Derick H Lau, MD

Professor Emeritus

  • 3703 Citations
  • 31 h-Index
1976 …2014
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Research Output 1976 2014

  • 3703 Citations
  • 31 h-Index
  • 124 Article
2014
9 Citations (Scopus)

Phase i study of the halichondrin B analogue eribulin mesylate in combination with cisplatin in advanced solid tumors

Koczywas, M., Frankel, P. H., Synold, T. W., Lenz, H. J., Mortimer, J. E., El-Khoueiry, A. B., Gandara, D. R., Cristea, M. C., Chung, V. M., Lim, D., Reckamp, K. L., Lau, D. H., Doyle, L. A., Ruel, C., Carroll, M. I. & Newman, E. M., Dec 9 2014, In : British Journal of Cancer. 111, 12, p. 2268-2274 7 p.

Research output: Contribution to journalArticle

eribulin
Cisplatin
Hypokalemia
Neoplasms
Appointments and Schedules
30 Citations (Scopus)

Quality of life among long-term survivors of head and neck cancer treated by intensity-modulated radiotherapy

Chen, A. M., Daly, M. E., Farwell, D. G., Vazquez, E., Courquin, J., Lau, D. H. & Purdy, J. A., Feb 2014, In : JAMA Otolaryngology - Head and Neck Surgery. 140, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

Intensity-Modulated Radiotherapy
Head and Neck Neoplasms
Survivors
Quality of Life
Saliva
2013
9 Citations (Scopus)

A pilot study (SWOG S0429) of weekly cetuximab and chest radiotherapy for poor-risk stage III non-small cell lung cancer

Chen, Y., Moon, J., Pandya, K. J., Lau, D. H., Kelly, K., Hirsch, F. R., Gaspar, L. E., Redman, M. & Gandara, D. R., 2013, In : Frontiers in Oncology. 3 AUG, 00219.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Radiotherapy
Thorax
Radiation
docetaxel
33 Citations (Scopus)

Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer

Chen, A. M., Li, J., Beckett, L. A., Zhara, T., Farwell, D. G., Lau, D. H., Gandour-Edwards, R. F., Vaughan, A. T. M. & Purdy, J. A., Jan 2013, In : Laryngoscope. 123, 1, p. 152-157 6 p.

Research output: Contribution to journalArticle

Oropharyngeal Neoplasms
Intensity-Modulated Radiotherapy
Tumor Burden
Neoplasms
Image-Guided Radiotherapy
25 Citations (Scopus)
Head and Neck Neoplasms
Radiation
Patient Selection
Hospitalization
Therapeutics
7 Citations (Scopus)
Pemetrexed
Non-Small Cell Lung Carcinoma
Nanoparticles
Neoplasms
Maximum Tolerated Dose
5 Citations (Scopus)

Southwestern oncology Group phase II trial (S0526) of pemetrexed in bronchioloalveolar carcinoma subtypes of advanced adenocarcinoma

Lau, D. H., Moon, J., Davies, A. M., Sanborn, R. E., Hirsch, F. R., Franklin, W. A., Ruzich, J. C., Redman, M. W. & Gandara, D. R., Jul 2013, In : Clinical Lung Cancer. 14, 4, p. 351-355 5 p.

Research output: Contribution to journalArticle

Pemetrexed
Bronchiolo-Alveolar Adenocarcinoma
Adenocarcinoma
Folic Acid Antagonists
Folate Receptor 1
2012
21 Citations (Scopus)

A phase I and pharmacokinetic study of oral 3-aminopyridine-2- carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: A California Cancer Consortium Study

Chao, J., Synold, T. W., Morgan, R. J., Kunos, C., Longmate, J., Lenz, H. J., Lim, D., Shibata, S., Chung, V., Stoller, R. G., Belani, C. P., Gandara, D. R., McNamara, M., Gitlitz, B. J., Lau, D. H., Ramalingam, S. S., Davies, A., Espinoza-Delgado, I., Newman, E. M. & Yen, Y., Mar 2012, In : Cancer Chemotherapy and Pharmacology. 69, 3, p. 835-843 9 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Toxicity
Tumors
Maximum Tolerated Dose
Neoplasms
33 Citations (Scopus)

Brachial plexus-associated neuropathy after high-dose radiation therapy for head-and-neck cancer

Chen, A. M., Hall, W. H., Li, J., Beckett, L. A., Farwell, D. G., Lau, D. H. & Purdy, J. A., Sep 1 2012, In : International Journal of Radiation Oncology Biology Physics. 84, 1, p. 165-169 5 p.

Research output: Contribution to journalArticle

Brachial Plexus Neuropathies
Head and Neck Neoplasms
radiation therapy
Radiotherapy
cancer
2 Citations (Scopus)
Feasibility Studies
Neoplasms
sorafenib
Hypophosphatemia
Foot
42 Citations (Scopus)

Intensity-modulated radiotherapy is associated with improved global quality of life among long-term survivors of head-and-neck cancer

Chen, A. M., Farwell, D. G., Luu, Q., Vazquez, E. G., Lau, D. H. & Purdy, J. A., Sep 1 2012, In : International Journal of Radiation Oncology Biology Physics. 84, 1, p. 170-175 6 p.

Research output: Contribution to journalArticle

Intensity-Modulated Radiotherapy
Head and Neck Neoplasms
Survivors
radiation therapy
cancer
6 Citations (Scopus)

Voice quality after organ-preservation therapy with definitive radiotherapy for laryngeal cancer

Lau, V. H., Leonard, R. J., Goodrich, S., Luu, Q., Farwell, D. G., Lau, D. H., Purdy, J. A. & Chen, A. M., Jul 2012, In : Head and Neck. 34, 7, p. 943-948 6 p.

Research output: Contribution to journalArticle

Voice Quality
Organ Preservation
Laryngeal Neoplasms
Radiotherapy
Phonation
2011
11 Citations (Scopus)

Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study

Ho, C., Sangha, R., Beckett, L. A., Tanaka, M., Lau, D. H., Eisen, D. B., Burich, R. A., Luciw, P. A., Khan, I., Mack, P., Gandara, D. R. & Davies, A. M., Aug 2011, In : Investigational New Drugs. 29, 4, p. 680-687 8 p.

Research output: Contribution to journalArticle

Exanthema
Skin
Acne Vulgaris
Epidermal Growth Factor Receptor
Neoplasms
23 Citations (Scopus)

Intercalated erlotinib-docetaxel dosing schedules designed to achieve pharmacodynamic separation: Results of a phase I/II trial

Sangha, R., Davies, A. M., Lara, P. N., Mack, P., Beckett, L. A., Hesketh, P. J., Lau, D. H., Li, T., Perkins, N. & Gandara, D. R., Dec 2011, In : Journal of Thoracic Oncology. 6, 12, p. 2112-2119 8 p.

Research output: Contribution to journalArticle

docetaxel
Appointments and Schedules
Maximum Tolerated Dose
Non-Small Cell Lung Carcinoma
Drug Therapy
8 Citations (Scopus)

Primary radiation therapy for head-and-neck cancer in the setting of human immunodeficiency virus

Klein, E. A., Guiou, M., Farwell, D. G., Luu, Q., Lau, D. H., Stuart, K., Vaughan, A. T. M., Vijayakumar, S. & Chen, A. M., Jan 1 2011, In : International Journal of Radiation Oncology Biology Physics. 79, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

human immunodeficiency virus
Head and Neck Neoplasms
radiation therapy
Radiotherapy
cancer
37 Citations (Scopus)
chemotherapy
Head and Neck Neoplasms
radiation therapy
Radiotherapy
cancer
15 Citations (Scopus)

Randomized phase II trial of concurrent versus sequential bortezomib plus docetaxel in advanced non-small-cell lung cancer: A california cancer consortium trial

Lara, P. N., Longmate, J., Reckamp, K., Gitlitz, B., Argiris, A., Ramalingam, S., Belani, C. P., Mack, P., Lau, D. H., Koczywas, M., Wright, J. J., Shepherd, F. A., Leighl, N. & Gandara, D. R., Jan 1 2011, In : Clinical Lung Cancer. 12, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Neoplasms
Proteasome Inhibitors
Survival
113 Citations (Scopus)

Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome

Chen, A. M., Chen, L. M., Vaughan, A. T. M., Sreeraman, R., Farwell, D. G., Luu, Q., Lau, D. H., Stuart, K., Purdy, J. A. & Vijayakumar, S., Feb 1 2011, In : International Journal of Radiation Oncology Biology Physics. 79, 2, p. 414-419 6 p.

Research output: Contribution to journalArticle

tobacco
Head and Neck Neoplasms
radiation therapy
Radiotherapy
Smoking
2010
102 Citations (Scopus)

Evaluating the role of prophylactic gastrostomy tube placement prior to definitive chemoradiotherapy for head and neck cancer

Chen, A. M., Li, B. Q., Lau, D. H., Farwell, D. G., Luu, Q., Stuart, K., Newman, K., Purdy, J. A. & Vijayakumar, S., Nov 4 2010, In : International Journal of Radiation Oncology Biology Physics. 78, 4, p. 1026-1032 7 p.

Research output: Contribution to journalArticle

Gastrostomy
Chemoradiotherapy
Head and Neck Neoplasms
cancer
tubes
32 Citations (Scopus)

Late esophageal toxicity after radiation therapy for head and neck cancer

Chen, A. M., Li, B. Q., Jennelle, R. L. S., Lau, D. H., Yang, C. C., Courquin, J., Vijayakumar, S. & Purdy, J. A., Feb 2010, In : Head and Neck. 32, 2, p. 178-183 6 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Radiotherapy
Esophageal Stenosis
Radiation Oncology
Incidence
2009
4 Citations (Scopus)

A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, T. H., Venugopal, S. K., Zhu, M., Wang, S. S., Lau, D. H., Lam, K., Clemens, D. L. & Zern, M. A., Feb 20 2009, In : Biochemical and Biophysical Research Communications. 379, 4, p. 876-881 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Ethanol
Green Fluorescent Proteins
Alcohols
Apoptosis

A population-based clinical trial of irinotecan and carboplatin

Lau, D. H., Huynh, M. & Johl, J., 2009, In : Journal of Oncology. 458528.

Research output: Contribution to journalArticle

irinotecan
Carboplatin
Clinical Trials
Maximum Tolerated Dose
Area Under Curve
63 Citations (Scopus)
Intensity-Modulated Radiotherapy
Gastrostomy
Head and Neck Neoplasms
Deglutition Disorders
Drug Therapy
40 Citations (Scopus)
Pemetrexed
Appointments and Schedules
Arm
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
5 Citations (Scopus)

LAS0811: From combinatorial chemistry to activation of antioxidant response element

Lau, D. H., Zhu, M., Baek, H., Liu, R., Song, A. & Lam, K., 2009, In : Journal of Biomedicine and Biotechnology. 2009, 420194.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Chemical activation
Chemoprevention
Molecules
NF-E2 Transcription Factor
35 Citations (Scopus)

Phase II trial of irinotecan and carboplatin for extensive or relapsed small-cell lung cancer

Lau, D. H., Chen, G., Huynh, M., Fehrenbacher, L., West, H., Lara, P. N., Yavorkovsky, L. L., Russin, M., Goldstein, D. & Gandara, D. R., Mar 20 2009, In : Journal of Clinical Oncology. 27, 9, p. 1401-1404 4 p.

Research output: Contribution to journalArticle

irinotecan
Carboplatin
Small Cell Lung Carcinoma
Area Under Curve
Drug Therapy
2008
5 Citations (Scopus)

Adjuvant treatment of stage IB NSCLC. The problem of stage subset heterogeneity

Calhoun, R., Jablons, D., Lau, D. H. & Gandara, D. R., Apr 30 2008, In : Oncology. 22, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Adjuvant Chemotherapy
Pharmacogenetics
Therapeutics
Survival Rate
23 Citations (Scopus)

Chemotherapy for brain metastases in small-cell lung cancer

Chen, G., Huynh, M., Chen, A., Fehrenbacher, L., Gandara, D. R. & Lau, D. H., Jan 2008, In : Clinical Lung Cancer. 9, 1, p. 35-38 4 p.

Research output: Contribution to journalArticle

irinotecan
Small Cell Lung Carcinoma
Carboplatin
Neoplasm Metastasis
Drug Therapy
31 Citations (Scopus)
Mediastinoscopy
Non-Small Cell Lung Carcinoma
Lymph Nodes
Confidence Intervals
Neoplasm Metastasis
424 Citations (Scopus)

Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023

Kelly, K., Chansky, K., Gaspar, L. E., Albain, K. S., Jett, J., Ung, Y. C., Lau, D. H., Crowley, J. J. & Gandara, D. R., 2008, In : Journal of Clinical Oncology. 26, 15, p. 2450-2456 7 p.

Research output: Contribution to journalArticle

docetaxel
1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Chemoradiotherapy
Non-Small Cell Lung Carcinoma
Placebos
2 Citations (Scopus)

Population-based phase i trial of irinotecan and epirubicin

Lau, D. H., Johl, J., Huynh, M., Davies, A., Tanaka, M., Lara, P. N. & Gandara, D. R., Jun 2008, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 31, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

irinotecan
Epirubicin
Maximum Tolerated Dose
Population
Topoisomerase II Inhibitors
27 Citations (Scopus)

The proteasome inhibitor bortezomib in combination with gemcitabine and carboplatin in advanced non-small cell lung cancer: A California Cancer Consortium phase I study

Davies, A. M., Ruel, C., Lara, P. N., Lau, D. H., Gumerlock, P. H., Bold, R. J., Shibata, S., Lenz, H. J., Schenkein, D. P. & Gandara, D. R., Jan 2008, In : Journal of Thoracic Oncology. 3, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

gemcitabine
Proteasome Inhibitors
Carboplatin
Non-Small Cell Lung Carcinoma
Neoplasms
2007
31 Citations (Scopus)

Advances in positron emission tomography technology have increased the need for surgical staging in non-small cell lung cancer

Lee, B. E., von Haag, D., Lown, T., Lau, D. H., Calhoun, R. & Follette, D., Mar 2007, In : Journal of Thoracic and Cardiovascular Surgery. 133, 3, p. 746-752 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Positron-Emission Tomography
Technology
Mediastinoscopy
Thoracotomy
4 Citations (Scopus)

A novel specific small molecule peptide for non-small cell lung cancer cell A549

Guo, L. L., Guo, Y., Lau, D. H. & Xu, Y. C., Oct 2007, In : Progress in Biochemistry and Biophysics. 34, 10, p. 1080-1085 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cells
Peptides
Molecules
Integrins
30 Citations (Scopus)

A phase II study of paclitaxel, carboplatin, and radiation with or without surgery for esophageal cancer

Wang, H., Ryu, J., Gandara, D. R., Bold, R. J., Urayama, S., Tanaka, M., Goldberg, Z., Follette, D., Narayan, S. & Lau, D. H., Feb 2007, In : Journal of Thoracic Oncology. 2, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

Carboplatin
Esophageal Neoplasms
Paclitaxel
Radiation
Chemoradiotherapy
20 Citations (Scopus)
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Drug Therapy
Protein-Tyrosine Kinases
Combination Drug Therapy
5 Citations (Scopus)

Erlotinib and vinorelbine in advanced malignant solid tumors: A phase I study

Davies, A. M., Ho, C., Hesketh, P. J., Beckett, L. A., Lara, P. N., Lau, D. H. & Gandara, D. R., Aug 2007, In : Investigational New Drugs. 25, 4, p. 351-355 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
Febrile Neutropenia
Maximum Tolerated Dose
Vinca Alkaloids

Erratum: Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment (Journal of Thoracic Oncology (2006) 1, (S20-S26))

Gandara, D. R., Aberle, D., Lau, D., Jett, J., Akhurst, T., Heelan, R., Mulshine, J., Berg, C. & Patz, E. F., Jan 2007, In : Journal of Thoracic Oncology. 2, 1, p. 11 1 p.

Research output: Contribution to journalArticle

Bronchiolo-Alveolar Adenocarcinoma
Thorax
18 Citations (Scopus)
Pemetrexed
Non-Small Cell Lung Carcinoma
Appointments and Schedules
Arm
Neoplasms
2006
1 Citation (Scopus)

A novel specific small molecule peptide for small cell lung cancer

Guo, L. L., Quo, Y., Lau, D. H., Xiao, S., Xu, Y. C. & Shen, H., Jun 2006, In : Progress in Biochemistry and Biophysics. 33, 6, p. 562-566 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cells
Peptides
Molecules
Cell adhesion
28 Citations (Scopus)

Bortezomib plus docetaxel in advanced non-small cell lung cancer and other solid tumors: A phase I california cancer consortium trial

Lara, P. N., Koczywas, M., Quinn, D. I., Lenz, H. J., Davies, A. M., Lau, D. H., Gumerlock, P. H., Longmate, J., Doroshow, J. H., Schenkein, D., Kashala, O. & Gandara, D. R., Feb 2006, In : Journal of Thoracic Oncology. 1, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Neoplasms
Maximum Tolerated Dose
Bortezomib
136 Citations (Scopus)

Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group study S0126

West, H. L., Franklin, W. A., McCoy, J., Gumerlock, P. H., Vance, R., Lau, D. H. M., Chansky, K., Crowley, J. J., Gandara, D. R. & Granados, B., Apr 20 2006, In : Journal of Clinical Oncology. 24, 12, p. 1807-1813 7 p.

Research output: Contribution to journalArticle

Bronchiolo-Alveolar Adenocarcinoma
Therapeutics
Exanthema
Epidermal Growth Factor Receptor
Survival
22 Citations (Scopus)

Peptide ligands targeting integrin α3β1 in non-small cell lung cancer

Lau, D. H., Guo, L., Liu, R., Marik, J. & Lam, K., Jun 2006, In : Lung Cancer. 52, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

Integrins
Non-Small Cell Lung Carcinoma
Ligands
Peptides
Lung Neoplasms
20 Citations (Scopus)

Phase II study of consolidation paclitaxel after concurrent chemoradiation in poor-risk stage III non-small-cell lung cancer: SWOG S9712

Davies, A. M., Chansky, K., Lau, D. H., Leigh, B. R., Gaspar, L. E., Weiss, G. R., Wozniak, A. J., Crowley, J. J. & Gandara, D. R., Nov 20 2006, In : Journal of Clinical Oncology. 24, 33, p. 5242-5246 5 p.

Research output: Contribution to journalArticle

Paclitaxel
Non-Small Cell Lung Carcinoma
Chemoradiotherapy
Esophagitis
Carboplatin
47 Citations (Scopus)

Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment

Gandara, D. R., Aberle, D., Lau, D. H., Jett, J., Akhurst, T., Mulshine, J., Berg, C. & Patz, E. F., Nov 2006, In : Journal of Thoracic Oncology. 1, 9 SUPPL.

Research output: Contribution to journalArticle

Bronchiolo-Alveolar Adenocarcinoma
Glass
Adenocarcinoma
Computer-Assisted Image Processing
Spiral Computed Tomography
25 Citations (Scopus)

Sequential vinorelbine and docetaxel in advanced non-small cell lung cancer patients age 70 and older and/or with a performance status of 2: A phase II trial of the Southwest Oncology Group (S0027)

Hesketh, P. J., Chansky, K., Lau, D. H., Doroshow, J. H., Moinpour, C. M., Chapman, R. A., Goodwin, J. W., Gross, H. M., Crowley, J. J. & Gandara, D. R., Jul 2006, In : Journal of Thoracic Oncology. 1, 6, p. 537-544 8 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Confidence Intervals
Survival
vinorelbine
2005
11 Citations (Scopus)

Complete response of brain metastases to irinotecan-based chemotherapy

Chou, R., Chen, A. & Lau, D. H., Apr 2005, In : Journal of Clinical Neuroscience. 12, 3, p. 242-245 4 p.

Research output: Contribution to journalArticle

irinotecan
Neoplasm Metastasis
Drug Therapy
Brain
Adenocarcinoma
9 Citations (Scopus)

Computer-assisted image analysis of bronchioloalveolar carcinoma

Lau, D. H., Seibert, J. A., Gandara, D. R., Laptalo, L., Geraghty, E. & Coulon, C., Mar 2005, In : Clinical Lung Cancer. 6, 5, p. 281-286 6 p.

Research output: Contribution to journalArticle

Bronchiolo-Alveolar Adenocarcinoma
Computer-Assisted Image Processing
Tomography
Software
Neoplasms
66 Citations (Scopus)

Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries

Aina, O. H., Marik, J., Liu, R., Lau, D. H. & Lam, K., May 2005, In : Molecular Cancer Therapeutics. 4, 5, p. 806-813 8 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Peptides
Cell Line
Integrins
Adenocarcinoma
38 Citations (Scopus)
Combined Modality Therapy
Non-Small Cell Lung Carcinoma
Clinical Trials
Therapeutics
Radiotherapy