Gerald L Denardo

Professor Emeritus

  • 8365 Citations
  • 51 h-Index
1962 …2017
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Research Output 1962 2017

2005
166 Citations (Scopus)

Development of tumor targeting bioprobes (111In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy

DeNardo, S. J., Denardo, G. L., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Magnetic Field Therapy
Biosensing Techniques
Nanoparticles
Monoclonal Antibodies
Neoplasms
21 Citations (Scopus)

Direct antilymphoma effects on human lymphoma cells of monotherapy and combination therapy with CD20 and HLA-DR antibodies and 90Y-labeled HLA-DR antibodies

Denardo, G. L., Tobin, E., Chan, K., Bradt, B. M. & DeNardo, S. J., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

HLA-DR Antigens
Lymphoma
Antibodies
Monoclonal Antibodies
Cell Line
8 Citations (Scopus)

Does paclitaxel (taxol) given after111In-labeled monoclonal antibodies increase tumor-cumulated activity in epithelial cancers?

Miers, L., Lamborn, K., Yuan, A., Richman, C. M., Natarajan, A., DeNardo, S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Paclitaxel
Monoclonal Antibodies
Neoplasms
Breast Neoplasms
Heterografts
25 Citations (Scopus)

Enhancement of the therapeutic index: From nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer

DeNardo, S. J., Richman, C. M., Albrecht, H., Burke, P. A., Natarajan, A., Yuan, A., Gregg, J., O'Donnell, R. T. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Radioimmunotherapy
Prostatic Neoplasms
Paclitaxel
Bone Marrow
Cathepsins
66 Citations (Scopus)
Radioimmunotherapy
Yttrium
Cathepsins
Indium
Paclitaxel

Implantation of different malignant human cell lines in an athymic mouse does not alter success and growth rates of either xenograft

Miers, L., DeNardo, S. J., Lamborn, K. & Denardo, G. L., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 614-619 6 p.

Research output: Contribution to journalArticle

Heterografts
Nude Mice
Cell Line
Growth
Blood Transfusion
2 Citations (Scopus)

MINERVA: A multi-modality plugin-based radiation therapy treatment planning system

Wemple, C. A., Wessol, D. E., Nigg, D. W., Cogliati, J. J., Milvich, M., Fredrickson, C. M., Perkins, M., Harkin, G. J., Hartmann-Siantar, C. L., Lehmann, J., Flickinger, T., Pletcher, D., Yuan, A. & Denardo, G. L., Dec 20 2005, In : Radiation Protection Dosimetry. 116, 1-4, p. 202-207 6 p.

Research output: Contribution to journalArticle

Radiotherapy
planning
radiation therapy
Planning
programmers
21 Citations (Scopus)

Monte Carlo treatment planning for molecular targeted radiotherapy within the MINERVA system

Lehmann, J., Siantar, C. H., Wessol, D. E., Wemple, C. A., Nigg, D., Cogliati, J., Daly, T., Descalle, M. A., Flickinger, T., Pletcher, D. & Denardo, G. L., Mar 7 2005, In : Physics in Medicine and Biology. 50, 5, p. 947-958 12 p.

Research output: Contribution to journalArticle

Radiotherapy
systems analysis
planning
radiation therapy
Planning
6 Citations (Scopus)

Planning time for peripheral blood stem cell infusion after high-dose targeted radionuclide therapy using dosimetry

Shen, S., DeNardo, S. J., Richman, C. M., Yuan, A., Siantar, C. H., O'Donnell, R. T., Kroger, L. A. & Denardo, G. L., 2005, In : Journal of Nuclear Medicine. 46, 6, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

Radioisotopes
Radioactivity
Therapeutics
Radioimmunotherapy
Cell Survival
8 Citations (Scopus)

Splenic volume change and nodal tumor response in non-Hodgkin's lymphoma patients after radioimmunotherapy using radiolabeled Lym-1 antibody

Shen, S., Denardo, G. L., Yuan, A., Hartmann-Siantar, C., O'Donnell, R. T. & DeNardo, S. J., 2005, In : Cancer Biotherapy and Radiopharmaceuticals. 20, 6, p. 662-670 9 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Antibodies
Neoplasms
Splenomegaly
28 Citations (Scopus)

Treatment of Non-Hodgkin's Lymphoma (NHL) with radiolabeled antibodies (mAbs)

Denardo, G. L., Jul 2005, In : Seminars in Nuclear Medicine. 35, 3 SPEC. ISS., p. 202-211 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Radioimmunotherapy
Monoclonal Antibodies
Antibodies
Radioisotopes
2004
22 Citations (Scopus)

Antilymphoma effects of anti-HLA-DR and CD20 monoclonal antibodies (Lym-1 and rituximab) on human lymphoma cells

Liu, C., Denardo, G. L., Tobin, E. & DeNardo, S., 2004, In : Cancer Biotherapy and Radiopharmaceuticals. 19, 5, p. 545-561 17 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Lymphoma
Apoptosis
Cell Line
Non-Hodgkin's Lymphoma
84 Citations (Scopus)

A review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies not four letter words

Mirick, G. R., Bradt, B. M., Denardo, S. J. & Denardo, G. L., 2004, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 48, 4, p. 251-257 7 p.

Research output: Contribution to journalReview article

Globulins
Anti-Idiotypic Antibodies
Monoclonal Antibodies
Radioimmunotherapy
Antibodies, Monoclonal, Humanized
49 Citations (Scopus)

Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: A multiinstitutional comparison

Wessels, B. W., Bolch, W. E., Bouchet, L. G., Breitz, H. B., Denardo, G. L., Meredith, R. F., Stabin, M. G. & Sgouros, G., Oct 1 2004, In : Journal of Nuclear Medicine. 45, 10, p. 1725-1733 9 p.

Research output: Contribution to journalArticle

Bone Marrow
Antibodies
Therapeutics
Medicine
Clinical Trials
10 Citations (Scopus)
Immunoconjugates
Cathepsins
Monoclonal Antibodies
Peptides
Liver

MINERVA: A multimodality plugin-based radiation therapy treatment planning system

Wemple, C. A., Wessol, D. E., Nigg, D. W., Cogliati, J. J., Milvich, M., Fredrickson, C. M., Perkins, M., Harkin, G. J., Hartmann-Siantar, C. L., Lehmann, J., Flickinger, T., Pletcher, D., Yuan, A. & Denardo, G. L., 2004, Transactions of the American Nuclear Society. Folkerts, D. K. (ed.). Vol. 91. p. 683-685 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Radiotherapy
Planning
1 Citation (Scopus)

New directions in radioimmunotherapy on non-Hodgkin's lymphoma

Denardo, G. L., Oct 2004, In : Clinical Lymphoma. 5, SUPPL. 1

Research output: Contribution to journalEditorial

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Clinical Trials
Direction compound
51 Citations (Scopus)

Production of Soluble ScFvs with C-Terminal-Free Thiol for Site-Specific Conjugation or Stable Dimeric ScFvs on Demand

Albrecht, H., Burke, P. A., Natarajan, A., Xiong, C. Y., Kalicinsky, M., Denardo, G. L. & DeNardo, S. J., Jan 2004, In : Bioconjugate Chemistry. 15, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

Reducing Agents
Sulfhydryl Compounds
Bacteriophages
Polyethylene glycols
Single-Chain Antibodies
17 Citations (Scopus)

Radiometals as payloads for radioimmunotherapy for lymphoma

Denardo, G. L., Kennel, S. J., Siegel, J. A. & DeNardo, S. J., Oct 2004, In : Clinical Lymphoma. 5, SUPPL. 1

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioisotopes
Lymphoma
Non-Hodgkin's Lymphoma
Monoclonal Antibodies
2003
43 Citations (Scopus)

Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts

Tuscano, J. M., O'Donnell, R. T., Miers, L. A., Kroger, L. A., Kukis, D. L., Lamborn, K. R., Tedder, T. F. & DeNardo, G. L., May 1 2003, In : Blood. 101, 9, p. 3641-3647 7 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Blocking Antibodies
Heterografts
Lymphoma
Cells
17 Citations (Scopus)

Application of MINERVA Monte Carlo simulations to targeted radionuclide therapy

Descalle, M. A., Hartmann Siantar, C. L., Dauffy, L., Nigg, D. W., Wemple, C. A., Yuan, A. & Denardo, G. L., 2003, In : Cancer Biotherapy and Radiopharmaceuticals. 18, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Radioisotopes
Photons
Molecular Targeted Therapy
Pamphlets
Radiotherapy
11 Citations (Scopus)

Characterization of human IgG antimouse antibody in patients with B-cell malignancies

Denardo, G. L., Mirick, G. R., Kroger, L. A., Bradt, B. M., Lamborn, K. R. & DeNardo, S. J., Oct 1 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticle

B-Lymphocytes
Immunoglobulin G
Antibodies
Neoplasms
Radioimmunotherapy
10 Citations (Scopus)

Documentation of idiotypic cascade after Lym-1 radioimmunotherapy in a patient with non-Hodgkin's lymphoma: Basis for extended survival?

Bradt, B. M., DeNardo, S. J., Mirick, G. R. & Denardo, G. L., Oct 1 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticle

Radioimmunotherapy
Documentation
Non-Hodgkin's Lymphoma
Survival
Antibodies
33 Citations (Scopus)

Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice

DeNardo, S. J., Yao, Z., Lam, K., Song, A., Burke, P. A., Mirick, G. R., Lamborn, K. R., O'Donnell, R. T. & Denardo, G. L., Oct 1 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticle

Lymphoma
Pharmacokinetics
Peptides
Neoplasms
Ligands
25 Citations (Scopus)
Radiometry
Radioimmunotherapy
Immunoconjugates
Prostatic Neoplasms
Monoclonal Antibodies
46 Citations (Scopus)

Human antiglobulin response to foreign antibodies: Therapeutic benefit?

Denardo, G. L., Bradt, B. M., Mirick, G. R. & DeNardo, S. J., May 1 2003, In : Cancer Immunology, Immunotherapy. 52, 5, p. 309-316 8 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Globulins
Antibodies
Survival
Therapeutics
8 Citations (Scopus)

Impact of interpatient pharmacokinetic variability on design considerations for therapy with radiolabeled MAbs

Denardo, G. L., Yuan, A., Goldstein, D., Richman, C. M., O'Donnell, R. T., Shen, S., Hartmann Siantar, C. & DeNardo, S., 2003, In : Cancer Biotherapy and Radiopharmaceuticals. 18, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Radioisotopes
Pharmacokinetics
Prescriptions
Therapeutics
Indium
11 Citations (Scopus)

Impact of nodal regression on radiation dose for lymphoma patients after radioimmunotherapy

Siantar, C. L. H., Denardo, G. L. & DeNardo, S. J., Aug 2003, In : Journal of Nuclear Medicine. 44, 8, p. 1322-1329 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioactivity
Lymphoma
Radiation
Non-Hodgkin's Lymphoma
18 Citations (Scopus)

Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates

Denardo, G. L., DeNardo, S. J., Peterson, J. J., Miers, L. A., Lam, K., Hartmann-Siantar, C. & Lamborn, K. R., Oct 1 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticle

Immunoconjugates
Cathepsins
Peptides
Liver
Radioimmunotherapy
9 Citations (Scopus)

Radioimmunotherapy: A Novel Treatment Modality for B-Cell Non-Hodgkin's Lymphoma

Juweid, M., Denardo, G. L., Graham, M. & Vose, J., 2003, In : Cancer Biotherapy and Radiopharmaceuticals. 18, 5, p. 673-674 2 p.

Research output: Contribution to journalEditorial

CD20 Antigens
Radioimmunotherapy
Phase III Clinical Trials
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
20 Citations (Scopus)

Selection and characterization of anti-MUC-1 scFvs intended for targeted therapy

Winthrop, M. D., DeNardo, S. J., Albrecht, H., Mirick, G. R., Kroger, L. A., Lamborn, K. R., Venclovas, Ç., Colvin, M. E., Burke, P. A. & Denardo, G. L., Oct 1 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticle

Antigens
Breast Neoplasms
Light
Single-Chain Antibodies
Mucin-1
2002
208 Citations (Scopus)

Cilengitide targeting of αvβ3 integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts

Burke, P. A., DeNardo, S. J., Miers, L. A., Lamborn, K. R., Matzku, S. & Denardo, G. L., Aug 1 2002, In : Cancer Research. 62, 15, p. 4263-4272 10 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Heterografts
Integrins
Apoptosis
Breast Neoplasms
43 Citations (Scopus)

Combined modality radioimmunotherapy: Promise and peril

Burke, P. A., DeNardo, S. J., Miers, L. A., Kukis, D. L. & Denardo, G. L., Feb 15 2002, In : Cancer. 94, 4 SUPPL., p. 1320-1331 12 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Paclitaxel
Apoptosis
Neoplasms
Breast Neoplasms
58 Citations (Scopus)

Combined modality radioimmunotherapy for human prostate cancer xenografts with taxanes and 90Yttrium-DOTA-peptide-ChL6

O'Donnell, R. T., Denardo, S. J., Miers, L. A., Lamborn, K. R., Kukis, D. L., Denardo, G. L. & Meyers, F. J., Jan 1 2002, In : Prostate. 50, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

docetaxel
Radioimmunotherapy
Taxoids
Heterografts
Prostatic Neoplasms
16 Citations (Scopus)

Radiation dosimetry for radionuclide therapy in a nonmyeloablative strategy

Denardo, G. L., Hartmann Siantar, C. L. & DeNardo, S. J., 2002, In : Cancer Biotherapy and Radiopharmaceuticals. 17, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Radiometry
Radioisotopes
Radiation
Bone Marrow
Pharmaceutical Preparations
100 Citations (Scopus)

Rationales, evidence, and design considerations for fractionated radioimmunotherapy

Denardo, G. L., Schlom, J., Buchsbaum, D. J., Meredith, R. F., O'Donoghue, J. A., Sgouros, G., Humm, J. L. & DeNardo, S. J., Feb 15 2002, In : Cancer. 94, 4 SUPPL., p. 1332-1348 17 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioisotopes
Radiation
Neoplasms
Maximum Tolerated Dose
13 Citations (Scopus)

Treatment planning for molecular targeted radionuclide therapy

Hartmann Siantar, C. L., Vetter, K., Denardo, G. L. & DeNardo, S. J., 2002, In : Cancer Biotherapy and Radiopharmaceuticals. 17, 3, p. 267-280 14 p.

Research output: Contribution to journalReview article

Molecular Targeted Therapy
Radioisotopes
Radiation
Therapeutics
Neoplasms

Year 2002: The best year yet for CB & R

Denardo, G. L. & Oldham, R. K., 2002, In : Cancer Biotherapy and Radiopharmaceuticals. 17, 6, p. 599-600 2 p.

Research output: Contribution to journalEditorial

Radiopharmaceuticals
Neoplasms
2001
24 Citations (Scopus)

Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: Bispecific antibodies for pretargeted radioimmunotherapy

DeNardo, D. G., Xiong, C. Y., Shi, X. B., Denardo, G. L. & DeNardo, S. J., 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 6, p. 525-535 11 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Radioimmunotherapy
HLA-DR Antigens
Genes
Libraries
44 Citations (Scopus)

Apoptosis-related gene and protein expression in human lymphoma xenografts (Raji) after low dose rate radiation using 67Cu-2IT-BAT-Lym-1 radioimmunotherapy

Kroger, L. A., Denardo, G. L., Gumerlock, P. H., Cheng Yi Xiong, Y. X., Winthrop, M. D., Xu Bao Shi, B. S., Mack, P., Leshchinsky, T. & Denardo, S. J., 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 3, p. 213-225 13 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Heterografts
Lymphoma
Radiation
Apoptosis

Cancer Biotherapy and Radiopharmaceuticals: Editorial

Denardo, G. L., 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 5, p. 345 1 p.

Research output: Contribution to journalEditorial

Biological Therapy
Radiopharmaceuticals
Neoplasms
3 Citations (Scopus)

Metabolite production in patients with lymphoma after radiometal-labeled antibody administration

Denardo, G. L., DeNardo, S. J., Kukis, D. L., O'Donnell, R. T., Shen, S., Mirick, G. R. & Meares, C. F., 2001, In : Journal of Nuclear Medicine. 42, 9, p. 1324-1333 10 p.

Research output: Contribution to journalArticle

Lymphoma
Antibodies
Non-Hodgkin's Lymphoma
Area Under Curve
Immunoconjugates
51 Citations (Scopus)

Radioimmunotherapy with 111In/90Y-2IT-BAD-m170 for metastatic prostate cancer

O'Donnell, R. T., DeNardo, S. J., Yuan, A., Shen, S., Richman, C. M., Lara, P. N., Griffith, I. J., Goldstein, D. S., Kukis, D. L., Martinez, G. S., Mirick, G. R., Denardo, G. L. & Meyers, F. J., 2001, In : Clinical Cancer Research. 7, 6, p. 1561-1568 8 p.

Research output: Contribution to journalArticle

Radioimmunotherapy
Prostatic Neoplasms
Maximum Tolerated Dose
Pain
Prostate-Specific Antigen
5 Citations (Scopus)

Radiolabeled anti-lymphoma antibodies.

Denardo, G. L., O'Donnell, R. T. & DeNardo, S. J., 2001, In : Cancer chemotherapy and biological response modifiers. 19, p. 297-308 12 p.

Research output: Contribution to journalArticle

Radioisotopes
Anti-Idiotypic Antibodies
Lymphoma
Bispecific Antibodies
Drug Approval
23 Citations (Scopus)

Role of radiation dosimetry in radioimmunotherapy planning and treatment dosing

Denardo, G. L., Juweid, M. E., White, C. A., Wiseman, G. A. & DeNardo, S. J., 2001, In : Critical Reviews in Oncology/Hematology. 39, 1-2, p. 203-218 16 p.

Research output: Contribution to journalArticle

Radiometry
Radioimmunotherapy
Radiation
Radioisotopes
Radiotherapy

Year 2001: An even better year for CB&R

Denardo, G. L. & Oldham, R. K., Dec 1 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 6, p. 449-450 2 p.

Research output: Contribution to journalEditorial

2000
13 Citations (Scopus)

131I-Lym-1 in mice implanted with human Burkitt's lymphoma (Raji) tumors: Loss of tumor specificity due to radiolysis

Denardo, G. L., DeNardo, S. J., Wessels, B. W., Kukis, D. L., Miyao, N. & Yuan, A., 2000, In : Cancer Biotherapy and Radiopharmaceuticals. 15, 6, p. 547-560 14 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Radiometry
Neoplasms
Thermoluminescent Dosimetry
Pharmacokinetics
3 Citations (Scopus)

Antibody phage display applications for nuclear medicine imaging and therapy

Winthrop, M. D., Denardo, G. L. & Denardo, S. J., 2000, In : Quarterly Journal of Nuclear Medicine. 44, 3, p. 284-295 12 p.

Research output: Contribution to journalReview article

Nuclear Medicine
Bacteriophages
Antibodies
Molecular Imaging
Therapeutics
38 Citations (Scopus)

A phase I study of 90Y-2IT-BAD-Lym-1 in patients with non-Hodgkin's lymphoma

O'Donnell, R. T., Shen, S., Denardo, S. J., Wun, T., Kukis, D. L., Goldstein, D. S. & Denardo, G. L., 2000, In : Anticancer Research. 20, 5 C, p. 3647-3655 9 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Maximum Tolerated Dose
Radio
Drug Therapy
Immunotherapy
31 Citations (Scopus)

Are Radiometal-Labeled Antibodies Better Than Iodine-131-Labeled Antibodies: Comparative Pharmacokinetics and Dosimetry of Copper-67-, Iodine-131-, and Yttrium-90-Labeled Lym-1 Antibody in Patients with Non-Hodgkin's Lymphoma

Denardo, G. L., DeNardo, S. J., O'Donnell, R. T., Kroger, L. A., Kukis, D. L., Meares, C. F., Goldstein, D. S. & Shen, S., Sep 2000, In : Clinical Lymphoma. 1, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Yttrium
Iodine
Non-Hodgkin's Lymphoma
Copper
Pharmacokinetics