Gerald L Denardo

Professor Emeritus

  • 8350 Citations
  • 51 h-Index
1962 …2017
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Research Output 1962 2017

2017

Foreword

DeNardo, G. L., Jan 1 2017, Receptor Binding Radiotracers. CRC Press, Vol. 2. p. v

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Foreword

DeNardo, G. L., Jan 1 2017, Basic Physics of Radiotracers. CRC Press, Vol. 2. p. F5

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Foreword

DeNardo, G. L., Jan 1 2017, Basic Physics of Radiotracers. CRC Press, p. vii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Foreword

Billinghurst, M. W. & DeNardo, G. L., Jan 1 2017, Studies of Cellular Functions Using Radiotracers. CRC Press, p. 1-250 250 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

2012
15 Citations (Scopus)

Concepts, consequences, and implications of theranosis

Denardo, G. L. & Denardo, S. J., May 2012, In : Seminars in Nuclear Medicine. 42, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Deoxyglucose
Therapeutics
Non-Hodgkin's Lymphoma
Peptide Aptamers
2011

A thrilling ride

Denardo, G. L., Jun 1 2011, In : Cancer Biotherapy and Radiopharmaceuticals. 26, 3, p. 259 1 p.

Research output: Contribution to journalEditorial

2010
6 Citations (Scopus)

Dose Intensified Molecular Targeted Radiotherapy for Cancer-Lymphoma as a Paradigm

Denardo, G. L. & DeNardo, S., Mar 2010, In : Seminars in Nuclear Medicine. 40, 2, p. 136-144 9 p.

Research output: Contribution to journalReview article

Lymphoma
Radiotherapy
Non-Hodgkin's Lymphoma
Neoplasms
Radioimmunotherapy

Pretherapy prediction of nephrotoxicity after Peptide Radionuclide Receptor Therapy (PRRT)

Denardo, G. L. & MacEy, D. J., Oct 1 2010, In : Cancer Biotherapy and Radiopharmaceuticals. 25, 5, p. 507-509 3 p.

Research output: Contribution to journalEditorial

Radiotherapy Dosage
Peptide Receptors
Radiopharmaceuticals
Radioisotopes
Kidney
2009

Editorial: Changes occur but often little really changes

Denardo, G. L., Aug 1 2009, In : Cancer Biotherapy and Radiopharmaceuticals. 24, 4, p. 377 1 p.

Research output: Contribution to journalEditorial

Health care in the united states in 2009: Both sides of the "counter"

Denardo, G. L. & Denardo, S. J., Oct 1 2009, In : Cancer Biotherapy and Radiopharmaceuticals. 24, 5, p. 515-517 3 p.

Research output: Contribution to journalEditorial

Professional-Patient Relations
Health Care Reform
Health Care Costs
Primary Health Care
Referral and Consultation
2 Citations (Scopus)

Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells

Balhorn, R., Hok, S., DeNardo, S., Natarajan, A., Mirick, G., Corzett, M. & Denardo, G. L., Apr 22 2009, In : Molecular Cancer. 8, 25.

Research output: Contribution to journalArticle

Arginine
Lymphoma
Ligands
Peptides
Confocal Microscopy
6 Citations (Scopus)

Molecular specific and cell selective cytotoxicity induced by a novel synthetic HLA-DR antibody mimic for lymphoma and leukemia

Denardo, G. L., Mirick, G. R., Hok, S., DeNardo, S. J., Beckett, L. A., Adamson, G. N. & Balhorn, R. L., 2009, In : International Journal of Oncology. 34, 2, p. 511-516 6 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Heterografts
Lymphoma
Leukemia
Ligands
2008

2008: State of affairs for Cancer Biotherapy & Radiopharmaceuticals

Denardo, G. L. & Oldham, R. K., Feb 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Biological Therapy
Radiopharmaceuticals
Neoplasms
46 Citations (Scopus)

Development of multivalent radioimmunonanoparticles for cancer imaging and therapy

Natarajan, A., Xiong, C. Y., Gruettner, C., Denardo, G. L. & DeNardo, S. J., Feb 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Therapeutics
Fever
Magnetic Fields
1 Citation (Scopus)

Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy

Natarajan, A., Kumaresan, P. R., DeNardo, S. J., Denardo, G. L., Mirick, G. & Lam, K., Sep 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 17, p. 4802-4805 4 p.

Research output: Contribution to journalArticle

Immunoconjugates
Radioimmunotherapy
Peptides
Tumors
Tissue

Molecular imaging/therapy: It's only useful if it's useful - And available

Denardo, G. L., Sep 1 2008, In : Journal of Nuclear Medicine. 49, 9

Research output: Contribution to journalComment/debate

Molecular Probe Techniques
Molecular Imaging
Diagnostic Imaging
Antineoplastic Agents
Neoplasms
78 Citations (Scopus)

NanoFerrite particle based radioimmunonanoparticles: Binding affinity and in vivo pharmacokinetics

Natarajan, A., Gruettner, C., Ivkov, R., Denardo, G. L., Mirick, G., Yuan, A., Foreman, A. & DeNardo, S. J., Jun 2008, In : Bioconjugate Chemistry. 19, 6, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Nanoparticles
Iron oxides
Magnetic Field Therapy
Immunoconjugates
6 Citations (Scopus)

Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging

Denardo, G. L., Natarajan, A., Hok, S., Mirick, G., DeNardo, S. J., Corzett, M., Sysko, V., Lehmann, J., Beckett, L. A. & Balhorn, R., Dec 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 6, p. 783-795 13 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Antibodies
Ligands
Lymphoma
Confocal Microscopy
38 Citations (Scopus)

Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice

Dadachova, E., Revskaya, E., Sesay, M. A., Damania, H., Boucher, R., Sellers, R. S., Howell, R. C., Burns, L., Thornton, G. B., Natarajan, A., Mirick, G. R., DeNardo, S. J., Denardo, G. L. & Casadevall, A., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 1116-1127 12 p.

Research output: Contribution to journalArticle

Rhenium
Melanins
Nude Mice
Immunoglobulin M
Melanoma
12 Citations (Scopus)

Short communication: Nanoparticle thermotherapy and external beam radiation therapy for human prostate cancer cells

Lehmann, J., Natarajan, A., Denardo, G. L., Ivkov, R., Foreman, A. R., Catapano, C., Mirick, G., Quang, T., Gruettner, C. & DeNardo, S. J., Apr 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

Induced Hyperthermia
Nanoparticles
Prostatic Neoplasms
Radiotherapy
Biosensing Techniques
42 Citations (Scopus)

Targeted radionuclide therapy

Williams, L. E., Denardo, G. L. & Meredith, R. F., 2008, In : Medical Physics. 35, 7, p. 3062-3068 7 p.

Research output: Contribution to journalArticle

Radioisotopes
Organ Size
Bone Marrow
B-Cell Lymphoma
Therapeutics
28 Citations (Scopus)

Turning the heat on cancer

Denardo, G. L. & DeNardo, S. J., Dec 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 6, p. 671-679 9 p.

Research output: Contribution to journalReview article

Hot Temperature
Neoplasms
Nanoparticles
Fever
Physics
10 Citations (Scopus)

Update: Systemic radiotherapy can cure lymphoma: A paradigm for other malignancies?

Denardo, G. L., DeNardo, S. J. & Balhorn, R., Aug 1 2008, In : Cancer Biotherapy and Radiopharmaceuticals. 23, 4, p. 383-397 15 p.

Research output: Contribution to journalReview article

Radioimmunotherapy
Lymphoma
Radiotherapy
Radioisotopes
Non-Hodgkin's Lymphoma
2007
12 Citations (Scopus)

Characteristics of dimeric (bis) bidentate selective high affinity ligands as HLA-DR10 beta antibody mimics targeting non-Hodgkin's lymphoma

Denardo, G. L., Hok, S., Natarajan, A., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Yuan, A., Perkins, J., Sysko, V. V., Lehmann, J. & Balhorn, R. L., Oct 2007, In : International Journal of Oncology. 31, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
HLA-DR Antigens
Ligands
Antibodies
Pharmacokinetics
10 Citations (Scopus)

Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines

Tobin, E., Denardo, G. L., Zhang, N., Epstein, A. L., Liu, C. & DeNardo, S., May 2007, In : Leukemia and Lymphoma. 48, 5, p. 944-956 13 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Immunotherapy
Lymphoma
Monoclonal Antibodies
Cell Line
42 Citations (Scopus)

Construction of di-scFv through a trivalent alkyne-azide 1,3-dipolar cycloaddition

Natarajan, A., Du, W., Xiong, C. Y., Denardo, G. L., DeNardo, S. J. & Gervay-Hague, J., 2007, In : Chemical Communications. 7, p. 695-697 3 p.

Research output: Contribution to journalArticle

Alkynes
Azides
Cycloaddition
Antigens
Sulfhydryl Compounds

Development of antibody directed nanoparticles for cancer therapy

Ivkov, R., DeNardo, S. J., Meirs, L. A., Natarajan, A., Denardo, G. L., Gruettner, C. & Foreman, A. R., 2007, Thermal Treatment of Tissue: Energy Delivery and Assessment IV. Vol. 6440. 64400I

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Antibodies
Magnetic fields
Nanoparticles
Tumors
Heterojunction bipolar transistors
22 Citations (Scopus)
Mucin-1
Prostatic Neoplasms
Breast Neoplasms
Radioimmunotherapy
Neoplasms
2 Citations (Scopus)

Effect of antilymphoma antibody, 131I-Lym-1, on peripheral blood lymphocytes in patients with non-Hodgkin's lymphoma

Schillaci, O., Denardo, G. L., DeNardo, S. J., Goldstein, D. S., Kroger, L. A., O'Donnell, R. T. & Lamborn, K. R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 521-530 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Lymphocytes
Antibodies
Lymphocyte Count
Spleen
1 Citation (Scopus)
Birth and Death Process
Count Data
Antibody
Therapy
Cancer
17 Citations (Scopus)

Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma

Denardo, G. L., Natarajan, A., Hok, S., Perkins, J., Cosman, M., DeNardo, S. J., Lightstone, F. C., Mirick, G. R., Miers, L. A. & Balhorn, R. L., Aug 2007, In : Journal of Nuclear Medicine. 48, 8, p. 1338-1347 10 p.

Research output: Contribution to journalArticle

HLA Antigens
Lymphoma
Pharmacokinetics
Ligands
Antibodies
2 Citations (Scopus)

Recombinant expression of the β-subunit of HLA-DR10 for the selection of novel lymphoma targeting molecules

Albrecht, H., Cosman, M., Ngu-Schwemlein, M., Corzett, M., Curran, K. W., Dolan, C., Fang, X., DeNardo, S. J., Denardo, G. L. & Balhorn, R., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 531-542 12 p.

Research output: Contribution to journalArticle

Lymphoma
Ligands
Protein Refolding
Radioimmunotherapy
HLA-DR10 antigen
1 Citation (Scopus)

Selecting an intervention time for intravascular enzymatic cleavage of peptide linkers to clear radioisotope from normal tissues

Hartmann Siantar, C. L., Denardo, G. L., Lam, K., Yuan, A., Daly, T. & DeNardo, S. J., Aug 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

Radioisotopes
Pharmacokinetics
Peptides
Neoplasms
Immunoconjugates
26 Citations (Scopus)

Selective high-affinity ligand antibody mimics for cancer diagnosis and therapy: Initial application to lymphoma/leukemia

Balhorn, R., Hok, S., Burke, P. A., Lightstone, F. C., Cosman, M., Zemla, A., Mirick, G., Perkins, J., Natarajan, A., Corzett, M., DeNardo, S. J., Albrecht, H., Gregg, J. & Denardo, G. L., Sep 15 2007, In : Clinical Cancer Research. 13, 18

Research output: Contribution to journalArticle

Antibody Affinity
Lymphoma
Leukemia
Ligands
Antibodies
12 Citations (Scopus)

Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia

Hok, S., Natarajan, A., Balhorn, R., DeNardo, S. J., Denardo, G. L. & Perkins, J., May 2007, In : Bioconjugate Chemistry. 18, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Leukemia
Ligands
Antibodies
Epitopes
6 Citations (Scopus)

The conundrum of personalized cancer management, drug development, and economics

Denardo, G. L., Dec 1 2007, In : Cancer Biotherapy and Radiopharmaceuticals. 22, 6, p. 719-721 3 p.

Research output: Contribution to journalEditorial

Personal Health Services
Radioimmunotherapy
Drug Approval
Economic Development
Radiopharmaceuticals
120 Citations (Scopus)

Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice

DeNardo, S. J., Denardo, G. L., Natarajan, A., Miers, L. A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Ivkov, R., Mar 1 2007, In : Journal of Nuclear Medicine. 48, 3, p. 437-444 8 p.

Research output: Contribution to journalArticle

Magnetic Fields
Biosensing Techniques
Nanoparticles
Hot Temperature
Breast Neoplasms
2006
19 Citations (Scopus)

Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting molecules

Burke, P. A., Gregg, J., Bakhtiar, B., Beckett, L. A., Denardo, G. L., Albrecht, H., deVere White, R. W. & De Nardo, S. J., Jul 2006, In : International Journal of Oncology. 29, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Glycoproteins
Prostate
Monoclonal Antibodies
Epitopes
3 Citations (Scopus)

Comparison of normal tissue pharmacokinetics with 111In/90Y monoclonal antibody m170 for breast and prostate cancer

Lehmann, J., Denardo, G. L., Yuan, A., Shen, S., O'Donnell, R. T., Richman, C. M. & DeNardo, S. J., Nov 15 2006, In : International Journal of Radiation Oncology Biology Physics. 66, 4, p. 1192-1198 7 p.

Research output: Contribution to journalArticle

antibodies
breast
Prostatic Neoplasms
Pharmacokinetics
cancer
25 Citations (Scopus)

Cure of incurable lymphoma

Denardo, G. L., Sysko, V. V. & DeNardo, S. J., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

antibodies
Lymphoma
drugs
Monoclonal Antibodies
Radioisotopes
24 Citations (Scopus)

Development of tumor targeting anti-MUC-1 multimer: Effects of di-scFv unpaired cysteine location on PEGylation and tumor binding

Xiong, C. Y., Natarajan, A., Shi, X. B., Denardo, G. L. & Denardo, S. J., Aug 2006, In : Protein Engineering, Design and Selection. 19, 8, p. 359-367 9 p.

Research output: Contribution to journalArticle

Cysteine
Tumors
Peptides
Polyethylene glycols
Cells
6 Citations (Scopus)

Development of tumor targeting magnetic nanoparticles for cancer therapy

Ivkov, R., DeNardo, S. J., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N. & Denardo, G. L., 2006, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. Vol. 2. p. 21-24 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumors
Magnetic fields
Nanoparticles
Polyethylene glycols
Bearings (structural)
10 Citations (Scopus)

Direct antilymphoma activity of novel, first-generation "antibody mimics" that bind HLA-DR10-positive non-Hodgkin's lymphoma cells

West, J., Perkins, J., Hok, S., Balhorn, R., Lightstone, F. C., Cosman, M., DeNardo, S. J. & Denardo, G. L., 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 6, p. 645-654 10 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Ligands
Antibodies
Radioisotopes
Deoxycholic Acid
26 Citations (Scopus)
Cysteine
Antigens
Escherichia coli Proteins
Sulfhydryl Compounds
Neoplasms
2 Citations (Scopus)
Yttrium Radioisotopes
Extravasation of Diagnostic and Therapeutic Materials
Immunotoxins
Radiotherapy
Monoclonal Antibodies
37 Citations (Scopus)

Survival benefit associated with human anti-mouse antibody (HAMA) in patients with B-cell malignancies

Azinovic, I., Denardo, G. L., Lamborn, K. R., Mirick, G., Goldstein, D., Bradt, B. M. & DeNardo, S. J., Dec 2006, In : Cancer Immunology, Immunotherapy. 55, 12, p. 1451-1458 8 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
B-Lymphocytes
Survival
Neoplasms
Radioimmunotherapy
38 Citations (Scopus)

Targeted radionuclide therapy for solid tumors: An overview

DeNardo, S. J. & Denardo, G. L., Oct 1 2006, In : International Journal of Radiation Oncology Biology Physics. 66, SUPPL. 2

Research output: Contribution to journalArticle

Radioimmunotherapy
Radioisotopes
radioactive isotopes
therapy
tumors
2005
142 Citations (Scopus)

Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer

Ivkov, R., DeNardo, S. J., Daum, W., Foreman, A. R., Goldstein, R. C., Nemkov, V. S. & Denardo, G. L., Oct 1 2005, In : Clinical Cancer Research. 11, 19 II

Research output: Contribution to journalArticle

Magnetic Fields
Nanoparticles
Hot Temperature
Neoplasms
Nude Mice
53 Citations (Scopus)

Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals

Natarajan, A., Xiong, C. Y., Albrecht, H., Denardo, G. L. & DeNardo, S. J., Jan 2005, In : Bioconjugate Chemistry. 16, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Drug products
Polyethylene glycols
Tumors
Pharmaceutical Preparations
Neoplasms
19 Citations (Scopus)
Radioimmunotherapy
Immunotherapy
Radiation
Radioisotopes
Non-Hodgkin's Lymphoma