David E Pleasure, MD

Professor

  • 11004 Citations
  • 59 h-Index
1966 …2018
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Projects 1976 2018

Canavan Disease
Phenotype
Acetyl Coenzyme A
Acetyltransferases
Acetates

PATHOGENESIS OF PERSISTENT VIRAL INJURY TO THE CNS

Pleasure, D. E., Lavi, E., Cohen, G., Gaulton, G., Weiss, S. R., Eisenberg, R. J. & Gonzalez-Scarano, F.

National Institutes of Health

1/1/936/30/04

Project: Research project

Cell Culture Techniques
Viral Tropism
Viruses
Herpes Simplex
Pleasure

PRIMATIVE NEURECTODERMAL TUMORS OF CHILDHOOD

Pleasure, D. E., Wong, A., Lange, B. & Phillips, P.

National Institutes of Health

9/30/929/29/95

Project: Research project

Growth Factor Receptors
Protein-Tyrosine Kinases
Carcinogenesis
Receptor Protein-Tyrosine Kinases
Cerebellar Neoplasms

NICHD MENTAL RETARDATION RESEARCH CENTER CORE GRANT

Pleasure, D. E., Pleasure, D. E., Rorke, L., Stolley, P., Parrish, J., Zasloff, M., Batshaw, M., Cnaan, A., Emanuel, B., Robinson, M. B., Ming, J., Epstein, D., Abel, E. T., Roberts, T., Putt, M. E., Kim, S., Falk, M., Zhou, Z., Golden, J., Cnaan, A., Emanuel, B., Coulter, D., Zimmerman, R., Lynch, D. R., Berlin, J., Surrey, S. & Yudkoff, M.

National Institutes of Health

8/1/9010/31/15

Project: Research project

Neurosciences
Intellectual Disability
Veterinary Schools
National Institute of Child Health and Human Development (U.S.)
Developmental Disabilities

Research Output 1966 2018

2 Citations (Scopus)

Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model

Bannerman, P., Guo, F., Chechneva, O., Burns, T., Zhu, X., Wang, Y., Kim, B., Singhal, N. K., McDonough, J. A. & Pleasure, D. E., Mar 7 2018, In : Molecular Therapy. 26, 3, p. 793-800 8 p.

Research output: Contribution to journalArticle

Canavan Disease
Brain
Gene Knockout Techniques
Acetyltransferases
Enzymes
gait
limbs (animal)
Gait
Names
Muscle

Pathophysiology and Treatment of Canavan Disease

Pleasure, D. E., Guo, F., Chechneva, O., Bannerman, P., McDonough, J., Burns, T., Wang, Y. & Hull, V., Jan 1 2018, (Accepted/In press) In : Neurochemical Research.

Research output: Contribution to journalArticle

Canavan Disease
Gene therapy
Genetic Therapy
N-acetylaspartate
2 Citations (Scopus)
Catenins
Spinal Cord Injuries
Cicatrix
Compaction
Chemical activation
1 Citation (Scopus)

Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells

Horiuchi, M., Suzuki-Horiuchi, Y., Akiyama, T., Itoh, A., Pleasure, D. E., Carstens, E. & Ito, T., Aug 1 2017, In : Journal of Neurochemistry. 142, 3, p. 378-391 14 p.

Research output: Contribution to journalArticle

Prosencephalon
Neurology
Stem Cells
Transcription Factors
Spinal Cord