Jian-Jian Li, MD; PhD

Professor

  • 5952 Citations
  • 44 h-Index
1992 …2020

Research output per year

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Research Output

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Article
2020

Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade

Liu, L., Xie, B., Fan, M., Candas-Green, D., Jiang, J. X., Wei, R., Wang, Y., Chen, H. W., Hu, Y. & Li, J. J., Jan 27 2020, In : Developmental Cell. 52, 2, p. 196-209.e9

Research output: Contribution to journalArticle

Open Access

Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA-damaging chemotherapy agents and radiation

Duan, Z., Andrews, N. P., Chen, C. Z., Fan, M., Wang, J., Shen, J., Li, J. J. & Chen, H. W., Jan 1 2020, In : Oncology Reports. 43, 1, p. 318-327 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo

Zhang, L., Jing, D., Jiang, N., Rojalin, T., Baehr, C. M., Zhang, D., Xiao, W., Wu, Y., Cong, Z., Li, J. J., Li, Y., Wang, L. & Lam, K. S., Feb 1 2020, In : Nature Nanotechnology. 15, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

CPT1A/2-Mediated FAO Enhancement—A Metabolic Target in Radioresistant Breast Cancer

Han, S., Wei, R., Zhang, X., Jiang, N., Fan, M., Huang, J. H., Xie, B., Zhang, L., Miao, W., Butler, A. C. P., Coleman, M. A., Vaughan, A. T., Wang, Y., Chen, H. W., Liu, J. & Li, J. J., Nov 15 2019, In : Frontiers in Oncology. 9, 1201.

Research output: Contribution to journalArticle

Open Access

Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells

Xie, B., Zhang, L., Hu, W., Fan, M., Jiang, N., Duan, Y., Jing, D., Xiao, W., Fragoso, R. C., Lam, K., Sun, L. Q. & Li, J-J., Jun 1 2019, In : Redox Biology. 24, 101189.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 Loss of function in glioblastoma

Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R. S., Gao, P., Lopez-Bertoni, H., Ying, M., Li, J-J., Laterra, J., Wilson, M. A. & Xia, S., Jan 1 2019, In : Cancer Research. 79, 10, p. 2697-2708 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J. X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A. D., Bold, R. J., Lara, P. N., Li, J. J., Chen, X., Lam, K. S., To, K. F., Kung, H. J., Fiehn, O., Zhao, R. & 2 others, Evans, R. M. & Chen, H. W., Dec 1 2019, In : Nature communications. 10, 1, 4621.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Targeted Profiling of Heat Shock Proteome in Radioresistant Breast Cancer Cells

Miao, W., Fan, M., Huang, M., Li, J-J. & Wang, Y., Feb 18 2019, In : Chemical Research in Toxicology. 32, 2, p. 326-332 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer

Zhang, L., Jing, D., Wang, L., Sun, Y., Li, J-J., Hill, B., Yang, F., Li, Y. & Lam, K., Nov 14 2018, In : Nano Letters. 18, 11, p. 7092-7103 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Nanoparticles for live cell microscopy: A surface-enhanced Raman scattering perspective

Navas-Moreno, M., Mehrpouyan, M., Chernenko, T., Candas, D., Fan, M., Li, J-J., Yan, M. & Chan, J. W., Dec 1 2017, In : Scientific Reports. 7, 1, 4066.

Research output: Contribution to journalArticle

23 Scopus citations
2016

All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy

Yan, Y., Li, Z., Xu, X., Chen, C., Wei, W., Fan, M., Chen, X., Li, J-J., Wang, Y. & Huang, J., 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 113.

Research output: Contribution to journalArticle

26 Scopus citations

Experimental approaches to study mitochondrial localization and function of a nuclear cell cycle kinase, Cdk1

Candas, D., Qin, L., Fan, M. & Li, J-J., Feb 25 2016, In : Journal of Visualized Experiments. 2016, 108, e53417.

Research output: Contribution to journalArticle

Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes

Wang, J., Duan, Z., Nugent, Z., Zou, J. X., Borowsky, A. D., Zhang, Y., Tepper, C. G., Li, J-J., Fiehn, O., Xu, J., Kung, H-J., Murphy, L. C. & Chen, H., Aug 10 2016, In : Cancer Letters. 378, 2, p. 69-79 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity

Miller, R. C., Murley, J. S., Rademaker, A. W., Woloschak, G. E., Li, J-J., Weichselbaum, R. R. & Grdina, D. J., Oct 1 2016, In : Free Radical Biology and Medicine. 99, p. 110-119 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair

Qin, L., Fan, M., Candas, D., Jiang, G., Papadopoulos, S., Tian, L., Woloschak, G., Grdina, D. J. & Li, J-J., Jun 18 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

33 Scopus citations

CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance

Liu, R., Fan, M., Candas, D., Qin, L., Zhang, X., Eldridge, A., Zou, J. X., Zhang, T., Juma, S., Jin, C., Li, R. F., Perks, J. R., Sun, L. Q., Vaughan, A. T. M., Hai, C. X., Gius, D. R. & Li, J-J., Sep 1 2015, In : Molecular Cancer Therapeutics. 14, 9, p. 2090-2102 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection

Jin, C., Qin, L., Shi, Y., Candas, D., Fan, M., Lu, C. L., Vaughan, A. T. M., Shen, R., Wu, L. S., Liu, R., Li, R. F., Murley, J. S., Woloschak, G., Grdina, D. J. & Li, J-J., 2015, In : Free Radical Biology and Medicine. 81, p. 77-87 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides

Sun, W., Wei, X., Niu, A., Ma, X., Li, J-J. & Gao, D., Dec 1 2015, In : Cancer Letters. 369, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

MKP1 mediates resistance to therapy in HER2-positive breast tumors

Candas, D. & Li, J-J., Oct 2 2015, In : Molecular and Cellular Oncology. 2, 4, e997518.

Research output: Contribution to journalArticle

2 Scopus citations

NFκB and survivin-mediated radio-adaptive response

Grdina, D. J., Murley, J. S., Miller, R. C., Woloschak, G. E. & Li, J-J., Apr 1 2015, In : Radiation Research. 183, 4, p. 391-397 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Profiling global kinome signatures of the radioresistant MCF-7/C6 breast cancer cells using MRM-based targeted proteomics

Guo, L., Xiao, Y., Fan, M., Li, J-J. & Wang, Y., Jan 2 2015, In : Journal of Proteome Research. 14, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

SIRT3 enhances glycolysis and proliferation in SIRT3-expressing gastric cancer cells

Cui, Y., Qin, L., Wu, J., Qu, X., Hou, C., Sun, W., Li, S., Vaughan, A. T. M., Li, J-J. & Liu, J., Jun 29 2015, In : PLoS One. 10, 6, e0129834.

Research output: Contribution to journalArticle

34 Scopus citations

The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

Nantajit, D., Lin, D. & Li, J-J., Oct 22 2015, In : Journal of Cancer Research and Clinical Oncology. 141, 10, p. 1697-1713 17 p.

Research output: Contribution to journalArticle

66 Scopus citations

Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition - A Warburg-reversing effect

Lu, C. L., Qin, L., Liu, H. C., Candas, D., Fan, M. & Li, J-J., Mar 25 2015, In : PLoS One. 10, 3, e0121046.

Research output: Contribution to journalArticle

59 Scopus citations
2014

Autologous tumor lysate-pulsed dendritic cell immunotherapy with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients

Gao, D., Li, C., Xie, X., Zhao, P., Wei, X., Sun, W., Liu, H. C., Alexandrou, A. T., Jones, J., Zhao, R. & Li, J-J., Apr 3 2014, In : PLoS One. 9, 4, e93886.

Research output: Contribution to journalArticle

71 Scopus citations

Blocking the formation of radiation-induced breast cancer stem cells

Wang, Y., Li, W., Patel, S. S., Cong, J., Zhang, N., Sabbatino, F., Liu, X., Qi, Y., Huang, P., Lee, H., Taghian, A., Li, J-J., DeLeo, A. B., Ferrone, S., Epperly, M. W., Ferrone, C. R., Ly, A., Brachtel, E. F. & Wang, X., 2014, In : Oncotarget. 5, 11, p. 3743-3755 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society

Duru, N., Candas, D., Jiang, G. & Li, J-J., Jan 2014, In : Journal of Cancer Research and Clinical Oncology. 140, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Breast cancer stem cells: Multiple capacities in tumor metastasis

Geng, S. Q., Alexandrou, A. T. & Li, J-J., Jul 10 2014, In : Cancer Letters. 349, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response

Alexandrou, A. T. & Li, J-J., Mar 20 2014, In : Antioxidants and Redox Signaling. 20, 9, p. 1463-1480 18 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cyclin B1/Cdk1 coordinates mitochondrial respiration for Cell-Cycle G2/M progression

Wang, Z., Fan, M., Candas, D., Zhang, T. Q., Qin, L., Eldridge, A., Wachsmann-Hogiu, S., Ahmed, K. M., Chromy, B. A., Nantajit, D., Duru, N., He, F., Chen, M., Finkel, T., Weinstein, L. S. & Li, J-J., Apr 28 2014, In : Developmental Cell. 29, 2, p. 217-232 16 p.

Research output: Contribution to journalArticle

134 Scopus citations
60 Scopus citations

Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance

Zou, J. X., Duan, Z., Wang, J., Sokolov, A., Xu, J., Chen, C. Z., Li, J-J. & Chen, H., Apr 1 2014, In : Molecular cancer research : MCR. 12, 4, p. 539-549 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells

Candas, D., Lu, C. L., Fan, M., Chuang, F., Sweeney, C. A., Borowsky, A. D. & Li, J-J., Dec 15 2014, In : Cancer Research. 74, 24, p. 7498-7509 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx

Candas, D. & Li, J-J., Apr 1 2014, In : Antioxidants and Redox Signaling. 20, 10, p. 1599-1617 19 p.

Research output: Contribution to journalArticle

134 Scopus citations
2013

A manganese superoxide dismutase (SOD2)-mediated adaptive response

Grdina, D. J., Murley, J. S., Miller, R. C., Mauceri, H. J., Sutton, H. G., Thirman, M. J., Li, J-J., Woloschak, G. E. & Weichselbaum, R. R., Feb 2013, In : Radiation Research. 179, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Comparing radiation toxicities across species: An examination of radiation effects in Mus musculus and Peromyscus leucopus

Liu, W., Haley, B., Kwasny, M. J., Li, J-J., Grdina, D. J., Paunesku, T. & Woloschak, G. E., Jun 2013, In : International Journal of Radiation Biology. 89, 6, p. 391-400 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress

Candas, D., Fan, M., Nantajit, D., Vaughan, A. T. M., Murley, J. S., Woloschak, G. E., Grdina, D. J. & Li, J-J., Jun 2013, In : Journal of Molecular Cell Biology. 5, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Enhanced radiation response in radioresistant MCF-7 cells by targeting peroxiredoxin II

Diaz, A. J. G., Tamae, D., Yen, Y., Li, J-J. & Wang, T., Oct 11 2013, In : Breast Cancer: Targets and Therapy. 5, p. 87-101 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular mechanisms and treatment of radiation-induced lung fibrosis

Ding, N. H., Li, J-J. & Sun, L. Q., 2013, In : Current Drug Targets. 14, 11, p. 1347-1356 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Survivin-associated adaptive response in radiation therapy

Grdina, D. J., Murley, J. S., Miller, R. C., Mauceri, H. J., Sutton, H. G., Li, J-J., Woloschak, G. E. & Weichselbaum, R. R., Jul 15 2013, In : Cancer Research. 73, 14, p. 4418-4428 11 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

Cancer stem cells and radiotherapy

Li, J-J., 2012, In : Medical radiology. 63, p. 49-57 9 p.

Research output: Contribution to journalArticle

HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells

Duru, N., Fan, M., Candas, D., Menaa, C., Liu, H. C., Nantajit, D., Wen, Y., Xiao, K., Eldridge, A., Chromy, B. A., Li, S., Spitz, D. R., Lam, K., Wicha, M. S. & Li, J-J., Dec 15 2012, In : Clinical Cancer Research. 18, 24, p. 6634-6647 14 p.

Research output: Contribution to journalArticle

118 Scopus citations

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

Eldridge, A., Fan, M., Woloschak, G., Grdina, D. J., Chromy, B. A. & Li, J-J., Nov 15 2012, In : Free Radical Biology and Medicine. 53, 10, p. 1838-1847 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy

Zhang, L., Yang, L., Li, J-J. & Sun, L., Oct 1 2012, In : Cancer Letters. 323, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

The effects of radiation and dose-Fractionation on cancer and non-Tumor disease development

Liu, W., Haley, B. M., Kwasny, M. J., Li, J-J., Grdina, D. J., Paunesku, T. & Woloschak, G. E., Dec 2012, In : International Journal of Environmental Research and Public Health. 9, 12, p. 4688-4703 16 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin

Yin, D. T., Wang, Q., Chen, L., Liu, M. Y., Han, C., Yan, Q., Shen, R., He, G., Duan, W., Li, J-J., Wani, A. & Gao, J. X., Nov 16 2011, In : PLoS One. 6, 11, e27154.

Research output: Contribution to journalArticle

35 Scopus citations

SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells

Murley, J. S., Kataoka, Y., Miller, R. C., Li, J-J., Woloschak, G. & Grdina, D. J., Jan 2011, In : Radiation Research. 175, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

YY1 is a novel potential therapeutic target for the treatment of HPV infection YInduced cervical cancer by arsenic trioxide

He, G., Wang, Q., Zhou, Y., Wu, X., Wang, L., Duru, N., Kong, X., Zhang, P., Wan, B., Sui, L., Guo, Q., Li, J-J. & Yu, L., Aug 2011, In : International Journal of Gynecological Cancer. 21, 6, p. 1097-1104 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response

Nantajit, D., Fan, M., Duru, N., Wen, Y., Reed, J. C. & Li, J-J., 2010, In : PLoS One. 5, 8, e12341.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis

Ye, Y., Yin, D. T., Chen, L., Zhou, Q., Shen, R., He, G., Yan, Q., Tong, Z., Issekutz, A. C., Shapiro, C. L., Barsky, S. H., Lin, H., Li, J-J. & Gao, J. X., 2010, In : PLoS One. 5, 10, e13406.

Research output: Contribution to journalArticle

57 Scopus citations