Jill L Silverman, PhD

Associate Adjunct Professor

  • 3446 Citations
  • 24 h-Index
20072020

Research output per year

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Research Output

  • 3446 Citations
  • 24 h-Index
  • 49 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter
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Article
2020

Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation

Petkova, S. P., Pride, M., Klocke, C., Fenton, T. A., White, J., Lein, P. J., Ellegood, J., Lerch, J. P., Silverman, J. L. & Waldau, B., Dec 1 2020, In : Scientific reports. 10, 1, 8204.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

Berg, E. L., Pedersen, L. R., Pride, M. C., Petkova, S. P., Patten, K. T., Valenzuela, A. E., Wallis, C., Bein, K. J., Wexler, A. S., Lein, P. J. & Silverman, J. L., Dec 1 2020, In : Translational psychiatry. 10, 1, 289.

Research output: Contribution to journalArticle

Open Access

Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats

Patten, K. T., González, E. A., Valenzuela, A., Berg, E., Wallis, C., Garbow, J. R., Silverman, J. L., Bein, K. J., Wexler, A. S. & Lein, P. J., Dec 1 2020, In : Translational psychiatry. 10, 1, 166.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

Dodge, A., Peters, M. M., Greene, H. E., Dietrick, C., Botelho, R., Chung, D., Willman, J., Nenninger, A. W., Ciarlone, S., Kamath, S. G., Houdek, P., Sumová, A., Anderson, A. E., Dindot, S. V., Berg, E. L., O'Geen, H., Segal, D. J., Silverman, J. L., Weeber, E. J. & Nash, K. R., Jan 1 2020, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L. C., Ren, C., Escamilla, C. O., Gibson, J. M., Sajadi, S., Pendry, R. J., Tan, T., Ellegood, J., Albert Basson, M., Blakely, R. D., Dindot, S. V., Golzio, C., Hahn, M. K., Katsanis, N., Robins, D. M. & 11 others, Silverman, J. L., Singh, K. K., Wevrick, R., Taylor, M. J., Hammill, C., Anagnostou, E., Pfeiffer, B. E., Stoodley, C. J., Lerch, J. P., du Lac, S. & Tsai, P. T., Sep 1 2020, In : Nature Neuroscience. 23, 9, p. 1102-1110 9 p.

Research output: Contribution to journalArticle

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., Adhikari, A., Fenton, T. A., Pedersen, L. R., Noakes, L. S., Nieman, B. J., Lerch, J. P., Harris, S., Born, H. A., Peters, M. M., Deng, P., Cameron, D. L., Fink, K. D., Beitnere, U., O’Geen, H. & 8 others, Anderson, A. E., Dindot, S. V., Nash, K. R., Weeber, E. J., Wöhr, M., Ellegood, J., Segal, D. J. & Silverman, J. L., Dec 1 2020, In : Translational psychiatry. 10, 1, 39.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration

Copping, N. A., Adhikari, A., Petkova, S. P. & Silverman, J. L., Dec 2019, In : Epilepsy and Behavior. 101, 106547.

Research output: Contribution to journalArticle

1 Scopus citations

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways

Lopez, S. J., Laufer, B. I., Beitnere, U., Berg, E. L., Silverman, J. L., O'Geen, H., Segal, D. J. & LaSalle, J. M., Nov 15 2019, In : Human molecular genetics. 28, 22, p. 3842-3852 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size

Le Duc, D., Giulivi, C., Hiatt, S. M., Napoli, E., Panoutsopoulos, A., Harlan De Crescenzo, A., Kotzaeridou, U., Syrbe, S., Anagnostou, E., Azage, M., Bend, R., Begtrup, A., Brown, N. J., Büttner, B., Cho, M. T., Cooper, G. M., Doering, J. H., Dubourg, C., Everman, D. B., Hildebrand, M. S. & 27 others, Santos, F. J. R., Kellam, B., Keller-Ramey, J., Lemke, J. R., Liu, S., Niyazov, D., Payne, K., Person, R., Quélin, C., Schnur, R. E., Smith, B. T., Strober, J., Walker, S., Wallis, M., Walsh, L., Yang, S., Yuen, R. K. C., Ziegler, A., Sticht, H., Pride, M. C., Orosco, L., Martínez-Cerdeño, V., Silverman, J. L., Crawley, J. N., Scherer, S. W., Zarbalis, K. S. & Jamra, R., Sep 1 2019, In : Brain : a journal of neurology. 142, 9, p. 2617-2630 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism

Jones, K. L., Pride, M. C., Edmiston, E., Yang, M., Silverman, J. L., Crawley, J. N. & van de Water, J., Jun 28 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome

Adhikari, A., Copping, N. A., Onaga, B., Pride, M. C., Coulson, R. L., Yang, M., Yasui, D. H., LaSalle, J. M. & Silverman, J. L., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

9 Scopus citations

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder

Berg, E. L., Copping, N. A., Rivera, J. K., Pride, M. C., Careaga, M., Bauman, M. D., Berman, R. F., Lein, P. J., Harony-Nicolas, H., Buxbaum, J. D., Ellegood, J., Lerch, J. P., Wöhr, M. & Silverman, J. L., Jan 1 2018, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

18 Scopus citations

Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice

Keil, K. P., Sethi, S., Wilson, M. D., Silverman, J. L., Pessah, I. N. & Lein, P. J., Jan 1 2018, (Accepted/In press) In : Genes, Brain and Behavior. e12526.

Research output: Contribution to journalArticle

4 Scopus citations

MGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex

Kelly, E., Schaeffer, S. M., Dhamne, S. C., Lipton, J. O., Lindemann, L., Honer, M., Jaeschke, G., Super, C. E., Lammers, S. H., Modi, M. E., Silverman, J. L., Dreier, J. R., Kwiatkowski, D. J., Rotenberg, A. & Sahin, M., May 1 2018, In : Neuropsychopharmacology. 43, 6, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Sex differences in the effects of a Kappa Opioid receptor antagonist in the forced swim test

Laman-Maharg, A., Williams, A. V., Zufelt, M. D., Minie, V. A., Ramos-Maciel, S., Hao, R., Sanchez, E. O., Copeland, T., Silverman, J. L., Leigh, A., Snyder, R., Ivy Carroll, F., Fennell, T. R. & Trainor, B. C., Feb 14 2018, In : Frontiers in Pharmacology. 9, FEB, 93.

Research output: Contribution to journalArticle

12 Scopus citations

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

Matt, L., Kirk, L. M., Chenaux, G., Speca, D. J., Puhger, K. R., Pride, M. C., Qneibi, M., Haham, T., Plambeck, K. E., Stern-Bach, Y., Silverman, J. L., Crawley, J., Hell, J. W. & Diaz, E. D., Feb 27 2018, In : Cell Reports. 22, 9, p. 2455-2468 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Germline Chd8 haploinsufficiency alters brain development in mouse

Gompers, A. L., Su-Feher, L., Ellegood, J., Copping, N. A., Riyadh, M. A., Stradleigh, T. W., Pride, M. C., Schaffler, M. D., Wade, A. A., Catta-Preta, R., Zdilar, I., Louis, S., Kaushik, G., Mannion, B. J., Plajzer-Frick, I., Afzal, V., Visel, A., Pennacchio, L. A., Dickel, D. E., Lerch, J. P. & 4 others, Crawley, J., Zarbalis, K., Silverman, J. L. & Nord, A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1062-1073 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome

Copping, N. A., Christian, S. G. B., Ritter, D. J., Saharul Islam, M., Buscher, N., Zolkowska, D., Pride, M. C., Berg, E. L., LaSalle, J. M., Ellegood, J., Lerch, J. P., Reiter, L. T., Silverman, J. L. & Dindot, S. V., Oct 15 2017, In : Human Molecular Genetics. 26, 20, p. 3995-4010 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

Dhamne, S. C., Silverman, J. L., Super, C. E., Lammers, S. H. T., Hameed, M. Q., Modi, M. E., Copping, N. A., Pride, M. C., Smith, D. G., Rotenberg, A., Crawley, J. & Sahin, M., Jun 15 2017, In : Molecular Autism. 8, 1, 26.

Research output: Contribution to journalArticle

41 Scopus citations
2016
27 Scopus citations

Methodological Considerations for Optimizing and Validating Behavioral Assays

Sukoff Rizzo, S. J. & Silverman, J. L., Dec 1 2016, In : Current protocols in mouse biology. 6, 4, p. 364-379 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task

Leach, P. T., Hayes, J., Pride, M., Silverman, J. L. & Crawley, J., Jan 1 2016, In : eNeuro. 3, 1

Research output: Contribution to journalArticle

10 Scopus citations

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

Flannery, B. M., Bruun, D. A., Rowland, D. J., Banks, C. N., Austin, A. T., Kukis, D. L., Li, Y., Ford, B. D., Tancredi, D. J., Silverman, J. L., Cherry, S. R. & Lein, P. J., Oct 12 2016, In : Journal of Neuroinflammation. 13, 1, 267.

Research output: Contribution to journalArticle

26 Scopus citations

Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan-McDermid Syndrome and autism

Copping, N. A., Berg, E. L., Foley, G. M., Schaffler, M. D., Onaga, B. L., Buscher, N., Silverman, J. L. & Yang, M., 2016, (Accepted/In press) In : Neuroscience.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine

Flannery, B. M., Silverman, J. L., Bruun, D. A., Puhger, K. R., McCoy, M. R., Hammock, B. D., Crawley, J. & Lein, P. J., Jan 1 2015, In : Neurotoxicology and Teratology. 47, p. 36-45 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cognitive abilities on transitive inference using a novel touchscreen technology for mice

Silverman, J. L., Gastrell, P. T., Karras, M. N., Friedman, M. S. & Crawley, J., May 1 2015, In : Cerebral Cortex. 25, 5, p. 1133-1142 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior

Genestine, M., Lin, L., Durens, M., Yan, Y., Jiang, Y., Prem, S., Bailoor, K., Kelly, B., Sonsalla, P. K., Matteson, P. G., Silverman, J. L., Crawley, J., Millonig, J. H. & DiCicco-Bloom, E., Jun 5 2015, In : Human Molecular Genetics. 24, 20, p. 5805-5827 23 p.

Research output: Contribution to journalArticle

24 Scopus citations

GABA B Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S. & Crawley, J., Mar 10 2015, In : Neuropsychopharmacology. 40, 9, p. 2228-2239 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

Hippocampal transcriptomic and proteomic alterations in the BTBR mouse model of autism spectrum disorder

Daimon, C. M., Jasien, J. M., Wood, W. H., Zhang, Y., Becker, K. G., Silverman, J. L., Crawley, J., Martin, B. & Maudsley, S., 2015, In : Frontiers in Physiology. 6, NOV, 324.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice

Brielmaier, J., Senerth, J. M., Silverman, J. L., Matteson, P. G., Millonig, J. H., Dicicco-Bloom, E. & Crawley, J., Mar 2014, In : Genes, Brain and Behavior. 13, 3, p. 286-298 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Long-term exposure to intranasal oxytocin in a mouse autism model

Bales, K. L., Friedman, M. S., Jacob, S., Crawley, J., Silverman, J. L., Larke, R. H., Sahagun, E., Puhger, K. R., Pride, M. C. & Mendoza, S. P., Jan 1 2014, In : Translational Psychiatry. 4, 11, e480.

Research output: Contribution to journalArticle

71 Scopus citations

Modeling fragile X syndrome in the Fmr1 knockout mouse

Kazdoba, T. M., Leach, P. T., Silverman, J. L. & Crawley, J., 2014, In : Intractable and Rare Diseases Research. 3, 4, p. 118-133 16 p.

Research output: Contribution to journalArticle

99 Scopus citations

The promising trajectory of autism therapeutics discovery

Silverman, J. L. & Crawley, J., 2014, In : Drug Discovery Today. 19, 7, p. 838-844 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

Silverman, J. L., Oliver, C. F., Karras, M. N., Gastrell, P. T. & Crawley, J., Jan 2013, In : Neuropharmacology. 64, p. 268-282 15 p.

Research output: Contribution to journalArticle

73 Scopus citations

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2

Wöhr, M., Silverman, J. L., Scattoni, M. L., Turner, S. M., Harris, M. J., Saxena, R. & Crawley, J., Aug 15 2013, In : Behavioural Brain Research. 251, p. 50-64 15 p.

Research output: Contribution to journalArticle

69 Scopus citations

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism

Silverman, J. L., Babineau, B. A., Oliver, C. F., Karras, M. N. & Crawley, J., May 2013, In : Neuropharmacology. 68, p. 210-222 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
2012

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4

Ey, E., Yang, M., Katz, A. M., Woldeyohannes, L., Silverman, J. L., Leblond, C. S., Faure, P., Torquet, N., Le Sourd, A. M., Bourgeron, T. & Crawley, J., 2012, In : Genes, Brain and Behavior. 11, 8, p. 928-941 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice

Brielmaier, J., Matteson, P. G., Silverman, J. L., Senerth, J. M., Kelly, S., Genestine, M., Millonig, J. H., DiCicco-Bloom, E. & Crawley, J., Jul 19 2012, In : PLoS One. 7, 7, e40914.

Research output: Contribution to journalArticle

96 Scopus citations

Low sociability in BTBR T+tf/J mice is independent of partner strain

Yang, M., Abrams, D. N., Zhang, J. Y., Weber, M. D., Katz, A. M., Clarke, A. M., Silverman, J. L. & Crawley, J., Dec 5 2012, In : Physiology and Behavior. 107, 5, p. 649-662 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H. & Crawley, J., Apr 25 2012, In : Science Translational Medicine. 4, 131, 131ra51.

Research output: Contribution to journalArticle

165 Scopus citations

Reduced excitatory neurotransmission and mild Autism-Relevant phenotypes in adolescent shank3 null mutant mice

Yang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., Zhang, J. Y., Harris, M. J., Saxena, R., Silverman, J. L., Buxbaum, J. D. & Crawley, J., May 9 2012, In : Journal of Neuroscience. 32, 19, p. 6525-6541 17 p.

Research output: Contribution to journalArticle

201 Scopus citations
2011

Automated three-chambered social approach task for mice

Yang, M., Silverman, J. L. & Crawley, J., Jul 2011, In : Current Protocols in Neuroscience. SUPPL. 56, 8.26.

Research output: Contribution to journalArticle

237 Scopus citations

Sociability and motor functions in Shank1 mutant mice

Silverman, J. L., Turner, S. M., Barkan, C. L., Tolu, S. S., Saxena, R., Hung, A. Y., Sheng, M. & Crawley, J., Mar 22 2011, In : Brain Research. 1380, p. 120-137 18 p.

Research output: Contribution to journalArticle

139 Scopus citations

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

Papaleo, F., Silverman, J. L., Aney, J., Tian, Q., Barkan, C. L., Chadman, K. K. & Crawley, J., Aug 2011, In : Learning and Memory. 18, 8, p. 534-544 11 p.

Research output: Contribution to journalArticle

81 Scopus citations
2010

Behavioural phenotyping assays for mouse models of autism

Silverman, J. L., Yang, M., Lord, C. & Crawley, J., Apr 2010, In : Nature Reviews Neuroscience. 11, 7, p. 490-502 13 p.

Research output: Contribution to journalArticle

758 Scopus citations

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M., Harris, M. J., Saxena, R., Silverman, J. L., Crawley, J., Zhou, Q., Hof, P. R. & Buxbaum, J. D., 2010, In : Molecular Autism. 1, 1, 15.

Research output: Contribution to journalArticle

340 Scopus citations

Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism

Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I. & Crawley, J., Dec 29 2010, In : Neuroscience. 171, 4, p. 1197-1208 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP

Silverman, J. L., Tolu, S. S., Barkan, C. L. & Crawley, J., Mar 2010, In : Neuropsychopharmacology. 35, 4, p. 976-989 14 p.

Research output: Contribution to journalArticle

253 Scopus citations
2007
42 Scopus citations