David E Pleasure, MD

Professor

  • 11245 Citations
  • 59 h-Index
1966 …2020

Research output per year

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Research Output

2020

Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice

Hull, V., Wang, Y., Burns, T., Zhang, S., Sternbach, S., McDonough, J., Guo, F. & Pleasure, D., Mar 1 2020, In : Annals of Neurology. 87, 3, p. 480-485 6 p.

Research output: Contribution to journalArticle

Author Correction: Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells (Nature Communications, (2014), 5, 1, (4430), 10.1038/ncomms5430)

Chen, C., Jiang, P., Xue, H., Peterson, S. E., Tran, H. T., McCann, A. E., Parast, M. M., Li, S., Pleasure, D. E., Laurent, L. C., Loring, J. F., Liu, Y. & Deng, W., Dec 1 2020, In : Nature communications. 11, 1, 1070.

Research output: Contribution to journalComment/debate

Open Access
2019

Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons

Wang, Y. Z., Fan, H., Ji, Y., Reynolds, K., Gu, R., Gan, Q., Yamagami, T., Zhao, T., Hamad, S., Bizen, N., Takebayashi, H., Chen, Y. P., Wu, S., Pleasure, D., Lam, K. & Zhou, C. J., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

2018

Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model

Bannerman, P., Guo, F., Chechneva, O., Burns, T., Zhu, X., Wang, Y., Kim, B., Singhal, N. K., McDonough, J. A. & Pleasure, D. E., Mar 7 2018, In : Molecular Therapy. 26, 3, p. 793-800 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pathophysiology and Treatment of Canavan Disease

Pleasure, D. E., Guo, F., Chechneva, O., Bannerman, P., McDonough, J., Burns, T., Wang, Y. & Hull, V., Jan 1 2018, (Accepted/In press) In : Neurochemical Research.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations
2017

Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells

Horiuchi, M., Suzuki-Horiuchi, Y., Akiyama, T., Itoh, A., Pleasure, D., Carstens, E. & Ito, T., Aug 1 2017, In : Journal of Neurochemistry. 142, 3, p. 378-391 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

New hearts for Friedreich patients

Pleasure, D. E., Apr 15 2017, In : Journal of the Neurological Sciences. 375, p. 474-475 2 p.

Research output: Contribution to journalEditorial

Suppressing N-acetyl-l-aspartate synthesis prevents loss of neurons in a murine model of Canavan leukodystrophy

Sohn, J., Bannerman, P., Guo, F., Burns, T., Miers, L., Croteau, C., Singhal, N. K., McDonough, J. A. & Pleasure, D. E., Jan 11 2017, In : Journal of Neuroscience. 37, 2, p. 413-421 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition

Singhal, N. K., Huang, H., Li, S., Clements, R., Gadd, J., Daniels, A., Kooijman, E. E., Bannerman, P., Burns, T., Guo, F., Pleasure, D. E., Freeman, E., Shriver, L. & McDonough, J., Jan 1 2017, In : Experimental Brain Research. 235, 1, p. 279-292 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Good Things Come in Threes: Genetically Engineered Neural Stem Cells Mitigate Chronic CNS Autoimmunity

Pleasure, D. E., Aug 1 2016, In : Molecular Therapy. 24, 8, p. 1338-1339 2 p.

Research output: Contribution to journalComment/debate

Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion

Jiang, P., Chen, C., Liu, X. B., Pleasure, D. E., Liu, Y. & Deng, W., May 10 2016, In : Cell Reports. 15, 6, p. 1303-1315 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mice hemizygous for a pathogenic mitofusin- 2 allele exhibit hind limb/foot gait deficits and phenotypic perturbations in nerve and muscle

Bannerman, P., Burns, T., Xu, J., Miers, L. & Pleasure, D. E., Dec 1 2016, In : PLoS One. 11, 12, e0167573.

Research output: Contribution to journalArticle

13 Scopus citations

Precision medicine for charcot-marie-tooth disease

Pleasure, D. E., Jun 1 2016, In : JAMA Neurology. 73, 6, p. 623-624 2 p.

Research output: Contribution to journalEditorial

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis

Moreno, M. A., Burns, T., Yao, P., Miers, L., Pleasure, D. E. & Soulika, A., Jan 15 2016, In : Journal of Neuroimmunology. 290, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
5 Scopus citations
2015

Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model

Guo, F., Bannerman, P., Mills Ko, E., Miers, L., Xu, J., Burns, T., Li, S., Freeman, E., McDonough, J. A. & Pleasure, D., May 1 2015, In : Annals of Neurology. 77, 5, p. 884-888 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

A brief review of recent Charcot-Marie-Tooth research and priorities

Ekins, S., Litterman, N. K., Arnold, R. J. G., Burgess, R. W., Freundlich, J. S., Gray, S. J., Higgins, J. J., Langley, B., Willis, D. E., Notterpek, L., Pleasure, D. E., Sereda, M. W. & Moore, A., Feb 26 2015, In : F1000Research. 4

Research output: Contribution to journalArticle

19 Scopus citations

Canonical Wnt signaling in the oligodendroglial lineage-puzzles remain

Guo, F., Lang, J., Sohn, J., Hammond, E., Chang, M. & Pleasure, D. E., Oct 1 2015, In : GLIA. 63, 10, p. 1671-1693 23 p.

Research output: Contribution to journalArticle

50 Scopus citations

The future of research in neuropathy

Ito, T. & Pleasure, D. E., Jan 1 2015, In : JAMA Neurology. 72, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS

Chung, S. H., Biswas, S., Selvaraj, V., Liu, X. B., Sohn, J., Jiang, P., Chen, C., Chmilewsky, F., Marzban, H., Horiuchi, M., Pleasure, D. E. & Deng, W., May 1 2015, In : Cell Death and Disease. 6, 5, e1748.

Research output: Contribution to journalArticle

10 Scopus citations

The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice

Sohn, J., Orosco, L., Guo, F., Chung, S. H., Bannerman, P., Ko, E. M., Zarbalis, K., Deng, W. & Pleasure, D. E., 2015, In : Journal of Neuroscience. 35, 9, p. 3756-3763 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

The wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of wnt/²-catenin signaling

Hammond, E., Lang, J., Maeda, Y., Pleasure, D. E., Angus-Hill, M., Xu, J., Horiuchi, M., Deng, W. & Guo, F., 2015, In : Journal of Neuroscience. 35, 12, p. 5007-5022 16 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury

Chechneva, O. V., Mayrhofer, F., Daugherty, D. J., Krishnamurty, R. G., Bannerman, P., Pleasure, D. E. & Deng, W., Jan 1 2014, In : Cell Death and Disease. 5, 10, e1481.

Research output: Contribution to journalArticle

37 Scopus citations

Astrocytes

Guo, F., Ma, J. & Pleasure, D. E., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 287-289 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chemokines

Soulika, A. & Pleasure, D. E., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 764-769 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in Mice with MOG peptide EAE

Moreno, M., Bannerman, P., Ma, J., Guo, F., Miers, L., Soulika, A. & Pleasure, D. E., 2014, In : Journal of Neuroscience. 34, 24, p. 8175-8185 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

Mills Ko, E., Ma, J. H., Guo, F., Miers, L., Lee, E., Bannerman, P., Burns, T., Ko, D., Sohn, J., Soulika, A. & Pleasure, D. E., Jun 12 2014, In : Journal of Neuroinflammation. 11, 105.

Research output: Contribution to journalArticle

28 Scopus citations

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

Orosco, L. A., Ross, A. P., Cates, S. L., Scott, S. E., Wu, D., Sohn, J., Pleasure, D. E., Pleasure, S. J., Adamopoulos, I. & Zarbalis, K., Sep 8 2014, In : Nature Communications. 5, 5692.

Research output: Contribution to journalArticle

39 Scopus citations

Neuronopathy in the motor neocortex in a chronic model of multiple sclerosis

Burns, T., Miers, L., Xu, J., Man, A., Moreno, M., Pleasure, D. E. & Bannerman, P., 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pax6 mediates β-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells

Gan, Q., Lee, A., Suzuki, R., Yamagami, T., Stokes, A., Nguyen, B. C., Pleasure, D. E., Wang, J., Chen, H. & Zhou, C., Jan 2014, In : Stem Cells. 32, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Role of astroglia in down's syndrome revealed by patient-derived human-induced pluripotent stem cells

Chen, C., Jiang, P., Xue, H., Peterson, S. E., Tran, H. T., McCann, A. E., Parast, M. M., Li, S., Pleasure, D. E., Laurent, L. C., Loring, J. F., Liu, Y. & Deng, W., Jul 18 2014, In : Nature Communications. 5, 4430.

Research output: Contribution to journalArticle

88 Scopus citations

Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus

Chetty, S., Friedman, A. R., Taravosh-Lahn, K., Kirby, E. D., Mirescu, C., Guo, F., Krupik, D., Nicholas, A., Geraghty, A. C., Krishnamurthy, A., Tsai, M. K., Covarrubias, D., Wong, A. T., Francis, D. D., Sapolsky, R. M., Palmer, T. D., Pleasure, D. E. & Kaufer, D., Dec 11 2014, In : Molecular Psychiatry. 19, 12, p. 1275-1283 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Toxic Neuropathies

Pleasure, D. E., Dec 3 2014, Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach. Elsevier Inc., p. 431-437 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates

Ito, T., Horiuchi, M., Ikeda, R. H., Xu, J., Bannerman, P., Pleasure, D. E., Penninger, J. M., Tournier, C. & Itoh, A., Aug 6 2014, In : Journal of Neuroscience. 34, 32, p. 10729-10742 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation

Zhao, T., Gan, Q., Stokes, A., Lassiter, R. N. T., Wang, Y., Chan, J., Han, J. X., Pleasure, D. E., Epstein, J. A. & Zhou, C., Jan 1 2014, In : Development (Cambridge). 141, 1, p. 148-157 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Adenomatous polyposis coli regulates oligodendroglial development

Lang, J., Maeda, Y., Bannerman, P., Xu, J., Horiuchi, M., Pleasure, D. E. & Guo, F., Feb 13 2013, In : Journal of Neuroscience. 33, 7, p. 3113-3130 18 p.

Research output: Contribution to journalArticle

54 Scopus citations

A TSPO ligand is protective in a mouse model of multiple sclerosis

Daugherty, D. J., Selvaraj, V., Chechneva, O. V., Liu, X. B., Pleasure, D. E. & Deng, W., Jun 2013, In : EMBO Molecular Medicine. 5, 6, p. 891-903 13 p.

Research output: Contribution to journalArticle

86 Scopus citations

Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells

Jiang, P., Chen, C., Liu, X. B., Selvaraj, V., Liu, W., Feldman, D. H., Liu, Y., Pleasure, D. E., Li, R. A. & Deng, W., Dec 2013, In : Stem Cells. 31, 12, p. 2620-2631 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
3 Scopus citations

hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

Jiang, P., Chen, C., Wang, R., Chechneva, O. V., Chung, S. H., Rao, M. S., Pleasure, D. E., Liu, Y., Zhang, Q. & Deng, W., 2013, In : Nature Communications. 4, 2196.

Research output: Contribution to journalArticle

40 Scopus citations

Olig2/Plp-positive progenitor cells give rise to bergmann glia in the cerebellum

Chung, S. H., Guo, F., Jiang, P., Pleasure, D. E. & Deng, W., Mar 2013, In : Cell Death and Disease. 4, 3

Research output: Contribution to journalArticle

14 Scopus citations

Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE

Moreno, M., Guo, F., Ko, E. M., Bannerman, P., Soulika, A. & Pleasure, D. E., Oct 15 2013, In : Journal of the Neurological Sciences. 333, 1-2, p. 55-59 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Whither hope for pharmacological treatment of charcot-marie-tooth disease type 1A?

Patel, P. I. & Pleasure, D., Aug 2013, In : JAMA Neurology. 70, 8, p. 969-971 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

Axon-glia synapses are highly vulnerable to white matter injury in the developing brain

Shen, Y., Liu, X. B., Pleasure, D. E. & Deng, W., Jan 2012, In : Journal of Neuroscience Research. 90, 1, p. 105-121 17 p.

Research output: Contribution to journalArticle

31 Scopus citations

Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development

Guo, F., Maeda, Y., Ko, E. M., Delgado, M., Horiuchi, M., Soulika, A., Miers, L., Burns, T., Ito, T., Shen, H., Lee, E., Sohn, J. & Pleasure, D. E., Jan 11 2012, In : Journal of Neuroscience. 32, 2, p. 639-645 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
32 Scopus citations

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia

Horiuchi, M., Wakayama, K., Itoh, A., Kawai, K., Pleasure, D. E., Ozato, K. & Ito, T., Sep 18 2012, In : Journal of Neuroinflammation. 9, 227.

Research output: Contribution to journalArticle

46 Scopus citations