• 7064 Citations
  • 35 h-Index
1993 …2021
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  • 3 Similar Profiles
Neoplasms Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Androgens Medicine & Life Sciences
Nuclear Receptor Coactivators Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Chromatin Medicine & Life Sciences

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Projects 2001 2021

Orphan Nuclear Receptors
Prostatic Neoplasms
Androgen Receptors
Neoplasms
Gene Expression
Epigenomics
Neoplasms
Prostatic Neoplasms
Therapeutics
Androgens

AR signal mediators in prostate cancer

Chen, H.

National Institutes of Health

7/20/096/30/12

Project: Research projectResearch Project

Androgen Receptors
Prostatic Neoplasms
Androgens
Hormones
Neoplasms

Role of coactivators in cell growth and tumorigenesis

Chen, H.

National Institutes of Health

2/1/0612/31/11

Project: Research projectResearch Project

Carcinogenesis
Proto-Oncogenes
Breast Neoplasms
Growth
Cell Proliferation

Protein acetylation as Mechanism of Hormone Signaling

Chen, H.

National Institutes of Health

7/1/012/28/14

Project: Research projectResearch Project

Hormones
Gene Expression
Acetylation
Estrogens
Steroid Receptors

Research Output 1993 2018

  • 7064 Citations
  • 35 h-Index
  • 61 Article
  • 1 Comment/debate

Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer

Xue, X., Zhang, Y., Wang, C., Zhang, M., Xiang, Q., Wang, J., Wang, A., Li, C., Zhang, C., Zou, L., Wang, R., Wu, S., Lu, Y., Chen, H., Ding, K., Li, G. & Xu, Y., May 25 2018, In : European Journal of Medicinal Chemistry. 152, p. 542-559 18 p.

Research output: Contribution to journalArticle

Benzoxazines
Castration
Prostatic Neoplasms
Derivatives
Proteins
1 Citations

Bioengineered noncoding RNAs selectively change cellular miRNome profiles for cancer therapy

Ho, P. Y., Duan, Z., Batra, N., Jilek, J. L., Tu, M. J., Qiu, J. X., Hu, Z., Wun, T., Lara, P. N., deVere White, R. W., Chen, H. & Yu, A., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 494-506 13 p.

Research output: Contribution to journalArticle

Untranslated RNA
MicroRNAs
Neoplasms
Bioengineering
Lung

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 othersWang, W. C., Chen, H. & Kung, H-J., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
2 Citations

Structure-Based Discovery and Optimization of Benzo [d] isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)

Zhang, M., Zhang, Y., Song, M., Xue, X., Wang, J., Wang, C., Zhang, C., Li, C., Xiang, Q., Zou, L., Wu, X., Wu, C., Dong, B., Xue, W., Zhou, Y., Chen, H., Wu, D., Ding, K. & Xu, Y., Apr 12 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 3037-3058 22 p.

Research output: Contribution to journalArticle

Isoxazoles
Castration
Prostatic Neoplasms
Therapeutic Uses
Heterografts
5 Citations

Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRα Signal Pathway

Chen, P., Wang, H., Yang, F., Chen, H., He, W. & Wang, J., 2016, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Curcumin
Cell death
Osteosarcoma
Signal Transduction
Cell Death