Gerald L Denardo

Professor Emeritus

  • 8365 Citations
  • 51 h-Index
1962 …2017
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Research Output 1962 2017

2000

Banner millennium 2000 year for CB&R and Mary Ann Liebert

Denardo, G. L. & Oldham, R. K., 2000, In : Cancer Biotherapy and Radiopharmaceuticals. 15, 6, p. 527-528 2 p.

Research output: Contribution to journalEditorial

10 Citations (Scopus)

Efficacy and toxicity of radioimmunotherapy with 90Y-DOTA-peptide-ChL6 for PC3-tumored mice

O'Donnell, R. T., DeNardo, S. J., Denardo, G. L., Miers, L., Lamborn, K. R., Kukis, D. L. & Meyers, F. J., Aug 1 2000, In : Prostate. 44, 3, p. 187-192 6 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Peptides
Prostatic Neoplasms
Heterografts
Nude Mice
51 Citations (Scopus)

Neovascular targeting with cyclic RGD peptide (cRGDf-ACHA) to enhance delivery of radioimmunotherapy

DeNardo, S. J., Burke, P. A., Leigh, B. R., O'Donnell, R. T., Miers, L. A., Kroger, L. A., Goodman, S. L., Matzku, S., Jonczyk, A., Lamborn, K. R. & Denardo, G. L., 2000, In : Cancer Biotherapy and Radiopharmaceuticals. 15, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Cyclic Peptides
Neoplasms
Capillary Permeability
Permeability
35 Citations (Scopus)

Radiation dosimetry for 90Y-2IT-BAD-Lym-1 extrapolated from pharmacokinetics using 111In-2IT-BAD-Lym-1 in patients with non-Hodgkin's lymphoma

DeNardo, G. L., O'Donnell, R. T., Shen, S., Kroger, L. A., Yuan, A., Meares, C. F., Kukis, D. L. & DeNardo, S. J., May 2000, In : Journal of Nuclear Medicine. 41, 5, p. 952-958 7 p.

Research output: Contribution to journalArticle

Radiometry
Non-Hodgkin's Lymphoma
Pharmacokinetics
Neoplasms
Radiation
3 Citations (Scopus)

Radioimmunotherapy in the treatment of non-hodgkin’s Lymphoma

Krieger, M. S., Weiden, P. L., Breitz, H. B., Press, O. & Denardo, G. L., Jan 1 2000, Radioimmunotherapy of Cancer. CRC Press, p. 245-263 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Incidence
Therapeutics
Global Health
5 Citations (Scopus)
Radioimmunodetection
Radiopharmaceuticals
Monoclonal Antibodies
Rabbits
Inflammation
1999
45 Citations (Scopus)

67Copper-2-iminothiolane-6-[p-(bromoacetamido)benzyl]-TETA-Lym-1 for radioimmunotherapy of non-Hodgkin's lymphoma

O'Donnell, R. T., Denardo, G. L., Kukis, D. L., Lamborn, K. R., Shen, S., Yuan, A., Goldstein, D. S., Mirick, G. R. & DeNardo, S. J., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Acids
Monoclonal Antibodies
Radiometry
70 Citations (Scopus)

67Cu-2IT-BAT-Lym-1 pharmacokinetics, radiation dosimetry, toxicity and tumor regression in patients with lymphoma

DeNardo, S. J., DeNardo, G. L., Kukis, D. L., Shen, S., Kroger, L. A., Denardo, D. A., Goldstein, D. S., Mirick, G. R., Salako, Q., Mausner, L. F., Srivastava, S. C. & Meares, C. F., Feb 1999, In : Journal of Nuclear Medicine. 40, 2, p. 302-310 9 p.

Research output: Contribution to journalArticle

Radiometry
Lymphoma
Pharmacokinetics
Neoplasms
Immunoconjugates
69 Citations (Scopus)

67Cu- versus 131I-labeled Lym-1 antibody: Comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma

Denardo, G. L., Kukis, D. L., Shen, S., DeNardo, D. A., Meares, C. F. & DeNardo, S. J., Mar 1999, In : Clinical Cancer Research. 5, 3, p. 533-541 9 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Pharmacokinetics
Antibodies
Radioimmunotherapy
Neoplasms
Gallium Radioisotopes
Gallium
Radionuclide Imaging
Antineoplastic Agents
Lymphoma
82 Citations (Scopus)

A clinical trial of radioimmunotherapy with 67Cu-2IT-BAT-Lym-1 for Non-Hodgkin's lymphoma

O'Donnell, R. T., Denardo, G. L., Kukis, D. L., Lamborn, K. R., Shen, S., Yuan, A., Goldstein, D. S., Carr, C. E., Mirick, G. R. & DeNardo, S. J., Dec 1999, In : Journal of Nuclear Medicine. 40, 12, p. 2014-2020 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Clinical Trials
Bone Marrow
Immunoconjugates
66 Citations (Scopus)

A new era for radiolabeled antibodies in cancer?

Denardo, S. J., Kroger, L. A. & Denardo, G. L., Oct 1 1999, In : Current Opinion in Immunology. 11, 5, p. 563-569 7 p.

Research output: Contribution to journalReview article

Radioimmunotherapy
Antibodies
Neoplasms
Lymphoma
Therapeutics
17 Citations (Scopus)

Antibody phage libraries for the next generation of tumor targeting radioimmunotherapeutics

DeNardo, S. J., Denardo, G. L., DeNardo, D. G., Xiong, C. Y., Shi, X. B., Winthrop, M. D., Kroger, L. A. & Carter, P., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Bacteriophages
Antibodies
Antigens
Neoplasms
Hybridomas
21 Citations (Scopus)

Critical Lym-1 binding residues on polymorphic HLA-DR molecules

Rose, L. M., Deng, C. T., Scott, S. L., Xiong, C. Y., Lamborn, K. R., Gumerlock, P. H., Denardo, G. L. & Meares, C. F., Aug 1999, In : Molecular Immunology. 36, 11-12, p. 789-797 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Determination of spleen size by scintigraphy

Silverman, S., Denardo, G. L. & Siegel, E., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 5, p. 407-411 5 p.

Research output: Contribution to journalArticle

Radionuclide Imaging
Spleen
Gamma Cameras
Technetium
Colloids
27 Citations (Scopus)

Development of a hyperimmune anti-MUC-1 single chain antibody fragments phage display library for targeting breast cancer

Winthrop, M. D., DeNardo, S. J. & Denardo, G. L., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Immunoglobulin Fragments
Radioimmunotherapy
Bacteriophages
Libraries
41 Citations (Scopus)

Dosimetry-based therapy in metastatic breast cancer patients using 90Y monoclonal antibody 170H.82 with autologous stem cell support and cyclosporin A

Richman, C. M., DeNardo, S. J., O'Donnell, R. T., Goldstein, D. S., Shen, S., Kukis, D. L., Kroger, L. A., Yuan, A., Boniface, G. R., Griffith, I. J. & Denardo, G. L., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Cyclosporine
Stem Cells
Monoclonal Antibodies
Breast Neoplasms
Immunoconjugates

Dosimetry for radioimmunotherapy: A rapidly evolving field - Editorial

Wilder, R. B., Shen, S. & Denardo, G. L., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 2, p. 67-70 4 p.

Research output: Contribution to journalEditorial

Radioimmunotherapy
11 Citations (Scopus)

Effect of 67Cu-2IT-BAT-Lym-1 therapy on BCL-2 gene and protein expression in a lymphoma mouse model

Kroger, L. A., DeNardo, S. J., Denardo, G. L., Xiong, C. Y., Winthrop, M. D. & Gumerlock, P. H., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Radioimmunotherapy
Lymphoma
Gene Expression
Proteins
Therapeutics
3 Citations (Scopus)

Efficient recombinant of Lym-1 scFv gene using multiple doubly- restricted DNA fragments

Shi, X. B., Gumerlock, P. H., Kroger, L., Denardo, G. L. & DeNardo, S. J., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

DNA
Genes
Radioimmunotherapy
Mutation
Genetic Recombination
39 Citations (Scopus)

Factors affecting 131I-Lym-1 pharmacokinetics and radiationdosimetry in patients with non-Hodgkin's lymphoma and chroniclymphocytic leukemia

Denardo, G. L., DeNardo, S. J., Shen, S., DeNardo, D. A., Mirick, G. R., Macey, D. J. & Lamborn, K. R., Aug 1999, In : Journal of Nuclear Medicine. 40, 8, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Leukemia
Pharmacokinetics
Radiometry
B-Cell Chronic Lymphocytic Leukemia

'Historical vignettes': Editorial

DeNardo, G. L. & Oldham, R. K., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 2, p. 65-66 2 p.

Research output: Contribution to journalEditorial

20th Century History
Iodine Radioisotopes
Thyroid Neoplasms
Neoplasm Metastasis
24 Citations (Scopus)

Milestones in the development of Lym-1 therapy

Denardo, G. L., O'Donnell, R. T., Rose, L. M., Mirick, G. R., Kroger, L. A. & DeNardo, S. J., Feb 1999, In : Hybridoma. 18, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Therapeutics
Survival
16 Citations (Scopus)

Phage library-derived human anti-TETA and anti-DOTA scFv for pretargeting RIT

DeNardo, S. J., Denardo, G. L., Brush, J. & Carter, P., Feb 1999, In : Hybridoma. 18, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Bacteriophages
Clone Cells
Metals
Libraries
3 Citations (Scopus)

Planar gamma camera quantitation of 123I, 99mTc or 111In in the liver and spleen of an abdominal phantom

Macey, D. J., Denardo, G. L. & DeNardo, S. J., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 4, p. 299-306 8 p.

Research output: Contribution to journalArticle

Gamma Cameras
Radioisotopes
Spleen
Liver
Radiometry
61 Citations (Scopus)

Practical determination of patient-specific marrow dose using radioactivity concentration in blood and body

Shen, S., DeNardo, G. L., Sgouros, G., O'Donnell, R. T. & DeNardo, S. J., Dec 1999, In : Journal of Nuclear Medicine. 40, 12, p. 2102-2106 5 p.

Research output: Contribution to journalArticle

Radioactivity
Bone Marrow
Radiation
Photons
Radioimmunotherapy
4 Citations (Scopus)

Preclinical evaluation of chimeric L6 antibody for the treatment of Kaposi's sarcoma with radioimmunotherapy

Leigh, B. R., Burke, P. A., Hong, A. M., O'Donnell, R. T., Howell, L. P., Miers, L. A., Denardo, G. L. & DeNardo, S. J., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Kaposi's Sarcoma
Antibodies
Therapeutics
Cell Culture Techniques
4 Citations (Scopus)

Radioimmunotherapy of acquired immunodeficiency syndrome (AIDS) associated lymphoma

O'Donnell, R. T., Leigh, B. R., Christensen, S. D., Goldstein, D. S., Kukis, D. L., Shen, S., Yuan, A., DeNardo, D. A., Kroger, L. A. & Denardo, G. L., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 3, p. 167-176 10 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Lymphoma
Acquired Immunodeficiency Syndrome
Maxillary Sinus
Poisons
4 Citations (Scopus)

Stability of monoclonal antibodies, Lym-1 and ChL6, and 2IT-BAD-Lym-1 immunoconjugate with ultra freezer storage

Kukis, D. L., DeNardo, S. J., Mills, S. L., Shen, S., O'Donnell, R. T. & Denardo, G. L., 1999, In : Cancer Biotherapy and Radiopharmaceuticals. 14, 5, p. 363-369 7 p.

Research output: Contribution to journalArticle

Immunoconjugates
Cellulose Acetate Electrophoresis
High Pressure Liquid Chromatography
Immunoglobulin G
Polyacrylamide Gel Electrophoresis
26 Citations (Scopus)

Strategies for developing effective radioimmunotherapy for solid tumors

Denardo, G. L., O'Donnell, R. T., Kroger, L. A., Richman, C. M., Goldstein, D. S., Shen, S. & DeNardo, S. J., Oct 1999, In : Clinical Cancer Research. 5, 10 SUPPL.

Research output: Contribution to journalArticle

Radioimmunotherapy
Neoplasms
Radiopharmaceuticals
Apoptosis
Bone Marrow Transplantation
55 Citations (Scopus)

Transfer of copper from a chelated 67Cu-antibody conjugate to ceruloplasmin in lymphoma patients

Mirick, G. R., O'Donnell, R. T., Denardo, S. J., Shen, S., Meares, C. F. & Denardo, G. L., Oct 1999, In : Nuclear Medicine and Biology. 26, 7, p. 841-845 5 p.

Research output: Contribution to journalArticle

Ceruloplasmin
Copper
Lymphoma
Antibodies
Radiopharmaceuticals
20th Century History
Radioimmunodetection
Radioimmunotherapy
Radiopharmaceuticals
Nuclear Medicine
1998
11 Citations (Scopus)

A preliminary cell kinetics model of thrombocytopenia after radioimmunotherapy

Shen, S., DeNardo, G. L., Jones, T. D., Wilder, R. B., O'Donnell, R. T. & DeNardo, S. J., Jul 1998, In : Journal of Nuclear Medicine. 39, 7, p. 1223-1229 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Thrombocytopenia
Radiation
Blood Platelets
Stromal Cells
38 Citations (Scopus)

A revolution in the treatment of non-Hodgkin's lymphoma

DeNardo, G. L., O'Donnell, R. T., Oldham, R. K. & DeNardo, S. J., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 4, p. 213-223 11 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Biological Therapy
Proxy
Therapeutics
Radioisotopes
9 Citations (Scopus)

Bone pain palliation

DeNardo, G. L., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 6, p. 407-477 71 p.

Research output: Contribution to journalReview article

Bone Neoplasms
Radiopharmaceuticals
Palliative Care
Bone and Bones
Pain

Cancer Biotherapy and Radiopharmaceuticals: Editorial

DeNardo, G. L. & Oldham, R. K., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 4, p. 211 1 p.

Research output: Contribution to journalEditorial

Biological Therapy
Radiopharmaceuticals
Neoplasms
1 Citation (Scopus)

Cancer Biotherapy and Radiopharmaceuticals: Editorial

DeNardo, G. L., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 5, p. 335-336 2 p.

Research output: Contribution to journalEditorial

Rhenium
Radioimmunotherapy
Biological Therapy
Radiopharmaceuticals
Antineoplastic Agents
25 Citations (Scopus)

Combined modality radioimmunotherapy with taxol and 90Y-Lym-1 for Raji lymphoma xenografts

O'Donnell, R. T., DeNardo, S. J., Miers, L. A., Kukis, D. L., Mirick, G. R., Kroger, L. A. & Denardo, G. L., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 5, p. 351-361 11 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Paclitaxel
Heterografts
Lymphoma
Nude Mice
26 Citations (Scopus)

Comparison of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''tetraacetic acid (DOTA)-peptide-ChL6, a novel immunoconjugate with catabolizable linker, to 2-iminothiolane-2[p-(bromoacetamido)benzyl]-DOTA-ChL6 in breast cancer xenografts

Denardo, G. L., Kroger, L. A., Meares, C. F., Richman, C. M., Salako, Q., Shen, S., Lamborn, K. R., Peterson, J. J., Miers, L. A., Zhong, G. R. & DeNardo, S. J., Oct 1998, In : Clinical Cancer Research. 4, 10, p. 2483-2490 8 p.

Research output: Contribution to journalArticle

Immunoconjugates
Heterografts
Breast Neoplasms
Peptides
Radioimmunotherapy
21 Citations (Scopus)

L6 monoclonal antibody binds prostate cancer

O'Donnell, R. T., DeNardo, S. J., Shi, X. B., Mirick, G. R., Denardo, G. L., Kroger, L. A. & Meyers, F. J., Oct 1 1998, In : Prostate. 37, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Monoclonal Antibodies
Nude Mice
Radioimmunotherapy
Heterografts
99 Citations (Scopus)

Low-dose, fractionated radioimmunotherapy for B-cell malignancies using 131I-LYM-1 antibody

Denardo, G. L., DeNardo, S. J., Lamborn, K. R., Goldstein, D. S., Levy, N. B., Lewis, J. P., O'Grady, L. F., Raventos, A., Kroger, L. A., Macey, D. J., McGahan, J. P., Mills, S. L. & Shen, S., 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 4, p. 239-254 16 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
B-Lymphocytes
Antibodies
Neoplasms
B-Cell Chronic Lymphocytic Leukemia
188 Citations (Scopus)

Maximum-tolerated dose, toxicity, and efficacy of 131I-Lym-1 antibody for fractionated radioimmunotherapy of non-Hodgkin's lymphoma

Denardo, G. L., DeNardo, S. J., Goldstein, D. S., Kroger, L. A., Lamborn, K. R., Levy, N. B., McGahan, J. P., Salako, Q., Shen, S. & Lewis, J. P., Oct 1998, In : Journal of Clinical Oncology. 16, 10, p. 3246-3256 11 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Maximum Tolerated Dose
Non-Hodgkin's Lymphoma
Antibodies
Radiometry
65 Citations (Scopus)

Maximum tolerated dose of 67Cu-2IT-BAT-LYM-1 for fractionated radioimmunotherapy of non-Hodgkin's lymphoma: A pilot study

Denardo, G. L., Denardo, S. J., Kukis, D. L., O'Donnell, R. T., Shen, S., Goldstein, D. S., Kroger, L. A., Salako, Q., Denardo, D. A., Mirick, G. R., Mausner, L. F., Srivastava, S. C. & Meares, C. F., Jul 1998, In : Anticancer Research. 18, 4 B, p. 2779-2788 10 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Maximum Tolerated Dose
Non-Hodgkin's Lymphoma
Radiation
Radiometry
25 Citations (Scopus)

New anti-Cu-TETA and anti-Y-DOTA monoclonal antibodies for potential use in the pre-targeted delivery of radiopharmaceuticals to tumor

Feng, X., Pak, R. H., Kroger, L. A., Moran, J. K., DeNardo, D. G., Meares, C. F., Denardo, G. L. & DeNardo, S. J., 1998, In : Hybridoma. 17, 2, p. 125-132 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Monoclonal Antibodies
Neoplasms
Hybridomas
Yttrium
72 Citations (Scopus)

Optimized conditions for chelation of yttrium-90-DOTA immunoconjugates

Kukis, D. L., DeNardo, S. J., DeNardo, G. L., O'Donnell, R. T. & Meares, C. F., Dec 1998, In : Journal of Nuclear Medicine. 39, 12, p. 2105-2110 6 p.

Research output: Contribution to journalArticle

Immunoconjugates
Yttrium
Radioimmunotherapy
Buffers
Reaction Time
17 Citations (Scopus)

Prolonged survival associated with immune response in a patient treated with Lym-1 mouse monoclonal antibody

DeNardo, S. J., Kroger, L. A., MacKenzie, M. R., Mirick, G. R., Shen, S. & Denardo, G. L., Feb 1998, In : Cancer Biotherapy and Radiopharmaceuticals. 13, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Survival
Antibodies
Delayed Emergence from Anesthesia
Radioimmunotherapy
13 Citations (Scopus)

Quantification of iodine-131 in tumors using a threshold based on image contrast

Denardo, G. L., Shen, S., DeNardo, S. J., Liao, S. Q., Lamborn, K. R., DeNardo, D. A. & Yuan, A., 1998, In : European Journal Of Nuclear Medicine. 25, 5, p. 497-502 6 p.

Research output: Contribution to journalArticle

Iodine
Neoplasms
Radioactivity
Biopsy
29 Citations (Scopus)

Synergistic therapy of breast cancer with Y90-chimeric L6 and paclitaxel in the xenografted mouse model: Development of a clinical protocol

DeNardo, S. J., Richman, C. M., Kukis, D. L., Shen, S., Lamborn, K. R., Miers, L. A., Kroger, L. A., Perez, E. A. & Denardo, G. L., 1998, In : Anticancer Research. 18, 6 A, p. 4011-4018 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Clinical Protocols
Paclitaxel
Breast Neoplasms
Therapeutics
42 Citations (Scopus)

Yttrium-90-DOTA-peptide-chimeric L6 radioimmunoconjugate: Efficacy and toxicity in mice bearing p53 mutant human breast cancer xenografts

DeNardo, S. J., Kukis, D. L., Miers, L. A., Winthrop, M. D., Kroger, L. A., Salako, Q., Shen, S., Lamborn, K. R., Gumerlock, P. H., Meares, C. F. & DeNardo, G. L., May 1998, In : Journal of Nuclear Medicine. 39, 5, p. 842-849 8 p.

Research output: Contribution to journalArticle

Immunoconjugates
Heterografts
Breast Neoplasms
Maximum Tolerated Dose
Lethal Dose 50
1997
5 Citations (Scopus)

Decreased C-MYC and BCL2 expression correlates with methylprednisolone- mediated inhibition of Raji lymphoma growth

Morris, G., Denardo, S. J., Denardo, G. L., Leshchinsky, T., Wu, B., Mack, P., Winthrop, M. D. & Gumerlock, P. H., Apr 1997, In : Biochemical and Molecular Medicine. 60, 2, p. 108-115 8 p.

Research output: Contribution to journalArticle

Methylprednisolone
Lymphoma
Growth
Tumors
Withholding Treatment