Gerardo Mackenzie

Associate Professor

  • 1707 Citations
  • 25 h-Index
20022020

Research output per year

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Research Output

  • 1707 Citations
  • 25 h-Index
  • 60 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate

(-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells

Verstraeten, S. V., Mackenzie, G., Oteiza, P. I. & Fraga, C. G., 2008, In : Free Radical Research. 42, 10, p. 864-872 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain

Mackenzie, G., Salvador, G. A., Romero, C., Keen, C. L. & Oteiza, P. I., Jul 15 2011, In : Free Radical Biology and Medicine. 51, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Aerosol administration of phospho-sulindac inhibits lung tumorigenesis

Cheng, K. W., Wong, C. C., Alston, N., Mackenzie, G., Huang, L., Ouyang, N., Xie, G., Wiedmann, T. & Rigas, B., Aug 1 2013, In : Molecular Cancer Therapeutics. 12, 8, p. 1417-1428 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms

Queisser, N., Schupp, N., Schwarz, E., Hartmann, C., Mackenzie, G. G. & Oteiza, P. I., Aug 1 2017, In : Molecular Carcinogenesis. 56, 8, p. 1868-1883 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice

Son, J. S., Khair, S., Pettet, D. W., Ouyang, N., Tian, X., Zhang, Y., Zhu, W., Mackenzie, G., Robertson, C. E., Ir, D., Frank, D. N., Rigas, B. & Li, E., Jun 29 2015, In : PLoS One. 10, 6, e0127985.

Research output: Contribution to journalArticle

25 Scopus citations

Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Trabert, B., Poole, E. M., White, E., Visvanathan, K., Adami, H. O., Anderson, G. L., Brasky, T. M., Brinton, L. A., Fortner, R. T., Gaudet, M., Hartge, P., Hoffman-Bolton, J., Jones, M., Lacey, J. V., Larsson, S. C., Mackenzie, G., Schouten, L. J., Sandler, D. P., O'Brien, K., Patel, A. V. & 11 others, Peters, U., Prizment, A., Robien, K., Setiawan, W. V., Swerdlow, A., Van Den Brandt, P. A., Weiderpass, E., Wilkens, L. R., Wolk, A., Wentzensen, N. & Tworoger, S. S., Oct 1 2018, In : Obstetrical and Gynecological Survey. 73, 10, p. 576-578 3 p.

Research output: Contribution to journalComment/debate

Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Ovarian Cancer Cohort Consortium (OC3), Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice

Mackenzie, G., Bartels, L. E., Xie, G., Papayannis, I., Alston, N., Vrankova, K., Ouyang, N. & Rigas, B., Jan 1 2013, In : Neoplasia (United States). 15, 10, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras

Mallangada, N. A., Vargas, J. M., Thomas, S., DiGiovanni, M. G., Vaeth, B. M., Nemesure, M. D., Wang, R., LaComb, J. F., Williams, J. L., Golub, L. M., Johnson, F. & Mackenzie, G., Sep 1 2018, In : Molecular Carcinogenesis. 57, 9, p. 1130-1143 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds

Huang, L., Mackenzie, G., Sun, Y., Ouyang, N., Xie, G., Vrankova, K., Komninou, D. & Rigas, B., Dec 15 2011, In : Cancer Research. 71, 24, p. 7617-7627 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Comparative study on the antioxidant capacity of wines and other plant-derived beverages

Actis-Goretta, L., Mackenzie, G., Oteiza, P. I. & Fraga, C. G., 2002, In : Annals of the New York Academy of Sciences. 957, p. 279-283 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice

Guorgui, J., Wang, R., Mattheolabakis, G. & Mackenzie, G., Jun 15 2018, In : Archives of Biochemistry and Biophysics. 648, p. 12-19 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

Mackenzie, G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M. & Oteiza, P. I., Jul 1 2008, In : International Journal of Cancer. 123, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

DHA-SBT-1214 taxoid nanoemulsion and anti–PD-L1 antibody combination therapy enhances antitumor efficacy in a syngeneic pancreatic adenocarcinoma model

Ahmad, G., Mackenzie, G. G., Egan, J. & Amiji, M. M., Jan 1 2019, In : Molecular Cancer Therapeutics. 18, 11, p. 1961-1972 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2

Zago, M. P., Mackenzie, G., Adamo, A. M., Keen, C. L. & Oteiza, P. I., Nov 2005, In : Antioxidants and Redox Signaling. 7, 11-12, p. 1773-1782 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Dimeric procyanidin B2 inhibits constitutively active NF-κB in Hodgkin's lymphoma cells independently of the presence of IκB mutations

Mackenzie, G., Adamo, A. M., Decker, N. P. & Oteiza, P. I., Apr 1 2008, In : Biochemical Pharmacology. 75, 7, p. 1461-1471 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Dimeric procyanidins are inhibitors of NF-κB-DNA binding

Mackenzie, G., Delfino, J. M., Keen, C. L., Fraga, C. G. & Oteiza, P. I., Nov 1 2009, In : Biochemical Pharmacology. 78, 9, p. 1252-1262 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines

Wei, R., Wirkus, J., Yang, Z., Machuca, J., Esparza, Y. & Mackenzie, G. G., Oct 15 2020, In : Archives of Biochemistry and Biophysics. 692, 108546.

Research output: Contribution to journalArticle

Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells.

Mackenzie, G., Carrasquedo, F., Delfino, J. M., Keen, C. L., Fraga, C. G. & Oteiza, P. I., 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 1, p. 167-169 3 p.

Research output: Contribution to journalArticle

165 Scopus citations
Open Access
9 Scopus citations

Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway

Nuttall, J. R., Supasai, S., Kha, J., Vaeth, B. M., Mackenzie, G., Adamo, A. M. & Oteiza, P. I., Nov 1 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1116-1123 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain

Aimo, L., Mackenzie, G., Keenan, A. H. & Oteiza, P. I., Nov 2010, In : Journal of Nutritional Biochemistry. 21, 11, p. 1069-1075 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells

Verstraeten, S. V., Zago, M. P., Mackenzie, G., Keen, C. L. & Oteiza, P. I., Mar 1 2004, In : Biochemical Journal. 378, 2, p. 579-587 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Liposomal irinotecan in the treatment of refractory pancreatic cancer

Bien, H., Mackenzie, G. & Choi, M., Nov 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 4, p. 376-383 8 p.

Research output: Contribution to journalReview article

Low intracellular zinc impairs the translocation of activated NF-κB to the nuclei in human neuroblastoma IMR-32 cells

Mackenzie, G., Paola Zago, M., Keen, C. L. & Oteiza, P. I., Sep 13 2002, In : Journal of Biological Chemistry. 277, 37, p. 34610-34617 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Metals in neurodegeneration: Involvement of oxidants and oxidant-sensitive transcription factors

Oteiza, P. I., Mackenzie, G. & Verstraeten, S. V., Feb 2004, In : Molecular Aspects of Medicine. 25, 1-2, p. 103-115 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: Modulation by zinc

Mackenzie, G., Keen, C. L. & Oteiza, P. I., Oct 2006, In : Journal of Neurochemistry. 99, 2, p. 402-415 14 p.

Research output: Contribution to journalArticle

51 Scopus citations

MiRNAs in gastrointestinal diseases: Can we effectively deliver RNA-based therapeutics orally?

Nawshad Hossian, A. K. M., MacKenzie, G. G. & Mattheolabakis, G., Jan 1 2019, In : Nanomedicine. 14, 21, p. 2873-2889 17 p.

Research output: Contribution to journalReview article

1 Scopus citations

Modulation of transcription factor NF-κB in Hodgkin's lymphoma cell lines: Effect of (-)-epicatechin

Mackenzie, G. & Oteiza, P. I., Oct 2006, In : Free Radical Research. 40, 10, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

NO-donating NSAIDs, PPARδ, and cancer: Does PPARδ contribute to colon carcinogenesis?

Mackenzie, G., Rasheed, S., Wertheim, W. & Rigas, B., Jun 23 2008, In : PPAR Research. 919572.

Research output: Contribution to journalReview article

5 Scopus citations

Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma

Luo, D., Liu, Y., Lin, S., Tan, L., Du, Z., Long, M., Zhu, Y., Peng, X., Zong, W., Mackenzie, G., Li, H. & Ouyang, N., Feb 1 2019, In : Oncology Reports. 41, 2, p. 1253-1263 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Pancreatic cancer: A critical review of dietary risk

Salem, A. A. & Mackenzie, G., Apr 1 2018, In : Nutrition Research. 52, p. 1-13 13 p.

Research output: Contribution to journalReview article

10 Scopus citations

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: An effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Huang, L., Wong, C. C., Mackenzie, G., Sun, Y., Cheng, K. W., Vrankova, K., Alston, N., Ouyang, N. & Rigas, B., Feb 28 2014, In : BMC Cancer. 14, 1, 141.

Research output: Contribution to journalArticle

16 Scopus citations

Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice

Mattheolabakis, G., Papayannis, I., Yang, J., Vaeth, B. M., Wang, R., Bandovic, J., Ouyang, N., Rigas, B. & Mackenzie, G., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 624-634 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: A redox-dependent effect

Zhao, W., Mackenzie, G., Murray, O. T., Zhang, Z. & Rigas, B., Mar 20 2009, In : Carcinogenesis. 30, 3, p. 512-519 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, and pharmacokinetics in mouse models

Xie, G., Sun, Y., Nie, T., Mackenzie, G., Huang, L., Kopelovich, L., Komninou, D. & Rigas, B., Jun 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 337, 3, p. 876-886 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: An effect controlled by the thioredoxin system

Sun, Y., Rowehl, L. M., Huang, L., Mackenzie, G., Vrankova, K., Komninou, D. & Rigas, B., Jan 31 2012, In : Breast Cancer Research. 14, 1, R20.

Research output: Contribution to journalArticle

21 Scopus citations

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice

Mackenzie, G., Sun, Y., Huang, L., Xie, G., Ouyang, N., Gupta, R. C., Johnson, F., Komninou, D., Kopelovich, L. & Rigas, B., Jan 1 2010, In : Gastroenterology. 139, 4, p. 1320-1332 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice

Mackenzie, G., Ouyang, N., Xie, G., Vrankova, K., Huang, L., Sun, Y., Komninou, D., Kopelovich, L. & Rigas, B., Jul 1 2011, In : Cancer Prevention Research. 4, 7, p. 1052-1060 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: Enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles

Zhu, R., Cheng, K. W., Mackenzie, G., Huang, L., Sun, Y., Xie, G., Vrankova, K., Constantinides, P. P. & Rigas, B., Nov 1 2012, In : Pharmaceutical Research. 29, 11, p. 3090-3101 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine-dependent effect

Huang, L., Zhu, C., Sun, Y., Xie, G., Mackenzie, G., Qiao, G., Komninou, D. & Rigas, B., Nov 1 2010, In : Carcinogenesis. 31, 11, p. 1982-1990 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine

Luo, D., Digiovanni, M. G., Wei, R., Lacomb, J. F., Williams, J. L., Rigas, B. & Mackenzie, G. G., Jul 14 2020, In : Carcinogenesis. 41, 7, p. 927-939 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation

Luo, D., Fraga-Lauhirat, M., Millings, J., Ho, C., Villarreal, E. M., Fletchinger, T. C., Bonfiglio, J. V., Mata, L., Nemesure, M. D., Bartels, L. E., Wang, R., Rigas, B. & Mackenzie, G. G., Dec 31 2019, In : Carcinogenesis. 40, 12, p. 1480-1491 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles

Mattheolabakis, G., Wang, R., Rigas, B. & Mackenzie, G., Oct 1 2017, In : International Journal of Oncology. 51, 4, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

Wei, R., Mao, L., Xu, P., Zheng, X., Hackman, R. M., MacKenzie, G. G. & Wang, Y., Nov 1 2018, In : Food and Function. 9, 11, p. 5682-5696 15 p.

Research output: Contribution to journalArticle

36 Scopus citations

Targeting glycolysis with epigallocatechin-3-gallate enhances the efficacy of chemotherapeutics in pancreatic cancer cells and xenografts

Wei, R., Hackman, R. M., Wang, Y. & Mackenzie, G. G., Oct 2019, In : Cancers. 11, 10, 1496.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

Mackenzie, G., Huang, L., Alston, N., Ouyang, N., Vrankova, K., Mattheolabakis, G., Constantinides, P. P. & Rigas, B., May 1 2013, In : PLoS One. 8, 5, e61532.

Research output: Contribution to journalArticle

48 Scopus citations

The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: In vitro and in vivo studies

Zhou, D., Papayannis, I., Mackenzie, G., Alston, N., Ouyang, N., Huang, L., Nie, T., Wong, C. C. & Rigas, B., Apr 1 2013, In : Carcinogenesis. 34, 4, p. 943-951 9 p.

Research output: Contribution to journalArticle

10 Scopus citations