. & Widdicombe, J., 2000, In : Journal of Anatomy. 197, 3, p. 361-372 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
17 Scopus citations
1999

Hepatocyte growth factor inhibits amiloride-sensitive Na+ channel function in cystic fibrosis airway epithelium in vitro

Shen, B. Q., Widdicombe, J. & Mrsny, R. J., Jun 1999, In : Pulmonary Pharmacology and Therapeutics. 12, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of CFTR chlorid channels alters salt absorption by cystic fibrosis airway epithelia in vitro

Zabner, J., Smith, J. J., Karp, P. H., Widdicombe, J. H. & Welsh, M. J., 1999, In : Pneumologie. 53, 9

Research output: Contribution to journalArticle

Restoration of cyclic adenosine monophosphate-stimulated chloride channel activity in human cystic fibrosis tracheobronchial submucosal gland cells by adenovirus-mediated and cationic lipid-mediated gene transfer

Jiang, C., Finkbeiner, W. E., Widdicombe, J. H., Fang, S. L., Wang, K. X., Nietupski, J. B., Hehir, K. M. & Cheng, S. H., 1999, In : American Journal of Respiratory Cell and Molecular Biology. 20, 6, p. 1107-1115 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
1998

CAMP-dependent absorption of chloride across airway epithelium

Widdicombe, J., 1998, In : American Journal of Physiology. 275, 6 PART 1

Research output: Contribution to journalArticle

1 Scopus citations

CAMP-dependent absorption of chloride across airway epithelium

Uyekubo, S. N., Fischer, H., Maminishkis, A., Illek, B., Miller, S. S. & Widdicombe, J., 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 6 19-6

Research output: Contribution to journalArticle

36 Scopus citations

Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes

Zhang, L., Wang, D., Fischer, H., Fan, P. D., Widdicombe, J., Kan, Y. W. & Dong, J. Y., Aug 18 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 17, p. 10158-10163 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Evidence that Calu-3 human airway cells secrete bicarbonate

Lee, M. C., Penland, C. M., Widdicombe, J. & Wine, J. J., Mar 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 274, 3 18-3

Research output: Contribution to journalArticle

73 Scopus citations

Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro

Zabner, J., Smith, J. J., Karp, P. H., Widdicombe, J. & Welsh, M. J., Sep 1998, In : Molecular Cell. 2, 3, p. 397-403 7 p.

Research output: Contribution to journalArticle

184 Scopus citations