Nephrology

Research Output 2000 2017

2017
11 Citations (Scopus)

Glutamine addiction in kidney cancer suppresses oxidative stress and can be exploited for real-time imaging

Abuaboud, O., Habib, S. L., Trott, J., Stewart, B., Liang, S., Chaudhari, A., Sutcliffe, J. & Weiss, R. H., Dec 1 2017, In : Cancer Research. 77, 23, p. 6746-6758 13 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Glutamine
Renal Cell Carcinoma
Glutaminase
Oxidative Stress
22 Citations (Scopus)

Metabolic reprogramming in clear cell renal cell carcinoma

Wettersten, H. I., Abuaboud, O., Lara, P. N. & Weiss, R. H., Jul 1 2017, In : Nature Reviews Nephrology. 13, 7, p. 410-419 10 p.

Research output: Contribution to journalReview article

Renal Cell Carcinoma
Drug Repositioning
Neoplasms
Citric Acid Cycle
Poisons
2016
2 Citations (Scopus)

Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease

Hwang, V. J., Zhou, X., Chen, X., Trott, J., Abuaboud, O., Shim, K., Dionne, L. K., Chmiel, K. J., Senapedis, W., Baloglu, E., Mahjoub, M. R., Li, X. & Weiss, R. H., Jul 26 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Catenins
Niacinamide
Transferases
NAD
24 Citations (Scopus)

Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth

Abuaboud, O., Chen, C-H., Senapedis, W., Baloglu, E., Argueta, C. & Weiss, R. H., Sep 1 2016, In : Molecular Cancer Therapeutics. 15, 9, p. 2119-2129 11 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Renal Cell Carcinoma
Growth
Catenins
Neoplasms
2 Citations (Scopus)
Epidemiology
Salmonella
Dairies
dairy cattle
epidemiology
11 Citations (Scopus)

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer

Trott, J. F., Kim, J., Abuaboud, O., Wettersten, H., Stewart, B., Berryhill, G., Uzal, F. A., Hovey, R. C., Chen, C-H., Anderson, K., Graef, A., Sarver, A. L., Modiano, J. F. & Weiss, R. H., 2016, In : Oncotarget. 7, 41, p. 66540-66557 18 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Renal Cell Carcinoma
Tryptophan
Interferons
Indoleamine-Pyrrole 2,3,-Dioxygenase
2015
67 Citations (Scopus)

Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis

Wettersten, H. I., Hakimi, A. A., Morin, D., Bianchi, C., Johnstone, M. E., Donohoe, D. R., Trott, J. F., Abuaboud, O., Stirdivant, S., Neri, B., Wolfert, R., Stewart, B., Perego, R., Hsieh, J. J. & Weiss, R. H., Jun 15 2015, In : Cancer Research. 75, 12, p. 2541-2552 12 p.

Research output: Contribution to journalArticle

Metabolomics
Kidney Neoplasms
Renal Cell Carcinoma
Proteomics
Metabolic Networks and Pathways
11 Citations (Scopus)

PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth

Abuaboud, O., Donohoe, D., Bultman, S., Fitch, M., Riiff, T., Hellerstein, M. & Weiss, R. H., Jun 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 11, p. C890-C898

Research output: Contribution to journalArticle

Peroxisome Proliferators
Kidney Neoplasms
Metabolic Networks and Pathways
Renal Cell Carcinoma
Glycolysis
2013
24 Citations (Scopus)

Inhibition of PPARα Induces Cell Cycle Arrest and Apoptosis, and Synergizes with Glycolysis Inhibition in Kidney Cancer Cells

Abuaboud, O., Wettersten, H. I. & Weiss, R. H., Aug 7 2013, In : PLoS One. 8, 8, e71115.

Research output: Contribution to journalArticle

kidney neoplasms
Peroxisome Proliferator-Activated Receptors
Kidney Neoplasms
glycolysis
Glycolysis
48 Citations (Scopus)

New opportunities from the cancer metabolome

Abuaboud, O. & Weiss, R. H., Jan 2013, In : Clinical Chemistry. 59, 1, p. 138-146 9 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolome
Metabolites
Neoplasms
Oncology
2012
66 Citations (Scopus)

Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis

Ganti, S., Taylor, S. L., Abuaboud, O., Yang, J., Evans, C. P., Osier, M. V., Alexander, D. C., Kim, K. & Weiss, R. H., Jul 15 2012, In : Cancer Research. 72, 14, p. 3471-3479 9 p.

Research output: Contribution to journalArticle

Metabolomics
Tumor Biomarkers
Kidney
Urine
Serum
2000
3 Citations (Scopus)
Platelet-Derived Growth Factor
Cell proliferation
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle