• 2440 Citations
  • 27 h-Index
19952020

Research output per year

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Research Output

  • 2440 Citations
  • 27 h-Index
  • 64 Article
  • 1 Chapter
  • 1 Comment/debate
2020

A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel

Zhu, A., Aierken, A., Yao, Z., Vu, S., Tian, Y., Zheng, J., Yang, S. & Yang, F., Apr 30 2020, In : Toxicon. 178, p. 41-49 9 p.

Research output: Contribution to journalArticle

Author Correction: Molecular basis for heat desensitization of TRPV1 ion channels (Nature Communications, (2019), 10, 1, (2134), 10.1038/s41467-019-09965-6)

Luo, L., Wang, Y., Li, B., Xu, L., Kamau, P. M., Zheng, J., Yang, F., Yang, S. & Lai, R., Dec 1 2020, In : Nature communications. 11, 1, 1798.

Research output: Contribution to journalComment/debate

Open Access
2019

A distinct structural mechanism underlies TRPV1 activation by piperine

Dong, Y., Yin, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

1 Scopus citations

Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia

Wang, H., Xu, Z., Lee, B. H., Vu, S., Hu, L., Lee, M., Bu, D., Cao, X., Hwang, S. T., Yang, Y., Zheng, J. & Lin, Z., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular basis for heat desensitization of TRPV1 ion channels

Luo, L., Wang, Y., Li, B., Xu, L., Kamau, P. M., Zheng, J., Yang, F., Yang, S. & Lai, R., Dec 1 2019, In : Nature communications. 10, 1, 2134.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

Yin, Y., Dong, Y., Vu, S., Yang, F., Yarov-Yarovoy, V., Tian, Y. & Zheng, J., Jan 1 2019, In : British Journal of Pharmacology. 176, 17, p. 3364-3377 14 p.

Research output: Contribution to journalArticle

The Latoia consocia Caterpillar Induces Pain by Targeting Nociceptive Ion Channel TRPV1

Yao, Z., Kamau, P. M., Han, Y., Hu, J., Luo, A., Luo, L., Zheng, J., Tian, Y. & Lai, R., Nov 27 2019, In : Toxins. 11, 12

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Molecular mechanism of the tree shrew’s insensitivity to spiciness

Han, Y., Li, B., Yin, T. T., Xu, C., Ombati, R., Luo, L., Xia, Y., Xu, L., Zheng, J., Zhang, Y., Yang, F., Wang, G. D., Yang, S. & Lai, R., Jul 12 2018, In : PLoS Biology. 16, 7, e2004921.

Research output: Contribution to journalArticle

9 Scopus citations

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Yang, F., Xiao, X., Lee, B. H., Vu, S., Yang, W., Yarov-Yarovoy, V. & Zheng, J., Dec 1 2018, In : Nature Communications. 9, 1, 2879.

Research output: Contribution to journalArticle

16 Scopus citations
2017

A bimodal activation mechanism underlies scorpion toxin-induced pain

Yang, S., Yang, F., Zhang, B., Lee, B. H., Li, B., Luo, L., Zheng, J. & Lai, R., Jan 1 2017, In : Science advances. 3, 8, 1700810.

Research output: Contribution to journalArticle

15 Scopus citations

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

Yang, F. & Zheng, J., Jan 2 2017, (Accepted/In press) In : Protein and Cell. p. 1-9 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2016

Development and application of patch-clamp fluorometry in life science research

Cheng, W., Li, M., Du, S. & Zheng, J., Feb 1 2016, In : Progress in Biochemistry and Biophysics. 43, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening

Ma, L., Yang, F., Vu, S. & Zheng, J., Sep 26 2016, In : Scientific Reports. 6, 33827.

Research output: Contribution to journalArticle

6 Scopus citations

Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

Kim, S., Barry, D. M., Liu, X. Y., Yin, S., Munanairi, A., Meng, Q. T., Cheng, W., Mo, P., Wan, L., Liu, S. B., Ratnayake, K., Zhao, Z. Q., Gautam, N., Zheng, J., Karunarathne, W. K. A. & Chen, Z. F., Jul 19 2016, In : Science Signaling. 9, 437, ra71.

Research output: Contribution to journalArticle

31 Scopus citations

Fluorescence microscopy in thermoTRP channel research

Yang, F. & Zheng, J., Apr 19 2016, TRP Channels. CRC Press, p. 319-352 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prokineticin 2 Plays a Pivotal Role in Psoriasis

He, X., Shen, C., Lu, Q., Li, J., Wei, Y., He, L., Bai, R., Zheng, J., Luan, N., Zhang, Z., Rong, M. & Lai, R., Nov 1 2016, In : EBioMedicine. 13, p. 248-261 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
26 Scopus citations
2015

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

Yang, S., Yang, F., Wei, N., Hong, J., Li, B., Luo, L., Rong, M., Yarov-Yarovoy, V., Zheng, J., Wang, K. & Lai, R., Sep 30 2015, In : Nature Communications. 6, 8297.

Research output: Contribution to journalArticle

46 Scopus citations

Calcium ion as cellular messenger

Zheng, J., Zeng, X. H. & Wang, S. Q., 2015, In : Science China Life Sciences. 58, 1

Research output: Contribution to journalArticle

10 Scopus citations

Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1)

Simonov, A. N., Holien, J. K., Yeung, J. C. I., Nguyen, A. D., Corbin, C. J., Zheng, J., Kuznetsov, V. L., Auchus, R. J., Conley, A. J., Bond, A. M., Parker, M. W., Rodgers, R. J. & Martin, L. L., Nov 1 2015, In : PLoS One. 10, 11, e0141252.

Research output: Contribution to journalArticle

18 Scopus citations

Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels

Ma, L., Lee, B. H., Clifton, H., Schaefer, S. & Zheng, J., 2015, In : Scientific Reports. 5, 8906.

Research output: Contribution to journalArticle

17 Scopus citations

Proton block of proton-activated TRPV1 current

Lee, B. H. & Zheng, J., 2015, In : Journal of General Physiology. 146, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

Yang, F., Xiao, X., Cheng, W., Yang, W., Yu, P., Song, Z., Yarov-Yarovoy, V. & Zheng, J., Jul 20 2015, In : Nature Chemical Biology. 11, 7, p. 518-524 7 p.

Research output: Contribution to journalArticle

121 Scopus citations

TRPV1 channels are involved in niacin-induced cutaneous vasodilation in mice

Clifton, H. L., Inceoglu, B., Ma, L., Zheng, J. & Schaefer, S., 2015, In : Journal of Cardiovascular Pharmacology. 65, 2, p. 184-191 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Application of fluorescence resonance energy transfer in protein studies

Ma, L., Yang, F. & Zheng, J., Dec 5 2014, In : Journal of Molecular Structure. 1077, p. 87-100 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

Yang, F., Ma, L., Cao, X., Wang, K. & Zheng, J., Jan 2014, In : Journal of General Physiology. 143, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold

Cao, X., Ma, L., Yang, F., Wang, K. & Zheng, J., Jan 2014, In : Journal of General Physiology. 143, 1, p. 75-90 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

High temperature sensitivity is intrinsic to voltage-gated potassium channels

Yang, F. & Zheng, J., 2014, In : eLife. 3, p. e03255

Research output: Contribution to journalArticle

24 Scopus citations

Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing

Ma, L., Lee, B. H., Mao, R., Cai, A., Jia, Y., Clifton, H., Schaefer, S., Xu, L. & Zheng, J., 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 6, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure and Function of the ThermoTRP Channel Pore

Zheng, J. & Ma, L., 2014, In : Current Topics in Membranes. 74, 1, p. 233-257 25 p.

Research output: Contribution to journalArticle

21 Scopus citations

The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation

Tang, Y. Q., Zhou, J. H., Yang, F., Zheng, J. & Wang, K., Sep 2 2014, In : Biophysical Journal. 107, 5, p. 1090-1104 15 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

A TRPV4 channel C-terminal folding recognition domain critical for trafficking and function

Lei, L., Cao, X., Yang, F., Shi, D. J., Tang, Y. Q., Zheng, J. & Wang, K., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10427-10439 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Domain-domain interactions in ion channels

Zheng, J., 2013, In : Journal of General Physiology. 142, 4, p. 347-350 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular mechanism of TRP channels

Zheng, J., 2013, In : Comprehensive Physiology. 3, 1, p. 221-242 22 p.

Research output: Contribution to journalArticle

164 Scopus citations
2012

A simple device to illustrate the Einthoven triangle

Jin, B. E., Wulff, H., Widdicombe, J., Zheng, J., Bers, D. M. & Puglisi, J. L., Dec 2012, In : American Journal of Physiology - Advances in Physiology Education. 36, 4, p. 319-324 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response

Cheng, W., Yang, F., Liu, S., Colton, C. K., Wang, C., Cui, Y., Cao, X., Zhu, M. X., Sun, C., Wang, K. & Zheng, J., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7279-7288 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes

Cao, X., Yang, F., Zheng, J. & Wang, K., Jul 27 2012, In : Journal of Biological Chemistry. 287, 31, p. 25905-25916 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

Cui, Y., Yang, F., Cao, X., Yarov-Yarovoy, V., Wang, K. & Zheng, J., Apr 2012, In : Journal of General Physiology. 139, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2011

FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor

Dong, B., Cheng, W., Li, W., Zheng, J., Wu, D., Matsumura, F. & Vogel, C. F. A., Apr 2011, In : Biochimica et Biophysica Acta - General Subjects. 1810, 4, p. 427-431 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of a tetrameric assembly domain in the C terminus of heat-activated TRPV1 channels

Zhang, F., Liu, S., Yang, F., Zheng, J. & Wang, K., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 15308-15316 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location

Ma, L., Rychkov, G. Y., Bykova, E. A., Zheng, J. & Bretag, A. H., Jun 1 2011, In : Biochemical Journal. 436, 2, p. 415-428 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Heteromerization of TRP channel subunits: Extending functional diversity

Cheng, W., Sun, C. & Zheng, J., 2010, In : Protein and Cell. 1, 9, p. 802-810 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Reply to Yao et al. Is the pore turret just thermoTRP channels' appendix?

Yang, F., Cui, Y., Wang, K. & Zheng, J., Aug 10 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 32

Research output: Contribution to journalArticle

4 Scopus citations

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

Yang, F., Cui, Y., Wang, K. & Zheng, J., Apr 13 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7083-7088 6 p.

Research output: Contribution to journalArticle

131 Scopus citations
2009

An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-methyl-D-aspartate receptors

Qiu, S., Zhang, X. M., Cao, J. Y., Yang, W., Yan, Y. G., Shan, L., Zheng, J. & Luo, J. H., Jul 24 2009, In : Journal of Biological Chemistry. 284, 30, p. 20285-20298 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1

Qu, Z., Cheng, W., Cui, Y., Cui, Y. & Zheng, J., Jun 12 2009, In : Journal of Biological Chemistry. 284, 24, p. 16473-16481 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Organization of cytochrome P450 enzymes involved in sex steroid synthesis: Protein-protein interactions in lipid membranes

Praporski, S., Ng, S. M., Nguyen, A. D., Corbin, C. J., Mechler, A., Zheng, J., Conley, A. J. & Martin, L. L., Nov 27 2009, In : Journal of Biological Chemistry. 284, 48, p. 33224-33232 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

PSD-95 regulates D1 dopamine receptor resensitization,but not receptor-mediated Gs-protein activation

Sun, P., Wang, J., Gu, W., Cheng, W., Jin, G. Z., Friedman, E., Zheng, J. & Zhen, X., May 2009, In : Cell Research. 19, 5, p. 612-624 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Temperature-dependent activation of neurons by continuous near-infrared laser

Liang, S., Yang, F., Zhou, C., Wang, Y., Li, S., Sun, C. K., Puglisi, J. L., Bers, D. M., Sun, C. & Zheng, J., Jan 2009, In : Cell Biochemistry and Biophysics. 53, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2008

Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization

Vetter, I., Cheng, W., Peiris, M., Wyse, B. D., Roberts-Thomson, S. J., Zheng, J., Monteith, G. R. & Cabot, P. J., Jul 11 2008, In : Journal of Biological Chemistry. 283, 28, p. 19540-19550 11 p.

Research output: Contribution to journalArticle

41 Scopus citations