Crystal M Ripplinger, PhD

Associate Professor

  • 2236 Citations
  • 24 h-Index
20012020

Research output per year

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Research Output

  • 2236 Citations
  • 24 h-Index
  • 55 Article
  • 3 Chapter
  • 3 Review article
  • 2 Editorial
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Article
2020

Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction

Wang, L., Olivas, A., Francis Stuart, S. D., Tapa, S., Blake, M. R., Woodward, W. R., Habecker, B. A. & Ripplinger, C. M., Mar 1 2020, In : American journal of physiology. Heart and circulatory physiology. 318, 3, p. H558-H565

Research output: Contribution to journalArticle

2019

Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts

Wang, L., Morotti, S., Tapa, S., Francis Stuart, S. D., Jiang, Y., Wang, Z., Myles, R. C., Brack, K. E., Ng, G. A., Bers, D. M., Grandi, E. & Ripplinger, C. M., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

2 Scopus citations

Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality

Lindsey, M. L., Jung, M., Yabluchanskiy, A., Cannon, P. L., Iyer, R. P., Flynn, E. R., DeLeon-Pennell, K. Y., Valerio, F. M., Harrison, C. L., Ripplinger, C. M., Hall, M. E. & Ma, Y., Feb 1 2019, In : Cardiovascular Research. 115, 2, p. 395-408 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Putting the pieces together using in vivo optical mapping

Wang, L. & Ripplinger, C. M., Sep 1 2019, In : Cardiovascular research. 115, 11, p. 1574-1575 2 p.

Research output: Contribution to journalArticle

Open Access
2018

Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation

Francis Stuart, S. D., Wang, L., Woodard, W. R., Ng, G. A., Habecker, B. A. & Ripplinger, C. M., Sep 1 2018, In : Journal of Physiology. 596, 17, p. 3977-3991 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model

Wang, Z., Wang, L., Tapa, S., Pinkerton, K. E., Chen, C-Y. & Ripplinger, C. M., Dec 1 2018, In : Environmental Health Perspectives. 126, 12, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility

Parrish, D. C., Francis Stuart, S. D., Olivas, A., Wang, L., Nykjaer, A., Ripplinger, C. M. & Habecker, B. A., Mar 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H415-H423

Research output: Contribution to journalArticle

5 Scopus citations
2017

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction

De Jesus, N. M., Wang, L., Lai, J., Rigor, R. R., Francis Stuart, S. D., Bers, D. M., Lindsey, M. L. & Ripplinger, C. M., 2017, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

23 Scopus citations

Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart

Lang, D., Sato, D., Jiang, Y., Ginsburg, K. S., Ripplinger, C. M. & Bers, D. M., Dec 8 2017, In : Circulation Research. 121, 12, p. 1379-1391 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics

Chiamvimonvat, N., Chen-Izu, Y., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., Izu, L. T., Qu, Z., Ripplinger, C. M., Vandenberg, J. I., Weiss, J. N., Koren, G., Banyasz, T., Grandi, E., Sanguinetti, M. C., Bers, D. M. & Nerbonne, J. M., 2017, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

32 Scopus citations

β-Adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia

Murphy, S. R., Wang, L., Wang, Z., Domondon, P., Di Lang, L., Habecker, B. A., Myles, R. C. & Ripplinger, C. M., Aug 28 2017, In : Frontiers in Physiology. 8, AUG, 630.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Habecker, B. A., Anderson, M. E., Birren, S. J., Fukuda, K., Herring, N., Hoover, D. B., Kanazawa, H., Paterson, D. J. & Ripplinger, C. M., Jul 15 2016, In : Journal of Physiology. 594, 14, p. 3853-3875 23 p.

Research output: Contribution to journalArticle

28 Scopus citations

Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation

Sirish, P., Li, N., Timofeyev, V., Zhang, X. D., Wang, L., Yang, J., Lee, K. S. S., Bettaieb, A., Ma, S. M., Lee, J. H., Su, D., Lau, V. C., Myers, R. E., Lieu, D. K., López, J. E., Young, J. N., Yamoah, E. N., Haj, F., Ripplinger, C. M., Hammock, B. D. & 1 others, Chiamvimonvat, N., May 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 5, e003721.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias

Gardner, R. T., Ripplinger, C. M., Myles, R. C. & Habecker, B. A., Feb 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 2, e001359.

Research output: Contribution to journalArticle

24 Scopus citations

Myocardial infarction causes transient cholinergic transdifferentiation of cardiac sympathetic nerves via gp130

Olivas, A., Gardner, R. T., Wang, L., Ripplinger, C. M., Woodward, W. R. & Habecker, B. A., Jan 13 2016, In : Journal of Neuroscience. 36, 2, p. 479-488 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

The nervous heart

Ripplinger, C. M., Noujaim, S. F. & Linz, D., Jan 1 2016, In : Progress in Biophysics and Molecular Biology. 120, 1-3, p. 199-209 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

A leap(frog) forward in understanding focal arrhythmia

Ripplinger, C. M., Mar 15 2015, In : Journal of Physiology. 593, 6, p. 1383-1384 2 p.

Research output: Contribution to journalArticle

Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation

De Jesus, N. M., Wang, L., Herren, A. W., Wang, J., Shenasa, F., Bers, D. M., Lindsey, M. L. & Ripplinger, C. M., Jan 1 2015, In : Heart Rhythm. 12, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation

Hammer, K. P., Ljubojevic, S., Ripplinger, C. M., Pieske, B. M. & Bers, D. M., Jul 1 2015, In : Journal of Molecular and Cellular Cardiology. 84, p. 1-9 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
20 Scopus citations

Dual Vm/Ca Imaging of Premature Ventricular Contractions: Bridging the Gap of Anatomical Scales

Ripplinger, C. M. & Efimov, I. R., Jun 4 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 3, p. 529-530 2 p.

Research output: Contribution to journalArticle

Ion channels in the heart

Bartos, D. C., Grandi, E. & Ripplinger, C. M., Jul 1 2015, In : Comprehensive Physiology. 5, 3, p. 1423-1464 42 p.

Research output: Contribution to journalArticle

45 Scopus citations
6 Scopus citations

Recent developments in biophysics & molecular biology of heart rhythm

Quinn, T. A. & Ripplinger, C. M., 2015, (Accepted/In press) In : Progress in Biophysics and Molecular Biology.

Research output: Contribution to journalArticle

Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

Gardner, R. T., Wang, L., Lang, B. T., Cregg, J. M., Dunbar, C. L., Woodward, W. R., Silver, J., Ripplinger, C. M. & Habecker, B. A., 2015, In : Nature Communications. 6, 6235.

Research output: Contribution to journalArticle

39 Scopus citations
2014

Invivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis

Satkunananthan, P. B., Anderson, M. J., De Jesus, N. M., Haudenschild, D. R., Ripplinger, C. M. & Christiansen, B. A., Oct 1 2014, In : Osteoarthritis and Cartilage. 22, 10, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: Ryanodine receptor refractoriness during alternans and fibrillation

Wang, L., Myles, R. C., De Jesus, N. M., Ohlendorf, A. K. P., Bers, D. M. & Ripplinger, C. M., Apr 25 2014, In : Circulation Research. 114, 9, p. 1410-1421 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9

DeLeon-Pennell, K. Y., de Castro Brás, L. E., Iyer, R. P., Bratton, D. R., Jin, Y. F., Ripplinger, C. M. & Lindsey, M. L., Nov 1 2014, In : Journal of Molecular and Cellular Cardiology. 76, p. 218-226 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

Erickson, J. R., Pereira, L., Wang, L., Han, G., Ferguson, A., Dao, K., Copeland, R. J., Despa, F., Hart, G. W., Ripplinger, C. M. & Bers, D. M., 2013, In : Nature. 502, 7471, p. 372-376 5 p.

Research output: Contribution to journalArticle

281 Scopus citations

Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes

Feinberg, A. W., Ripplinger, C. M., Van Der Meer, P., Sheehy, S. P., Domian, I., Chien, K. R. & Parker, K. K., Nov 19 2013, In : Stem Cell Reports. 1, 5, p. 387-396 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2012

A tissue-engineered jellyfish with biomimetic propulsion

Nawroth, J. C., Lee, H., Feinberg, A. W., Ripplinger, C. M., McCain, M. L., Grosberg, A., Dabiri, J. O. & Parker, K. K., Aug 2012, In : Nature Biotechnology. 30, 8, p. 792-797 6 p.

Research output: Contribution to journalArticle

319 Scopus citations

Bionic jellyfish

Nawroth, J. C., Lee, H., Feinberg, A. W., Ripplinger, C. M., McCain, M. L., Grosberg, A., Dabiri, J. O. & Parker, K. K., Oct 1 2012, In : Assay and Drug Development Technologies. 10, 5, p. 397-399 3 p.

Research output: Contribution to journalArticle

Contractile and electrophysiologic characterization of optimized self-organizing engineered heart tissue

Sondergaard, C. S., Mathews, G., Wang, L., Jeffreys, A., Sahota, A., Wood, M., Ripplinger, C. M. & Si, M. S., Oct 2012, In : Annals of Thoracic Surgery. 94, 4, p. 1241-1249 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

Feinberg, A. W., Alford, P. W., Jin, H., Ripplinger, C. M., Werdich, A. A., Sheehy, S. P., Grosberg, A. & Parker, K. K., Aug 2012, In : Biomaterials. 33, 23, p. 5732-5741 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Human biological pacemakers intrinsic variability and stability: Editorial

Ripplinger, C. M. & Bers, D. M., Feb 21 2012, In : Circulation. 125, 7, p. 856-858 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inflammation modulates murine venous thrombosis resolution in vivo: Assessment by multimodal fluorescence molecular imaging

Ripplinger, C. M., Kessinger, C. W., Li, C., Kim, J. W., McCarthy, J. R., Weissleder, R., Henke, P. K., Lin, C. P. & Jaffer, F. A., Nov 2012, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 11, p. 2616-2624 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia

Myles, R. C., Wang, L., Kang, C., Bers, D. M. & Ripplinger, C. M., May 25 2012, In : Circulation Research. 110, 11, p. 1454-1464 11 p.

Research output: Contribution to journalArticle

87 Scopus citations
2011

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

Moreno, J. D., Zhu, Z. I., Yang, P. C., Bankston, J. R., Jeng, M. T., Kang, C., Wang, L., Bayer, J. D., Christini, D. J., Trayanova, N. A., Ripplinger, C. M., Kass, R. S. & Clancy, C. E., Aug 31 2011, In : Science Translational Medicine. 3, 98, 98ra83.

Research output: Contribution to journalArticle

140 Scopus citations

Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy

Ambrosi, C. M., Ripplinger, C. M., Efimov, I. R. & Fedorov, V. V., Jan 2011, In : Heart Rhythm. 8, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2009

Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction

Li, W., Ripplinger, C. M., Lou, Q. & Efimov, I. R., Jul 2009, In : Heart Rhythm. 6, 7, p. 1020-1027 8 p.

Research output: Contribution to journalArticle

40 Scopus citations
45 Scopus citations

Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms

Lombardi, R., Rodriguez, G., Chen, S. N., Ripplinger, C. M., Li, W., Chen, J., Willerson, J. T., Betocchi, S., Wickline, S. A., Efimov, I. R. & Marian, A. J., Mar 17 2009, In : Circulation. 119, 10, p. 1398-1407 10 p.

Research output: Contribution to journalArticle

83 Scopus citations
2008

Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue

Hucker, W. J., Ripplinger, C. M., Fleming, C. P., Fedorov, V. V., Rollins, A. M. & Efimov, I. R., 2008, In : Journal of Biomedical Optics. 13, 5, 054012.

Research output: Contribution to journalArticle

30 Scopus citations

Quantification of cardiac fiber orientation using optical coherence tomography

Fleming, C. P., Ripplinger, C. M., Webb, B., Efimov, I. R. & Rollins, A. M., 2008, In : Journal of Biomedical Optics. 13, 3, 030505.

Research output: Contribution to journalArticle

53 Scopus citations

Quantitative panoramic imaging of epicardial electrical activity

Lou, Q., Ripplinger, C. M., Bayly, P. V. & Efimov, I. R., Oct 2008, In : Annals of Biomedical Engineering. 36, 10, p. 1649-1658 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Effects of pacing rate on mechanical restitution within the in vivo canine heart: Study of the force-frequency relationship

Ahlberg, S. E., Ripplinger, C. M., Skadsberg, N. D., Iaizzo, P. A. & Mulligan, L. J., Feb 2007, In : Journal of Cardiovascular Electrophysiology. 18, 2, p. 212-217 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy

Ripplinger, C. M., Li, W., Hadley, J., Chen, J., Rothenberg, F., Lombardi, R., Wickline, S. A., Marian, A. J. & Efimov, I. R., Nov 2007, In : Circulation Research. 101, 10, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

Qu, F., Ripplinger, C. M., Nikolski, V. P., Grimm, C. & Efimov, I. R., Jul 2007, In : Journal of Biomedical Optics. 12, 4, 044019.

Research output: Contribution to journalArticle

35 Scopus citations