Gerardo Mackenzie

Associate Professor

  • 1707 Citations
  • 25 h-Index
20022020

Research output per year

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Research Output

  • 1707 Citations
  • 25 h-Index
  • 60 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate
2002

Comparative study on the antioxidant capacity of wines and other plant-derived beverages

Actis-Goretta, L., Mackenzie, G., Oteiza, P. I. & Fraga, C. G., 2002, In : Annals of the New York Academy of Sciences. 957, p. 279-283 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Low intracellular zinc impairs the translocation of activated NF-κB to the nuclei in human neuroblastoma IMR-32 cells

Mackenzie, G., Paola Zago, M., Keen, C. L. & Oteiza, P. I., Sep 13 2002, In : Journal of Biological Chemistry. 277, 37, p. 34610-34617 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress

Mackenzie, G. G., Keen, C. L. & Oteiza, P. I., 2002, In : Developmental Neuroscience. 24, 2-3, p. 125-133 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells.

Mackenzie, G., Carrasquedo, F., Delfino, J. M., Keen, C. L., Fraga, C. G. & Oteiza, P. I., 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 1, p. 167-169 3 p.

Research output: Contribution to journalArticle

165 Scopus citations

Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells

Verstraeten, S. V., Zago, M. P., Mackenzie, G., Keen, C. L. & Oteiza, P. I., Mar 1 2004, In : Biochemical Journal. 378, 2, p. 579-587 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Metals in neurodegeneration: Involvement of oxidants and oxidant-sensitive transcription factors

Oteiza, P. I., Mackenzie, G. & Verstraeten, S. V., Feb 2004, In : Molecular Aspects of Medicine. 25, 1-2, p. 103-115 13 p.

Research output: Contribution to journalArticle

64 Scopus citations
2005

Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2

Zago, M. P., Mackenzie, G., Adamo, A. M., Keen, C. L. & Oteiza, P. I., Nov 2005, In : Antioxidants and Redox Signaling. 7, 11-12, p. 1773-1782 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Zinc, oxidant-triggered cell signaling, and human health

Oteiza, P. I. & Mackenzie, G., Aug 2005, In : Molecular Aspects of Medicine. 26, 4-5 SPEC. ISS., p. 245-255 11 p.

Research output: Contribution to journalArticle

82 Scopus citations
2006

Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: Modulation by zinc

Mackenzie, G., Keen, C. L. & Oteiza, P. I., Oct 2006, In : Journal of Neurochemistry. 99, 2, p. 402-415 14 p.

Research output: Contribution to journalArticle

51 Scopus citations

Modulation of transcription factor NF-κB in Hodgkin's lymphoma cell lines: Effect of (-)-epicatechin

Mackenzie, G. & Oteiza, P. I., Oct 2006, In : Free Radical Research. 40, 10, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

α-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-κB and AP-1 transcription factors in human neuroblastoma IMR-32 cells

Mackenzie, G., Zago, M. P., Erlejman, A. G., Aimo, L., Keen, C. L. & Oteiza, P. I., Jan 2006, In : Free Radical Research. 40, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT

Mackenzie, G. & Oteiza, P. I., Jan 2007, In : Journal of Cellular Physiology. 210, 1, p. 246-256 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Zinc deficiency in neuronal biology

Mackenzie, G., Zago, M. P., Aimo, L. & Oteiza, P. I., 2007, In : IUBMB Life. 59, 4-5, p. 299-307 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2008

(-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells

Verstraeten, S. V., Mackenzie, G., Oteiza, P. I. & Fraga, C. G., 2008, In : Free Radical Research. 42, 10, p. 864-872 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

Mackenzie, G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M. & Oteiza, P. I., Jul 1 2008, In : International Journal of Cancer. 123, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Dimeric procyanidin B2 inhibits constitutively active NF-κB in Hodgkin's lymphoma cells independently of the presence of IκB mutations

Mackenzie, G., Adamo, A. M., Decker, N. P. & Oteiza, P. I., Apr 1 2008, In : Biochemical Pharmacology. 75, 7, p. 1461-1471 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

NO-donating NSAIDs, PPARδ, and cancer: Does PPARδ contribute to colon carcinogenesis?

Mackenzie, G., Rasheed, S., Wertheim, W. & Rigas, B., Jun 23 2008, In : PPAR Research. 919572.

Research output: Contribution to journalReview article

5 Scopus citations
2009

Dimeric procyanidins are inhibitors of NF-κB-DNA binding

Mackenzie, G., Delfino, J. M., Keen, C. L., Fraga, C. G. & Oteiza, P. I., Nov 1 2009, In : Biochemical Pharmacology. 78, 9, p. 1252-1262 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: A redox-dependent effect

Zhao, W., Mackenzie, G., Murray, O. T., Zhang, Z. & Rigas, B., Mar 20 2009, In : Carcinogenesis. 30, 3, p. 512-519 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin

Hua, A., Mackenzie, G. & Rigas, B., Oct 1 2009, In : International Journal of Oncology. 35, 4, p. 837-844 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Zinc and the cytoskeleton in neuronal signaling

Mackenzie, G. G. & Oteiza, P. I., Jan 1 2009, Micronutrients and Brain Health. CRC Press, p. 149-161 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2010

Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain

Aimo, L., Mackenzie, G., Keenan, A. H. & Oteiza, P. I., Nov 2010, In : Journal of Nutritional Biochemistry. 21, 11, p. 1069-1075 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice

Mackenzie, G., Sun, Y., Huang, L., Xie, G., Ouyang, N., Gupta, R. C., Johnson, F., Komninou, D., Kopelovich, L. & Rigas, B., Jan 1 2010, In : Gastroenterology. 139, 4, p. 1320-1332 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine-dependent effect

Huang, L., Zhu, C., Sun, Y., Xie, G., Mackenzie, G., Qiao, G., Komninou, D. & Rigas, B., Nov 1 2010, In : Carcinogenesis. 31, 11, p. 1982-1990 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The plasma membrane plays a central role in cells response to mechanical stress

Verstraeten, S. V., Mackenzie, G. & Oteiza, P. I., Sep 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 9, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

The role of zinc in the modulation of neuronal proliferation and apoptosis

Adamo, A. M., Zago, M. P., Mackenzie, G., Aimo, L., Keen, C. L., Keenan, A. & Oteiza, P. I., Jan 2010, In : Neurotoxicity Research. 17, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

52 Scopus citations
2011

A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain

Mackenzie, G., Salvador, G. A., Romero, C., Keen, C. L. & Oteiza, P. I., Jul 15 2011, In : Free Radical Biology and Medicine. 51, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds

Huang, L., Mackenzie, G., Sun, Y., Ouyang, N., Xie, G., Vrankova, K., Komninou, D. & Rigas, B., Dec 15 2011, In : Cancer Research. 71, 24, p. 7617-7627 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
43 Scopus citations

Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, and pharmacokinetics in mouse models

Xie, G., Sun, Y., Nie, T., Mackenzie, G., Huang, L., Kopelovich, L., Komninou, D. & Rigas, B., Jun 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 337, 3, p. 876-886 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice

Mackenzie, G., Ouyang, N., Xie, G., Vrankova, K., Huang, L., Sun, Y., Komninou, D., Kopelovich, L. & Rigas, B., Jul 1 2011, In : Cancer Prevention Research. 4, 7, p. 1052-1060 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats

Huang, L., Mackenzie, G., Ouyang, N., Sun, Y., Xie, G., Johnson, F., Komninou, D. & Rigas, B., Apr 1 2011, In : British Journal of Pharmacology. 162, 7, p. 1521-1533 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
2012

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: An effect controlled by the thioredoxin system

Sun, Y., Rowehl, L. M., Huang, L., Mackenzie, G., Vrankova, K., Komninou, D. & Rigas, B., Jan 31 2012, In : Breast Cancer Research. 14, 1, R20.

Research output: Contribution to journalArticle

21 Scopus citations

Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: Enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles

Zhu, R., Cheng, K. W., Mackenzie, G., Huang, L., Sun, Y., Xie, G., Vrankova, K., Constantinides, P. P. & Rigas, B., Nov 1 2012, In : Pharmaceutical Research. 29, 11, p. 3090-3101 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine

Xie, G., Nie, T., Mackenzie, G., Sun, Y., Huang, L., Ouyang, N., Alston, N., Zhu, C., Murray, O. T., Constantinides, P. P., Kopelovich, L. & Rigas, B., Apr 1 2012, In : British Journal of Pharmacology. 165, 7, p. 2152-2166 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Aerosol administration of phospho-sulindac inhibits lung tumorigenesis

Cheng, K. W., Wong, C. C., Alston, N., Mackenzie, G., Huang, L., Ouyang, N., Xie, G., Wiedmann, T. & Rigas, B., Aug 1 2013, In : Molecular Cancer Therapeutics. 12, 8, p. 1417-1428 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice

Mackenzie, G., Bartels, L. E., Xie, G., Papayannis, I., Alston, N., Vrankova, K., Ouyang, N. & Rigas, B., Jan 1 2013, In : Neoplasia (United States). 15, 10, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

Mackenzie, G., Huang, L., Alston, N., Ouyang, N., Vrankova, K., Mattheolabakis, G., Constantinides, P. P. & Rigas, B., May 1 2013, In : PLoS One. 8, 5, e61532.

Research output: Contribution to journalArticle

48 Scopus citations

The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: In vitro and in vivo studies

Zhou, D., Papayannis, I., Mackenzie, G., Alston, N., Ouyang, N., Huang, L., Nie, T., Wong, C. C. & Rigas, B., Apr 1 2013, In : Carcinogenesis. 34, 4, p. 943-951 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats

Mattheolabakis, G., Mackenzie, G., Huang, L., Ouyang, N., Cheng, K. W. & Rigas, B., Jun 1 2013, In : Pharmaceutical Research. 30, 6, p. 1471-1482 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: An effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Huang, L., Wong, C. C., Mackenzie, G., Sun, Y., Cheng, K. W., Vrankova, K., Alston, N., Ouyang, N. & Rigas, B., Feb 28 2014, In : BMC Cancer. 14, 1, 141.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice

Son, J. S., Khair, S., Pettet, D. W., Ouyang, N., Tian, X., Zhang, Y., Zhu, W., Mackenzie, G., Robertson, C. E., Ir, D., Frank, D. N., Rigas, B. & Li, E., Jun 29 2015, In : PLoS One. 10, 6, e0127985.

Research output: Contribution to journalArticle

25 Scopus citations

Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway

Nuttall, J. R., Supasai, S., Kha, J., Vaeth, B. M., Mackenzie, G., Adamo, A. M. & Oteiza, P. I., Nov 1 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1116-1123 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: An effect mediated by cyclin D1

Bartels, L. E., Mattheolabakis, G., Vaeth, B. M., LaComb, J. F., Wang, R., Zhi, J., Komninou, D., Rigas, B. & Mackenzie, G., Oct 29 2015, In : Carcinogenesis. 37, 4, p. 420-429 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Liposomal irinotecan in the treatment of refractory pancreatic cancer

Bien, H., Mackenzie, G. & Choi, M., Nov 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 4, p. 376-383 8 p.

Research output: Contribution to journalReview article

Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice

Mattheolabakis, G., Papayannis, I., Yang, J., Vaeth, B. M., Wang, R., Bandovic, J., Ouyang, N., Rigas, B. & Mackenzie, G., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 624-634 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth

Choy, Y. Y., Fraga, M., Mackenzie, G., Waterhouse, A. L., Cremonini, E. & Oteiza, P. I., 2016, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms

Queisser, N., Schupp, N., Schwarz, E., Hartmann, C., Mackenzie, G. G. & Oteiza, P. I., Aug 1 2017, In : Molecular Carcinogenesis. 56, 8, p. 1868-1883 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles

Mattheolabakis, G., Wang, R., Rigas, B. & Mackenzie, G., Oct 1 2017, In : International Journal of Oncology. 51, 4, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms

Supasai, S., Aimo, L., Adamo, A. M., Mackenzie, G. & Oteiza, P. I., Apr 1 2017, In : Redox Biology. 11, p. 469-481 13 p.

Research output: Contribution to journalArticle

14 Scopus citations