• 34926 Citations
  • 97 h-Index
1975 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Behavioral analyses of animal models of intellectual and developmental disabilities

Crawley, J. N., Fagiolini, M., Harrison, F. E., Samaco, R., Wozniak, D. F. & Robinson, M. B., Jan 1 2019, (Accepted/In press) In : Neurobiology of Learning and Memory. 107087.

Research output: Contribution to journalEditorial

Behavioral Evaluation of Angelman Syndrome Mice at Older Ages

Dutta, R. & Crawley, J. N., Jan 1 2019, (Accepted/In press) In : Neuroscience.

Research output: Contribution to journalArticle

Open Access

Erratum: Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size (Brain (2019) 142: 2617-2630) DOI: 10.1093/brain/awz198

Le Duc, D., Giulivi, C., Hiatt, S. M., Napoli, E., Panoutsopoulos, A., De Crescenzo, A. H., Kotzaeridou, U., Syrbe, S., Anagnostou, E., Azage, M., Bend, R., Begtrup, A., Brown, N. J., Büttner, B., Cho, M. T., Cooper, G. M., Doering, J. H., Dubourg, C., Everman, D. B., Hildebrand, M. S. & 27 others, Santos, F. J. R., Kellam, B., Keller-Ramey, J., Lemke, J. R., Liu, S., Niyazov, D., Payne, K., Person, R., Quélin, C., Schnur, R. E., Smith, B. T., Strober, J., Walker, S., Wallis, M., Walsh, L., Yang, S., Yuen, R. K. C., Ziegler, A., Sticht, H., Pride, M. C., Orosco, L., Martínez-Cerdenõ, V., Silverman, J. L., Crawley, J. N., Scherer, S. W., Zarbalis, K. S. & Jamra, R., Nov 1 2019, In : Brain. 142, 11, p. E63

Research output: Contribution to journalComment/debate

Open Access

Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism

Rhine, M. A., Parrott, J. M., Schultz, M. N., Kazdoba, T. M. & Crawley, J., Jan 1 2019, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

6 Scopus citations

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size

Le Duc, D., Giulivi, C., Hiatt, S. M., Napoli, E., Panoutsopoulos, A., Harlan De Crescenzo, A., Kotzaeridou, U., Syrbe, S., Anagnostou, E., Azage, M., Bend, R., Begtrup, A., Brown, N. J., Büttner, B., Cho, M. T., Cooper, G. M., Doering, J. H., Dubourg, C., Everman, D. B., Hildebrand, M. S. & 27 others, Santos, F. J. R., Kellam, B., Keller-Ramey, J., Lemke, J. R., Liu, S., Niyazov, D., Payne, K., Person, R., Quélin, C., Schnur, R. E., Smith, B. T., Strober, J., Walker, S., Wallis, M., Walsh, L., Yang, S., Yuen, R. K. C., Ziegler, A., Sticht, H., Pride, M. C., Orosco, L., Martínez-Cerdeño, V., Silverman, J. L., Crawley, J. N., Scherer, S. W., Zarbalis, K. S. & Jamra, R., Sep 1 2019, In : Brain : a journal of neurology. 142, 9, p. 2617-2630 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rigor in science and science reporting: Updated guidelines for submissions to Molecular Autism

Buxbaum, J. D., Baron-Cohen, S., Anagnostou, E., Ashwin, C., Betancur, C., Chakrabarti, B., Crawley, J., Hoekstra, R. A., Hof, P. R., Lai, M. C., Lombardo, M. V. & Schumann, C., Feb 4 2019, In : Molecular Autism. 10, 1, 6.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations

Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities

Lauterborn, J. C., Schultz, M. N., Le, A. A., Amani, M., Friedman, A. E., Leach, P. T., Gall, C. M., Lynch, G. S. & Crawley, J., Dec 1 2019, In : Translational Psychiatry. 9, 1, 166.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism

Jones, K. L., Pride, M. C., Edmiston, E., Yang, M., Silverman, J. L., Crawley, J. N. & van de Water, J., Jun 28 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Drug development for neurodevelopmental disorders: Lessons learned from fragile X syndrome

Berry-Kravis, E. M., Lindemann, L., Jønch, A. E., Apostol, G., Bear, M. F., Carpenter, R. L., Crawley, J., Curie, A., Des Portes, V., Hossain, F., Gasparini, F., Gomez-Mancilla, B., Hessl, D. R., Loth, E., Scharf, S. H., Wang, P. P., Von Raison, F., Hagerman, R. J., Spooren, W. & Jacquemont, S., Mar 28 2018, In : Nature Reviews Drug Discovery. 17, 4, p. 280-298 19 p.

Research output: Contribution to journalReview article

77 Scopus citations

MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome

Vogel Ciernia, A., Yasui, D. H., Pride, M. C., Durbin-Johnson, B., Noronha, A. B., Chang, A., Knotts, T. A., Rutkowsky, J. R., Ramsey, J. J., Crawley, J. & LaSalle, J. M., Dec 1 2018, In : Human Molecular Genetics. 27, 23, p. 4077-4093 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice

Stoppel, L. J., Kazdoba, T. M., Schaffler, M. D., Preza, A. R., Heynen, A., Crawley, J. & Bear, M. F., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 513-524 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rigor and reproducibility in rodent behavioral research

Gulinello, M., Mitchell, H. A., Chang, Q., Timothy O'Brien, W., Zhou, Z., Abel, T., Wang, L., Corbin, J. G., Veeraragavan, S., Samaco, R. C., Andrews, N. A., Fagiolini, M., Cole, T. B., Burbacher, T. M. & Crawley, J., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

9 Scopus citations

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

Matt, L., Kirk, L. M., Chenaux, G., Speca, D. J., Puhger, K. R., Pride, M. C., Qneibi, M., Haham, T., Plambeck, K. E., Stern-Bach, Y., Silverman, J. L., Crawley, J., Hell, J. W. & Diaz, E. D., Feb 27 2018, In : Cell Reports. 22, 9, p. 2455-2468 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
8 Scopus citations

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models

Deurloo, M. H. S., Turlova, E., Chen, W. L., Lin, Y. W., Tam, E., Tassew, N. G., Wu, M., Huang, Y. C., Crawley, J., Monnier, P. P., Groffen, A. J. A., Sun, H. S., Osborne, L. R. & Feng, Z. P., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders

Sukoff Rizzo, S. J. & Crawley, J., Feb 8 2017, In : Annual Review of Animal Biosciences. 5, p. 371-389 19 p.

Research output: Contribution to journalReview article

18 Scopus citations

Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering

Vogel Ciernia, A., Pride, M. C., Durbin-Johnson, B., Noronha, A., Chang, A., Yasui, D. H., Crawley, J. & LaSalle, J. M., May 15 2017, In : Human Molecular Genetics. 26, 10, p. 1839-1854 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Germline Chd8 haploinsufficiency alters brain development in mouse

Gompers, A. L., Su-Feher, L., Ellegood, J., Copping, N. A., Riyadh, M. A., Stradleigh, T. W., Pride, M. C., Schaffler, M. D., Wade, A. A., Catta-Preta, R., Zdilar, I., Louis, S., Kaushik, G., Mannion, B. J., Plajzer-Frick, I., Afzal, V., Visel, A., Pennacchio, L. A., Dickel, D. E., Lerch, J. P. & 4 others, Crawley, J., Zarbalis, K., Silverman, J. L. & Nord, A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1062-1073 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders

Yan, L., Shamir, A., Skirzewski, M., Leiva-Salcedo, E., Kwon, O. B., Karavanova, I., Paredes, D., Malkesman, O., Bailey, K. R., Vullhorst, D., Crawley, J. & Buonanno, A., Mar 21 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

21 Scopus citations

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

Dhamne, S. C., Silverman, J. L., Super, C. E., Lammers, S. H. T., Hameed, M. Q., Modi, M. E., Copping, N. A., Pride, M. C., Smith, D. G., Rotenberg, A., Crawley, J. & Sahin, M., Jun 15 2017, In : Molecular Autism. 8, 1, 26.

Research output: Contribution to journalArticle

40 Scopus citations
2016

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Crawley, J., Heyer, W. D. & LaSalle, J. M., Mar 1 2016, In : Trends in Genetics. 32, 3, p. 139-146 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Behavioral phenotypes of genetic mouse models of autism

Kazdoba, T. M., Leach, P. T. & Crawley, J., Jan 1 2016, In : Genes, Brain and Behavior. 15, 1, p. 7-26 20 p.

Research output: Contribution to journalArticle

56 Scopus citations

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Kazdoba, T. M., Hagerman, R. J., Zolkowska, D., Rogawski, M. A. & Crawley, J., Jan 1 2016, In : Psychopharmacology. 233, 2, p. 309-323 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task

Leach, P. T., Hayes, J., Pride, M., Silverman, J. L. & Crawley, J., Jan 1 2016, In : eNeuro. 3, 1

Research output: Contribution to journalArticle

10 Scopus citations

Translational mouse models of autism: Advancing toward pharmacological therapeutics

Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Friedman, M. S. & Crawley, J., Jan 1 2016, Current Topics in Behavioral Neurosciences. Springer Verlag, Vol. 28. p. 1-52 52 p. (Current Topics in Behavioral Neurosciences; vol. 28).

Research output: Chapter in Book/Report/Conference proceedingChapter

53 Scopus citations
2015

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks

Yang, M., Lewis, F. C., Sarvi, M. S., Foley, G. M. & Crawley, J., Dec 1 2015, In : Learning and Memory. 22, 12, p. 622-632 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

16p11.2 deletion syndrome mice display sensory and ultrasonic vocalization deficits during social interactions

Yang, M., Mahrt, E. J., Lewis, F., Foley, G., Portmann, T., Dolmetsch, R. E., Portfors, C. V. & Crawley, J., Oct 1 2015, In : Autism Research. 8, 5, p. 507-521 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

3D visualization of the regional differences

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., Geschwind, D. H., Pacey, L. K., Hampson, D. R., Laliberté, C. L., Mills, A. A., Tam, E., Osborne, L. R., Kouser, M., Espinosa-Becerra, F., Xuan, Z. & 13 others, Powell, C. M., Raznahan, A., Robins, D. M., Nakai, N., Nakatani, J., Takumi, T., van Eede, M. C., Kerr, T. M., Muller, C., Blakely, R. D., Veenstra-VanderWeele, J., Henkelman, R. M. & Lerch, J. P., Feb 1 2015, In : Molecular Psychiatry. 20, 1, p. 1 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

Ellegood, J. & Crawley, J., Jun 3 2015, In : Neurotherapeutics. 12, 3, p. 521-533 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine

Flannery, B. M., Silverman, J. L., Bruun, D. A., Puhger, K. R., McCoy, M. R., Hammock, B. D., Crawley, J. & Lein, P. J., Jan 1 2015, In : Neurotoxicology and Teratology. 47, p. 36-45 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Clustering autism: Using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J., Lin, L., Genestine, M., Dicicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., Geschwind, D. H., Pacey, L. K., Hampson, D. R., Laliberté, C. L., Mills, A. A., Tam, E., Osborne, L. R., Kouser, M., Espinosa-Becerra, F., Xuan, Z. & 13 others, Powell, C. M., Raznahan, A., Robins, D. M., Nakai, N., Nakatani, J., Takumi, T., Van Eede, M. C., Kerr, T. M., Muller, C., Blakely, R. D., Veenstra-Vander Weele, J., Henkelman, R. M. & Lerch, J. P., Feb 5 2015, In : Molecular Psychiatry. 20, 1, p. 118-125 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

Cognitive abilities on transitive inference using a novel touchscreen technology for mice

Silverman, J. L., Gastrell, P. T., Karras, M. N., Friedman, M. S. & Crawley, J., May 1 2015, In : Cerebral Cortex. 25, 5, p. 1133-1142 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Curiosity as an approach to ethoexperimental analysis: Behavioral neuroscience as seen by students and colleagues of Bob Blanchard

Pearson, B. L., Crawley, J., Eilam, D., Pentkowski, N. S. & Summers, C. H., Dec 18 2015, (Accepted/In press) In : Neuroscience and Biobehavioral Reviews.

Research output: Contribution to journalArticle

4 Scopus citations

Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior

Genestine, M., Lin, L., Durens, M., Yan, Y., Jiang, Y., Prem, S., Bailoor, K., Kelly, B., Sonsalla, P. K., Matteson, P. G., Silverman, J. L., Crawley, J., Millonig, J. H. & DiCicco-Bloom, E., Jun 5 2015, In : Human Molecular Genetics. 24, 20, p. 5805-5827 23 p.

Research output: Contribution to journalArticle

24 Scopus citations

GABA B Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S. & Crawley, J., Mar 10 2015, In : Neuropsychopharmacology. 40, 9, p. 2228-2239 12 p.

Research output: Contribution to journalArticle

98 Scopus citations

Hippocampal transcriptomic and proteomic alterations in the BTBR mouse model of autism spectrum disorder

Daimon, C. M., Jasien, J. M., Wood, W. H., Zhang, Y., Becker, K. G., Silverman, J. L., Crawley, J., Martin, B. & Maudsley, S., 2015, In : Frontiers in Physiology. 6, NOV, 324.

Research output: Contribution to journalArticle

20 Scopus citations

In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

Yang, M., Lewis, F., Foley, G. & Crawley, J., Jul 1 2015, In : Physiology and Behavior. 146, p. 16-27 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: Current status and future perspectives

Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., Ring, R. H., Lajonchere, C., Esclassan, F., Talpos, J., Noldus, L. P. J. J., Burbach, J. P. H. & Steckler, T., Mar 2014, In : Psychopharmacology. 231, 6, p. 1125-1146 22 p.

Research output: Contribution to journalArticle

53 Scopus citations

Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome

Portmann, T., Yang, M., Mao, R., Panagiotakos, G., Ellegood, J., Dolen, G., Bader, P. L., Grueter, B. A., Goold, C., Fisher, E., Clifford, K., Rengarajan, P., Kalikhman, D., Loureiro, D., Saw, N. L., Zhengqui, Z., Miller, M. A., Lerch, J. P., Henkelman, R. M., Shamloo, M. & 3 others, Malenka, R. C., Crawley, J. & Dolmetsch, R. E., May 22 2014, In : Cell Reports. 7, 4, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

94 Scopus citations

Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice

Brielmaier, J., Senerth, J. M., Silverman, J. L., Matteson, P. G., Millonig, J. H., Dicicco-Bloom, E. & Crawley, J., Mar 2014, In : Genes, Brain and Behavior. 13, 3, p. 286-298 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Long-term exposure to intranasal oxytocin in a mouse autism model

Bales, K. L., Friedman, M. S., Jacob, S., Crawley, J., Silverman, J. L., Larke, R. H., Sahagun, E., Puhger, K. R., Pride, M. C. & Mendoza, S. P., Jan 1 2014, In : Translational Psychiatry. 4, 11, e480.

Research output: Contribution to journalArticle

70 Scopus citations

Modeling fragile X syndrome in the Fmr1 knockout mouse

Kazdoba, T. M., Leach, P. T., Silverman, J. L. & Crawley, J., 2014, In : Intractable and Rare Diseases Research. 3, 4, p. 118-133 16 p.

Research output: Contribution to journalArticle

98 Scopus citations

The promising trajectory of autism therapeutics discovery

Silverman, J. L. & Crawley, J., 2014, In : Drug Discovery Today. 19, 7, p. 838-844 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

Silverman, J. L., Oliver, C. F., Karras, M. N., Gastrell, P. T. & Crawley, J., Jan 2013, In : Neuropharmacology. 64, p. 268-282 15 p.

Research output: Contribution to journalArticle

73 Scopus citations

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2

Wöhr, M., Silverman, J. L., Scattoni, M. L., Turner, S. M., Harris, M. J., Saxena, R. & Crawley, J., Aug 15 2013, In : Behavioural Brain Research. 251, p. 50-64 15 p.

Research output: Contribution to journalArticle

68 Scopus citations

Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

Kerr, T. M., Muller, C. L., Miah, M., Jetter, C. S., Pfeiffer, R., Shah, C., Baganz, N., Anderson, G. M., Crawley, J., Sutcliffe, J. S., Blakely, R. D. & Veenstra-Vanderweele, J., 2013, In : Molecular Autism. 4, 1, 35.

Research output: Contribution to journalArticle

29 Scopus citations

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism

Silverman, J. L., Babineau, B. A., Oliver, C. F., Karras, M. N. & Crawley, J., May 2013, In : Neuropharmacology. 68, p. 210-222 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Low home cage social behaviors in BTBR T+tf/J mice during juvenile development

Babineau, B. A., Yang, M., Berman, R. F. & Crawley, J., Apr 2013, In : Physiology and Behavior. 114-115, p. 49-54 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Male mice emit distinct ultrasonic vocalizations when the female leaves the social interaction arena

Yang, M., Loureiro, D., Kalikhman, D. & Crawley, J., Nov 19 2013, In : Frontiers in Behavioral Neuroscience. NOV, 159.

Research output: Contribution to journalArticle

41 Scopus citations

Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging

Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P. & Crawley, J., Apr 15 2013, In : NeuroImage. 70, p. 288-300 13 p.

Research output: Contribution to journalArticle

71 Scopus citations