Gerardo Mackenzie

Assistant Professor

  • 1689 Citations
  • 25 h-Index
20022020

Research output per year

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Research Output

  • 1689 Citations
  • 25 h-Index
  • 60 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate
2020

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines

Wei, R., Wirkus, J., Yang, Z., Machuca, J., Esparza, Y. & Mackenzie, G. G., Oct 15 2020, In : Archives of Biochemistry and Biophysics. 692, 108546.

Research output: Contribution to journalArticle

Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine

Luo, D., Digiovanni, M. G., Wei, R., Lacomb, J. F., Williams, J. L., Rigas, B. & Mackenzie, G. G., Jul 14 2020, In : Carcinogenesis. 41, 7, p. 927-939 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations
2019

Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Ovarian Cancer Cohort Consortium (OC3), Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

DHA-SBT-1214 taxoid nanoemulsion and anti–PD-L1 antibody combination therapy enhances antitumor efficacy in a syngeneic pancreatic adenocarcinoma model

Ahmad, G., Mackenzie, G. G., Egan, J. & Amiji, M. M., Jan 1 2019, In : Molecular Cancer Therapeutics. 18, 11, p. 1961-1972 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
8 Scopus citations

MiRNAs in gastrointestinal diseases: Can we effectively deliver RNA-based therapeutics orally?

Nawshad Hossian, A. K. M., MacKenzie, G. G. & Mattheolabakis, G., Jan 1 2019, In : Nanomedicine. 14, 21, p. 2873-2889 17 p.

Research output: Contribution to journalReview article

Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma

Luo, D., Liu, Y., Lin, S., Tan, L., Du, Z., Long, M., Zhu, Y., Peng, X., Zong, W., Mackenzie, G., Li, H. & Ouyang, N., Feb 1 2019, In : Oncology Reports. 41, 2, p. 1253-1263 11 p.

Research output: Contribution to journalArticle

Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation

Luo, D., Fraga-Lauhirat, M., Millings, J., Ho, C., Villarreal, E. M., Fletchinger, T. C., Bonfiglio, J. V., Mata, L., Nemesure, M. D., Bartels, L. E., Wang, R., Rigas, B. & Mackenzie, G. G., Dec 31 2019, In : Carcinogenesis. 40, 12, p. 1480-1491 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting glycolysis with epigallocatechin-3-gallate enhances the efficacy of chemotherapeutics in pancreatic cancer cells and xenografts

Wei, R., Hackman, R. M., Wang, Y. & Mackenzie, G. G., Oct 2019, In : Cancers. 11, 10, 1496.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Trabert, B., Poole, E. M., White, E., Visvanathan, K., Adami, H. O., Anderson, G. L., Brasky, T. M., Brinton, L. A., Fortner, R. T., Gaudet, M., Hartge, P., Hoffman-Bolton, J., Jones, M., Lacey, J. V., Larsson, S. C., Mackenzie, G., Schouten, L. J., Sandler, D. P., O'Brien, K., Patel, A. V. & 11 others, Peters, U., Prizment, A., Robien, K., Setiawan, W. V., Swerdlow, A., Van Den Brandt, P. A., Weiderpass, E., Wilkens, L. R., Wolk, A., Wentzensen, N. & Tworoger, S. S., Oct 1 2018, In : Obstetrical and Gynecological Survey. 73, 10, p. 576-578 3 p.

Research output: Contribution to journalComment/debate

A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras

Mallangada, N. A., Vargas, J. M., Thomas, S., DiGiovanni, M. G., Vaeth, B. M., Nemesure, M. D., Wang, R., LaComb, J. F., Williams, J. L., Golub, L. M., Johnson, F. & Mackenzie, G., Sep 1 2018, In : Molecular Carcinogenesis. 57, 9, p. 1130-1143 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice

Guorgui, J., Wang, R., Mattheolabakis, G. & Mackenzie, G., Jun 15 2018, In : Archives of Biochemistry and Biophysics. 648, p. 12-19 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pancreatic cancer: A critical review of dietary risk

Salem, A. A. & Mackenzie, G., Apr 1 2018, In : Nutrition Research. 52, p. 1-13 13 p.

Research output: Contribution to journalReview article

10 Scopus citations

Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

Wei, R., Mao, L., Xu, P., Zheng, X., Hackman, R. M., MacKenzie, G. G. & Wang, Y., Nov 1 2018, In : Food and Function. 9, 11, p. 5682-5696 15 p.

Research output: Contribution to journalArticle

30 Scopus citations
2017

Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms

Queisser, N., Schupp, N., Schwarz, E., Hartmann, C., Mackenzie, G. G. & Oteiza, P. I., Aug 1 2017, In : Molecular Carcinogenesis. 56, 8, p. 1868-1883 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles

Mattheolabakis, G., Wang, R., Rigas, B. & Mackenzie, G., Oct 1 2017, In : International Journal of Oncology. 51, 4, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms

Supasai, S., Aimo, L., Adamo, A. M., Mackenzie, G. & Oteiza, P. I., Apr 1 2017, In : Redox Biology. 11, p. 469-481 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Liposomal irinotecan in the treatment of refractory pancreatic cancer

Bien, H., Mackenzie, G. & Choi, M., Nov 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 4, p. 376-383 8 p.

Research output: Contribution to journalReview article

Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice

Mattheolabakis, G., Papayannis, I., Yang, J., Vaeth, B. M., Wang, R., Bandovic, J., Ouyang, N., Rigas, B. & Mackenzie, G., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 624-634 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth

Choy, Y. Y., Fraga, M., Mackenzie, G., Waterhouse, A. L., Cremonini, E. & Oteiza, P. I., 2016, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice

Son, J. S., Khair, S., Pettet, D. W., Ouyang, N., Tian, X., Zhang, Y., Zhu, W., Mackenzie, G., Robertson, C. E., Ir, D., Frank, D. N., Rigas, B. & Li, E., Jun 29 2015, In : PLoS One. 10, 6, e0127985.

Research output: Contribution to journalArticle

25 Scopus citations

Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway

Nuttall, J. R., Supasai, S., Kha, J., Vaeth, B. M., Mackenzie, G., Adamo, A. M. & Oteiza, P. I., Nov 1 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1116-1123 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: An effect mediated by cyclin D1

Bartels, L. E., Mattheolabakis, G., Vaeth, B. M., LaComb, J. F., Wang, R., Zhi, J., Komninou, D., Rigas, B. & Mackenzie, G., Oct 29 2015, In : Carcinogenesis. 37, 4, p. 420-429 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: An effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Huang, L., Wong, C. C., Mackenzie, G., Sun, Y., Cheng, K. W., Vrankova, K., Alston, N., Ouyang, N. & Rigas, B., Feb 28 2014, In : BMC Cancer. 14, 1, 141.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Aerosol administration of phospho-sulindac inhibits lung tumorigenesis

Cheng, K. W., Wong, C. C., Alston, N., Mackenzie, G., Huang, L., Ouyang, N., Xie, G., Wiedmann, T. & Rigas, B., Aug 1 2013, In : Molecular Cancer Therapeutics. 12, 8, p. 1417-1428 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice

Mackenzie, G., Bartels, L. E., Xie, G., Papayannis, I., Alston, N., Vrankova, K., Ouyang, N. & Rigas, B., Jan 1 2013, In : Neoplasia (United States). 15, 10, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

Mackenzie, G., Huang, L., Alston, N., Ouyang, N., Vrankova, K., Mattheolabakis, G., Constantinides, P. P. & Rigas, B., May 1 2013, In : PLoS One. 8, 5, e61532.

Research output: Contribution to journalArticle

48 Scopus citations

The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: In vitro and in vivo studies

Zhou, D., Papayannis, I., Mackenzie, G., Alston, N., Ouyang, N., Huang, L., Nie, T., Wong, C. C. & Rigas, B., Apr 1 2013, In : Carcinogenesis. 34, 4, p. 943-951 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats

Mattheolabakis, G., Mackenzie, G., Huang, L., Ouyang, N., Cheng, K. W. & Rigas, B., Jun 1 2013, In : Pharmaceutical Research. 30, 6, p. 1471-1482 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: An effect controlled by the thioredoxin system

Sun, Y., Rowehl, L. M., Huang, L., Mackenzie, G., Vrankova, K., Komninou, D. & Rigas, B., Jan 31 2012, In : Breast Cancer Research. 14, 1, R20.

Research output: Contribution to journalArticle

21 Scopus citations

Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: Enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles

Zhu, R., Cheng, K. W., Mackenzie, G., Huang, L., Sun, Y., Xie, G., Vrankova, K., Constantinides, P. P. & Rigas, B., Nov 1 2012, In : Pharmaceutical Research. 29, 11, p. 3090-3101 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine

Xie, G., Nie, T., Mackenzie, G., Sun, Y., Huang, L., Ouyang, N., Alston, N., Zhu, C., Murray, O. T., Constantinides, P. P., Kopelovich, L. & Rigas, B., Apr 1 2012, In : British Journal of Pharmacology. 165, 7, p. 2152-2166 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain

Mackenzie, G., Salvador, G. A., Romero, C., Keen, C. L. & Oteiza, P. I., Jul 15 2011, In : Free Radical Biology and Medicine. 51, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds

Huang, L., Mackenzie, G., Sun, Y., Ouyang, N., Xie, G., Vrankova, K., Komninou, D. & Rigas, B., Dec 15 2011, In : Cancer Research. 71, 24, p. 7617-7627 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
43 Scopus citations

Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, and pharmacokinetics in mouse models

Xie, G., Sun, Y., Nie, T., Mackenzie, G., Huang, L., Kopelovich, L., Komninou, D. & Rigas, B., Jun 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 337, 3, p. 876-886 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice

Mackenzie, G., Ouyang, N., Xie, G., Vrankova, K., Huang, L., Sun, Y., Komninou, D., Kopelovich, L. & Rigas, B., Jul 1 2011, In : Cancer Prevention Research. 4, 7, p. 1052-1060 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats

Huang, L., Mackenzie, G., Ouyang, N., Sun, Y., Xie, G., Johnson, F., Komninou, D. & Rigas, B., Apr 1 2011, In : British Journal of Pharmacology. 162, 7, p. 1521-1533 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
2010

Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain

Aimo, L., Mackenzie, G., Keenan, A. H. & Oteiza, P. I., Nov 2010, In : Journal of Nutritional Biochemistry. 21, 11, p. 1069-1075 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice

Mackenzie, G., Sun, Y., Huang, L., Xie, G., Ouyang, N., Gupta, R. C., Johnson, F., Komninou, D., Kopelovich, L. & Rigas, B., Jan 1 2010, In : Gastroenterology. 139, 4, p. 1320-1332 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine-dependent effect

Huang, L., Zhu, C., Sun, Y., Xie, G., Mackenzie, G., Qiao, G., Komninou, D. & Rigas, B., Nov 1 2010, In : Carcinogenesis. 31, 11, p. 1982-1990 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The plasma membrane plays a central role in cells response to mechanical stress

Verstraeten, S. V., Mackenzie, G. & Oteiza, P. I., Sep 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 9, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

The role of zinc in the modulation of neuronal proliferation and apoptosis

Adamo, A. M., Zago, M. P., Mackenzie, G., Aimo, L., Keen, C. L., Keenan, A. & Oteiza, P. I., Jan 2010, In : Neurotoxicity Research. 17, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

Dimeric procyanidins are inhibitors of NF-κB-DNA binding

Mackenzie, G., Delfino, J. M., Keen, C. L., Fraga, C. G. & Oteiza, P. I., Nov 1 2009, In : Biochemical Pharmacology. 78, 9, p. 1252-1262 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: A redox-dependent effect

Zhao, W., Mackenzie, G., Murray, O. T., Zhang, Z. & Rigas, B., Mar 20 2009, In : Carcinogenesis. 30, 3, p. 512-519 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin

Hua, A., Mackenzie, G. & Rigas, B., Oct 1 2009, In : International Journal of Oncology. 35, 4, p. 837-844 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Zinc and the cytoskeleton in neuronal signaling

Mackenzie, G. G. & Oteiza, P. I., Jan 1 2009, Micronutrients and Brain Health. CRC Press, p. 149-161 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

(-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells

Verstraeten, S. V., Mackenzie, G., Oteiza, P. I. & Fraga, C. G., 2008, In : Free Radical Research. 42, 10, p. 864-872 9 p.

Research output: Contribution to journalArticle

23 Scopus citations