• 8504 Citations
  • 51 h-Index
1962 …2018

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Article
2012

Concepts, consequences, and implications of theranosis

Denardo, G. L. & Denardo, S. J., May 2012, In : Seminars in Nuclear Medicine. 42, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells

Balhorn, R., Hok, S., DeNardo, S., Natarajan, A., Mirick, G., Corzett, M. & Denardo, G. L., Apr 22 2009, In : Molecular Cancer. 8, 25.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular specific and cell selective cytotoxicity induced by a novel synthetic HLA-DR antibody mimic for lymphoma and leukemia

Denardo, G. L., Mirick, G. R., Hok, S., DeNardo, S. J., Beckett, L. A., Adamson, G. N. & Balhorn, R. L., 2009, In : International Journal of Oncology. 34, 2, p. 511-516 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2008

Development of multivalent radioimmunonanoparticles for cancer imaging and therapy

Natarajan, A., Xiong, C. Y., Gruettner, C., Denardo, G. L. & DeNardo, S. J., Feb 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy

Natarajan, A., Kumaresan, P. R., DeNardo, S. J., DeNardo, G. L., Mirick, G. & Lam, K. S., Sep 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 17, p. 4802-4805 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

NanoFerrite particle based radioimmunonanoparticles: Binding affinity and in vivo pharmacokinetics

Natarajan, A., Gruettner, C., Ivkov, R., Denardo, G. L., Mirick, G., Yuan, A., Foreman, A. & DeNardo, S. J., Jun 2008, In : Bioconjugate Chemistry. 19, 6, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging

DeNardo, G. L., Natarajan, A., Hok, S., Mirick, G., DeNardo, S. J., Corzett, M., Sysko, V., Lehmann, J., Beckett, L. & Balhorn, R., Dec 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 6, p. 783-795 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice

Dadachova, E., Revskaya, E., Sesay, M. A., Damania, H., Boucher, R., Sellers, R. S., Howell, R. C., Burns, L., Thornton, G. B., Natarajan, A., Mirick, G. R., DeNardo, S. J., Denardo, G. L. & Casadevall, A., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 1116-1127 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Short communication: Nanoparticle thermotherapy and external beam radiation therapy for human prostate cancer cells

Lehmann, J., Natarajan, A., DeNardo, G. L., Ivkov, R., Foreman, A. R., Catapano, C., Mirick, G., Quang, T., Gruettner, C. & DeNardo, S. J., Apr 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Targeted radionuclide therapy

Williams, L. E., Denardo, G. L. & Meredith, R. F., 2008, In : Medical Physics. 35, 7, p. 3062-3068 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
2007

Characteristics of dimeric (bis) bidentate selective high affinity ligands as HLA-DR10 beta antibody mimics targeting non-Hodgkin's lymphoma

DeNardo, G. L., Hok, S., Natarajan, A., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Yuan, A., Perkins, J., Sysko, V. V., Lehmann, J. & Balhorn, R. L., Oct 2007, In : International Journal of Oncology. 31, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines

Tobin, E., Denardo, G. L., Zhang, N., Epstein, A. L., Liu, C. & DeNardo, S., May 2007, In : Leukemia and Lymphoma. 48, 5, p. 944-956 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Construction of di-scFv through a trivalent alkyne-azide 1,3-dipolar cycloaddition

Natarajan, A., Du, W., Xiong, C. Y., Denardo, G. L., DeNardo, S. J. & Gervay-Hague, J., 2007, In : Chemical Communications. 7, p. 695-697 3 p.

Research output: Contribution to journalArticle

42 Scopus citations
23 Scopus citations

Effect of antilymphoma antibody, 131I-Lym-1, on peripheral blood lymphocytes in patients with non-Hodgkin's lymphoma

Schillaci, O., Denardo, G. L., DeNardo, S. J., Goldstein, D. S., Kroger, L. A., O'Donnell, R. T. & Lamborn, K. R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 521-530 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma

Denardo, G. L., Natarajan, A., Hok, S., Perkins, J., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Miers, L. A. & Balhorn, R. L., Aug 2007, In : Journal of Nuclear Medicine. 48, 8, p. 1338-1347 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Recombinant expression of the β-subunit of HLA-DR10 for the selection of novel lymphoma targeting molecules

Albrecht, H., Cosman, M., Ngu-Schwemlein, M., Corzett, M., Curran, K. W., Dolan, C., Fang, X., DeNardo, S. J., Denardo, G. L. & Balhorn, R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 531-542 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selecting an intervention time for intravascular enzymatic cleavage of peptide linkers to clear radioisotope from normal tissues

Hartmann Siantar, C. L., Denardo, G. L., Lam, K., Yuan, A., Daly, T. & DeNardo, S. J., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Selective high-affinity ligand antibody mimics for cancer diagnosis and therapy: Initial application to lymphoma/leukemia

Balhorn, R., Hok, S., Burke, P. A., Lightstone, F. C., Cosman, M., Zemla, A., Mirick, G., Perkins, J., Natarajan, A., Corzett, M., DeNardo, S. J., Albrecht, H., Gregg, J. & Denardo, G. L., Sep 15 2007, In : Clinical Cancer Research. 13, 18

Research output: Contribution to journalArticle

27 Scopus citations

Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia

Hok, S., Natarajan, A., Balhorn, R., DeNardo, S. J., Denardo, G. L. & Perkins, J., May 2007, In : Bioconjugate Chemistry. 18, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice

DeNardo, S. J., Denardo, G. L., Natarajan, A., Miers, L. A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Mar 1 2007, In : Journal of Nuclear Medicine. 48, 3, p. 437-444 8 p.

Research output: Contribution to journalArticle

126 Scopus citations
2006

Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting molecules

Burke, P. A., Gregg, J., Bakhtiar, B., Beckett, L. A., Denardo, G. L., Albrecht, H., deVere White, R. W. & De Nardo, S. J., Jul 2006, In : International Journal of Oncology. 29, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Comparison of normal tissue pharmacokinetics with 111In/90Y monoclonal antibody m170 for breast and prostate cancer

Lehmann, J., DeNardo, G. L., Yuan, A., Shen, S., O'Donnell, R. T., Richman, C. M. & DeNardo, S. J., Nov 15 2006, In : International Journal of Radiation Oncology Biology Physics. 66, 4, p. 1192-1198 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cure of incurable lymphoma

Denardo, G. L., Sysko, V. V. & DeNardo, S. J., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

25 Scopus citations

Development of tumor targeting anti-MUC-1 multimer: Effects of di-scFv unpaired cysteine location on PEGylation and tumor binding

Xiong, C. Y., Natarajan, A., Shi, X. B., Denardo, G. L. & Denardo, S. J., Aug 2006, In : Protein Engineering, Design and Selection. 19, 8, p. 359-367 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Direct antilymphoma activity of novel, first-generation "antibody mimics" that bind HLA-DR10-positive non-Hodgkin's lymphoma cells

West, J., Perkins, J., Hok, S., Balhorn, R., Lightstone, F. C., Cosman, M., DeNardo, S. J. & Denardo, G. L., 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 6, p. 645-654 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
27 Scopus citations

Survival benefit associated with human anti-mouse antibody (HAMA) in patients with B-cell malignancies

Azinovic, I., Denardo, G. L., Lamborn, K. R., Mirick, G., Goldstein, D., Bradt, B. M. & DeNardo, S. J., Dec 2006, In : Cancer Immunology, Immunotherapy. 55, 12, p. 1451-1458 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Targeted radionuclide therapy for solid tumors: An overview

DeNardo, S. J. & Denardo, G. L., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

39 Scopus citations
2005

Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer

Ivkov, R., DeNardo, S. J., Daum, W., Foreman, A. R., Goldstein, R. C., Nemkov, V. S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

145 Scopus citations

Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals

Natarajan, A., Xiong, C. Y., Albrecht, H., Denardo, G. L. & DeNardo, S. J., Jan 2005, In : Bioconjugate Chemistry. 16, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
19 Scopus citations

Development of tumor targeting bioprobes (111In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy

DeNardo, S. J., Denardo, G. L., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

172 Scopus citations

Direct antilymphoma effects on human lymphoma cells of monotherapy and combination therapy with CD20 and HLA-DR antibodies and 90Y-labeled HLA-DR antibodies

Denardo, G. L., Tobin, E., Chan, K., Bradt, B. M. & DeNardo, S. J., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

22 Scopus citations

Does paclitaxel (taxol) given after111In-labeled monoclonal antibodies increase tumor-cumulated activity in epithelial cancers?

Miers, L., Lamborn, K., Yuan, A., Richman, C. M., Natarajan, A., DeNardo, S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

8 Scopus citations

Enhancement of the therapeutic index: From nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer

DeNardo, S. J., Richman, C. M., Albrecht, H., Burke, P. A., Natarajan, A., Yuan, A., Gregg, J., O'Donnell, R. T. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

25 Scopus citations
67 Scopus citations

Implantation of different malignant human cell lines in an athymic mouse does not alter success and growth rates of either xenograft

Miers, L., DeNardo, S. J., Lamborn, K. & Denardo, G. L., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 614-619 6 p.

Research output: Contribution to journalArticle

MINERVA: A multi-modality plugin-based radiation therapy treatment planning system

Wemple, C. A., Wessol, D. E., Nigg, D. W., Cogliati, J. J., Milvich, M., Fredrickson, C. M., Perkins, M., Harkin, G. J., Hartmann-Siantar, C. L., Lehmann, J., Flickinger, T., Pletcher, D., Yuan, A. & DeNardo, G. L., Dec 20 2005, In : Radiation Protection Dosimetry. 116, 1-4, p. 202-207 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Monte Carlo treatment planning for molecular targeted radiotherapy within the MINERVA system

Lehmann, J., Siantar, C. H., Wessol, D. E., Wemple, C. A., Nigg, D., Cogliati, J., Daly, T., Descalle, M. A., Flickinger, T., Pletcher, D. & DeNardo, G., Mar 7 2005, In : Physics in Medicine and Biology. 50, 5, p. 947-958 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Planning time for peripheral blood stem cell infusion after high-dose targeted radionuclide therapy using dosimetry

Shen, S., DeNardo, S. J., Richman, C. M., Yuan, A., Siantar, C. H., O'Donnell, R. T., Kroger, L. A. & Denardo, G. L., 2005, In : Journal of Nuclear Medicine. 46, 6, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Splenic volume change and nodal tumor response in non-Hodgkin's lymphoma patients after radioimmunotherapy using radiolabeled Lym-1 antibody

Shen, S., Denardo, G. L., Yuan, A., Hartmann-Siantar, C., O'Donnell, R. T. & DeNardo, S. J., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 662-670 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment of Non-Hodgkin's Lymphoma (NHL) with radiolabeled antibodies (mAbs)

Denardo, G. L., Jul 2005, In : Seminars in Nuclear Medicine. 35, 3 SPEC. ISS., p. 202-211 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2004

Antilymphoma effects of anti-HLA-DR and CD20 monoclonal antibodies (Lym-1 and rituximab) on human lymphoma cells

Liu, C., Denardo, G. L., Tobin, E. & DeNardo, S., 2004, In : Cancer Biotherapy and Radiopharmaceuticals. 19, 5, p. 545-561 17 p.

Research output: Contribution to journalArticle

22 Scopus citations

Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: A multiinstitutional comparison

Wessels, B. W., Bolch, W. E., Bouchet, L. G., Breitz, H. B., Denardo, G. L., Meredith, R. F., Stabin, M. G. & Sgouros, G., Oct 1 2004, In : Journal of Nuclear Medicine. 45, 10, p. 1725-1733 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
10 Scopus citations

Production of Soluble ScFvs with C-Terminal-Free Thiol for Site-Specific Conjugation or Stable Dimeric ScFvs on Demand

Albrecht, H., Burke, P. A., Natarajan, A., Xiong, C. Y., Kalicinsky, M., Denardo, G. L. & DeNardo, S. J., Jan 2004, In : Bioconjugate Chemistry. 15, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Radiometals as payloads for radioimmunotherapy for lymphoma

Denardo, G. L., Kennel, S. J., Siegel, J. A. & DeNardo, S. J., Oct 2004, In : Clinical Lymphoma. 5, SUPPL. 1

Research output: Contribution to journalArticle

17 Scopus citations
2003

Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts

Tuscano, J. M., O'Donnell, R. T., Miers, L. A., Kroger, L. A., Kukis, D. L., Lamborn, K. R., Tedder, T. F. & DeNardo, G. L., May 1 2003, In : Blood. 101, 9, p. 3641-3647 7 p.

Research output: Contribution to journalArticle

44 Scopus citations