• 2668 Citations
  • 28 h-Index
1976 …2021
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Research Output 1996 2019

  • 2668 Citations
  • 28 h-Index
  • 87 Article
  • 3 Chapter
2019
1 Citation (Scopus)

The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle

Gutiérrez-Casado, E., Khraiwesh, H., López-Domínguez, J. A., Montero-Guisado, J., López-Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., González-Reyes, J. A. & Villalba, J. M., May 16 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 6, p. 760-769 10 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Dietary Fats
Autophagy
Skeletal Muscle
Soybean Oil
2018
3 Citations (Scopus)

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Roberts, M. N., Wallace, M. A., Tomilov, A. A., Zhou, Z., Marcotte, G. R., Tran, D., Perez, G., Gutierrez-Casado, E., Koike, S., Knotts, T. A., Imai, D. M., Griffey, S. M., Kim, K., Hagopian, K., McMackin, M. Z., Haj, F. G., Baar, K., Cortopassi, G. A., Ramsey, J. J. & Lopez-Dominguez, J. A., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Ketogenic Diet
Manuscripts
Students

Estimated heat production, blood parameters and mitochondrial DNA copy number of Nellore bulls (Bos indicus) with high and low residual feed intake

Baldassini, W. A., Ramsey, J. J., Branco, R. H., Bonilha, S. F. M., Chiaratti, M. R., Chaves, A. S. & Lanna, D. P. D., Nov 1 2018, In : Livestock Science. 217, p. 140-147 8 p.

Research output: Contribution to journalArticle

Thermogenesis
Nellore
zebu
heat production
Mitochondrial DNA
Dairies
Oxygen Consumption
Liver
Protons
Respiration
2 Citations (Scopus)

MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome

Vogel Ciernia, A., Yasui, D. H., Pride, M. C., Durbin-Johnson, B., Noronha, A. B., Chang, A., Knotts, T. A., Rutkowsky, J. R., Ramsey, J. J., Crawley, J. & LaSalle, J. M., Dec 1 2018, In : Human Molecular Genetics. 27, 23, p. 4077-4093 17 p.

Research output: Contribution to journalArticle

Rett Syndrome
Protein Isoforms
Phenotype
Exons
Mutation
2017
60 Citations (Scopus)

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Roberts, M. N., Wallace, M. A., Tomilov, A., Zhou, Z., Marcotte, G. R., Tran, D., Perez, G., Gutierrez-Casado, E., Koike, S., Knotts, T. A., Imai, D., Griffey, S. M., Kim, K., Hagopian, K., Haj, F., Baar, K., Cortopassi, G. A., Ramsey, J. J. & Lopez-Dominguez, J. A., Sep 5 2017, In : Cell Metabolism. 26, 3, p. 539-546.e5

Research output: Contribution to journalArticle

Ketogenic Diet
Carbohydrate-Restricted Diet
Diet
Glycolysis
Acetylation
3 Citations (Scopus)

Effects of obesity, energy restriction and neutering on the faecal microbiota of cats

Fischer, M. M., Kessler, A. M., Kieffer, D. A., Knotts, T. A., Kim, K., Wei, A., Ramsey, J. J. & Fascetti, A. J., Sep 29 2017, (Accepted/In press) In : British Journal of Nutrition. p. 1-12 12 p.

Research output: Contribution to journalArticle

Microbiota
Cats
Obesity
Weight Loss
Sarcina
2 Citations (Scopus)
Manganese
Oxygen Consumption
oxygen consumption
protons
manganese

The influence of Shc proteins and high-fat diet on energy metabolism of mice

Baldassini, W. A., Ramsey, J. J., Hagopian, K. & Lanna, D. P. D., Dec 1 2017, In : Cell Biochemistry and Function. 35, 8, p. 527-537 11 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Energy Metabolism
Fats
Citric Acid Cycle
2016
7 Citations (Scopus)

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice

Calvo-Rubio, M., Burón, M. I., López-Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Villalba, J. M. & González-Reyes, J. A., Jun 1 2016, In : Aging Cell. 15, 3, p. 477-487 11 p.

Research output: Contribution to journalArticle

Dietary Fats
Kidney
Rodentia
Glomerular Basement Membrane
Soybean Oil
1 Citation (Scopus)

Lack of glucuronidation products of trans-resveratrol in plasma and urine of cats

Burnett, K., Puschner, B., Ramsey, J. J., Lin, Y., Wei, A. & Fascetti, A. J., 2016, (Accepted/In press) In : Journal of Animal Physiology and Animal Nutrition.

Research output: Contribution to journalArticle

resveratrol
Cats
urine
Urine
cats
Coccidiosis
coccidiosis
Oxygen Consumption
oxygen consumption
protons
1 Citation (Scopus)
Liver
Proteins
Gluconeogenesis
Metabolism
Insulin Receptor
2 Citations (Scopus)

Omega-3 fatty acids partially revert the metabolic gene expression profile induced by long-term calorie restriction

López-Domínguez, J. A., Cánovas, Á., Medrano, J. F., Islas-Trejo, A., Kim, K., Taylor, S. L., Villalba, J. M., López-Lluch, G., Navas, P. & Ramsey, J. J., May 1 2016, In : Experimental Gerontology. 77, p. 29-37 9 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Nutrition
Transcriptome
Gene expression
Fish Oils
6 Citations (Scopus)

p46Shc inhibits thiolase and lipid oxidation in mitochondria

Tomilov, A., Tomilova, N., Shan, Y., Hagopian, K., Bettaieb, A., Kim, K., Pelicci, P. G., Haj, F., Ramsey, J. J. & Cortopassi, G. A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12575-12585 11 p.

Research output: Contribution to journalArticle

Mitochondria
Lipids
Oxidation
Enzymes
Energy Metabolism
2015
1 Citation (Scopus)

Conducting indirect calorimetry studies in companion animals

Gooding, M. A., McKnight, L. L., Ramsey, J. J. & Shoveller, A. K., Jan 1 2015, Indirect Calorimetry: Techniques, Computations and Applications. Wageningen Academic Publishers, p. 247-274 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Indirect Calorimetry
Acclimatization
Pets
calorimetry
Calorimetry
10 Citations (Scopus)

Dietary fat and aging modulate apoptotic signaling in liver of calorie-restricted mice

López-Domínguez, J. A., Khraiwesh, H., González-Reyes, J. A., López-Lluch, G., Navas, P., Ramsey, J. J., De Cabo, R., Burón, M. I. & Villalba, J. M., Apr 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 4, p. 399-409 11 p.

Research output: Contribution to journalArticle

Dietary Fats
Caspase 9
Fats
Liver
Apoptosis Inducing Factor
8 Citations (Scopus)
Phosphofructokinase-1
Enzyme activity
Muscle
skeletal muscle
Skeletal Muscle
8 Citations (Scopus)

The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice

Villalba, J. M., López-Domínguez, J. A., Chen, Y., Khraiwesh, H., González-Reyes, J. A., del Río, L. F., Gutiérrez-Casado, E., del Río, M., Calvo-Rubio, M., Ariza, J., de Cabo, R., López-Lluch, G., Navas, P., Hagopian, K., Burón, M. I. & Ramsey, J. J., Oct 31 2015, In : Biogerontology. 16, 5, p. 655-670 16 p.

Research output: Contribution to journalArticle

Dietary Fats
Skeletal Muscle
Monounsaturated Fatty Acids
Fatty Acids
Membranes
2014
12 Citations (Scopus)

Early effects of neutering on energy expenditure in adult male cats

Wei, A., Fascetti, A. J., Kim, K., Lee, A., Graham, J. L., Havel, P. J. & Ramsey, J. J., Feb 26 2014, In : PLoS One. 9, 2, e89557.

Research output: Contribution to journalArticle

castration
energy expenditure
Energy Metabolism
Cats
cats
5 Citations (Scopus)
Dietary Proteins
Body Composition
energy expenditure
Energy Metabolism
dietary protein
4 Citations (Scopus)

Mitochondria in health and disease

Magalhães, J., Venditti, P., Adhihetty, P. J., Ramsey, J. J. & Ascensão, A., 2014, In : Oxidative Medicine and Cellular Longevity. 2014, 814042.

Research output: Contribution to journalArticle

Mitochondria
Animals
Health
Oxidation-Reduction
14 Citations (Scopus)

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

Khraiwesh, H., López-Domínguez, J. A., Fernández del Río, L., Gutierrez-Casado, E., López-Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Burón, M. I., Villalba, J. M. & González-Reyes, J. A., 2014, In : Experimental Gerontology. 56, p. 77-88 12 p.

Research output: Contribution to journalArticle

Dietary Fats
Hepatocytes
Mitochondria
Fusion reactions
Mitochondrial Dynamics
10 Citations (Scopus)

Shc depletion stimulates brown fat activity in vivo and in vitro

Tomilov, A., Bettaieb, A., Kim, K., Sahdeo, S., Tomilova, N., Lam, A., Hagopian, K., Connell, M., Fong, J., Rowland, D., Griffey, S. M., Ramsey, J. J., Haj, F. & Cortopassi, G. A., Dec 1 2014, In : Aging Cell. 13, 6, p. 1049-1058 10 p.

Research output: Contribution to journalArticle

Brown Adipose Tissue
Energy Metabolism
Insulin Resistance
Obesity
In Vitro Techniques
19 Citations (Scopus)

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

López-Domínguez, J. A., Ramsey, J. J., Tran, D., Imai, D., Koehne, A., Laing, S. T., Griffey, S. M., Kim, K., Taylor, S. L., Hagopian, K., Villalba, J. M., López-Lluch, G., Navas, P. & McDonald, R. B., Nov 19 2014, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 10, p. 1181-1188 8 p.

Research output: Contribution to journalArticle

Dietary Fats
Unsaturated Fatty Acids
Omega-3 Fatty Acids
Phospholipids
Fatty Acids
9 Citations (Scopus)

The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction

Chen, Y., Hagopian, K., Bibus, D., Villalba, J. M., López-Lluch, G., Navas, P., Kim, K. & Ramsey, J. J., 2014, In : Physiological Research. 63, 1, p. 57-71 15 p.

Research output: Contribution to journalArticle

Muscle Mitochondrion
Reactive Oxygen Species
Skeletal Muscle
Lipids
Protons
2013
25 Citations (Scopus)

Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats

Khraiwesh, H., López-Domínguez, J. A., López-Lluch, G., Navas, P., De Cabo, R., Ramsey, J. J., Villalba, J. M. & González-Reyes, J. A., Sep 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 9, p. 1023-1034 12 p.

Research output: Contribution to journalArticle

Dietary Fats
Hepatocytes
Mitochondria
Mitochondrial Dynamics
Mitochondrial Size
5 Citations (Scopus)

Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations

Hagopian, K., Soo Hoo, R., López-Domínguez, J. A. & Ramsey, J. J., Dec 5 2013, In : Life Sciences. 93, 24, p. 941-948 8 p.

Research output: Contribution to journalArticle

Enzyme activity
Liver
Mitochondria
Enzymes
Population
5 Citations (Scopus)

Determining Energy Requirements

Ramsey, J. J., Aug 23 2013, Applied Veterinary Clinical Nutrition. Wiley Blackwell, p. 23-45 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

energy requirements
11 Citations (Scopus)

Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorierestricted mice

López-Domínguez, J. A., Khraiwesh, H., González-Reyes, J. A., López-Lluch, G., Navas, P., Ramsey, J. J., De Cabo, R., Burón, M. I. & Villalba, J. M., Dec 2013, In : Age. 35, 6, p. 2027-2044 18 p.

Research output: Contribution to journalArticle

Dietary Fats
Mitochondrial Membranes
Skeletal Muscle
Caspase 10
Cell Membrane
19 Citations (Scopus)

The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction

Chen, Y., Hagopian, K., Bibus, D., Villalba, J. M., Opez-Lluch, G. L., Navas, P., Kim, K., McDonald, R. B. & Ramsey, J. J., Feb 2013, In : Bioscience Reports. 33, 1, p. 83-95 13 p., A9.

Research output: Contribution to journalArticle

Mitochondria
Liver Mitochondrion
Liver
Protons
Lipids
2012
28 Citations (Scopus)

Hepatic Src homology phosphatase 2 regulates energy balance in mice

Nagata, N., Matsuo, K., Bettaieb, A., Bakke, J., Matsuo, I., Graham, J., Xi, Y., Liu, S., Tomilov, A., Tomilova, N., Gray, S., Jung, D. Y., Ramsey, J. J., Kim, J. K., Cortopassi, G. A., Havel, P. J. & Haj, F., Jul 2012, In : Endocrinology. 153, 7, p. 3158-3169 12 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Liver
High Fat Diet
Lipid Metabolism
Energy Metabolism
8 Citations (Scopus)

Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis

Hagopian, K., Tomilov, A., Tomilova, N., Kim, K., Taylor, S. L., Lam, A. K., Cortopassi, G. A., McDonald, R. B. & Ramsey, J. J., Dec 2012, In : Metabolism: Clinical and Experimental. 61, 12, p. 1703-1713 11 p.

Research output: Contribution to journalArticle

Fatty Acids
Enzymes
Proteins
Acetyl-CoA C-Acetyltransferase
Hydroxybutyrate Dehydrogenase
3 Citations (Scopus)

The influence of acute, late-life calorie restriction on whole body energy metabolism in p66Shc(-/-) mice

Stern, J. H., Kim, K. & Ramsey, J. J., Jun 2012, In : Mechanisms of Ageing and Development. 133, 6, p. 414-420 7 p.

Research output: Contribution to journalArticle

Energy Metabolism
Indirect Calorimetry
Body Weight
Calorimetry
High Fat Diet
22 Citations (Scopus)

The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction

Chen, Y., Hagopian, K., McDonald, R. B., Bibus, D., López-Lluch, G., Villalba, J. M., Navas, P. & Ramsey, J. J., Nov 2012, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 67, 11, p. 1121-1131 11 p.

Research output: Contribution to journalArticle

Muscle Mitochondrion
Protons
Skeletal Muscle
Mitochondrial Membranes
Lipids
4 Citations (Scopus)

The Influence of Shc Proteins and Aging on Whole Body Energy Expenditure and Substrate Utilization in Mice

Stern, J. H., Kim, K. & Ramsey, J. J., Nov 7 2012, In : PLoS One. 7, 11, e48790.

Research output: Contribution to journalArticle

energy expenditure
Energy Metabolism
Aging of materials
mice
Substrates
52 Citations (Scopus)

The p66 Shc knocked out mice are short lived under natural condition

Giorgio, M., Berry, A., Berniakovich, I., Poletaeva, I., Trinei, M., Stendardo, M., Hagopian, K., Ramsey, J. J., Cortopassi, G. A., Migliaccio, E., Nötzli, S., Amrein, I., Lipp, H. P., Cirulli, F. & Pelicci, P. G., Feb 2012, In : Aging Cell. 11, 1, p. 162-168 7 p.

Research output: Contribution to journalArticle

Reproduction
Gene Targeting
Body Temperature Regulation
Energy Metabolism
Genes
2011
21 Citations (Scopus)

Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver

Hagopian, K., Chen, Y., Simmons Domer, K., Soo Hoo, R., Bentley, T., McDonald, R. B. & Ramsey, J. J., 2011, In : Journal of Bioenergetics and Biomembranes. 43, 3, p. 227-236 10 p.

Research output: Contribution to journalArticle

Caloric Restriction
Succinic Acid
Hydrogen Peroxide
Rotenone
Reactive Oxygen Species
17 Citations (Scopus)

Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

Parrado-Fernández, C., López-Lluch, G., Rodríguez-Bies, E., Santa-Cruz, S., Navas, P., Ramsey, J. J. & Villalba, J. M., Jun 15 2011, In : Free Radical Biology and Medicine. 50, 12, p. 1728-1736 9 p.

Research output: Contribution to journalArticle

Ubiquinone
Muscle
Tissue
Skeletal Muscle
Liver
20 Citations (Scopus)

Effect of water content in a canned food on voluntary food intake and body weight in cats

Wei, A., Fascetti, A. J., Villaverde, C., Wong, R. K. & Ramsey, J. J., Jul 2011, In : American Journal of Veterinary Research. 72, 7, p. 918-923 6 p.

Research output: Contribution to journalArticle

Preserved Food
canned foods
food intake
Cats
Eating
14 Citations (Scopus)

Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food

Wei, A., Fascetti, A. J., Liu, K. J., Villaverde, C., Green, A. S., Manzanilla, E. G., Havel, P. J. & Ramsey, J. J., Jun 2011, In : Journal of Animal Physiology and Animal Nutrition. 95, 3, p. 359-367 9 p.

Research output: Contribution to journalArticle

high protein diet
energy balance
Cats
cats
Diet
41 Citations (Scopus)

The Shc locus regulates insulin signaling and adiposity in mammals

Tomilov, A., Ramsey, J. J., Hagopian, K., Giorgio, M., Kim, K., Lam, A., Migliaccio, E., Lloyd, K. C. K., Berniakovich, I., Prolla, T. A., Pelicci, P. & Cortopassi, G. A., Feb 2011, In : Aging Cell. 10, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Adiposity
Mammals
Insulin
Fats
Protein Isoforms
2010
18 Citations (Scopus)

Application of modular kinetic analysis to mitochondrial oxidative phosphorylation in skeletal muscle of birds exposed to acute heat stress

Kikusato, M., Ramsey, J. J., Amo, T. & Toyomizu, M., Jul 2010, In : FEBS Letters. 584, 14, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Birds
Muscle
Skeletal Muscle
Hot Temperature

Bioenergetics

Ramsey, J. J. & Hagopian, K., 2010, Encyclopedia of herontology. Elsevier Inc., p. 170-177 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Energy Metabolism
39 Citations (Scopus)

Complex i-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice

Hagopian, K., Weber, K. L., Hwee, D. T., van Eenennaam, A. L., López-Lluch, G., Villalba, J. M., Burón, I., Navas, P., German, J. B., Watkins, S. M., Chen, Y., Wei, A., McDonald, R. B. & Ramsey, J. J., 2010, In : PLoS One. 5, 9, p. 1-11 11 p., e12696.

Research output: Contribution to journalArticle

electron transport chain
Enzyme activity
Electron Transport
Hydrogen Peroxide
hydrogen peroxide
42 Citations (Scopus)

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice

Tomilov, A., Bicocca, V., Schoenfeld, R. A., Giorgio, M., Migliaccio, E., Ramsey, J. J., Hagopian, K., Pelicci, P. G. & Cortopassi, G. A., 2010, In : Journal of Biological Chemistry. 285, 2, p. 1153-1165 13 p.

Research output: Contribution to journalArticle

Macrophages
Knockout Mice
Superoxides
Phosphorylation
Oxidants
24 Citations (Scopus)

Honoring Clive McCay and 75 years of calorie restriction research

McDonald, R. B. & Ramsey, J. J., Jul 2010, In : Journal of Nutrition. 140, 7, p. 1205-1210 6 p.

Research output: Contribution to journalArticle

20th Century History
Caloric Restriction
Research
2009
8 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
beef cows
skeletal muscle
free fatty acids
Weight Loss
8 Citations (Scopus)

Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver

Hagopian, K., Ramsey, J. J. & Weindruch, R., 2009, In : Biogerontology. 10, 4, p. 471-479 9 p.

Research output: Contribution to journalArticle

Caloric Restriction
Sorbitol
Liver
Enzymes
Pyruvic Acid
17 Citations (Scopus)

Differences in mitochondrial efficiency between lines of mice divergently selected for heat loss

McDonald, J. M., Ramsey, J. J., Miner, J. L. & Nielsen, M. K., Oct 2009, In : Journal of Animal Science. 87, 10, p. 3105-3113 9 p.

Research output: Contribution to journalArticle

Hot Temperature
heat
mice
feed intake
Adenosine Diphosphate