James M Angelastro, PhD; BS

Associate Professor

  • 1740 Citations
  • 21 h-Index
1990 …2020

Research output per year

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Research Output

  • 1740 Citations
  • 21 h-Index
  • 40 Article
  • 2 Chapter
  • 1 Short survey
  • 1 Review article
2020

Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer

Allen, S. A., Datta, S., Sandoval, J., Tomilov, A., Sears, T., Woolard, K., Angelastro, J. M. & Cortopassi, G. A., Jan 2020, In : Mitochondrion. 50, p. 19-24 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dominant-negative ATF5 compromises cancer cell survival by targeting CEBPB and CEBPD

Sun, X., Jefferson, P., Zhou, Q., Angelastro, J. M. & Greene, L. A., Feb 1 2020, In : Molecular Cancer Research. 18, 2, p. 216-228 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

PRMT1 promotes neuroblastoma cell survival through ATF5

Hua, Z. Y., Hansen, J. N., He, M., Dai, S. K., Choi, Y., Fulton, M. D., Lloyd, S. M., Szemes, M., Sen, J., Ding, H. F., Angelastro, J. M., Fei, X., Li, H. P., Wu, C. R., Yang, S. Y., Malik, K., Bao, X., George Zheng, Y., Liu, C. M., Schor, N. F. & 2 others, Li, Z. J. & Li, X. G., May 1 2020, In : Oncogenesis. 9, 5, 50.

Research output: Contribution to journalArticle

Open Access
2019

Dominant-negative ATF5 rapidly depletes survivin in tumor cells

Sun, X., Angelastro, J. M., Merino, D., Zhou, Q., Siegelin, M. D. & Greene, L. A., Oct 1 2019, In : Cell Death and Disease. 10, 10, 709.

Research output: Contribution to journalArticle

Open Access
2017

Expression and targeting of transcription factor ATF5 in dog gliomas

York, D., Sproul, C. D., Chikere, N., Dickinson, P. J. & Angelastro, J. M., 2017, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journalArticle

3 Scopus citations

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination

Wald, J. H., Hatakeyama, J., Printsev, I., Cuevas, A., Fry, W. H. D., Saldana, M. J., Vandervorst, K., Rowson-Hodel, A., Angelastro, J. M., Sweeney, C. A. & Carraway, K. L., Sep 7 2017, In : Oncogene. 36, 36, p. 5158-5167 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting ATF5 in Cancer

Angelastro, J. M., Jul 1 2017, In : Trends in Cancer. 3, 7, p. 471-474 4 p.

Research output: Contribution to journalShort survey

10 Scopus citations

The transcription factor ATF5: Role in cellular differentiation, stress responses, and cancer

Sears, T. K. & Angelastro, J. M., 2017, In : Oncotarget. 8, 48, p. 84595-84609 15 p.

Research output: Contribution to journalReview article

8 Scopus citations
2016

A synthetic cell-penetrating dominant-negative ATF5 peptide exerts anticancer activity against a broad spectrum of treatment-resistant cancers

Karpel-Massler, G., Horst, B. A., Shu, C., Chau, L., Tsujiuchi, T., Bruce, J. N., Canoll, P., Greene, L. A., Angelastro, J. M. & Siegelin, M. D., Sep 15 2016, In : Clinical Cancer Research. 22, 18, p. 4698-4711 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Regression/Eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide

Cates, C. C., Arias, A. D., Nakayama Wong, L. S., Lamé, M. W., Sidorov, M., Cayanan, G., Rowland, D. J., Fung, J., Karpel-Massler, G., Siegelin, M. D., Greene, L. A. & Angelastro, J. M., Mar 15 2016, In : Oncotarget. 7, 11, p. 12718-12730 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

Mitochondrial dysfunction in Pten Haplo-insufficient mice with social deficits and repetitive behavior: Interplay between Pten and p53

Napoli, E., Ross-Inta, C., Wong, S., Hung, C., Fujisawa, Y., Sakaguchi, D., Angelastro, J. M., Omanska-Klusek, A., Schoenfeld, R. & Giulivi, C. R., Aug 10 2012, In : PLoS One. 7, 8, e42504.

Research output: Contribution to journalArticle

66 Scopus citations

Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells

Lee, H. Y., Angelastro, J. M., Kenney, A. M., Mason, C. A. & Greene, L. A., Jun 2012, In : Developmental Neurobiology. 72, 6, p. 789-804 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas

Arias, A., Lamé, M. W., Santarelli, L., Hen, R., Greene, L. A. & Angelastro, J. M., Feb 2012, In : Oncogene. 31, 6, p. 739-751 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development

Cunningham, C. L., Martinez-Cerdeno, V., Porras, E. N., Prakash, A. N., Angelastro, J. M., Willemsen, R., Hagerman, P. J., Pessah, I. N., Berman, R. F. & Noctor, S. C., Jan 2011, In : Human Molecular Genetics. 20, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

59 Scopus citations
2010

Overexpression of CD133 promotes drug resistance in C6 glioma cells

Angelastro, J. M. & Lamé, M. W., Aug 2010, In : Molecular Cancer Research. 8, 8, p. 1105-1115 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
2009

Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in C6 glioma and MCF-7 breast cancer cells

Li, G., Li, W., Angelastro, J. M., Greene, L. A. & Liu, D. X., Jun 2009, In : Molecular Cancer Research. 7, 6, p. 933-943 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

The transcription factor ATF5: Role in neurodevelopment and neural tumors

Greene, L. A., Lee, H. Y. & Angelastro, J. M., Jan 2009, In : Journal of Neurochemistry. 108, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

53 Scopus citations
2007

Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme

Schrot, R. J., Ma, J. H., Greco, C. M., Arias, A. D. & Angelastro, J. M., Nov 2007, In : Journal of Neuro-Oncology. 85, 2, p. 149-157 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
58 Scopus citations
2006

Cultured PC12 cells: A model for neuronal function, differentiation, and survival

Teng, K. K., Angelastro, J. M., Cunningham, M. E. & Greene, L. A., 2006, Cell Biology, Four-Volume Set. Elsevier Inc., Vol. 1. p. 171-176 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Microtubule Dynamics: Bioenergetics and Control

Purich, D. L. & Angelastro, J. M., Nov 27 2006, Advances in Enzymology and Related Areas of Molecular Biology. John Wiley and Sons Inc., Vol. 69. p. 121-154 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5

Angelastro, J. M., Canoll, P. D., Kuo, J., Weicker, M., Costa, A., Bruce, J. N. & Greene, L. A., Feb 9 2006, In : Oncogene. 25, 6, p. 907-916 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2005

Analysis of gene expression changes in a cellular model of Parkinson disease

Ryu, E. J., Angelastro, J. M. & Greene, L. A., Feb 2005, In : Neurobiology of Disease. 18, 1, p. 54-74 21 p.

Research output: Contribution to journalArticle

62 Scopus citations

ATF5 regulates the proliferation and differentiation of oligodendrocytes

Mason, J. L., Angelastro, J. M., Ignatova, T. N., Kukekov, V. G., Lin, G., Greene, L. A. & Goldman, J. E., Jul 2005, In : Molecular and Cellular Neuroscience. 29, 3, p. 372-380 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes

Angelastro, J. M., Mason, J. L., Ignatova, T. N., Kukekov, V. G., Stengren, G. B., Goldman, J. E. & Greene, L. A., Apr 13 2005, In : Journal of Neuroscience. 25, 15, p. 3889-3899 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

You can't go home again: Transcriptionally driven alteration of cell signaling by NGF

Greene, L. A. & Angelastro, J. M., Oct 2005, In : Neurochemical Research. 30, 10, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons

Jabado, O., Wang, Q., Rideout, H. J., Yeasmin, M., Guo, K. X., Vekrellis, K., Papantonis, S., Angelastro, J. M., Troy, C. M. & Stefanis, L., Jun 2004, In : Cell Death and Differentiation. 11, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2003

Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons

Angelastro, J. M., Ignatova, T. N., Kukekov, V. G., Steindler, D. A., Stengren, G. B., Mendelsohn, C. & Greene, L. A., Jun 1 2003, In : Journal of Neuroscience. 23, 11, p. 4590-4600 11 p.

Research output: Contribution to journalArticle

98 Scopus citations
2002

Blue-white selection step enhances the yield of SAGE concatemers

Angelastro, J. M., Ryu, E. J., Törõcsik, B., Fiske, B. K. & Greene, L. A., 2002, In : BioTechniques. 32, 3, p. 484-486 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease

Ryu, E. J., Harding, H. P., Angelastro, J. M., Vitolo, O. V., Ron, D. & Greene, L. A., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10690-10698 9 p.

Research output: Contribution to journalArticle

430 Scopus citations

Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins

Angelastro, J. M., Töröcsik, B. & Greene, L. A., Feb 28 2002, In : BMC Neuroscience. 3, 3.

Research output: Contribution to journalArticle

30 Scopus citations

The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth

Töröcsik, B., Angelastro, J. M. & Greene, L. A., Oct 15 2002, In : Journal of Neuroscience. 22, 20, p. 8971-8980 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2001

Characterization of a Novel Isoform of Caspase-9 That Inhibits Apoptosis

Angelastro, J. M., Moon, N. Y., Liu, D. X., Yang, A. S., Greene, L. A. & Franke, T. F., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 12190-12200 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Death in the balance: Alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation

Troy, C. M., Rabacchi, S. A., Hohl, J. B., Angelastro, J. M., Greene, L. A. & Shelanski, M. L., Jul 15 2001, In : Journal of Neuroscience. 21, 14, p. 5007-5016 10 p.

Research output: Contribution to journalArticle

120 Scopus citations
2000

Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling

Angelastro, J. M., Klimaschewski, L., Tang, S., Vitolo, O. V., Weissman, T. A., Donlin, L. T., Shelanski, M. L. & Greene, L. A., Sep 12 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 19, p. 10424-10429 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
21 Scopus citations
1998

Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine

Angelastro, J. M., Ho, C. L., Frappier, T., Liem, R. K. H. & Greene, L. A., Feb 1998, In : Journal of Neurochemistry. 70, 2, p. 540-549 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
1994

Microtubule dynamics: Bioenergetics and control

Purich, D. L. & Angelastro, J. M., 1994, In : ADV.ENZYMOL.RELAT.AREAS MOL.BIOL.. 69, p. 121-154 34 p.

Research output: Contribution to journalArticle

11 Scopus citations
2 Scopus citations
1993

Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors

Volonté, C., Angelastro, J. M. & Greene, L. A., Oct 5 1993, In : Journal of Biological Chemistry. 268, 28, p. 21410-21415 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
1992

2′-Deoxy-GTP in the microtubule cytoskeleton of neuronal cells cultured with nerve growth factor

Angelastro, J. M. & Purich, D. L., Dec 25 1992, In : Journal of Biological Chemistry. 267, 36, p. 25685-25689 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Adenine and guanine nucleotide content of triton-extracted cytoskeletal fractions of nonmuscle cells

Angelastro, J. M. & Purich, D. L., 1992, In : Analytical Biochemistry. 204, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
1991

Evidence against impaired brain microtubule protein polymerization at high glucose concentrations or during diabetes mellitus

Eaker, E. Y., Angelastro, J. M., Purich, D. L. & Sninsky, C. A., Jun 1991, In : Journal of Neurochemistry. 56, 6, p. 2087-2093 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
1990

Apparently irreversible GTP hydrolysis attends tubulin self-assembly

Angelastro, J. M. & Purich, D. L., 1990, In : European Journal of Biochemistry. 191, 2, p. 507-511 5 p.

Research output: Contribution to journalArticle

8 Scopus citations