Gerald L Denardo

Professor Emeritus

  • 8350 Citations
  • 51 h-Index
1962 …2017
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Research Output 1962 2017

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Article
2012
15 Citations (Scopus)

Concepts, consequences, and implications of theranosis

Denardo, G. L. & Denardo, S. J., May 2012, In : Seminars in Nuclear Medicine. 42, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Deoxyglucose
Therapeutics
Non-Hodgkin's Lymphoma
Peptide Aptamers
2009
2 Citations (Scopus)

Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells

Balhorn, R., Hok, S., DeNardo, S., Natarajan, A., Mirick, G., Corzett, M. & Denardo, G. L., Apr 22 2009, In : Molecular Cancer. 8, 25.

Research output: Contribution to journalArticle

Arginine
Lymphoma
Ligands
Peptides
Confocal Microscopy
6 Citations (Scopus)

Molecular specific and cell selective cytotoxicity induced by a novel synthetic HLA-DR antibody mimic for lymphoma and leukemia

Denardo, G. L., Mirick, G. R., Hok, S., DeNardo, S. J., Beckett, L. A., Adamson, G. N. & Balhorn, R. L., 2009, In : International Journal of Oncology. 34, 2, p. 511-516 6 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Heterografts
Lymphoma
Leukemia
Ligands
2008
46 Citations (Scopus)

Development of multivalent radioimmunonanoparticles for cancer imaging and therapy

Natarajan, A., Xiong, C. Y., Gruettner, C., Denardo, G. L. & DeNardo, S. J., Feb 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Therapeutics
Fever
Magnetic Fields
1 Citation (Scopus)

Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy

Natarajan, A., Kumaresan, P. R., DeNardo, S. J., Denardo, G. L., Mirick, G. & Lam, K., Sep 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 17, p. 4802-4805 4 p.

Research output: Contribution to journalArticle

Immunoconjugates
Radioimmunotherapy
Peptides
Tumors
Tissue
78 Citations (Scopus)

NanoFerrite particle based radioimmunonanoparticles: Binding affinity and in vivo pharmacokinetics

Natarajan, A., Gruettner, C., Ivkov, R., Denardo, G. L., Mirick, G., Yuan, A., Foreman, A. & DeNardo, S. J., Jun 2008, In : Bioconjugate Chemistry. 19, 6, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Nanoparticles
Iron oxides
Magnetic Field Therapy
Immunoconjugates
6 Citations (Scopus)

Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging

Denardo, G. L., Natarajan, A., Hok, S., Mirick, G., DeNardo, S. J., Corzett, M., Sysko, V., Lehmann, J., Beckett, L. A. & Balhorn, R., Dec 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 6, p. 783-795 13 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Antibodies
Ligands
Lymphoma
Confocal Microscopy
38 Citations (Scopus)

Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice

Dadachova, E., Revskaya, E., Sesay, M. A., Damania, H., Boucher, R., Sellers, R. S., Howell, R. C., Burns, L., Thornton, G. B., Natarajan, A., Mirick, G. R., DeNardo, S. J., Denardo, G. L. & Casadevall, A., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 1116-1127 12 p.

Research output: Contribution to journalArticle

Rhenium
Melanins
Nude Mice
Immunoglobulin M
Melanoma
12 Citations (Scopus)

Short communication: Nanoparticle thermotherapy and external beam radiation therapy for human prostate cancer cells

Lehmann, J., Natarajan, A., Denardo, G. L., Ivkov, R., Foreman, A. R., Catapano, C., Mirick, G., Quang, T., Gruettner, C. & DeNardo, S. J., Apr 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

Induced Hyperthermia
Nanoparticles
Prostatic Neoplasms
Radiotherapy
Biosensing Techniques
42 Citations (Scopus)

Targeted radionuclide therapy

Williams, L. E., Denardo, G. L. & Meredith, R. F., 2008, In : Medical Physics. 35, 7, p. 3062-3068 7 p.

Research output: Contribution to journalArticle

Radioisotopes
Organ Size
Bone Marrow
B-Cell Lymphoma
Therapeutics
2007
12 Citations (Scopus)

Characteristics of dimeric (bis) bidentate selective high affinity ligands as HLA-DR10 beta antibody mimics targeting non-Hodgkin's lymphoma

Denardo, G. L., Hok, S., Natarajan, A., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Yuan, A., Perkins, J., Sysko, V. V., Lehmann, J. & Balhorn, R. L., Oct 2007, In : International Journal of Oncology. 31, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
HLA-DR Antigens
Ligands
Antibodies
Pharmacokinetics
10 Citations (Scopus)

Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines

Tobin, E., Denardo, G. L., Zhang, N., Epstein, A. L., Liu, C. & DeNardo, S., May 2007, In : Leukemia and Lymphoma. 48, 5, p. 944-956 13 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Immunotherapy
Lymphoma
Monoclonal Antibodies
Cell Line
42 Citations (Scopus)

Construction of di-scFv through a trivalent alkyne-azide 1,3-dipolar cycloaddition

Natarajan, A., Du, W., Xiong, C. Y., Denardo, G. L., DeNardo, S. J. & Gervay-Hague, J., 2007, In : Chemical Communications. 7, p. 695-697 3 p.

Research output: Contribution to journalArticle

Alkynes
Azides
Cycloaddition
Antigens
Sulfhydryl Compounds
22 Citations (Scopus)
Mucin-1
Prostatic Neoplasms
Breast Neoplasms
Radioimmunotherapy
Neoplasms
2 Citations (Scopus)

Effect of antilymphoma antibody, 131I-Lym-1, on peripheral blood lymphocytes in patients with non-Hodgkin's lymphoma

Schillaci, O., Denardo, G. L., DeNardo, S. J., Goldstein, D. S., Kroger, L. A., O'Donnell, R. T. & Lamborn, K. R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 521-530 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Lymphocytes
Antibodies
Lymphocyte Count
Spleen
1 Citation (Scopus)
Birth and Death Process
Count Data
Antibody
Therapy
Cancer
17 Citations (Scopus)

Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma

Denardo, G. L., Natarajan, A., Hok, S., Perkins, J., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Miers, L. A. & Balhorn, R. L., Aug 2007, In : Journal of Nuclear Medicine. 48, 8, p. 1338-1347 10 p.

Research output: Contribution to journalArticle

HLA Antigens
Lymphoma
Pharmacokinetics
Ligands
Antibodies
2 Citations (Scopus)

Recombinant expression of the β-subunit of HLA-DR10 for the selection of novel lymphoma targeting molecules

Albrecht, H., Cosman, M., Ngu-Schwemlein, M., Corzett, M., Curran, K. W., Dolan, C., Fang, X., DeNardo, S. J., Denardo, G. L. & Balhorn, R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 531-542 12 p.

Research output: Contribution to journalArticle

Lymphoma
Ligands
Protein Refolding
Radioimmunotherapy
HLA-DR10 antigen
1 Citation (Scopus)

Selecting an intervention time for intravascular enzymatic cleavage of peptide linkers to clear radioisotope from normal tissues

Hartmann Siantar, C. L., Denardo, G. L., Lam, K., Yuan, A., Daly, T. & DeNardo, S. J., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

Radioisotopes
Pharmacokinetics
Peptides
Neoplasms
Immunoconjugates
26 Citations (Scopus)

Selective high-affinity ligand antibody mimics for cancer diagnosis and therapy: Initial application to lymphoma/leukemia

Balhorn, R., Hok, S., Burke, P. A., Lightstone, F. C., Cosman, M., Zemla, A., Mirick, G., Perkins, J., Natarajan, A., Corzett, M., DeNardo, S. J., Albrecht, H., Gregg, J. & Denardo, G. L., Sep 15 2007, In : Clinical Cancer Research. 13, 18

Research output: Contribution to journalArticle

Antibody Affinity
Lymphoma
Leukemia
Ligands
Antibodies
12 Citations (Scopus)

Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia

Hok, S., Natarajan, A., Balhorn, R., DeNardo, S. J., Denardo, G. L. & Perkins, J., May 2007, In : Bioconjugate Chemistry. 18, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Leukemia
Ligands
Antibodies
Epitopes
120 Citations (Scopus)

Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice

DeNardo, S. J., Denardo, G. L., Natarajan, A., Miers, L. A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Mar 1 2007, In : Journal of Nuclear Medicine. 48, 3, p. 437-444 8 p.

Research output: Contribution to journalArticle

Magnetic Fields
Biosensing Techniques
Nanoparticles
Hot Temperature
Breast Neoplasms
2006
19 Citations (Scopus)

Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting molecules

Burke, P. A., Gregg, J., Bakhtiar, B., Beckett, L. A., Denardo, G. L., Albrecht, H., deVere White, R. W. & De Nardo, S. J., Jul 2006, In : International Journal of Oncology. 29, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Glycoproteins
Prostate
Monoclonal Antibodies
Epitopes
3 Citations (Scopus)

Comparison of normal tissue pharmacokinetics with 111In/90Y monoclonal antibody m170 for breast and prostate cancer

Lehmann, J., Denardo, G. L., Yuan, A., Shen, S., O'Donnell, R. T., Richman, C. M. & DeNardo, S. J., Nov 15 2006, In : International Journal of Radiation Oncology Biology Physics. 66, 4, p. 1192-1198 7 p.

Research output: Contribution to journalArticle

antibodies
breast
Prostatic Neoplasms
Pharmacokinetics
cancer
25 Citations (Scopus)

Cure of incurable lymphoma

Denardo, G. L., Sysko, V. V. & DeNardo, S. J., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

antibodies
Lymphoma
drugs
Monoclonal Antibodies
Radioisotopes
24 Citations (Scopus)

Development of tumor targeting anti-MUC-1 multimer: Effects of di-scFv unpaired cysteine location on PEGylation and tumor binding

Xiong, C. Y., Natarajan, A., Shi, X. B., Denardo, G. L. & Denardo, S. J., Aug 2006, In : Protein Engineering, Design and Selection. 19, 8, p. 359-367 9 p.

Research output: Contribution to journalArticle

Cysteine
Tumors
Peptides
Polyethylene glycols
Cells
10 Citations (Scopus)

Direct antilymphoma activity of novel, first-generation "antibody mimics" that bind HLA-DR10-positive non-Hodgkin's lymphoma cells

West, J., Perkins, J., Hok, S., Balhorn, R., Lightstone, F. C., Cosman, M., DeNardo, S. J. & Denardo, G. L., 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 6, p. 645-654 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Ligands
Antibodies
Radioisotopes
Deoxycholic Acid
26 Citations (Scopus)
Cysteine
Antigens
Escherichia coli Proteins
Sulfhydryl Compounds
Neoplasms
37 Citations (Scopus)

Survival benefit associated with human anti-mouse antibody (HAMA) in patients with B-cell malignancies

Azinovic, I., Denardo, G. L., Lamborn, K. R., Mirick, G., Goldstein, D., Bradt, B. M. & DeNardo, S. J., Dec 2006, In : Cancer Immunology, Immunotherapy. 55, 12, p. 1451-1458 8 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
B-Lymphocytes
Survival
Neoplasms
Radioimmunotherapy
38 Citations (Scopus)

Targeted radionuclide therapy for solid tumors: An overview

DeNardo, S. J. & Denardo, G. L., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioisotopes
radioactive isotopes
therapy
tumors
2005
142 Citations (Scopus)

Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer

Ivkov, R., DeNardo, S. J., Daum, W., Foreman, A. R., Goldstein, R. C., Nemkov, V. S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Magnetic Fields
Nanoparticles
Hot Temperature
Neoplasms
Nude Mice
53 Citations (Scopus)

Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals

Natarajan, A., Xiong, C. Y., Albrecht, H., Denardo, G. L. & DeNardo, S. J., Jan 2005, In : Bioconjugate Chemistry. 16, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Drug products
Polyethylene glycols
Tumors
Pharmaceutical Preparations
Neoplasms
19 Citations (Scopus)
Radioimmunotherapy
Immunotherapy
Radiation
Radioisotopes
Non-Hodgkin's Lymphoma
165 Citations (Scopus)

Development of tumor targeting bioprobes (111In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy

DeNardo, S. J., Denardo, G. L., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Magnetic Field Therapy
Biosensing Techniques
Nanoparticles
Monoclonal Antibodies
Neoplasms
21 Citations (Scopus)

Direct antilymphoma effects on human lymphoma cells of monotherapy and combination therapy with CD20 and HLA-DR antibodies and 90Y-labeled HLA-DR antibodies

Denardo, G. L., Tobin, E., Chan, K., Bradt, B. M. & DeNardo, S. J., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

HLA-DR Antigens
Lymphoma
Antibodies
Monoclonal Antibodies
Cell Line
8 Citations (Scopus)

Does paclitaxel (taxol) given after111In-labeled monoclonal antibodies increase tumor-cumulated activity in epithelial cancers?

Miers, L., Lamborn, K., Yuan, A., Richman, C. M., Natarajan, A., DeNardo, S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Paclitaxel
Monoclonal Antibodies
Neoplasms
Breast Neoplasms
Heterografts
25 Citations (Scopus)

Enhancement of the therapeutic index: From nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer

DeNardo, S. J., Richman, C. M., Albrecht, H., Burke, P. A., Natarajan, A., Yuan, A., Gregg, J., O'Donnell, R. T. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Radioimmunotherapy
Prostatic Neoplasms
Paclitaxel
Bone Marrow
Cathepsins
66 Citations (Scopus)
Radioimmunotherapy
Yttrium
Cathepsins
Indium
Paclitaxel

Implantation of different malignant human cell lines in an athymic mouse does not alter success and growth rates of either xenograft

Miers, L., DeNardo, S. J., Lamborn, K. & Denardo, G. L., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 614-619 6 p.

Research output: Contribution to journalArticle

Heterografts
Nude Mice
Cell Line
Growth
Blood Transfusion
2 Citations (Scopus)

MINERVA: A multi-modality plugin-based radiation therapy treatment planning system

Wemple, C. A., Wessol, D. E., Nigg, D. W., Cogliati, J. J., Milvich, M., Fredrickson, C. M., Perkins, M., Harkin, G. J., Hartmann-Siantar, C. L., Lehmann, J., Flickinger, T., Pletcher, D., Yuan, A. & Denardo, G. L., Dec 20 2005, In : Radiation Protection Dosimetry. 116, 1-4, p. 202-207 6 p.

Research output: Contribution to journalArticle

Radiotherapy
planning
radiation therapy
Planning
programmers
21 Citations (Scopus)

Monte Carlo treatment planning for molecular targeted radiotherapy within the MINERVA system

Lehmann, J., Siantar, C. H., Wessol, D. E., Wemple, C. A., Nigg, D., Cogliati, J., Daly, T., Descalle, M. A., Flickinger, T., Pletcher, D. & Denardo, G. L., Mar 7 2005, In : Physics in Medicine and Biology. 50, 5, p. 947-958 12 p.

Research output: Contribution to journalArticle

Radiotherapy
systems analysis
planning
radiation therapy
Planning
6 Citations (Scopus)

Planning time for peripheral blood stem cell infusion after high-dose targeted radionuclide therapy using dosimetry

Shen, S., DeNardo, S. J., Richman, C. M., Yuan, A., Siantar, C. H., O'Donnell, R. T., Kroger, L. A. & Denardo, G. L., 2005, In : Journal of Nuclear Medicine. 46, 6, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

Radioisotopes
Radioactivity
Therapeutics
Radioimmunotherapy
Cell Survival
8 Citations (Scopus)

Splenic volume change and nodal tumor response in non-Hodgkin's lymphoma patients after radioimmunotherapy using radiolabeled Lym-1 antibody

Shen, S., Denardo, G. L., Yuan, A., Hartmann-Siantar, C., O'Donnell, R. T. & DeNardo, S. J., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 662-670 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Antibodies
Neoplasms
Splenomegaly
28 Citations (Scopus)

Treatment of Non-Hodgkin's Lymphoma (NHL) with radiolabeled antibodies (mAbs)

Denardo, G. L., Jul 2005, In : Seminars in Nuclear Medicine. 35, 3 SPEC. ISS., p. 202-211 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Radioimmunotherapy
Monoclonal Antibodies
Antibodies
Radioisotopes
2004
22 Citations (Scopus)

Antilymphoma effects of anti-HLA-DR and CD20 monoclonal antibodies (Lym-1 and rituximab) on human lymphoma cells

Liu, C., Denardo, G. L., Tobin, E. & DeNardo, S., 2004, In : Cancer Biotherapy and Radiopharmaceuticals. 19, 5, p. 545-561 17 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Lymphoma
Apoptosis
Cell Line
Non-Hodgkin's Lymphoma
49 Citations (Scopus)

Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: A multiinstitutional comparison

Wessels, B. W., Bolch, W. E., Bouchet, L. G., Breitz, H. B., Denardo, G. L., Meredith, R. F., Stabin, M. G. & Sgouros, G., Oct 1 2004, In : Journal of Nuclear Medicine. 45, 10, p. 1725-1733 9 p.

Research output: Contribution to journalArticle

Bone Marrow
Antibodies
Therapeutics
Medicine
Clinical Trials
10 Citations (Scopus)
Immunoconjugates
Cathepsins
Monoclonal Antibodies
Peptides
Liver
50 Citations (Scopus)

Production of Soluble ScFvs with C-Terminal-Free Thiol for Site-Specific Conjugation or Stable Dimeric ScFvs on Demand

Albrecht, H., Burke, P. A., Natarajan, A., Xiong, C. Y., Kalicinsky, M., Denardo, G. L. & DeNardo, S. J., Jan 2004, In : Bioconjugate Chemistry. 15, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

Reducing Agents
Sulfhydryl Compounds
Bacteriophages
Polyethylene glycols
Single-Chain Antibodies
17 Citations (Scopus)

Radiometals as payloads for radioimmunotherapy for lymphoma

Denardo, G. L., Kennel, S. J., Siegel, J. A. & DeNardo, S. J., Oct 2004, In : Clinical Lymphoma. 5, SUPPL. 1

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioisotopes
Lymphoma
Non-Hodgkin's Lymphoma
Monoclonal Antibodies
2003
43 Citations (Scopus)

Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts

Tuscano, J. M., O'Donnell, R. T., Miers, L. A., Kroger, L. A., Kukis, D. L., Lamborn, K. R., Tedder, T. F. & DeNardo, G. L., May 1 2003, In : Blood. 101, 9, p. 3641-3647 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Blocking Antibodies
Heterografts
Lymphoma
Cells