• 5093 Citations
  • 41 h-Index
1973 …2016

Research output per year

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Research Output

  • 5093 Citations
  • 41 h-Index
  • 142 Article
  • 3 Chapter
  • 1 Conference contribution
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Article
2016

Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice

Carratt, S. A., Morin, D., Buckpitt, A. R., Edwards, P. C. & Van Winkle, L. S., Mar 30 2016, In : Toxicology Letters. 246, p. 35-41 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene

Kültz, D., Li, J., Sacchi, R., Morin, D., Buckpitt, A. R. & Van Winkle, L., Aug 1 2015, In : Proteomics. 15, 15, p. 2655-2668 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Simultaneous quantification of multiple urinary naphthalene metabolites by liquid chromatography tandem mass spectrometry

Ayala, D. C., Morin, D. & Buckpitt, A. R., Apr 8 2015, In : PLoS One. 10, 4, e0121937.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts

Schebb, N. H., Muvvala, J. B., Morin, D., Buckpitt, A. R., Hammock, B. D. & Rice, R. H., 2014, In : Drug Metabolism and Disposition. 42, 7, p. 1098-1102 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene

Cichocki, J. A., Smith, G. J., Mendoza, R., Buckpitt, A. R., Van winkle, L. S. & Morris, J. B., 2014, In : Toxicological Sciences. 139, 1, p. 234-244 11 p., kfu031.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey

Buckpitt, A. R., Morin, D., Murphy, S., Edwards, P. & Van Winkle, L., Jul 5 2013, In : Toxicology and Applied Pharmacology. 270, 2, p. 97-105 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry

Pham, N. T., Jewell, W. T., Morin, D. & Buckpitt, A. R., Aug 30 2012, In : Chemico-Biological Interactions. 199, 2, p. 120-128 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry

Pham, N. T., Jewell, W. T., Morin, D., Jones, A. D. & Buckpitt, A. R., Aug 3 2012, In : PLoS One. 7, 8, e42053.

Research output: Contribution to journalArticle

10 Scopus citations

Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma

Plopper, C., Joad, J. P., Miller, L., Schelegle, E. S., Fanucchi, M. V., Van Winkle, L. S., Tyler, N. K., Avdalovic, M. V., Evans, M. J., Lasley, W. L., Buckpitt, A. R., Pinkerton, K. E., Tarkington, B. K., Davis, S., Nishio, S. J., Gershwin, L. J., Wu, R. & Hyde, D. M., Jul 2012, In : Clinical and Experimental Allergy. 42, 7, p. 1104-1118 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: Species comparisons

DeStefano-Shields, C., Morin, D. & Buckpitt, A. R., May 2010, In : Environmental Health Perspectives. 118, 5, p. 647-652 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Free flow electrophoresis separation and AMS quantitation of 14C-naphthalene-protein adducts

Buchholz, B. A., Haack, K. W., Sporty, J. L., Buckpitt, A. R. & Morin, D., Apr 2010, In : Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 268, 7-8, p. 1324-1327 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate

Spiess, P. C., Morin, D., Williams, C. R. & Buckpitt, A. R., Sep 1 2010, In : American Journal of Respiratory Cell and Molecular Biology. 43, 3, p. 316-325 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2009

Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization

DiMaio Knych, H. K., DeStefano Shields, C., Buckpitt, A. R. & Stanley, S. D., May 1 2009, In : Archives of Biochemistry and Biophysics. 485, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Toxicity and metabolism of methylnaphthalenes: Comparison with naphthalene and 1-nitronaphthalene

Lin, C. Y., Wheelock, Å. M., Morin, D., Baldwin, R. M., Lee, M. G., Taff, A., Plopper, C., Buckpitt, A. R. & Rohde, A., Jun 16 2009, In : Toxicology. 260, 1-3, p. 16-27 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Upper respiratory tract uptake of naphthalene

Morris, J. B. & Buckpitt, A. R., 2009, In : Toxicological Sciences. 111, 2, p. 383-391 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase

Morisseau, C., Newman, J. W., Wheelock, C. E., Hill, T., Morin, D., Buckpitt, A. R. & Hammock, B. D., Apr 2008, In : Chemical Research in Toxicology. 21, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Measurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysis

Spiess, P. C., Morin, D., Jewell, W. T. & Buckpitt, A. R., May 2008, In : Chemical Research in Toxicology. 21, 5, p. 1074-1085 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
19 Scopus citations
2007

Asthma/allergic airways disease: Does postnatal exposure to environmental toxicants promote airway pathobiology?

Plopper, C., Smiley-Jewell, S. M., Miller, L., Fanucchi, M. V., Evans, M. J., Buckpitt, A. R., Avdalovic, M. V., Gershwin, L. J., Joad, J. P., Kajekar, R., Larson, S., Pinkerton, K. E., Van Winkle, L. S., Schelegle, E. S., Pieczarka, E. M., Wu, R. & Hyde, D. M., Jan 2007, In : Toxicologic Pathology. 35, 1, p. 97-110 14 p.

Research output: Contribution to journalArticle

57 Scopus citations
29 Scopus citations
2006

Asthma: A comparison of animal models using stereological methods

Hyde, D. M., Miller, L., Schelegle, E. S., Fanucchi, M. V., Van Winkle, L. S., Tyler, N. K., Avdalovic, M. V., Evans, M. J., Kajekar, R., Buckpitt, A. R., Pinkerton, K. E., Joad, J. P., Gershwine, L. J., Wu, R. & Plopper, C., Dec 1 2006, In : European Respiratory Review. 15, 101, p. 122-135 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques

Lin, C. Y., Boland, B. C., Lee, Y. J., Salemi, M. R., Morin, D., Miller, L., Plopper, C. & Buckpitt, A. R., Feb 2006, In : Proteomics. 6, 3, p. 972-982 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis

Wheelock, Å. M., Morin, D., Bartosiewicz, M. & Buckpitt, A. R., Mar 2006, In : Proteomics. 6, 5, p. 1385-1398 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2005

Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4

Baldwin, R. M., Shultz, M. A. & Buckpitt, A. R., Feb 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 857-865 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes

Lin, C. Y., Isbell, M. A., Morin, D., Boland, B. C., Salemi, M. R., Jewell, W. T., Weir, A. J., Fanucchi, M. V., Baker, G. L., Plopper, C. & Buckpitt, A. R., May 2005, In : Chemical Research in Toxicology. 18, 5, p. 802-813 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells

Schoenfeld, R. A., Napoli, E., Wong, A., Zhan, S., Reutenauer, L., Morin, D., Buckpitt, A. R., Taroni, F., Lonnerdal, B., Ristow, M., Puccio, H. & Cortopassi, G. A., Dec 15 2005, In : Human Molecular Genetics. 14, 24, p. 3787-3799 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Identification of proteins adducted by reactive naphthalene metabolites in vitro

Isbell, M. A., Morin, D., Boland, B., Buckpitt, A. R., Salemi, M. & Presley, J., Nov 2005, In : Proteomics. 5, 16, p. 4197-4204 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
27 Scopus citations

In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung

Wheelock, Å. M., Boland, B. C., Isbell, M., Morin, D., Wegesser, T. C., Plopper, C. & Buckpitt, A. R., Aug 2005, In : American Journal of Respiratory Cell and Molecular Biology. 33, 2, p. 130-137 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
7 Scopus citations

Software-induced variance in two-dimensional gel electrophoresis image analysis

Wheelock, Å. M. & Buckpitt, A. R., Dec 2005, In : Electrophoresis. 26, 23, p. 4508-4520 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
2004

Assessing gene expression in lung subcompartments utilizing in situ RNA preservation

Baker, G. L., Shultz, M. A., Fanucchi, M. V., Morin, D. M., Buckpitt, A. R. & Plopper, C., Jan 2004, In : Toxicological Sciences. 77, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Comparison of Pulmonary/Nasal CYP2F Expression Levels in Rodents and Rhesus Macaque

Baldwin, R. M., Jewell, W. T., Fanucchi, M. V., Plopper, C. & Buckpitt, A. R., Apr 2004, In : Journal of Pharmacology and Experimental Therapeutics. 309, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Gene Expression Analysis in Response to Lung Toxicants: I. Sequencing and Microarray Development

Shultz, M. A., Zhang, L., Gu, Y. Z., Baker, G. L., Fannuchi, M. V., Padua, A. M., Gurske, W. A., Morin, D., Penn, S. G., Jovanovich, S. B., Plopper, C. G. & Buckpitt, A. R., Mar 2004, In : American Journal of Respiratory Cell and Molecular Biology. 30, 3, p. 296-310 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice

Phimister, A. J., Lee, M. G., Morin, D., Buckpitt, A. R. & Plopper, C., Nov 2004, In : Toxicological Sciences. 82, 1, p. 268-278 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity

Wheelock, Å. M., Zhang, L., Tran, M. U., Morin, D., Penn, S., Buckpitt, A. R. & Ploppet, C. G., Feb 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 2 30-2

Research output: Contribution to journalArticle

29 Scopus citations

Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques

Boland, B., Lin, C. Y., Morin, D., Miller, L., Plopper, C. & Buckpitt, A. R., Aug 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2003

Measurement of glutathione conjugates.

Shultz, M. A., Morin, D., Chan, K. W. & Buckpitt, A. R., 2003, In : Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]. Chapter 6

Research output: Contribution to journalArticle

2002

IARC Monographs on the evaluation of carcinogenic risks to humans: Some traditional herbal medicines, some mycotoxins, naphthalene and styrene

Anttila, A., Bhat, R. V., Bond, J. A., Borghoff, S. J., Bosch, F. X., Carlson, G. P., Castegnaro, M., Cruzan, G., Gelderblom, W. C. A., Hass, U., Henry, S. H., Herbert, R. A., Jackson, M., Jiang, T., Kinghorn, A. D., Knasmüller, S., Levy, L., McGregor, D., Miller, J. D., Mori, H. & 34 others, Olin, S. S., Park, D. L., Pitt, J. I., Riley, R. T., Schmeiser, H. H., Siemiatycki, J., Vanherweghem, J. L., Wild, C. P., Yoshizawa, T., Buckpitt, A. R., Coates, P. M., Foureman, G. L., Green, T., Jameson, C. W., Longfellow, D., Baan, R., Bird, M., Cheney, J., Franceschi, S., Friesen, M., Grosse, Y., Junghans, T., Napalkov, N., Partensky, C., Rice, J., Sewram, V., Stayner, L., Straif, K., Suonio, E., Egraz, S., Kajo, B., Lézère, M., Mitchell, J. & Perez, E., 2002, In : IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 82

Research output: Contribution to journalArticle

39 Scopus citations

Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool

West, J. A. A., Williams, K. J., Toskala, E., Nishio, S. J., Fleschner, C. A., Forman, H. J., Buckpitt, A. R. & Plopper, C., 2002, In : American Journal of Pathology. 160, 3, p. 1115-1127 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Naphthalene-induced respiratory tract toxicity: Metabolic mechanisms of toxicity

Buckpitt, A. R., Boland, B., Isbell, M., Morin, D., Shultz, M., Baldwin, R., Chan, K., Karlsson, A., Lin, C., Taff, A., West, J., Fanucchi, M., Van Winkle, L. & Plopper, C., 2002, In : Drug Metabolism Reviews. 34, 4, p. 791-820 30 p.

Research output: Contribution to journalArticle

101 Scopus citations

Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration

Giri, S. N., Wang, Q., Xie, Y., Lango, J., Morin, D., Margolin, S. B. & Buckpitt, A. R., Jul 2002, In : Biopharmaceutics and Drug Disposition. 23, 5, p. 203-211 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivlty of naphthalene epoxidation

Pakenham, G., Lango, J., Buonarati, M., Morin, D. & Buckpitt, A. R., 2002, In : Drug Metabolism and Disposition. 30, 3, p. 247-253 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2001

Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae)

Schelegle, E. S., Gershwin, L. J., Miller, L., Fanucchi, M. V., Van Winkle, L. S., Gerriets, J. P., Walby, W. F., Omlor, A. M., Buckpitt, A. R., Tarkington, B. K., Wong, V. J., Joad, J. P., Pinkerton, K. E., Wu, R., Evans, M. J., Hyde, D. M. & Plopper, C., 2001, In : American Journal of Pathology. 158, 1, p. 333-341 9 p.

Research output: Contribution to journalArticle

91 Scopus citations
148 Scopus citations

Early events in naphthalene-induced acute Clara cell toxicity II. Comparison of glutathione depletion and histopathology by airway location

Plopper, C., Van Winkle, L. S., Fanucchi, M. V., Malburg, S. R. C., Nishio, S. J., Chang, A. & Buckpitt, A. R., 2001, In : American Journal of Respiratory Cell and Molecular Biology. 24, 3, p. 272-281 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Factors modulating the epithelial response to toxicants in tracheobronchial airways

Plopper, C., Buckpitt, A. R., Evans, M., Van Winkle, L., Fanucchi, M., Smiley-Jewell, S., Lakritz, J., West, J., Lawson, G., Paige, R., Miller, L. & Hyde, D., Mar 7 2001, In : Toxicology. 160, 1-3, p. 173-180 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats

West, J. A. A., Pakehham, G., Morin, D., Fleschner, C. A., Buckpitt, A. R. & Plopper, C., Jun 1 2001, In : Toxicology and Applied Pharmacology. 173, 2, p. 114-119 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments

Shultz, M. A., Morin, D., Chang, A. M. & Buckpitt, A. R., 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 2, p. 510-519 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants

Bartosiewicz, M. J., Jenkins, D., Penn, S., Emery, J. & Buckpitt, A. R., Jun 2001, In : Journal of Pharmacology and Experimental Therapeutics. 297, 3, p. 895-905 11 p.

Research output: Contribution to journalArticle

127 Scopus citations