Gerald L Denardo

Professor Emeritus

  • 8365 Citations
  • 51 h-Index
1962 …2017
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Research Output 1962 2017

1997
51 Citations (Scopus)

Efficacy and toxicity of 67Cu-2IT-BAT-Lym-1 radioimmunoconjugate in mice implanted with human Burkitt's lymphoma (Raji)

Denardo, G. L., Kukis, D. L., Shen, S., Mausner, L. F., Meares, C. F., Srivastava, S. C., Miers, L. A. & DeNardo, S. J., 1997, In : Clinical Cancer Research. 3, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Immunoconjugates
Burkitt Lymphoma
Neoplasms
Lymphoma
Monoclonal Antibodies
11 Citations (Scopus)

Enhancement of 67Cu-2IT-BAT-LYM-1 therapy in mice with human Burkitt's lymphoma (Raji) using interleukin-2

Denardo, G. L., Kukis, D. L., DeNardo, S. J., Shen, S., Mausner, L. F., O'Donnell, R. T., Lamborn, K. R., Meyers, F. J., Srivastava, S. C. & Miers, L. A., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2576-2582 7 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Interleukin-2
Therapeutics
Neoplasms
Radiation
28 Citations (Scopus)

Imaging for improved prediction of myelotoxicity after radioimmunotherapy

DeNardo, D. A., Denardo, G. L., O'Donnell, R. T., Lim, S. M., Shen, S., Yuan, A. & DeNardo, S. J., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2558-2566 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Bone Marrow
Radiation
Radioactivity
Biopsy
16 Citations (Scopus)

Impact of splenomegaly on therapeutic response and I-131-LYM-1 dosimetry in patients B-lymphocytic malignancies

Shen, S., Denardo, G. L., O'Donnell, R. T., Yuan, A., DeNardo, D. A. & DeNardo, S. J., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2553-2557 5 p.

Research output: Contribution to journalArticle

Splenomegaly
Spleen
Neoplasms
Radiation
Therapeutics
25 Citations (Scopus)

Importance of temporal relationships in combined modality radioimmunotherapy of breast carcinoma

DeNardo, S. J., Kroger, L. A., Lamborn, K. R., Miers, L. A., O'Donnell, R. T., Kukis, D. L., Richman, C. M. & Denardo, G. L., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2583-2590 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Paclitaxel
Breast Neoplasms
Peptides
Antibodies
59 Citations (Scopus)

Increased survival associated with radiolabeled Lym-1 therapy for non- Hodgkin's lymphoma and chronic lymphocytic leukemia

Denardo, G. L., Lamborn, K. R., Goldstein, D. S., Kroger, L. A. & DeNardo, S. J., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2706-2711 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Survival
Therapeutics
Radioimmunotherapy
9 Citations (Scopus)

Peripheral blood stem cell mobilization for hematopoietic support of radioimmunotherapy in patients with breast carcinoma

Richman, C. M., Schuermann, T. C., Wun, T., Malik, R., O'Donnell, R. T., Denardo, G. L. & DeNardo, S. J., Dec 15 1997, In : Cancer. 80, 12 SUPPL., p. 2728-2732 5 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Radioimmunotherapy
Breast Neoplasms
Drug Therapy
Granulocyte-Macrophage Progenitor Cells
8 Citations (Scopus)

Practical determination of organ S values for individual patients for therapy

Shen, S., Denardo, G. L., Macey, D. J., O'Donnell, R. T., Yuan, A., DeNardo, D. A. & DeNardo, S. J., Jul 1997, In : Nuclear Medicine and Biology. 24, 5, p. 447-449 3 p.

Research output: Contribution to journalArticle

Radioisotopes
Reference Values
Radiation
Therapeutics
43 Citations (Scopus)

Prediction of myelotoxicity using radiation doses to marrow from body, blood and marrow sources

Lim, S. M., DeNardo, G. L., DeNardo, D. A., Shen, S., Yuan, A., O'Donnell, R. T. & DeNardo, S. J., Sep 1997, In : Journal of Nuclear Medicine. 38, 9, p. 1374-1378 5 p.

Research output: Contribution to journalArticle

Bone Marrow
Radiation
Hematocrit
Granulocytes
Linear Models
11 Citations (Scopus)

Prediction of myelotoxicity using semi-quantitative marrow image scores

Lim, S., DeNardo, G. L., DeNardo, D. A., O'Donnell, R. T., Yuan, A. & DeNardo, S. J., Nov 1997, In : Journal of Nuclear Medicine. 38, 11, p. 1749-1753 5 p.

Research output: Contribution to journalArticle

Bone Marrow
Radioimmunotherapy
Injections
Blood Cell Count
Body Surface Area
61 Citations (Scopus)

Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody

Denardo, S. J., O'Grady, L. F., Richman, C. M., Goldstein, D. S., O'Donnell, R. T., Denardo, D. A., Kroger, L. A., Lamborn, K. R., Hellström, K. E., Hellström, I. & Denardo, G. L., 1997, In : Anticancer Research. 17, 3 B, p. 1745-1751 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Breast Neoplasms
Antibodies
Neoplasms
Maximum Tolerated Dose
92 Citations (Scopus)

Radioimmunotherapy for breast cancer using indium- 111/Yttrium-90 BrE- 3: Results of a phase I clinical trial

DeNardo, S. J., Kramer, E. L., O'Donnell, R. T., Richman, C. M., Salako, Q. A., Shen, S., Noz, M., Glenn, S. D., Ceriani, R. L. & Denardo, G. L., 1997, In : Journal of Nuclear Medicine. 38, 8, p. 1180-1185 6 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Yttrium
Clinical Trials, Phase I
Indium
Pentetic Acid
20 Citations (Scopus)

Reproducibility of operator processing for radiation dosimetry

Shen, S., Denardo, G. L., DeNardo, S. J., Yuan, A., DeNardo, D. A. & Lamborn, K. R., Jan 1997, In : Nuclear Medicine and Biology. 24, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

Radiometry
Radioimmunotherapy
Half-Life
Radiation
Neoplasms
102 Citations (Scopus)

Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: Efficacy and toxicity in breast cancer xenografts

Denardo, S. J., Kukis, D. L., Kroger, L. A., O'Donnell, R. T., Lamborn, K. R., Miers, L. A., Denardo, D. G., Meares, C. F. & Denardo, G. L., Apr 15 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4000-4004 5 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Yttrium
Paclitaxel
Heterografts
Breast Neoplasms
28 Citations (Scopus)

Treatment-related parameters predicting efficacy of Lym-1 radioimmunotherapy in patients with B-lymphocytic malignancies

Lamborn, K. R., Denardo, G. L., DeNardo, S. J., Goldstein, D. S., Shen, S., Larkin, E. C. & Kroger, L. A., Aug 1997, In : Clinical Cancer Research. 3, 8, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Karnofsky Performance Status
Aptitude
Survival
Pharmacokinetics
55 Citations (Scopus)

Trials and tribulations: Oncological antibody imaging comes to the fore

Zuckier, L. S. & Denardo, G. L., 1997, In : Seminars in Nuclear Medicine. 27, 1, p. 10-29 20 p.

Research output: Contribution to journalReview article

Radioimmunodetection
United States Food and Drug Administration
Antibodies
Immunoglobulins
Patient Care

Tribute to Ralph A. Reisfeld, Ph.D.

Denardo, G. L., Dec 15 1997, In : Cancer. 80, 12 Suppl, p. 2345-2346 2 p.

Research output: Contribution to journalArticle

20th Century History
Immunotherapy
Neoplasms
78 Citations (Scopus)

Yttrium-90/indium-111-DOTA-peptide-chimeric L6: Pharmacokinetics, dosimetry and initial results in patients with incurable breast cancer

Denardo, S. J., Richman, C. M., Goldstein, D. S., Shen, S., Sajlako, Q., Kukis, D. L., Meares, C. F., Yuan, A., Welborn, J. L. & Denardo, G. L., 1997, In : Anticancer Research. 17, 3 B, p. 1735-1744 10 p.

Research output: Contribution to journalArticle

Yttrium
Pharmacokinetics
Immunoconjugates
Breast Neoplasms
Peptides
1996
8 Citations (Scopus)

Accurate measurement of copper-67 in the presence of copper-64 contaminant using a dose calibrator

Denardo, G. L., Kukis, D. L., Shen, S. & DeNardo, S. J., Feb 1996, In : Journal of Nuclear Medicine. 37, 2, p. 302-306 5 p.

Research output: Contribution to journalArticle

Copper
Gamma Rays
Isotopes
Spectrum Analysis
Radiopharmaceuticals
59 Citations (Scopus)

Antibody responses to macrocycles in lymphoma

DeNardo, G. L., Mirick, G. R., Kroger, L. A., O'Donnell, R. T., Meares, C. F. & DeNardo, S. J., Mar 1996, In : Journal of Nuclear Medicine. 37, 3, p. 451-456 6 p.

Research output: Contribution to journalArticle

Antibody Formation
Lymphoma
Chelating Agents
Antibodies
Immunoconjugates
5 Citations (Scopus)

Application of the linear-quadratic model to myelotoxicity associated with radioimmunotherapy

Wilder, R. B., Denardo, G. L., Sheri, S., Fowler, J. F., Wessels, B. W. & DeNardo, S. J., 1996, In : European Journal Of Nuclear Medicine. 23, 8, p. 953-957 5 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Linear Models
Bone Marrow
Platelet Count
Granulocytes
41 Citations (Scopus)

A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

Erwin, W. D., Groch, M. W., Macey, D. J., Denardo, G. L., DeNardo, S. J. & Shen, S., May 1996, In : Nuclear Medicine and Biology. 23, 4, p. 525-532 8 p.

Research output: Contribution to journalArticle

Radioimmunodetection
Radioimmunotherapy
Radioisotopes
Clinical Medicine
Nuclear Medicine
26 Citations (Scopus)

Dosimetric evaluation of copper-64 in copper-67-2IT-BAT-Lym-1 for radioimmunotherapy

Shen, S., Denardo, G. L., DeNardo, S. J., Salako, Q., Morris, G., Banks, D., Yuan, A. & DeNardo, D. A., Jan 1996, In : Journal of Nuclear Medicine. 37, 1, p. 146-150 5 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Copper
Radiation
Bone Marrow
Therapeutics
57 Citations (Scopus)

Lymphoma-selective antibody Lym-1 recognizes a discontinuous epitope on the light chain of HLA-DR10

Rose, L. M., Gunasekera, A. H., DeNardo, S. J., Denardo, G. L. & Meares, C. F., 1996, In : Cancer Immunology Immunotherapy. 43, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

Epitopes
Lymphoma
Light
Antigens
Antibodies
4 Citations (Scopus)
Radioimmunodetection
Kidney Tubules
Radioisotopes
Kidney
Amino Acids
36 Citations (Scopus)

Prediction of radiation doses from therapy using tracer studies with iodine-131-labeled antibodies

DeNardo, D. A., DeNardo, G. L., Yuan, A., Shen, S., DeNardo, S. J., Macey, D. J., Lamborn, K. R., Mahe, M., Groch, M. W. & Erwin, W. D., Dec 1996, In : Journal of Nuclear Medicine. 37, 12, p. 1970-1975 6 p.

Research output: Contribution to journalArticle

Iodine
Radiotherapy
Antibodies
Bone Marrow
Therapeutics
136 Citations (Scopus)

Radioimmunotherapy: Recent results and future directions

Wilder, R. B., Denardo, G. L. & DeNardo, S. J., Apr 1996, In : Journal of Clinical Oncology. 14, 4, p. 1383-1400 18 p.

Research output: Contribution to journalReview article

Radioimmunotherapy
Radioisotopes
Antibodies
Antigenic Modulation
Bispecific Antibodies
1995
27 Citations (Scopus)

Analysis of antiglobulin (HAMA) response in a group of patients with B-lympkocytic malignancies treated with 131I-Lym-1

Denardo, G. L., Kroger, L. A., Mirick, G. R., Lamborn, K. R. & De Nardo, S. J., 1995, In : International Journal of Biological Markers. 10, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Antibody Formation
Anti-Idiotypic Antibodies
Antibodies
Neoplasms
Human Development
94 Citations (Scopus)

Effect of the extent of chelate substitution on the immunoreactivity and biodistribution of 2IT-BAT-Lym-1 immunoconjugates

Kukis, D. L., Denardo, G. L., DeNardo, S. J., Mirick, G. R., Miers, L. A., Greiner, D. P. & Meares, C. F., 1995, In : Cancer Research. 55, 4, p. 878-884 7 p.

Research output: Contribution to journalArticle

Immunoconjugates
Chelating Agents
Antibodies
Antigens
Competitive Binding
35 Citations (Scopus)

Estimation of radiation absorbed doses to the red marrow in radioimmunotherapy

Macey, D. J., DeNardo, S. J., Denardo, G. L., DeNardo, D. A. & Shen, S., 1995, In : Clinical Nuclear Medicine. 20, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Bone Marrow
Radiation
B-Cell Chronic Lymphocytic Leukemia
37 Citations (Scopus)
Carcinoma, Ductal, Breast
Tumors
Monoclonal Antibodies
Tissue
Staining and Labeling
21 Citations (Scopus)

Pharmacokinetics and normal organ dosimetry following intraperitoneal rhenium-186-labeled monoclonal antibody

Breitz, H. B., Durham, J. S., Fisher, D. R., Weiden, P. L., Denardo, G. L., Goodgold, H. M. & Nelp, W. B., 1995, In : Journal of Nuclear Medicine. 36, 5, p. 754-761 8 p.

Research output: Contribution to journalArticle

Rhenium
Ascitic Fluid
Pharmacokinetics
Monoclonal Antibodies
Radioactivity
57 Citations (Scopus)

Pharmacokinetics of chimeric L6 conjugated to indium-111- and yttrium-90- DOTA-peptide in tumor-bearing mice

DeNardo, S. J., Zhong, G. R., Salako, Q., Li, M., Denardo, G. L. & Meares, C. F., 1995, In : Journal of Nuclear Medicine. 36, 5, p. 829-836 8 p.

Research output: Contribution to journalArticle

Yttrium
Indium
Pharmacokinetics
Peptides
Neoplasms
18 Citations (Scopus)

Prognostic factors for radioimmunotherapy in patients with B-lymphocytic malignancies

Denardo, G. L., Lamborn, K. R., DeNardo, S. J., Goldstein, D. S., Dolber-Smith, E. G., Kroger, L. A., Larkin, E. C. & Shen, S., 1995, In : Cancer Research. 55, 23 SUPPL.

Research output: Contribution to journalArticle

Radioimmunotherapy
Neoplasms
Karnofsky Performance Status
Interleukin-2 Receptors
L-Lactate Dehydrogenase
60 Citations (Scopus)
Radioimmunotherapy
Blood Cells
Stem Cells
Breast Neoplasms
Antibodies
34 Citations (Scopus)

Radioimmunotherapy of lymphoma: A UC Davis experience

Lewis, J. P., Denardo, G. L. & Denardo, S. J., 1995, In : Hybridoma. 14, 2, p. 115-120 6 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Lymphoma
Neoplasms
B-Lymphocytes
Therapeutics
9 Citations (Scopus)

Review of a four-year experience iodinating monoclonal antibodies with therapeutic amounts of I-131

Denardo, G. L., Mills, S. L., Kukis, D. L., Anderson, V. & DeNardo, S. J., 1995, In : Antibody, Immunoconjugates, and Radiopharmaceuticals. 8, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

Radiopharmaceuticals
Air
Monoclonal Antibodies
Radioimmunotherapy
Radiation
18 Citations (Scopus)

Yttrium-90 chimeric L6 therapy of human breast cancer in nude mice and apoptosis-related messenger RNA expression

DeNardo, S. J., Gumerlock, P. H., Winthrop, M. D., Mack, P., Chi, S. G., Lamborn, K. R., Shen, S., Miers, L. A., deVere White, R. W. & Denardo, G. L., 1995, In : Cancer Research. 55, 23 SUPPL.

Research output: Contribution to journalArticle

Yttrium
Nude Mice
Apoptosis
Breast Neoplasms
Messenger RNA
1994
61 Citations (Scopus)

A comparative study of copper-67 radiolabeling and kinetic stabilities of antibody-macrocycle chelate conjugates

Kukis, D. L., Diril, H., Greiner, D. P., DeNardo, S. J., Denardo, G. L., Salako, Q. A. & Meares, C. F., 1994, In : Cancer. 73, SUPPL., p. 779-786 8 p.

Research output: Contribution to journalArticle

Immunoconjugates
Copper
Antibodies
Radioimmunotherapy
Chelating Agents
60 Citations (Scopus)

Comparative toxicity studies of yttrium-90 MX-DTPA and 2-IT-BAD conjugated monoclonal antibody (BrE-3)

Denardo, G. L., Kroger, L. A., DeNardo, S. J., Miers, L. A., Salako, Q., Kukis, D. L., Fand, I., Shen, S., Renn, O. & Meares, C. F., 1994, In : Cancer. 73, SUPPL., p. 1012-1022 11 p.

Research output: Contribution to journalArticle

Yttrium
Pentetic Acid
Chelating Agents
Skeleton
Immunoconjugates
53 Citations (Scopus)

Effect of lym‐1 radioimmunoconjugate on refractory chronic lymphocytic leukemia

Denardo, G. L., Lewis, J. P., Denardo, S. J. & O'Grady, L. F., 1994, In : Cancer. 73, 5, p. 1425-1432 8 p.

Research output: Contribution to journalArticle

Immunoconjugates
B-Cell Chronic Lymphocytic Leukemia
Thrombocytopenia
Therapeutics
Monoclonal Antibodies
45 Citations (Scopus)

Overview of radiation myelotoxicity secondary to radioimmunotherapy using 131 i‐lym‐1 as a model

Denardo, G. L., Denardo, S. J., Macey, D. J., Shen, S. & Kroger, L. A., 1994, In : Cancer. 73, 3 S, p. 1038-1048 11 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Radiation
Bone Marrow Examination
Bone Marrow
Neoplasms
17 Citations (Scopus)

Overview of radioimmunotherapy in advanced breast cancer using I-131 chimeric L6

DeNardo, S. J., O'Grady, L. F., Richman, C. M. & Denardo, G. L., 1994, In : Advances in Experimental Medicine and Biology. 353, p. 203-211 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Stem cells
Tumors
Breast Neoplasms
Toxicity
71 Citations (Scopus)

Planar gamma camera imaging and quantitation of yttrium-90 bremsstrahlung

Shen, S., DeNardo, G. L., Yuan, A., DeNardo, D. A. & DeNardo, S. J., 1994, In : Journal of Nuclear Medicine. 35, 8, p. 1381-1389 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Yttrium
Radionuclide Imaging
Radiometry
Photons
46 Citations (Scopus)

Quantitative bremsstrahlung imaging of yttrium-90 using a wiener

Shen, S., Denardo, G. L. & DeNardo, S. J., 1994, In : Medical Physics. 21, 9, p. 1409-1417 9 p.

Research output: Contribution to journalArticle

Yttrium
Radioisotopes
Neoplasms
Radioimmunotherapy
Gamma Cameras
57 Citations (Scopus)

The biologic window for chimeric L6 radioimmunotherapy

DeNardo, S. J., Mirick, G. R., Kroger, L. A., O'Grady, L. F., Erickson, K. L., Yuan, A., Lamborn, K. R., Hellstrom, I., Hellstrom, K. E. & Denardo, G. L., 1994, In : Cancer. 73, SUPPL., p. 1023-1032 10 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Monoclonal Antibodies
Neoplasms
Interleukin-2 Receptors
Serum
2 Citations (Scopus)

Treatment of cancer with intratumoral infusion of radioisotopes

Wilder, R. B., Denardo, G. L. & Denardo, S. J., Oct 15 1994, In : International Journal of Radiation Oncology, Biology, Physics. 30, 3, p. 737-739 3 p.

Research output: Contribution to journalEditorial

neoplasms
Brachytherapy
Radioisotopes
cancer
Monoclonal Antibodies

Use of response surface statistical designs to detect effects of biologic response modifiers such as IL-2

Denardo, G. L., Lamborn, K. R., DeNardo, S. J. & Kroger, L. A., 1994, In : Biotechnology Therapeutics. 5, 1-2, p. 15-26 12 p.

Research output: Contribution to journalArticle

Interleukin-2
Neoplasm Antibodies
Antibodies
Nude Mice
Research Design
1993
42 Citations (Scopus)

Body and blood clearance and marrow radiation dose of 131I-lym-l in patients with b-cell malignancies

Denardo, G. L., Mahe, M. A., Denardo, S. J., Macey, D. J., Mirick, G. R., Erwin, W. D. & Groch, M. W., 1993, In : Nuclear Medicine Communications. 14, 7, p. 587-595 9 p.

Research output: Contribution to journalArticle

Bone Marrow
Radiation
Neoplasms
B-Lymphocytes
Monoclonal Antibodies
29 Citations (Scopus)

Immunoadsorption: An enhancement strategy for radioimmunotherapy

DeNardo, G. L., Maddock, S. W., Sgouros, G., Scheibe, P. O. & DeNardo, S. J., 1993, In : Journal of Nuclear Medicine. 34, 6, p. 1020-1027 8 p.

Research output: Contribution to journalEditorial