• 14032 Citations
  • 68 h-Index
1975 …2020

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Article
2020

Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice

Rutkowsky, J. M., Knotts, T. A., Allen, P. D., Pessah, I. N. & Ramsey, J. J., Jan 1 2020, (Accepted/In press) In : FASEB Journal.

Research output: Contribution to journalArticle

Open Access
2019

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

Sethi, S., Morgan, R. K., Feng, W., Lin, Y., Li, X., Luna, C., Koch, M., Bansal, R., Duffel, M. W., Puschner, B., Zoeller, R. T., Lehmler, H. J., Pessah, I. N. & Lein, P. J., Apr 2 2019, In : Environmental Science and Technology. 53, 7, p. 3948-3958 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations

Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome

Ma, L., Herren, A. W., Espinal, G., Randol, J., McLaughlin, B., Martinez-Cerdeño, V., Pessah, I. N., Hagerman, R. J. & Hagerman, P. J., Sep 3 2019, In : Acta neuropathologica communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice

Rude, K. M., Pusceddu, M. M., Keogh, C. E., Sladek, J. A., Rabasa, G., Miller, E. N., Sethi, S., Keil, K. P., Pessah, I. N., Lein, P. J. & Gareau, M. G., Oct 1 2019, In : Environmental Pollution. p. 708-721 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Influence of nanomolar deltamethrin on the hallmarks of primary cultured cortical neuronal network and the role of ryanodine receptors

Zheng, J., Yu, Y., Feng, W., Li, J., Liu, J., Zhang, C., Dong, Y., Pessah, I. N. & Cao, Z., Jun 1 2019, In : Environmental health perspectives. 127, 6, 067003.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) with Skeletal Muscle Ryanodine Receptor Type 1

Truong, K. M., Cherednichenko, G. & Pessah, I. N., Jun 1 2019, In : Toxicological Sciences. 170, 2, p. 509-524 16 p.

Research output: Contribution to journalArticle

Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca 2+ concentration

Zheng, J., Chen, J., Zou, X., Zhao, F., Guo, M., Wang, H., Zhang, T., Zhang, C., Feng, W., Pessah, I. N. & Cao, Z., Jan 1 2019, In : NeuroToxicology. 70, p. 112-121 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018
13 Scopus citations

Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example

Li, X., Holland, E. B., Feng, W., Zheng, J., Dong, Y., Pessah, I. N., Duffel, M. W., Robertson, L. W. & Lehmler, H. J., Jun 1 2018, In : Environmental Science and Pollution Research. 25, 17, p. 16508-16521 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice

Keil, K. P., Sethi, S., Wilson, M. D., Silverman, J. L., Pessah, I. N. & Lein, P. J., Jan 1 2018, (Accepted/In press) In : Genes, Brain and Behavior. e12526.

Research output: Contribution to journalArticle

4 Scopus citations

Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics

Zheng, J., McKinnie, S. M. K., El Gamal, A., Feng, W., Dong, Y., Agarwal, V., Fenical, W., Kumar, A., Cao, Z., Moore, B. S. & Pessah, I. N., May 1 2018, In : Environmental Science and Technology. 52, 9, p. 5469-5478 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

An extended structure-Activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors

Holland, E. B., Feng, W., Zheng, J., Dong, Y., Li, X., Lehmler, H. J. & Pessah, I. N., 2017, In : Toxicological Sciences. 155, 1, p. 170-181 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome

Robin, G., Lopez-Padrino, J. R., Espinal, G. M., Hulsizer, S., Hagerman, P. J. & Pessah, I. N., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2649-2666 18 p.

Research output: Contribution to journalArticle

16 Scopus citations

Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits.

Barnych, B., Vasylieva, N., Joseph, T., Hulsizer, S., Nguyen, H. M., Cajka, T., Pessah, I. N., Wulff, H., Gee, S. J. & Hammock, B. D., Jun 22 2017, In : Chemistry - A European Journal. 23, 35, p. 8466-8472 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A

Zhang, R. & Pessah, I. N., Apr 1 2017, In : Molecular Pharmacology. 91, 4, p. 428-436 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enantioselectivity of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks

Feng, W., Zheng, J., Robin, G., Dong, Y., Ichikawa, M., Inoue, Y., Mori, T., Nakano, T. & Pessah, I. N., Dec 19 2017, In : Environmental Science and Technology. 51, 24, p. 14406-14416 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures

Cao, Z., Xu, J., Hulsizer, S., Cui, Y., Dong, Y. & Pessah, I. N., Jan 1 2017, In : NeuroToxicology. 58, p. 11-22 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye

Nik, A. M., Pressly, B., Singh, V., Antrobus, S., Hulsizer, S., Rogawski, M. A., Wulff, H. & Pessah, I. N., Jul 1 2017, In : Molecular Pharmacology. 92, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison

Holland, E. B., Goldstone, J. V., Pessah, I. N., Whitehead, A., Reid, N. M., Karchner, S. I., Hahn, M. E., Nacci, D. E., Clark, B. W. & Stegeman, J. J., 2017, In : Aquatic Toxicology. 192, p. 105-115 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes

Dunaway, K. W., Islam, M. S., Coulson, R. L., Lopez, S. J., Vogel Ciernia, A., Chu, R. G., Yasui, D. H., Pessah, I. N., Lott, P., Mordaunt, C., Meguro-Horike, M., Horike, S. I., Korf, I. F. & LaSalle, J. M., Dec 13 2016, In : Cell Reports. 17, 11, p. 3035-3048 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay

Ahn, K. C., Ranganathan, A., Bever, C. S., Hwang, S. H., Holland, E. B., Morisseau, K., Pessah, I. N., Hammock, B. D. & Gee, S. J., Apr 5 2016, In : Environmental Science and Technology. 50, 7, p. 3754-3761 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

Ronjat, M., Feng, W., Dardevet, L., Dong, Y., Al Khoury, S., Chatelain, F. C., Vialla, V., Chahboun, S., Lesage, F., Darbon, H., Pessah, I. N. & De Waard, M., Apr 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 17, p. E2460-E2468

Research output: Contribution to journalArticle

4 Scopus citations
14 Scopus citations
2015

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

Bruun, D. A., Cao, Z., Inceoglu, B., Vito, S. T., Austin, A. T., Hulsizer, S., Hammock, B. D., Tancredi, D. J., Rogawski, M. A., Pessah, I. N. & Lein, P. J., Aug 1 2015, In : Neuropharmacology. 95, p. 332-342 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA

Fritsch, E. B., Stegeman, J. J., Goldstone, J. V., Nacci, D. E., Champlin, D., Jayaraman, S., Connon, R. E. & Pessah, I. N., Feb 1 2015, In : Aquatic Toxicology. 159, p. 156-166 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
19 Scopus citations

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed K<inf>Ca</inf>2 Activator and Na<inf>V</inf> Blocker, is a Potent Novel Anticonvulsant

Coleman, N., Nguyen, H. M., Cao, Z., Brown, B. M., Jenkins, D. P., Zolkowska, D., Chen, Y. J., Tanaka, B. S., Goldin, A. L., Rogawski, M. A., Pessah, I. N. & Wulff, H., Jan 1 2015, In : Neurotherapeutics. 12, 1, p. 234-249 16 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle

Altamirano, F., Eltit, J. M., Robin, G., Linares, N., Ding, X., Pessah, I. N., Allen, P. D. & López, J. R., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 19180-19190 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nanomolar Bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity

Cao, Z., Cui, Y., Nguyen, H. M., Jenkins, D. P., Wulff, H. & Pessah, I. N., Apr 2014, In : Molecular Pharmacology. 85, 4, p. 630-639 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms

Yang, D., Kania-Korwel, I., Ghogha, A., Chen, H., Stamou, M., Bose, D. D., Pessah, I. N., Lehmler, H. J. & Lein, P. J., 2014, In : Toxicological Sciences. 138, 2, p. 379-392 14 p.

Research output: Contribution to journalArticle

41 Scopus citations
21 Scopus citations
2013

Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation

Vogel, C. F. A., Wu, D., Goth, S. R., Baek, J., Lollies, A., Domhardt, R., Grindel, A. & Pessah, I. N., 2013, In : Immunology and Cell Biology. 91, 9, p. 568-575 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Autism-specific maternal autoantibodies recognize critical proteins in developing brain

Braunschweig, D., Krakowiak, P., Duncanson, P., Boyce, R., Hansen, R. L., Ashwood, P., Hertz-Picciotto, I., Pessah, I. N. & Van de Water, J. A., 2013, In : Translational Psychiatry. 3, e277.

Research output: Contribution to journalArticle

127 Scopus citations

Enhanced asynchronous Ca2+ oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion

Cao, Z., Hulsizer, S., Cui, Y., Pretto, D. L., Kim, K. H., Hagerman, P. J., Tassone, F. & Pessah, I. N., May 10 2013, In : Journal of Biological Chemistry. 288, 19, p. 13831-13841 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Global increases in both common and rare copy number load associated with autism

Girirajan, S., Johnson, R. L., Tassone, F., Balciuniene, J., Katiyar, N., Fox, K., Baker, C., Srikanth, A., Yeoh, K. H., Khoo, S. J., Nauth, T. B., Hansen, R. L., Ritchie, M., Hertz-Picciotto, I., Eichler, E. E., Pessah, I. N. & Selleck, S. B., Jul 2013, In : Human Molecular Genetics. 22, 14, p. 2870-2880 11 p., ddt136.

Research output: Contribution to journalArticle

52 Scopus citations

Identification of expanded alleles of the FMR1 gene in the childhood autism risks from genes and environment (CHARGE) study

Tassone, F., Choudhary, N. S., Tassone, F., Durbin-Johnson, B., Hansen, R. L., Hertz-Picciotto, I. & Pessah, I. N., Mar 2013, In : Journal of Autism and Developmental Disorders. 43, 3, p. 530-539 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia

Eltit, J. M., Ding, X., Pessah, I. N., Allen, P. D. & Lopez, J. R., Mar 2013, In : FASEB Journal. 27, 3, p. 991-1000 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
28 Scopus citations
16 Scopus citations

Structure-activity relationship of selected Meta-and Para-hydroxylated non-dioxin like polychlorinated biphenyls: From single RyR1 channels to muscle dysfunction

Niknam, Y., Feng, W., Cherednichenko, G., Dong, Y., Joshi, S. N., Vyas, S. M., Lehmler, H. J. & Pessah, I. N., Dec 2013, In : Toxicological Sciences. 136, 2, p. 500-513 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas)

Fritsch, E. B., Connon, R. E., Werner, I., Davies, R. E., Beggel, S., Feng, W. & Pessah, I. N., Feb 19 2013, In : Environmental Science and Technology. 47, 4, p. 2008-2017 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism

Walker, C. K., Anderson, K. W., Milano, K. M., Ye, S., Tancredi, D. J., Pessah, I. N., Hertz-Picciotto, I. & Kliman, H. J., Aug 1 2013, In : Biological Psychiatry. 74, 3, p. 204-211 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

Behavioral correlates of maternal antibody status among children with autism

Braunschweig, D., Duncanson, P., Boyce, R., Hansen, R. L., Ashwood, P., Pessah, I. N., Hertz-Picciotto, I. & Van de Water, J. A., Jul 2012, In : Journal of Autism and Developmental Disorders. 42, 7, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with allopregnanolone

Cao, Z., Hulsizer, S., Tassone, F., Tang, H. T., Hagerman, R. J., Rogawski, M. A., Hagerman, P. J. & Pessah, I. N., Jul 2012, In : Human Molecular Genetics. 21, 13, p. 2923-2935 13 p., dds118.

Research output: Contribution to journalArticle

56 Scopus citations

Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin

Feng, W., Hwang, H. S., Kryshtal, D. O., Yang, T., Padilla, I. T., Tiwary, A. K., Puschner, B., Pessah, I. N. & Knollmann, B. C., Nov 2012, In : Molecular Pharmacology. 82, 5, p. 993-1000 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model

Kaplan, E. S., Cao, Z., Hulsizer, S., Tassone, F., Berman, R. F., Hagerman, P. J. & Pessah, I. N., Nov 2012, In : Journal of Neurochemistry. 123, 4, p. 613-621 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle

Barrientos, G. C., Feng, W., Truong, K., Matthaei, K. I., Yang, T., Allen, P. D., Lopez, J. R. & Pessah, I. N., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2863-2876 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice

Koenig, C. M., Walker, C. K., Qi, L., Pessah, I. N. & Berman, R. F., Jun 13 2012, In : PLoS One. 7, 6, e38911.

Research output: Contribution to journalArticle

2 Scopus citations
75 Scopus citations